Abstract:This Small Business Innovation Research (SBIR) Phase I project focuses on technical feasibility of a remotely-controlled implantable drug infusion pump miniaturized to a standard pill form factor. Technical challenges include the development of a low-power inductively-powered… more
Abstract:…veral different levels and will contribute toward maintaining the United States edge in the area of high-tech biomedicine. Initial target market for the QPI-based instrument consists of scientists with access to research grade microscopes in the biotech and pharmaceutical… more
Abstract:… metrology. 2. Quantitative measurement will enhance process control, improve reliability prediction and design validation in semiconductors, photo-voltaic, bio-medical devices and catalysts. 3. Video and dynamic-imaging will advance nano-scale research in pharmaceutical and… more
Abstract:… in biomedical and clinical research. A reliable label-free imaging tool with the capability to identify chemical bond information at the molecular level will potentially bring about revolutionary advances in many fields of basic and applied biological science, including drug… more
Abstract:… of significant germicidal capabilities of non-thermal plasma could be advantageous for patient care. The broader impact/commercial potential of this project is the creation of a unique, portable, and low-cost device that will allow for treatment of wounds without inducing … more
Abstract:…aracterization of polymer based biodegradable nanoparticles of novel inhibitors of cell proliferation. The development of polymer-based biodegradable nanoparticles is guided by the desire to improve overall survival and quality of life by increasing the bioavailability of drug… more
Abstract:… a one to two orders of magnitude price reduction over current grippers that achieve similar performance. The first target market will be industrial manufacturing, focusing on tasks where variations in object shape are prevalent (e.g. food handling, pharmaceuticals, bin picking,… more
Abstract:… will be to determine the utility of a parsable ontology for supporting ideation and innovation by connecting diverse knowledge domains. The broader impact/commercial potential of this project spans multiple fields and markets, including but not limited to pharmaceuticals,… more
Abstract:… 2% of the solar irradiance, the nanofiber mesh responds to radiation from the full solar spectrum. And solar power is free. Apart from water remediation, immediate uses of the nanofiber mesh technology are envisioned in filtration, as well as in biomedical and pharmaceutical… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project proposes a new expression platform in Escherichia coli applicable to both drug discovery and biopharmaceutical manufacturing. It solves and leverages recombinant protein misfolding in E. coli. Small molecular weight… more
Abstract:… genomic engineering is anticipated, the robust fermentation and expression characteristics of C1 are expected to remain intact. The broad impact/commercial potential of this project is in its effect on lowering the cost of manufacturing biopharmaceutical drugs.… more
Abstract:… power over all existing methods to determine CAD risk. The broader impact/commercial potential of this project is to enable rapid assessment of HDL function and accurately predict CAD risk, a multi-billion-dollar commercial opportunity in the medical diagnostics and drug… more
Abstract:… potency based on a chemical structure and inform design of safer alternative chemicals based on chemical reactivity and physical properties. The broader impact/commercial potential of this project is to provide the cosmetics, consumer chemicals, pharmaceuticals,… more
Abstract:…. Wound infections, whether acute or chronic, affects millions of Americans and have significant monetary and physiologic impacts on patient quality of life. Current therapies that rely on antibiotics are becoming limited due to the frequency of antibiotic drug resistance.… more
Abstract:…vo to model clinical performance and validated sensor performance in pilot clinical studies. We have also developed a prototype preclinical platform feedback control loop (including controller design elements) for closed-loop infusional propofol anesthesia to automate drug… more
Abstract:The overall goal of this proposed program (through Phase III) is to build a space-worthy Drug Stability Analyzer that can determine the extent of drug degradation. It will be able to monitor the drug active pharmaceutical ingredient (API) and its degradation product… more
Abstract:… format alongside a diluent, and automatically delivering the beneficial agent to a patient after reconstitution. The device comprises an automatic needle insertion mechanism and automatic needle retraction mechanism and is safe and disabled after use. The primary drug… more
Abstract:… and its intensity and develop a pain detection algorithm software. Our long-term goal (Phase 2, 3) is to develop and commercialize a user-friendly brain wave sensing device that utilizes our pain detection algorithm software to be used by DoD, physicians, pharmaceutical… more
Abstract:… or holistic manner involved the use of animal models which are expensive, labor-intensive, time consuming, low throughput, and may not always be highly predictive of human responses. Many of these key developmental pathways overlap with targets of modern oncology drug… more
Abstract:… plasma modules capable of efficiently producing ozone for water treatment. The conservation of water resources for human consumption is a growing national priority. Contamination of ground municipal water by animal manure, fertilizer and pharmaceuticals, for example,… more
Abstract:…erility assurance applications for NASA spacecraft bioburden reduction, DHS pathogen decontamination and EPA wastewater treatment efficiency monitoring, we envision that GEB will become and essential tool in the fight against microbial contamination in pharmaceutical, health… more
Abstract:…ddle and inner ear components of hearing are not capable of producing well-calibrated and high-quality acoustic stimuli that cover the entire frequency range of human hearing and are thus unsuited for rapid evaluation of the range of inner ear damage from ototoxic drugs, noise… more
Abstract:… project is to develop STC101, a biosmilar Herceptin . Trastuzumab is a monoclonal antibody made against the HER2 protein that is overexpressed in 20-25% of patients with breast cancer. Because of high cost associated with prescribing Herceptin , a generic version of this drug… more
Abstract:DESCRIPTION (provided by applicant): Chemotherapy-induced ototoxicity is damage to the inner ear that is caused by the side effects of administered drugs. This can lead to permanent hearing loss and/or tinnitus (continuous ringing in the ear) in the patient. Some of the most… more
Abstract:DESCRIPTION (provided by applicant): Current approaches to treat sudden sensorineural hearing loss (SSNHL) do not maintain inner ear drug concentrations within an appropriate therapeutic window for sufficient lengths of time to achieve therapeutic effect.A novel delivery system… more
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