Abstract:This Small Business Innovation Research (SBIR) Phase I project will develop a new platform technology to exploit previously inaccessible microbial diversity to discover novel broad-spectrum antibiotics. The project focuses on symbioses between marine invertebrates and microorganisms known to be rich… more
Abstract:…, prefilled autoinjectors must be immediately available and thus highly portable, and they must be suitable for use by nonmedical personnel. Similarly, rapid distribution and administration of targeted vaccines is critical during a biological outbreak. Storage of drug… more
Abstract:…e superior in both performance and cost and will have a wide commercial impact. The development of a Radio p-Chip will provide a powerful new tool for cell biology and in particular for the in vivo studying of a wide variety of human diseases and have implications for drug… more
Abstract:… optoelectronic components on a monolithic semiconductor structure. Commercial Applications and Other Benefits: The sensor technology developed during the proposed program will have widespread commercial application. Industrial process monitoring, pharmaceutical manufacturing… more
Abstract:… tools are plagued with numerous problems, such as damaging cells and lack of resolution, which recent innovations fail to address. The proposed nano-patch clamp addresses these problems and enables single cell analysis (SCA) for basic or clinical studies and drug discovery.… more
Abstract:…, electric fields, and magnetic fields. The instrument will employ software which automates the Phase I algorithms to calculate the electronic and optical parameters of the semiconductor samples. The instrument will be suitable THz spectroscopy of pharmaceuticals,… more
Abstract:… the advanced prototype BURN-PLUS dressing with Endoform dermal template. BURN-PLUS is an occlusive island dressing with an adhesive apron bonded onto a super absorbent, microbicidal, pad that provides sustained release of two pre-loaded, FDA-cleared drugs: doxycycline … more
Abstract:… and velocity vectors. Non-Cooperative targets must be addressed with radar sensors that detect, acquire, track, and determine the targets collision potential as well as support the clearing maneuvers. ADS-B signals lack encryption and can be readily spoofed for drug… more
Abstract:…e to increase in concert with the epidemic of obesity. The overall objective ofthe proposed research is to discover a PPAR?-sparing thiazolidinedione (TZD) which displays efficacy in a rodent model of non-alcoholic fatty liver disease (NAFLD) and demonstrates the necessary … more
Abstract:… the industry problem of biofouling will reduce energy and maintenance demand, thus decreasing the costs associated with water filtration and produced water. Furthermore, the technology has broad applicability to a number of other filtration markets such as … more
Abstract:… up to 18T range. NMR spectroscopy is a non- destructive technique for mapping molecular structures and learning how molecules function and relate to each other. This is important for many applications that have benefits to the public including discovering new drugs, … more
Abstract:… II and lower UAV platforms, and perform trade studies to develop baseline algorithms that will fit within the SWAP limits. BENEFIT: Ground moving target detection and characterization algorithms have benefits and applications to military, homeland security, counter-drug,… more
Abstract:…Iontophoresis is a medication delivery method that can be used to reduce the risk of systemic side effects as opposed to oral medications by delivering a greater concentration of medication to a local area with a very low systemic dose. The result is a noninvasive drug delivery… more
Abstract:… platform for long-term storage of any given CBT antidote that does not present a significant logistical burden, Physical Optics Corporation (POC) proposes to develop a Microfluidic Pneumatic Autoinjector (MPA) platform. The MPA will provide an innovative universal drug… more
Abstract:…, target-specific delivery system for topical treatment of peripheral neuropathy (PN), Physical Optics Corporation (POC) proposes to develop Nano Therapeutics for Peripheral Neuropathy (NATPEN). The NATPEN will include a nanocarrier (NC) loaded with specific drugs, a… more
Abstract:…. Treatment typically occurs after KOA begins interfering with Activities of Daily Living, via a staged process starting with training programs with the goal of reducing the tibiofemoral force on the diseased knee compartment for mild cases, progressing to drugs and… more
Abstract:… alleviate these shortcomings by providing lucrative, general approaches for phosphorylation analyses. The technologies will enable general phosphorylation detection, cost-effective cancer inhibitor screenings, and kinase/phosphatase activity quantitation for new drug… more
Abstract:… this biomarker to characterize wound infections. We will show that we can accurately detect, characterize and distinguish the presence of MDR pathogens in the milieu of commensal bacteria that are often present at a wound site. With the availability of drugs that can… more
Abstract:…eir interactions with others in all areas of businesses and intelligence, such as online social networking, marketing and advertisement, banking and finance, logistics and transportation, telecommunications, healthcare and hospitals, homeland security, bio-engineering and drug… more
Abstract:…tivities over next 2-3 years we will reproducibly prepare the Sn-117m in high enough quantities to perform chelation and conjugation experiments that could be used in human clinical studies; (ii) To develop Sn-117m labeled chelates/molecular versions of pharmaceuticals that… more
Abstract:Through the creation of carbon neutral biofuels and environmentally friendly methods for chemical and pharmaceutical synthesis, synthetic biology hopes to produce biology-based solutions to some of the worlds grand challengesdisease, energy supply, and pollution. Many of these… more
Abstract:… is emulsified with a carrier system that when dried captures the liquid ingredient in a powdered form. High temperature spray drying remains the preferred method of drying many thermally sensitive materials such as foods, chemicals, probiotics, pharmaceuticals, and in many… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will develop a platform technology that improves drug delivery. Many drugs, such as blood factors, require frequent dosing because they do not last long in the body and/or require delivery via a… more
Abstract:Many protein-based drugs have limited efficacy due to a short half-life or require intravenous delivery because of low bioavailability when given subcutaneously. Extend Biosciences is developing proprietary carrier molecules that will allow proteins to access a transport pathway… more
Abstract:… its ability to dewater suspended solids using less than a tenth of the energy of incumbent methods like centrifugation. Using the microhole membrane to help scale this technology can slash energy use and processing costs in the areas of algae and biofuels, pharmaceuticals,… more
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