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Displaying 142026 – 142050 of 145235 Awards
Company: NEUGENESIS CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 1985 / 1
Abstract: WE WILL IDENTIFY AND CHARACTERIZE ALL THE MHC CLASS II BETA CHAIN GENES AND PSEUDOGENES IN A CELL LINE CONTAINING A SINGLE COPY OF THE MHC. THE SEQUENCE INFORMATION OBTAINED WILL BE USED TO CONSTRUCT A SERIES OF VECTORS THAT PERMIT RAPID CONSTRUCTION OF HYBRID HUMAN-MURINE CLASS II GENES CONTAINING… more
Company: NEUGENESIS CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 1985 / 1
Abstract: THE OBJECTIVE IS TO DEVELOP AN IN VITRO IMMUNIZATION SYSTEM TO PRODUCE HUMAN MONOCLONAL ANTIBODIES TO CELL SURFACE ANTIGENS OF HUMAN BREAST CARCINOMA, COLON CARCINOMA, AND MALIGNANT MELANOMA. HUMAN MONOCLONAL ANTIBODIES ARE DESIRABLE FOR A VARIETY OF REASONS, INCLUDING: A.THE MAJORITY OF ANTIBODIES… more
Company: NEUGENESIS CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 1985 / 1
Abstract: HUMAN T-CELL LYMPHOTROPHIC VIRUSES ARE COMPOSED OF AT LEAST THREE MEMBERS, INCLUDING THE HTLV-I VIRUS WHICH IS THE ETIOLOGIC AGENT OF ADULT T-CELL LEUKEMIA/LYMPHOMA AND THE RECENTLY WELL-CHARACTERIZED HTLV-III (ARV, LAV) GENOME WHICH TRANSMITS ACQUIRED IMMUNE DEFICIENCY SYNDROME (AIDS). THE… more
Company: NEUGENESIS CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 1985 / 1
Abstract: NON-A, NON-B (NANB) HEPATITIS IS A MAJOR CAUSE OF LIVER DISEASE IN BOTH THE DEVELOPED AND UNDEVELOPED COUNTRIES OF THE WORLD. WHILE A LARGE BODY OF DATA STRONGLY SUGGESTS AN INFECTIOUS AGENT, EFFORTS TO ISOLATE SUCH AN AGENT HAVE THUS FAR NOT BEEN REWARDING. THIS PROPOSAL OUTLINES STEPS WHICH TAKE… more
Company: NEUGENESIS CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 1985 / 1
Abstract: THE ESSENTIAL PLAN OF THIS PROPOSAL IS TO USE OOCYTE MICROINJECTION TO CREATE STRAINS OF MICE THAT ARE TOLERANT TO THE SPECIES-SPECIFIC DETERMINANTS THAT DISTINGUISH HUMAN CLASS I, DR, DC, OR SB ANTIGENS AS A GROUP FROM THEIR MURINE ANALOGUES INDEPENDENT OF THEIR ALLELIC VARIATIONS. THESE STRAINS OF… more
Company: NEUGENESIS CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 1985 / 1
Abstract: N/A
Company: GENELABS TECHNOLOGIES, INC. Agency/Program/Year/Phase: HHS / SBIR / 1985 / 1
Abstract: N/A
Company: General Digital Industries Inc Agency/Program/Year/Phase: NASA / SBIR / 1985 / 1
Abstract: N/A
Company: General Oceanics Inc Agency/Program/Year/Phase: DOD / SBIR / 1985 / 1
Abstract: THE PROPOSAL DEALS WITH TESTING A NEW TYPE OF DOPPLER ACOUSTIC CURRENT PROFILER FOR MEASUREMENT OF PROFILES OF WATER VELOCITY. THIS NEW PROFILER MEASURES VELOCITY TRANSVERSELY TO A MAIN ACOUSTIC BEAM AND FEATURES MEASUREMENTS FROM A SINGLE SCATTERING VOLUME. CONSEQUENTLY, THIS TRANSVERSE DOPPLER… more
Company: General Pneumatics Corp Agency/Program/Year/Phase: DOE / SBIR / 1985 / 1
Abstract: THIS PROJECT IS TO DEVLOPE A LOW-TEMPERATURE ROTARY EXPANDER FOR USE WITH A LONG-LIVED HELIUM LIQUEFIER FOR RELIQUEFACTION OF VAPOR BOIL-OFF FROM HELIUM STORAGE DEWARS. THE LIQUEFIER IS A THREE-FLUID, CLOSED-CYCLE, LINDE-HAMPSON (CASCADE JOULE-THOMSON) SYSTEM OPERATING WITH ARGON, NEON, AND HELIUM… more
Company: General Pneumatics Corp Agency/Program/Year/Phase: NASA / SBIR / 1985 / 1
Abstract: RESEARCH IS PROPOSED LEADING TO THE DEVELOPMENT OF A REFRIGERATOR FOR USE IN SPACECRAFT TO PROVIDE COOLING FOR LOW TEMPERATURE STORAGE OF FOOD AND BIOLOGICAL SAMPLES IN THE TEMPERATURE RANGE 0 DEGREES F AND CAPACITIES IN THE RANGE 1 TO 2 KW. THE SYSTEM PROPOSED OPERATES ON THE STIRLING REFRIGERATION… more
Company: General Pneumatics Corp Agency/Program/Year/Phase: DOD / SBIR / 1985 / 1
Abstract: DEVELOPMENT IS PROPOSED OF A SMALL, SELF-CONTAINED POWER UNIT CAPABLE OF OPERATING UNATTENDED FOR LONG PERIODS WITH GREAT RELIABILITY. THE UNIT IS INTENDED FOR INCORPORATED AS THE STORAGE BATTERY TRICKLE CHARGER IN A DATA GATHERING AND COMMUNICATIONS SYSTEM FOR THE ARCTIC AND OTHER REMOTE ISOLATED… more
Company: General Pneumatics Corp Agency/Program/Year/Phase: DOE / SBIR / 1985 / 1
Abstract: LIQUID HELIUM IS STORED IN THERMALLY-INSULATED DEWAR VESSEKS AT CRYOGENIC TEMPERATURES. NATURAL HEAT LEAK THROUGH THE WALLS OF THE DEWAR CAUSES SOME OF THE LIQUID TO BOIL OFF. THE COLD VAPOR MAY BE USED TO COOL THE SHIELDS OF THE DEWAR AND SOME MAY BE USED TO COOL APARATUS OR EQUIPMENT ADJACENT TO… more
Company: GENERAL SCIENCES, INC. Agency/Program/Year/Phase: DOD / SBIR / 1985 / 1
Abstract: N/A
Company: General Software Corpon Agency/Program/Year/Phase: HHS / SBIR / 1985 / 1
Abstract: THE OBJECTIVE OF THIS PROJECT IS TO INVESTIGATE THE USE OF SEVERAL TECHNOLOGIES WHICH, TAKEN TOGETHER IN A COMPLETE SYSTEM, PROVIDE THE CAPABILITY TO TRACK PHARMACEUTICAL PRODUCTS/SERVICES IN BOTH A RETROSPECTIVE AND PROSPECTIVE MANNER. THE APPROACH IS TO DESIGN A SYSTEM USING BAR CODES, OCR, AND… more
Company: General Software Corpon Agency/Program/Year/Phase: HHS / SBIR / 1985 / 1
Abstract: THE DEVELOPMENT OF A SOFTWARE PACKAGE FOR THE STATISTICAL ANALYSIS OF EPIDEMIOLOGICAL DATA AND A PACKAGE FOR THE PRODUCTION OF MANUSCRIPT BIBLIOGRAPHIES IS PROPOSED. THE USER-FRIENDLY PACKAGES WILL BE DEVELOPED FOR IMPLEMENTATION ON IBM XT AND AT SYSTEMS FOR USE BY NCI RESEARCH PERSONNEL. PHASE I OF… more
Company: General Technology Inc Agency/Program/Year/Phase: DOD / SBIR / 1985 / 2
Abstract: GENERAL TECHNOLOGY APPLICATIONS HAS MADE DEVELOPMENTS AND FILED PATENTS IN THE FIELD OF CHEMICAL PROCESSING WHICH MAKE POSSIBLE LOW SHEAR, LOW FRICTION, TIME-INSENSITIVE BLENDING AND MIXING OF CHEMICALLY REACTIVE AND PHYSICALLY INTERACTIVE MATERIALS. THIS TECHNOLOGY OFFERS A UNIQUE OPPORTUNITY TO… more
Company: General Technology Inc Agency/Program/Year/Phase: DOD / SBIR / 1985 / 2
Abstract: SOLID LUBRICATION OFFERS SIGNIFICANT ADVANTAGES FOR ROLLING ELEMENT BEARINGS AND MACHINERY EXPOSED TO EXTREME CONDITIONS. A MAJOR CONSTRAINT IS THAT CURRENT DESIGNS FOR SUCH BEARINGS ARE BASED ON HYDRODYNAMIC LUBRICATION (OIL AND GREASE). THE CHALLENGE IS TO IDENTIFY A NEW CONCEPT THAT FOCUSES THE… more
Company: General Technology Inc Agency/Program/Year/Phase: DOD / SBIR / 1985 / 1
Abstract: N/A
Company: GENESIS LABORATORIES, INC Agency/Program/Year/Phase: HHS / SBIR / 1985 / 1
Abstract: THE LONG-TERM OBJECTIVE OF THIS WORK IS TO DEVELOP A RAPID, COLORIMETRIC, NON-INSTRUMENT-DEPENDENT ASSAY FOR PSYCHOACTIVE MARIJUANA CONSTITUENTS, NOTABLY 9-TETRAHYDROCANNIBINOL. GENESIS LABS' ""IMMUNOSTRIP'' ASSAY (PROTECTED BY PATENT) IS CONSTRUCTED IN A CONFIGURATION THAT IS APPLICABLE FOR THE… more
Company: GENESIS LABORATORIES, INC Agency/Program/Year/Phase: HHS / SBIR / 1985 / 1
Abstract: N/A
Company: GENESIS LABORATORIES, INC Agency/Program/Year/Phase: HHS / SBIR / 1985 / 1
Abstract: N/A
Company: Genesys Research, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1985 / 1
Abstract: HAMSTER OVARY CELLS IN RESPONSE TO PRESENT CONCERNS REGARDING THE EFFICACY OF THE L5178Y MOUSE LYMPHOMA CELL MUTAGENESIS ASSAY (MLA) AT THE TK LOCUS, THERE ARE NEEDS TO EXAMINE FURTHER THE HYPOTHESIS THAT THE PRESENCE OF SMALL MOUSE LYMPHOMA COLONIES IN A BIMODAL DISTRIBUTION OF COLONY SIZES IS… more
Company: Genesys Research, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1985 / 1
Abstract: IN RESPONSE TO PRESENT CONCERNS REGARDING THE EFFICACY OF THE L5178Y MOUSE LYMPHOMA CELL MUTAGENESIS ASSAY (MLA) AT THE TK LOCUS, THERE ARE NEEDS TO DETERMINE WHETHER VARIABILITY IN MUTATION FREQUENCY RATIOS BETWEEN EXPERIMENTS IS COMPOUND SPECIFIC OR THE RESULT OF VARIABILITY IN TESTING CONDITIONS… more
Company: Genetic Diagnostics Corp Agency/Program/Year/Phase: HHS / SBIR / 1985 / 1
Abstract: RECENT STUDIES IN MANY LABORATORIES HAVE DEMONSTRATED THE PRESENCE OF 2 UBIQUITOUS, CLOSELY RELATED ENZYMES, THE CALCIUM-ACTIVATED PROTEASES (CAP I AND II). IN BRAIN, THE CAP ENZYMES ACT ON NEUROFILAMENT PROTEINS AND LEAD TO THE DEGRADATION OF THESE NEURONAL COMPONENTS. THE NEUROFILAMENT PROTEINS… more
Displaying 142026 – 142050 of 145235 Awards
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