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Company: Gas Curtain Technology Agency/Program/Year/Phase: DOD / SBIR / 1986 / 1
Abstract: ELECTRONIC COMPONENT PACKING DENSITY IS INCREASING RAPIDLY BECAUSE OF REQUIREMENTS FOR GREATER RELIABILITY, GREATER RESISTANCE TO VIBRATION AND SHORTER SIGNAL PATH. SMT TECHNIQUES, REPRESENTING STATE-OF-THEART, REQUIRE ADVANCED SOLDERING TECHNOLOGY INCLUDING DUAL-WAVE, IR, ULTRASONIC AND BLANKETED… more
Company: Gas Desulfurization Agency/Program/Year/Phase: DOE / SBIR / 1986 / 1
Abstract: CLOSELY CONTROLLED LABORATORY RESULTS SHOW THAT CERIUM OXIDE CAN BE USED TO REDUCE THE H2S CONTENT OF FUEL GASES WITH A CO/C02 RATIO OF 5.1 FROM 10,000 PPM TO 3 TO 6 PPM AT 1601/2873F (872/1022C). THE SULFUR CONTAINING CERIUM COMPOUND WAS REGENERATED SO THAT IT WAS CAPABLE OF AGAIN REACTING WITH THE… more
Company: NEUGENESIS CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 1986 / 2
Abstract: HUMAN CLASS II HISTOCOMPATIBILITY ANTIGEN TYPING IS ALREADY OF SUBSTANTIAL IMPORTANCE IN DETERMING DISEASE SUSCEPTIBILITY IN INDIVIDUALS. PRESENT SEROLOGIC METHODS OF CLASS II ANTIGEN TYPING ARE LIMITED BY THE POLYCLONAL NATURE OF MANY ANTISERA, BY THE FACT THAT MANY OF THE AVAILABLE HUMAN ANTISERA… more
Company: NEUGENESIS CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 1986 / 2
Abstract: THE IMMUNE RESPONSE IN MAN IS REGULATED BY ORDERED INTERACTIONS BETWEEN FUNCTIONALLY AND PHENOTYPICALLY DISTINCT LYMPHOID CELLS (T CELLS AND THEIR SUBSETS, B CELLS AND MONOCYTES) IN THE CONTEXT OF IA-LIKE MOLECULES ENCODED BY THE HLA COMPLEX OF GENES. THUS, THE PRODUCTS OF THESE GENES (E.G., DR, DS,… more
Company: NEUGENESIS CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 1986 / 1
Abstract: UNTIL VERY RECENTLY, THE SIZES OF DNA FRAGMENTS THAT COULD BE DEALT WITH BY CLONING AND ELECTROPHORETIC TECHNIQUES WEREGENERALLY ONE TO TWO ORDERS OF MAGNITUDE BELOW THOSE NEEDED FOR A PRACTICAL AND SYSTEMATIC MOLECULAR DESCRIPTION OF HUMAN DNA RELATIONSHIPS OVER THE RANGE DEALT WITH BY CLASSICAL… more
Company: NEUGENESIS CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 1986 / 1
Abstract: MOUSE AND RAT MONOCLONAL ANTIBODIES WILL BE PRODUCED AGAINSTHTLV-III, THE HUMAN RETROVIRUS ASSOCIATED WITH AIDS AND A SPECTRUM OF RELATED SYNDROMES. GENE LABS WILL EMPLOY INTACTHTLV-III VIRIONS COUPLED TO KLH AS AN IMMUNOGEN AND USE A SENSITIVE ELISA ASSAY, BASED ON PURIFIED HTLV-III AS THE ANTIGEN… more
Company: NEUGENESIS CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 1986 / 1
Abstract: IN THIS PROJECT, GENE LABS, INC. WILL PRODUCE AND CHARACTERIZE HUMAN MONOCLONAL ANTIBODIES TO HTLV-III, THE HUMAN RETROVIRUS ASSOCIATED WITH AIDS AND A SPECTRUM OF RELATED SYNDROMES. GENE LABS HAS SUCCESSFULLY USED THE SBC-H20 HETEROMYELOMA CELL LINE AS THE FUSION PARTNER FOR THE GENERATION OF… more
Company: NEUGENESIS CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 1986 / 1
Abstract: THE GOAL OF THIS PROPOSED RESEARCH IS TO DEFINE THE MOLECU- LAR STRUCTURES THAT DETERMINE THE ANTIGENETIC REACTIVITY OF THE HUMAN RH SYSTEM. USING PREEXISTING HUMAN MONOCLONAL ANTIBODIES DIRECTED AGAINST A LARGE G DETERMINANT AND ONE DIRECTED AGAINST A DETERMINANT FOUND ON RH D+ CELLS BUT NOT DU… more
Company: NEUGENESIS CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 1986 / 1
Abstract: HUMAN T-CELL LYMPHOTROPHIC VIRUS TYPE I (HTLV-I) IS THE CAUSATIVE AGENT OF AN AGGRESSIVE FORM OF T-CELL LEUKEMIA ENDEMIC TO CERTAIN GEOGRAPHIC AREAS BUT ALSO CURRENTLY INCREASING IN FREQUENCY IN THE SAME POPULATION AT RISK FOR DEVELOPING AIDS. SERO-EPIDEMIOLOGIC DATA SUGGEST THE PRESENCE OF A… more
Company: NEUGENESIS CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 1986 / 1
Abstract: THIS PROJECT WILL PRODUCE MOUSE AND RAT MONOCLONAL ANTIBODIES TO THE LEUKEMOGENIC HUMAN RETROVIRUS, HTLV-I. STABLE, IMMUNOGLOBULIN-SECRETING HTLV-I ELISA-REACTIVE SUBCLONES WILL BE ISOLATED AND THEIR VIRAL ANTIGEN SPECIFICITY CONFIRMED BY IMMUNOPRECIPITATION, WESTERN BLOTTING, AND IMMUNOFLUORESCENCE… more
Company: NEUGENESIS CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 1986 / 1
Abstract: HTLV-III/LAV IS A RECENTLY DESCRIBED HUMAN RETROVIRUS LINKEDBOTH MOLECULAR- AND SEROEPIDEMIOLOGICALLY TO THE CURRENT EPIDEMIC OF AIDS. IT SHOULD BE POSSIBLE NOT ONLY TO INTERFERE WITH VIRAL PROPOGATION IN A CHEMOTHERAPEUTIC MANNER BUT ALSO TO EFFECT IMMUNOPROPHYLAXIS IN THE AT-RISK POPULATION, AS… more
Company: GENELABS TECHNOLOGIES, INC. Agency/Program/Year/Phase: HHS / SBIR / 1986 / 2
Abstract: THE HUMAN IMMUNE RESPONSE IS GOVERNED BY ORDERED INTERACTIONS BETWEEN FUNCTIONALLY AND PHENOTYPICALLY DISTINCT LYMPOID CELLS (T CELLS AND THEIR SUBSETS, B CELLS) AND MONOCYTES IN THE CONTEXT OF IA-LIKE MOLECULES ENCODED BY THE HLA COMPLEX OF GENES. THUS,THE PRODUCTS OF THESE HLA CLASS II GENES (DP… more
Company: General Digital Industries Inc Agency/Program/Year/Phase: DOD / SBIR / 1986 / 1
Abstract: IN AN EFFORT TO COMPENSATE FOR THE DECLINING SKILL LEVELS OF SHIPYARD WELDERS, THIS PROGRAM RESEARCHES THE FEASIBILITY OF BUILDING AN ADAPTIVE WELD CONTROL SYSTEM USING A RULE-BASED EXPERT SYSTEM AND APPROPRIATE SENSORS. THE SHIPYARD WELDING PROCESS THAT CAN BENEFIT MOST FROM SUCH A CONTROL SYSTEM… more
Company: General Pneumatics Corp Agency/Program/Year/Phase: NASA / SBIR / 1986 / 2
Abstract: CRYOCOOLERS AND GAS LIQUEFIERS UTILIZE ISENTHALPIC EXPANSION OF COOLED GAS IN JOULE-THOMSON NOZZLES. TO EFFECTIVELY OPTIMIZE USAGE OF THE COMPRESSED GAS, A VARIABLE GAS MASS FLOW RATE IS NECESSARY. A HIGH FLOW RATE IS REQUIRED INITIALLY WITH A PROGRESSIVE REDUCTION AS THE DESIGN CONDITION IS… more
Company: GENERAL SCIENCES, INC. Agency/Program/Year/Phase: DOD / SBIR / 1986 / 1
Abstract: THE USE OF HIGHLY EXOTHERMIC SELF PROPAGATING INTERMETALLIC REACTIONS IN PROPOSED TO BOND TOGETHER LOW COST ANISTROPIC GRAPHITIC MATERIALS WHICH HAVE SHOWN PROMISE AS LASER RESISTANT MATERIALS DUE TO HIGH REFLECTIVITY AND HIGH HEAT OF VAPORIZATION. IN ADDITION SEVERAL TECHNIQUES ARE PROPOSED IN… more
Company: General Technology Inc Agency/Program/Year/Phase: DOD / SBIR / 1986 / 2
Abstract: A NEW HIGH-FREQUENCY, NONFOULING, FOUR-ELECTRODE, OPEN-CELL CONDUCTIVITY SENSOR FOR OCEANIC USE IS PROPOSED. THIS SENSOR IS TO REPLACE THE COMMONLY USED CONDUCTIVITY CELL MADE BY N. BROWN INSTRUMENT SYSTEM. THE NEW SENSOR WILL BE DESIGNED TO MINIMIZE OR ELIMINATE PROBLEMS ASSOCIATED WITH N. BROWN… more
Company: GENESIS LABORATORIES, INC Agency/Program/Year/Phase: HHS / SBIR / 1986 / 2
Abstract: THE LONG-TERM OBJECTIVE OF THIS WORK IS TO DEVELOP A RAPID, COLORIMETRIC, INSTRUMENT-DEPENDENT ASSAY FOR CARDIO-DIGITALIS CONSTITUENTS, NOTABLY DIGOXIN AND DIGITOXIN. GENESIS LABS' ""IMMUNOSTRIP'' ASSAY (PROTECTED BY PATENT) IS CONSTRUCTED IN A CONFIGURATION THAT IS APPLICABLE FOR THE RAPID… more
Company: Genesys Research, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1986 / 1
Abstract: IN VITRO CYTOGENETIC TESTS TO EVALUATE THE GENETIC HAZARDS OF CHEMICALS ARE INCREASING IN IMPORTANCE FOR PREDICTING IN VIVO EFFECTS. IN PARTICULAR, STUDIES HAVE DEMONSTRATED (1) THE RELEVANCE OF CHROMOSOMAL MUTATION TO INHERITANCE IN GERMCELLS; (2) THAT SPECIFIC CHROMOSOMAL DEFECTS ARE ASSOCIATED… more
Company: Genetic Diagnostics Corp Agency/Program/Year/Phase: HHS / SBIR / 1986 / 2
Abstract: RECENT ADVANCES IN BIOCHEMISTRY AND IMMUNOLOGY NOW MAKE POSSIBLE NEW APPROACHES FOR DETECTION AND TREATMENT OF INFECTIOUS DISEASES. OUR GROUP IS COMMITTED TO SUCH TECHNOLOGICAL APPLICATIONS, AND THIS PHASE I PROPOSAL IS IN RESPONSE TO THE STATED INTEREST OF THE N.I.A.D.A. IN SUCH INNOVATIVE… more
Company: Genetic Diagnostics Corp Agency/Program/Year/Phase: HHS / SBIR / 1986 / 2
Abstract: AS THE USE OF MARIHUANA HAS CONTINUED TO GROW, THE NEED FOR ACCURATE AND RELIABLE MEANS OF MEASURING CANNABINOID LEVELS HAS BECOME MORE URGENT. THIS PHASE I APPLICATION OUTLINES OUR INTEREST IN DEVELOPING SUCH A CANNABINOID ASSAY WHICH WILL BE RAPID, NON-ISOTOPIC, AND CAPABLE OF BEING PERFORMED IN A… more
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