Abstract:… (rBChE), the major cholinesterase in human which has low substrate specificity and thus offers broad spectrum protection by binding OP's prior to their damaging neurons. Natural BChE levels are too low to afford protection however, and exogenous enzymes… more
Abstract:…present two of the greatest technical challenges of modern space flight. The impact of nonlinear effects in both path planning and estimation is often most noticeable when the spacecraft under consideration transitions through a region of space where multiple exogenous… more
Abstract:… is still a challenge. Desirable analytical systems will cover large areas, monitor continuously, operate for years with little or no maintenance, be cost effective, and differentiate between CO2 variations due to natural processes and those due to leaks of exogenous gas.… more
Abstract:… reflections toform a 3-D image in much the same way that ultrasound measures sound reflections, is attractive for dental imaging because it permits the evaluation of microscopic tissue morphology at m-scale resolutions without the need for ionizing radiation or exogenous… more
Abstract:… cell biology into tissue replacement therapies. Conventional separation techniques, such as microscope-assisted manual isolation is time consuming whereas fluorescence-activated cell sorting, and magnetic-activated cell sorting, require intensive labor, exogenous labeling or… more
Abstract:…s may be encouraged to perform the harvesting procedure with the introduction of the proposed concept. The increase in use of the patient?s own bone will benefit patients because of the widely accepted clinical benefits of autogenous bone graft compared to synthetic or exogenous… more
Abstract:… wounds also are often in an ischemic state, due to decreased vascularity. The increased MMP activity, decreased vascularity, and unstable ECM production in a chronic wound environment all lead to continued skin degradation and subsequent ulceration. Providing an … more
Abstract:… be able to increase endogenous beta cell mass and the function of beta cells, normalizing hyperglycemia and reversing diabetes. These compounds will represent a new class of anti-diabetic drugs, orally administered, negating the need for repeated injections of exogenous… more
Abstract:… devices for use in a pre-clinical laboratory testing. Specific Aim 2: Research wound healing in a diabetic mouse model by comparingresults of the eNO treatment to a placebo. If successful, this study would be the first to demonstrate that short-duration, exogenous NO… more
Abstract:… and insulin antigen, targeted to a key immune cell type, dendritic cells(DCs). Dendritic cells are professional antigen presenting cells (APCs), directly involved in T cell and B cell immunity, including the maintenance of tolerance to self-antigens. Moreover, exogenous… more
Abstract:…ury or disease especially at advanced stages and /or other pathologies/ lesions in patients with renal failure is still a major challenge in clinic. X-ray computed tomography (CT) and MRI areroutinely used in clinic to image the anatomy of kidneys and other organs. Exogenous… more
Abstract:… interactions is that it eliminates th need for separating the unbound ligands from ligands captured by receptors. The time to identification is reduced since there is no need to segregate sample from the capture particle before detection. Importantly, attachment of an exogenous… more
Abstract:… in which the membrane of a polymerized liposome nanoparticle (PLN) displays functional acetylcholinesterase, the primary target for OPs, while a therapeutic cargo is encapsulated (e.g., oxime). During an OP exposure, the AChE is inhibited (the same as exogenous… more
Abstract:…uel cell. The anode of the fuel cell is a metal sheet that is deposited with enzymes that may simultaneously oxidize a mixture of fuels. The cathode complexes facilitate direct electron transfer for oxygen reduction reaction. The configured system does not require exogenous… more
Abstract:DESCRIPTION (provided by applicant): All forms of diabetes are characterized by the death of insulin producing cells. In Type 1 diabetes (T1D), this leads to the reliance on exogenous insulin for survival. In addition, there is cell loss in T2D and inindividuals who lose… more
Abstract:Exogenous topical NO has been demonstrated as a broad-spectrum antimicrobial agent (Ghaffari, 2006), and is capable of providing numerous wound healing benefits if delivered at the proper concentrations (Shekhter, 2005). Practical deployment of NO however is missing due to the… more
Abstract:… product having significant advantages in manufacturing economy, activity, and inhibition resistance over current animal and synthetic surfactant drugs. PUBLIC HEALTH RELEVANCE: This SBIR competitive renewal grant will continue the development of a synthetic … more
Abstract:… form a very compact (0.5 cmx 0.5cm x0.5cm) swept source with a range of 200-400nm, a scanning speed of 10-100msec and an output power of 10mW. This source would be incorporated into a handheld functional Diffuse Optical Spectroscopic Imaging device (not requiring exogenous… more
Abstract:… hospitalization and 3,500 of these lead to fatal outcomes. The economic impact of these injuries extends far beyond the cost on the nation's healthcare system to include loss of wages; costs relating to deformities; and emotional trauma. The use of exogenous nitric oxide… more
Abstract:… assayed for their ability to interfere with the binding of labeled LDLR extracellular domain to PCSK9. The variants with the greatest activity will then be tested in a cellular LDL uptake assay to determine how well they inhibit the LDLR-lowering activity of exogenously added… more
Abstract:… The project has four specific aims: 1) Continue development of the Fatzo mouse to achieve genetic and phenotypic homogeneity of traits for obesity and metabolic syndrome. Confirm normal function of LepR and Lep genes by experimental evidence of responsiveness to exogenous… more
Abstract:… of Stratatech's platform technology, the NIKS cells, a consistent source of non-tumorigenic, pathogen-free human keratinocyte progenitors. The ability to genetically engineer NIKS keratinocytes and generate three- dimensional skin tissuethat produces exogenous protein… more
Abstract:… downstream to cloned promoter and transcriptional regulatory elements. In an exogenousreporter, the vector is introduced into recipient cells where expression proceeds either transiently, or after random and stable integration into the genome. Exogenous… more
Abstract:… (TKDG; an intermediate of TDP-deoxysugars) we plan to increase the accumulation of the TKDG precursor beyond previous reports. Additional over-expression of endogenous TKDG biosynthetic proteins mayfurther optimize TKDG production. Finally, exogenous… more
Abstract:…between large environmental samples and sample preparation and detection components requiring
very small volumes, (b) deficiencies in removing inhibitory environmental material and (c) an inability to separate, and thus, differentiate whole
pathogens from exogenous materials… more
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