Abstract:… interactions is that it eliminates th need for separating the unbound ligands from ligands captured by receptors. The time to identification is reduced since there is no need to segregate sample from the capture particle before detection. Importantly, attachment of an exogenous… more
Abstract:… in which the membrane of a polymerized liposome nanoparticle (PLN) displays functional acetylcholinesterase, the primary target for OPs, while a therapeutic cargo is encapsulated (e.g., oxime). During an OP exposure, the AChE is inhibited (the same as exogenous… more
Abstract:…uel cell. The anode of the fuel cell is a metal sheet that is deposited with enzymes that may simultaneously oxidize a mixture of fuels. The cathode complexes facilitate direct electron transfer for oxygen reduction reaction. The configured system does not require exogenous… more
Abstract:DESCRIPTION (provided by applicant): All forms of diabetes are characterized by the death of insulin producing cells. In Type 1 diabetes (T1D), this leads to the reliance on exogenous insulin for survival. In addition, there is cell loss in T2D and inindividuals who lose… more
Abstract:Exogenous topical NO has been demonstrated as a broad-spectrum antimicrobial agent (Ghaffari, 2006), and is capable of providing numerous wound healing benefits if delivered at the proper concentrations (Shekhter, 2005). Practical deployment of NO however is missing due to the… more
Abstract:… product having significant advantages in manufacturing economy, activity, and inhibition resistance over current animal and synthetic surfactant drugs. PUBLIC HEALTH RELEVANCE: This SBIR competitive renewal grant will continue the development of a synthetic … more
Abstract:… form a very compact (0.5 cmx 0.5cm x0.5cm) swept source with a range of 200-400nm, a scanning speed of 10-100msec and an output power of 10mW. This source would be incorporated into a handheld functional Diffuse Optical Spectroscopic Imaging device (not requiring exogenous… more
Abstract:… hospitalization and 3,500 of these lead to fatal outcomes. The economic impact of these injuries extends far beyond the cost on the nation's healthcare system to include loss of wages; costs relating to deformities; and emotional trauma. The use of exogenous nitric oxide… more
Abstract:… assayed for their ability to interfere with the binding of labeled LDLR extracellular domain to PCSK9. The variants with the greatest activity will then be tested in a cellular LDL uptake assay to determine how well they inhibit the LDLR-lowering activity of exogenously added… more
Abstract:… The project has four specific aims: 1) Continue development of the Fatzo mouse to achieve genetic and phenotypic homogeneity of traits for obesity and metabolic syndrome. Confirm normal function of LepR and Lep genes by experimental evidence of responsiveness to exogenous… more
Abstract:… of Stratatech's platform technology, the NIKS cells, a consistent source of non-tumorigenic, pathogen-free human keratinocyte progenitors. The ability to genetically engineer NIKS keratinocytes and generate three- dimensional skin tissuethat produces exogenous protein… more
Abstract:… downstream to cloned promoter and transcriptional regulatory elements. In an exogenousreporter, the vector is introduced into recipient cells where expression proceeds either transiently, or after random and stable integration into the genome. Exogenous… more
Abstract:… (TKDG; an intermediate of TDP-deoxysugars) we plan to increase the accumulation of the TKDG precursor beyond previous reports. Additional over-expression of endogenous TKDG biosynthetic proteins mayfurther optimize TKDG production. Finally, exogenous… more
Abstract:…between large environmental samples and sample preparation and detection components requiring
very small volumes, (b) deficiencies in removing inhibitory environmental material and (c) an inability to separate, and thus, differentiate whole
pathogens from exogenous materials… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project will optimize and pilot test the patent-pending Exogen system for the generation of biogas during wastewater treatment. Based on a newly discovered process called electromethanogenesis, ExogenTM uses applied… more
Abstract:… non-stinging, volatile hydrophobic solvent for treatment of first and second degree burn wounds with reduction of scar formation, wherein a transparent, flexible substrate for human cell attachment, viability and proliferation is formed without any added exogenous biological… more
Abstract:…. Moreover, the extensive preclinical and clinical safety/efficacy experience with KL4 surfactant (gt1000 treated patients), and its potential FDA approval in early 2012 for prevention of neonatal RDS should facilitate the regulatory approval of the drug as a MCM. Exogenous… more
Abstract:… dicarboxylic acid production from engineered microbes. In Phase I, we constructed and characterized three dicarboxylic acid screens applicable for short- to medium-chain microbially produced diacids (up to C7). The screens are based on microbial sensing of exogenous… more
Abstract:… therapy to correct anemia in these patients based on our discovery that the aconitase enzyme product, namely isocitrate, functions as a second messenger mediating iron's signal to stimulate erythropoiesis. We established the clinical utility by showing that exogenous… more
Abstract:…ly identified a novel mechanism underlying the shift in MOR signaling: a MOR splice variant encoding a functional 6 transmembrane (6TM) receptor. This 6TM isoform was identified in a study designed to determine the genetic basis for variability in sensitivity to exogenous… more
Abstract:…, is essential for applications to regenerative medicine. Unfortunately, conventional separation techniques for stem cells such as microscope-assisted manual isolation, fluorescence-activated cell sorting and magnetic-activated cell sorting require exogenous labeling or… more
Abstract:… phenotype. Like the vasculature, recreating anatomical and physiological features important to normal liver function is necessary for aneffective ex vivo model. For example, the biological response of the liver in vivo to both endogenous substrates as well as … more
Abstract:…, iliac crest harvest is associated with a significant number of complications and often provides an inadequate volume of graft.6 To address these limitations, much work has been done to improve alternative grafts with better osteoconductive matrices and exogenous delivery… more
Abstract:… performance goal for Phase 1 is a closed amplicon RT-PCR array for the detection of enterovirus, herpes viruses (HSV-1, HSV-2, VZV, CMV, HHV-6), and WestNile virus, with an analytical LoD of d 50 genome copies per reaction. The assay will contain an exogenously spiked,… more
Abstract:…lupus and invarious mouse animal models and identified a specific pentapeptide (DWEYS) that is present in the N methyl D aspartate receptor (NMDAR) as a cross- reactive protein antigen for the anti-dsDNA autoantibodies that are common in lupus patients. Exogenously supplied… more
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