Abstract:…. Commercial Applications and Other Benefits: The prototype X-band RF electron source we propose would find immediate application as a tabletop Ultrafast Electron Diffraction (UED) system for time-resolved chemical imaging, and as a resource for the pharmaceutical industry… more
Abstract:… and efficient software package providing instant modeling/simulation for insights into the physical mixing process. BENEFIT: The results from this research will have significant benefits and broad commercial application in the Air Force, DoD labs, food, pharmaceutical,… more
Abstract:…ving patient care through the identification and active management of cohorts of patients with potentially problematic treatment patterns. In Phase II Commonwealth will develop a software prototype (with working name RemCB) and pilot it in the targeted dissemination of drug… more
Abstract:…, which requires a safety argument will be simplified through compositional assurance arguments. Numerous safety-critical industries will benefit from formal reasoning and compositional safety arguments, including: - the medical-device industry, for example drug… more
Abstract:…technology will allow the DOE to utilize new detector technology at its synchrotron light source sites which will enable faster X-ray analysis for many diverse fields such as crystallography, catalyst development, forensic sciences, the development of new pharmaceuticals,… more
Abstract:… for wire processing. This will serve as the basis for a pilot operation that will supply 2212 conductor development and production. Applications that benefit from this kind of 2212 conductor include 1) High field MRI machines used widely in medical and pharmaceutical research,… more
Abstract:… overall efficiency of the FAEE production process. Commercial Applications and Other Benefits: In addition to biofuel, the proposed microfluidic automation technology has combinatorial DNA construction and functional screening in these industries: 1) pharmaceuticals,… more
Abstract:…. 2. Quantitative measurement will enhance process control, improve reliability prediction and design validation in semiconductors, photo-voltaic, bio-medical devices and catalysts. 3. Video and dynamic-imaging will advance nano-scale research in pharmaceutical and… more
Abstract:DESCRIPTION (provided by applicant): Coronary artery disease (CAD) is a national and worldwide epidemic that places the largest clinical and economic burden on the healthcare system of any disease condition. Patients with stable and acute coronary conditions are often treated with percutaneous… more
Abstract:DESCRIPTION (provided by applicant): A critical need currently exists in the pharmaceutical market for microparticles that can accurately and effectively control the release of poorly water-soluble compounds. Although these poorly water-soluble drugs areprojected to have high… more
Abstract:… plus down-regulation of afferent phase IgE antibody production. This phase 2 proposals comprises complimentary mechanism-of action experiments, efficacy studies and critical preclinical activities that are expected to provide a strong Investigational New Drug (IND… more
Abstract:… are independently predictable, simple to control, and do not show the initial bursts of drug release or terminal drug-dumping characteristic of encapsulating systems. Commercial success will be achieved by a) partnerships where we use our technology for proprietary drugs of … more
Abstract:…, reminders, monitors, and usage communicators have enabled an array of home health aids to support users and caregivers in pill management and monitoring. Beyond bulk pills, additional medication forms, such as topicals, are gaining popularity in unique drug delivery… more
Abstract:… (FTD), Lewy body (LBD), and Parkinson's disease (PD) with dementia (PDD). Success of this project will provide blood miRNA-based diagnostics for MCI, and predict conversion from MCI to AD, unprecedented tests to monitor disease onset, progression, and drug… more
Abstract:… Connectivity MRI for Alzheimer's Disease , is written in response to (PA-11-134) Lab to Marketplace: Tools for Brain and Behavioral Research (SBIR [R43/R44]) . Alzheimer's disease (AD) is the most common form of dementia. However, developing drugs that… more
Abstract:DESCRIPTION (provided by applicant): The long-term goal of this project is to identify and validate biomarkers of mitochondrial dysfunction due to environmental stressors. Diverse acute insults from surgery, trauma, ischemia/reperfusion (I/R) and drug andenvironmental chemical… more
Abstract:…y system for bevacizumab (anti-VEGF antibody) to treat wet age-related macular degeneration (AMD). The premise is based on: (1)the demonstrated efficacy of monthly intravitreal injections of the monoclonal bevacizumab in treating wet AMD that is accompanied by a high cost of … more
Abstract:Develop an inexpensive, easy to use, aerosolized delivery system of a combination of anti-tubercular drugs that could be used for the treatment of multi-drug resistant tuberculosis (MDR TB ). PUBLIC HEALTH RELEVANCE
Abstract:… trammeled G protein coupled receptors, their discovery is more often serendipitousand few if any predictive computational models exist for it. The field suffers from a paucity of actual biased ligands, whose incompletely explored ranks include even marketed drugs such as… more
Abstract:DESCRIPTION (provided by applicant): Bioactive small molecules can act on multiple targets, and these off-target activities underlie many of the adverse reactions from which drugs suffer. The motivating idea of this proposal is that these Adverse Drug Reaction (ADR) targets may… more
Abstract:… in standard stereo displays. In this program HSI will study and design key components of this system. As it evolves this holography development will provide new realism to displays including near to eye, multiuser monitors, and projection displays. BENEFIT: Drug creation,… more
Abstract:DESCRIPTION (provided by applicant): There is a critical need to improve the accuracy of preclinical drug efficacy and toxicity screening and testing through the development of human hepatocyte (liver) in vitro culture systems that more effectively mimic the human in vivo… more
Abstract:… Phase II research. First, this proposal will validate an innovative technology for targeting protein-protein interactions by progressively converting a peptide ligand into a smaller more drug-like molecule, thus addressing a major technological gap in pharmaceutical discovery.… more
Abstract:…, phosphorylated tau (p-tau) and other neurotoxic proteins including APP and alpha-synuclein (aSYN) which also cause neurodegeneration in Alzheimer's Disease (AD) and Parkinson's Disease (PD), respectively. We have developed the first small molecule drug, Posiphen,… more
Abstract:DESCRIPTION (provided by APPLICANT): An overlooked, neglected, yet significant problem in the United States today is the use and abuse of tobacco, alcohol, and other drugs by individuals with intellectual disabilities (ID). Increasing numbers of people with ID are living… more
There are several categories such as “By Agency”, “By Year”, “By State” etc.
Select a checkbox within a category to refine your search results.
Each of your selections is listed in the “Narrow Search Filters” bar. You can uncheck these selections to remove them.
Search for Either Criteria
When you select multiple values within a category, the results will include values that match either of the selections.
For example, selecting “2005” and “2007” in the “By Year” category will display results that include either 2005 OR 2007 in the results.
Narrowing the Search Results
You can refine your search results across categories. To narrow down your results, select multiple values across different categories. The results will only include values that match the selections across the categories.
For example, selecting “2005” in the “By Year” category and “NASA” in the “By Agency” category will only display the results that contain both “2005” AND “NASA” in the results.