Abstract:DESCRIPTION (provided by applicant): Prior to the advent of capsule endoscopes (CE), imaging and examination of the small bowel was difficult. Today, a patient swallows the capsule with an imaging camera, which is then carried passively through the gastrointestinal (GI) tract by peristalsis. The… more
Abstract:DESCRIPTION (provided by applicant): Koronis Biomedical Technologies (KBT) proposes to develop an inhaler training system for respiratory educators with the goal of improving patients' use of dry powder inhalers (DPIs) and pressurized metered dose inhalers(pMDIs) appropriately. Studies have… more
Abstract:DESCRIPTION (provided by applicant): In this phase I project, Koronis Biomedical Technologies (KBT) proposes to develop an electroencephalography (EEG) based neurofeedback video game to enable individuals to improve neurocognitive processes associated withAttention Deficit Hyperactivity Disorder… more
Abstract:DESCRIPTION (provided by applicant): This project proposes to develop and evaluate a hand rehabilitation system for chronic hemiparetic stroke survivors that have lost their ability to full control their hand. Stroke is the leading cause of adult disability, and is the third leading cause of death… more
Abstract:Project Summary/Abstract Koronis Biomedical Technology Corporation (KBT) proposes to develop and evaluate a miniature ultra-low power pulse oximeter for long-term wearable monitoring. There continues to be a clinical need for an unobtrusive pulse oximetersensor that is small and can be worn… more
Abstract:DESCRIPTION (provided by applicant): The mission of CarboNix LLC is the clinically effective abatement of common indoor allergens that cause allergic reactions and frequently induce asthma, especially in economically-disadvantaged children. CarboNix LLC proposes a Phase II SBIR research program that… more
Abstract:DESCRIPTION (provided by applicant): This project aims to generate blood tests for: 1. mild cognitive impairment (MCI), and 2. conversion risk from MCI to full-blown Alzheimer's disease (AD). We have reported that systemic footprints, increases in key micro- RNA (miR) levels, are identifiable… more
Abstract:DESCRIPTION (provided by applicant): B-precursor acute lymphoblastic leukemia (BPL) is the most common form of cancer in children and adolescents. This project addresses an urgent and unmet need for the treatment of aggressive, treatment refractory BPL. Two recent studies have found a deletion of… more
Abstract:DESCRIPTION (provided by applicant): Severe oxalate-related conditions such as primary hyperoxaluria (PH), secondary hyperoxaluria (SH) (as a result of short bowel syndrome, chronic inflammatory bowel disease, cystic fibrosis, post bariatric, and other malabsorption syndromes), Zellweger spectrum… more
Abstract:The overall goal of this Phase I SBIR application is to develop a non-cell-based means of inhibiting coagulation and platelet activation on engineered vascular grafts, so that small-diameter arterial grafts may be available off the shelf. This arterial graft will consist of human engineered tissue… more
Abstract:DESCRIPTION (provided by applicant): The goal of this Phase IIB SBIR application is to test the Sentien cellular bioreactor product (the Sentinel ) in a first-in-man study to assess safety and preliminary efficacy. Fifteen post-cardiac surgery patients that are diagnosed with acute kidney injury and… more
Abstract:DESCRIPTION (provided by applicant): Non-small cell lung cancer (NSCLC) is the most common lung cancer. Half of NSCLC shows WNT activation, marking poor survival. StemSynergy Therapeutics Inc (SSTI) has identified a family of WNT inhibitors based on a novel chemical scaffold, with our lead molecule… more
Abstract:The objective of the proposed work is to determine whether Dioxide Materials' miniature C02 sensors have the potential to be adapted for autonomous measurement of ocean carbon. The existing sensors have many advantages for measurements of ocean carbon. They are much smaller and less costly than… more
Abstract:ABSTRACT: The objective of this project is to move an energy efficient process for the conversion of carbon dioxide and water into syngas, a key feedstock for the production of synthetic chemicals. BENEFIT: If we are successful we will have a new process to convert air water and sunlight into… more
Abstract:Abstract Chronic pain occurs in a social context, frequently impacting couples in a committed relationship. Most couples have a reciprocal influence on one another. Partners of people with chronic pain are both affected by pain and may play a (positive ornegative) role in pain management. Depending… more
Abstract:DESCRIPTION (provided by applicant): Asthma is increasingly common and expensive. Current estimates place the number of people in the US with asthma at over 25M. Asthma accounts for one-quarter of all emergency room visits in the US. Direct treatment and indirect patient costs rose from 53B in 2002… more
Abstract:ABSTRACT: Tactical weapons have followed an evolutionary pattern of progressive capability that allows them to be ever more lethal against specific targets, but the resulting systems are highly optimized,"stove-piped"solutions to a very specific set of requirements. Modern warfare… more
Abstract:ABSTRACT: We propose to develop and demonstrate a rapid store trajectory analysis tool that uses pre-computed, highly-resolved Detached Eddy Simulation (DES) Computational Fluid Dynamics (CFD) data which has been compressed and stored in an easily reusable and distributable format. The tool will… more
Abstract:ABSTRACT: The thermal spray process has many inherent complexities within each sub-process including feedstock manufacturing, component surface preparation and masking, torch parameter selection, robot trajectory and laboratory coating evaluation. Each sub-process is governed by rigid… more
Abstract:ABSTRACT: ReliaCoat Technologies, LLC, in conjunction with program collaborators of Boeing Company and Sulzer Metco propose to develop an innovative engineered thermal spray coating solution for landing gear ID application. EHC coating replacement effort has led to HVOF WC-CoCr coating for landing… more
Abstract:NASA's future X-ray astronomy missions will require X-ray optics that have large effective areas, are lightweight, and cost effective. Recent X-ray telescopes, such as the Chandra Observatory, utilized reflectors made from zerodur which were up to 20mm thick. The thickness of these reflectors… more
Abstract:ABSTRACT: The purpose of the project is to develop and deliver an integrated cooling, heating, and power system that operates from multiple energy sources can be easily incorporated onto a building similar to a standard air conditioning system. The objective of the project is to build a prototype… more
Abstract:ABSTRACT: The objective of this sequential Phase II SBIR is to deliver a Technology Readiness Level 6 (TRL-6) airborne HF, VHF and UHF RF direction finding system that is suitable for integration with SUAS and to demonstrate it in a realistic airborne environment against representative signals. … more
Abstract:ABSTRACT: We propose to develop a compact and very capable micro airborne relay system which will will extend broadband communications range and provide the ability to transfer multiple HD video and data streams beyond the horizon. We can leverage technology we have previously developed which will… more
Abstract:The Office of Nuclear Energy, fuel cycle research and development program, requires improved radioisotope detectors for spent fuel rod monitoring and process control. Processing spent fuel rods releases large amounts of the fission by-product gas krypton-85 (Kr-85). This beta emitting radioisotope… more
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