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Company: Genetics Institute Inc. Agency/Program/Year/Phase: HHS / SBIR / 1986 / 1
Abstract: CURRENT TECHNIQUES FOR THE DIAGNOSIS OF GENETIC DISEASE ARE LIMITED BY AN INABILITY TO DETECT THE MAJORITY OF MUTATIONS AND POLYMORPHISMS IN DNA. DNA MOLECULES THAT DIFFER BY ONE OR A FEW BASE PAIRS CAN MOST EFFICIENTLY BE DISTINGUISHED BYDENATURING GRADIENT GEL ELECTROPHORESIS DUE TO SEQUENCE… more
Company: Genetics Institute Inc. Agency/Program/Year/Phase: HHS / SBIR / 1986 / 1
Abstract: THE OBJECTIVE OF THE PROJECT IS TO ESTABLISH HUMAN HEMATO- POIETIC PROGENITOR GROWTH FACTOR-DEPENDENT CELL LINES IN CULTURE. TO ACCOMPLISH THIS, RESEARCHERS WILL FIRST DESIGN AND CONSTRUCT RETROVIRAL VECTORS THAT CAN INFECT AND EXPRESSCLONED GENES IN APPROPRIATE CELL TYPES. THESE WOULD CARRY BOTH A… more
Company: Genex Corpon Agency/Program/Year/Phase: DOC / SBIR / 1986 / 1
Abstract: BOVINE PANCREATIC RIBONUCLEASE A (RNASE A) IS A MODEL SYSTEMFOR ESTABLISHING RULES THAT GOVERN PROTEIN STABILITY AND FOLDING. BY LEARNING AND APPLYING THESE RULES, MORE ROBUST ENZYMES OF VARIOUS TYPES COULD BE DESIGNED FOR COMMERCIAL APPLICATIONS. SYNTHESIS, CLONING AND EXPRESSION IN… more
Company: Genex Corpon Agency/Program/Year/Phase: HHS / SBIR / 1986 / 1
Abstract: L-ASPARAGINASE IS AN IMPORTANT ADDITION TO COMBINATION CHEMOTHERAPY PROTOCOLS FOR CHILDHOOD ACUTE LYMPHOCYTIC LEUKEMIA. HOWEVER, IMMUNOLOGICAL REACTIONS TO THIS FOREIGN PROTEIN CAN GREATLY LIMIT ITS THERAPEUTIC EFFECTIVENESS. THEREFORE, THE PRODUCTION OF NON-CROSS REACTING L- ASPARAGINASE VARIANTS… more
Company: Genzyme Corp. Agency/Program/Year/Phase: HHS / SBIR / 1986 / 1
Abstract: THE SPECIFIC AIM OF THIS PHASE I PROJECT IS TO PURIFY TO HOMOGENEITY ACIDIC A-D-MANNOSIDASE FROM HUMAN PLACENTAS AND BOVINE KIDNEYS. IT IS ANTICIPATED THAT BY EMPLOYING A COMBINATION OF CHROMATOGRAPHIC TECHNIQUES ON AFFINITY, HIGH-PERFORMANCE ANION EXCHANGE, AND/OR HIGH PERFORMANCE GEL FILTRATION… more
Company: GEO-CENTERS, INC. Agency/Program/Year/Phase: DOD / SBIR / 1986 / 1
Abstract: THE DEVELOPMENT OF A MINIATURIZED ALL SOLID STATE MAGNETIC SENSOR CHIP IS PROPOSED. THE SENSOR EXPLOITS THE MAGNETOELASTIC RESPONSE OF AN AMORPHOUS METAL FILM. PHASE I RESEARCH IS DIRECTED TOWARDS ESTABLISHING THE PRINCIPLE OF OPERATION OF THE PROPOSED SOLID STATE MAGNETIC SENSOR, IDENTIFYING THE… more
Company: Geochemical Services Inc Agency/Program/Year/Phase: DOD / SBIR / 1986 / 1
Abstract: A NOVEL APPROACH TO SENSITIVE DIRECT ANALYSIS OF III-V COMPOUNDS AND OTHER SEMICONDUCTOR MATERIALS IS PROPOSED. FEASIBILITY DEPENDS ON THE SUCCESSFUL MODIFICATION OF HARDWARE AND SOFTWARE OF A COMMERCIALLY AVAILABLE INDUCTIVELY COUPLED PLASMA MASS SPECTROMETER (ICP/MS). FOR ROUTINE BULK ANALYSIS OF… more
Company: Geomet Technologies, Inc. Agency/Program/Year/Phase: DOD / SBIR / 1986 / 1
Abstract: DEFEAT OF COMBAT VEHICLES IS PRINCIPALLY SOUGHT THROUGH DIRECT-FIRE WEAPONS AND THE EFFECTS OF CONVENTIONAL MUNITIONS. THE DESIRED EFFECT IS FIRST TO ACHIEVE A CATASTROPHIC KILL (K-KILL) OR, FAILING THAT, TO INFLICT A FIREPOWER OR MOBILITY KILL. ADVANCEMENT IN ARMOR PROTECTION HAS SHOWN, HOWEVER,… more
Company: Geomet Technologies, Inc. Agency/Program/Year/Phase: DOD / SBIR / 1986 / 1
Abstract: A PHASE I PROGRAM IS PROPOSED TO METHODICALLY EXAMINE AND ORGANIZE BATTLEFIELD METEOROLOGICAL DATA AND INFORMATION IN SUPPORT OF ARMY MISSION AREAS. A KNOWLEDGE ENGINEERING PROCEDURE IS DISCUSSED THAT WILL FIRST IDENTIFY KEY AVAILABLE BATTLEFIELD METEOROLOGICAL RESOURCES AND SECONDLY DEVELOP AN… more
Company: Geoscience Ltd Agency/Program/Year/Phase: NRC / SBIR / 1986 / 1
Abstract: THE PROPOSED PROGRAM CONSISTS OF THE DEVELOPMENT OF A TECHNIQUE AND A SYSTEM TO MEASURE THE RADIOACTIVE DECAY OF OF RADWASTE CONTAINED IN STORAGE CANISTERS, CASKS AND VAULTS. THE SYSTEM BEING CONSIDERED DEALS WITH THE DIRECT MEASUREMENT OF THE AFTERHEAT BEING GENERATED IN THE RADWASTEVOLUMES. THE… more
Company: Giner, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1986 / 2
Abstract: THIS RESEARCH PLAN IS DIRECTED TOWARDS IMPROVING ARTIFICIAL KIDNEY TECHNOLOGY, ONE OF THE SPECIFIC AREAS OF INTEREST TO THE NATIONAL INSTITUTE OF ARTHRITIS, DIABETES, AND DIGESTIVEAND KIDNEY DISEASES. BY THE MIDDLE OF 1977 MORE THAN 36,000PATIENTS WERE BEING REGULARLY TREATED FOR UREMIA BY… more
Company: Giner, Inc. Agency/Program/Year/Phase: DOD / SBIR / 1986 / 2
Abstract: AN ELECTROCHEMICAL METHOD IS PROPOSED FOR THE SEPARATION OF HYDROGEN FROM A REFORMED-HYDROCARBON FUEL-GAS STREAM FOR DIRECT FEED INTO A FIELD PORTABLE PHOSPHORIC ACID FUEL CELL USED BY THE U.S. ARMY. THIS ELECTROCHEMICAL HYDROGEN SEPARATOR (EHS) IS BASED ON CURRENT PHOSPHORIC ACID FUEL CELL… more
Company: Giner, Inc. Agency/Program/Year/Phase: DOD / SBIR / 1986 / 2
Abstract: A BENCH SCALE TEST PROGRAM IS PROPOSED TO EVALUATE USE OF CUO/ZNO DESULFURIZATION SORBENTS FOR THE NOT REGENERABLE SULFUR REMOVAL FROM LOGISTIC HYDROCARBON FUELS REFORMED FOR USE IN DISPERSED PHOSPHORIC ACID FUEL CELL POWER PLANTS. AN EFFICIENT REGENERABLE DESULFURIZATION PROCESS OPERATING WITHIN… more
Company: Giner, Inc. Agency/Program/Year/Phase: NASA / SBIR / 1986 / 2
Abstract: INNOVATIVE APPROACHES TO SOLVE THE PROBLEMS ENCOUNTERED AT BOTH THE ANODE AND CATHODE OF THE HYDROGEN-BROMINE BATTERY SYSTEM ARE ADDRESSED. ADVANCED INERT CATALYSTS WILL BE PREPARED AS THE POSITIVE ELECTRODE MATERIAL AND TESTED FOR THEIR RESISTANCE AGAINST BROMINE INTERCALATON AND SUBSEQUENT… more
Company: Giner, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1986 / 2
Abstract: THE OBJECTIVE OF THIS EFFORT IS THE DEVELOPMENT OF A COMPACT, EFFICIENT, AND ECONOMICAL PORTABLE ARTIFICIAL KIDNEY BASED ON ELECTROCHEMICAL REGENERATIVE DIALYSIS. IN THIS SYSTEM, AN ELECTROCHEMICAL REACTOR IS USED TO DEGRADE WASTE PRODUCTS, PRINCIPALLY UREA, TO BENIGN GASEOUS REACTION PRODUCTS. THE… more
Company: Giner, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1986 / 1
Abstract: AN IMPROVED CARBON MONOXIDE ELECTROCHEMICAL DETECTOR IS PROPOSED FOR VALIDATING SMOKING BEHAVIOR AND DEMONSTRATING THE HEALTH RISK OF SMOKING. THE PROPOSED POTENTIODYNAMIC MEASUREMENT SHOULD BE UNAFFECTED BY GASES AND VAPORS THAT ARE OFTEN FOUND IN A SMOKER'S BREATH (H2S, ETHANOL, ACETONE,ETC.).… more
Company: Giner, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1986 / 1
Abstract: THIS PROPOSAL IS ADDRESSED TO IMPROVEMENTS IN THE INTERNAL RECHARGEABLE BATTERIES FOR VENTRICULAR ASSIST SYSTEMS (VAS).THE MAJOR GOAL OF THIS PROGRAM IS TO DEVELOP AN IMPLANTABLE BATTERY THAT IS SUITABLE FOR VAS BACKUP IN TERMS OF STORED ENERGY, POWER, WEIGHT, VOLUME, AND LONG-TERM DURABILITY. THE… more
Company: Giner, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1986 / 1
Abstract: THE PURPOSE OF THIS RESEARCH IS TO DEVELOP A DEVICE BASED ONA NOVEL ELECTROCHEMICAL METHOD FOR THE DETERMINATION OF LITHIUM THAT CAN BE USED IN A PSYCHIATRIST'S OFFICE FOR THE ANALYSIS OF SERUM OR SALIVA SAMPLES. VARIOUS ELECTRODE DESIGNS AND EXPERIMENTAL TECHNIQUES WILL BE TESTED TO ESTAB-LISH THE… more
Company: GLOBAL INFORMATION SYSTEMS TECHNOLOGY Agency/Program/Year/Phase: DOD / SBIR / 1986 / 1
Abstract: N/A
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