Abstract:DESCRIPTION (provided by applicant): Cancers selected for the NIH's The Cancer Genome Atlas (TCGA) project have been chosen because of their poor prognosis and overall public health impact. Select tissue samples have been profiled for gene and miRNA expression, promoter methylation, DNA… more
Abstract:This Small Business Technology Transfer Research (STTR) Phase I project is seeking to develop a novel cost-effective strategy to modify dental implants with biomimetic nanofibers for controlled regeneration of gingival tissue. In order to seal the dental implants from bacteria and consequently… more
Abstract:DESCRIPTION (provided by applicant): Globally, an estimated 16.2% of the human population is infected with HSV-2 including gt17% of the U.S. adult population. Genital herpes is associated with an increased risk of HIV acquisition and transmission and HSV-2infection can cause neonatal herpes with… more
Abstract:Burkholderia pseudomallei and Burkholderia mallei are highly pathogenic Gram-negative bacteria and the causative agents of melioidosis and glanders, respectively. These infections, which occur in humans and other animals, are endemic is wide regions of the developing world. Translational research… more
Abstract:DESCRIPTION (provided by applicant): Protein-RNA interactions make a profound contribution to the regulatory logic of post- transcriptional control of gene expression. Tools to decipher this intricate layer of molecular interactions on a global scale are coming to the forefront of molecular biology… more
Abstract:DESCRIPTION (provided by applicant): Babesia microti, the primary etiologic agent of human babesiosis, is a tick borne eukaryotic apicomplexan pathogen that is an increasing threat to the US public health. Although B. microti is primarily a tick borne pathogen, it can be transmitted by transfusion… more
Abstract:DESCRIPTION (provided by applicant): Ophthalmic vascular diseases impact millions of Americans. Age-related macular degeneration and diabetic retinopathy are the two major diseases with a well- known vascular factor. The role of the vascular system in glaucoma and retinopathy of prematurity is more… more
Abstract:DESCRIPTION (provided by applicant): Each year, over 20 million ophthalmic surgeries are performed worldwide. Indications for ophthalmic surgery include potentially blinding diseases, such as cataracts, diabetic retinopathy, macular disease, and retinal detachment. Surgeons performing these delicate… more
Abstract:DESCRIPTION (provided by applicant): In this study, we propose a Non-Destructive Molecular Extraction (NDME) platform to perform quantitative proteomics analysis of FFPE specimens with SILAC cell dot controls. The NDME technique can directly extract proteins from a single fixed tissue section… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will focus on the understanding, development, and commercialization of new ultra-softening shape memory polymer (SMP) systems for use as novel earpiece materials. Currently, earpieces such as earphones and earplugs utilize tough,… more
Abstract:DESCRIPTION (provided by applicant): Depression, dementia, schizophrenia, substance abuse, developmental disorders and speech- related disabilities can feature impairments in the ability to express emotions. Development of treatments for these impairmentspresents a formidable challenge. In this… more
Abstract:PROJECT SUMMARY Cardiac valve repair or replacement is indicated when progression of degenerative disease or bacterial infection of the native valve results in valvular dysfunction, thereby impacting cardiac output. Both procedures require the use of a woven or knitted polyester material with an… more
Abstract:DESCRIPTION (provided by applicant): Fungal infections, particularly in immunocompromised patients, are a serious and growing problem. Although antifungal therapeutics have improved greatly, failures and relapse are common. Aspergillus fumigatus is a primary cause of these infections in several… more
Abstract:ABSTRACT: Mid-wave infrared (MWIR) imagers that possess more integrated on-chip capabilities are desired for military applications such as miniature seekers for strapped down weapons or for small unmanned air systems (SUAS). High operating temperature (HOT) MWIR detectors have raised the operating… more
Abstract:Instruments employing X-ray, gamma ray and particle detection are utilized in different sectors from medicine to industry and from basic to applied science. The solid-state detector array with detection ASIC is the primary technology of space-based high-energy astronomy missions that are managed by… more
Abstract:NASA/JPL thermopile detector linear arrays, wire bonded to Black Forest Engineering (BFE) CMOS readout integrated circuits (ROICs), have been utilized in NASA missions such as the Mars Climate Sounder (MCS) and the Diviner Lunar Radiometer Experiment (DLRE). JPL linear array thermopile detectors are… more
Abstract:One of the major benefits of tactical cloud computing is improved net-centric capabilities and operations with the objective of information dominance. The reassign-able pools of computing resources and efficient information across operational boundaries can produce a more accurate and up to date… more
Abstract:Our objective is to develop an innovative cognitive knowledge-aided information processing framework to take very high rate intelligence data streams over wide areas and autonomously highlight Areas-of-Interest (AOIs) and targets for the image analyst without a priori knowledge of the area or… more
Abstract:Vehicle fires from FEM/IED attacks present multiple threats to personnel; an initial short duration fire from the products of combustion/explosion of the FEM/IED and a secondary, longer duration fire from ignition of vehicle fuel, tires, engine, or the surrounding environment. The Marines are… more
Abstract:ABSTRACT: ASTM standards exist currently to characterize various combustion characteristics of flammable chemicals such as flammability limits, flash point, minimum ignition energy, and auto ignition temperature. There are no such well-accepted characterization protocols for hot surface ignition… more
Abstract:To reduce the cost of space travel, NASA is developing In-Situ Resource Utilization (ISRU) methods to collect and convert local resources into products that can be used during the mission. Towards this objective, BlazeTech is proposing the development of an innovative system to filter Mars dust from… more
Abstract:Thermal injury is common in military conflicts due primarily to the widespread use of explosive devices. Though scar formation is a natural process of wound healing, burns can produce scars that are excessive, physically debilitating and functionally damaging. Synedgen has demonstrated the efficacy… more
Abstract:Radiotherapy is a well-established treatment for cancer, however pelvic radiotherapy can result in radiation proctitis, particularly after treatment of prostate or cervical cancer. In severe cases, radiation proctitis can result in the need to reduce the intensity of radiotherapy, ultimately… more
Abstract:BlueRISC's proposed solution provides a fundamentally new approach to enable autonomous detection of exploitation attempts as well as healing of
silent vulnerabilities. It follows a hybrid approach consisting of (i) new static silent vulnerability point and associated path… more
Abstract:The proposed SW-dMTM mobile security solution is lean and fully-software-based. The goal is to provide the required Roots of Trust (RoTs) and
trusted security services via a fully software implementation while maintaining the heightened level of assurance typically only achieved through
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