Abstract:DESCRIPTION (provided by applicant): The broad long-term goal of this research is to reduce morbidity due to arthritis by developing long-lasting injectable intra-articular drug delivery systems. Intra-articular steroids have been a mainstay of treatment for arthritis for more… more
Abstract:… to septicemia, increasinghospital stays and costs, and ultimately discontinuation of radiotherapy. This impacts overall effectiveness of cancer therapy so development of an agent for prevention and treatment of OM is clearly an unmet need. Terapio is developing a drug,… more
Abstract:… a panel of synapse proteins, many of which have been shown to be modulated in response to opiate administration. In this Phase I/II study, antibodies against a panel of about 150 synaptic proteins will be developed and used to probe the changes of these proteins upon drug… more
Abstract:… liquid handling, user-friendly experiment tools, and sophisticated neural analysis software. For scientists, this integration will significantly improve their ability to extact functional information from neural cultures; paving the way for new progress in drug discovery… more
Abstract:…. Milestone: Data showing sensitivity and specificity near 100%. Phase II plan: To convert the biosensor into a marketable prototype for research and clinical laboratories, and to use the prototype for a study designed to obtain 510 (k) clearance from the Food and Drug… more
Abstract:… glioblastoma multiforme (GBM, high grade glioma), a deadly and invasive brain tumor with no effective treatment. Of the 12,000 patients expected to be diagnosed with GBM this year, most will succumb within a year. There is an urgent demand for an efficacious anti-glioma drug.… more
Abstract:DESCRIPTION (provided by applicant): Resistance to chemotherapeutic drugs is an ongoing problem that results in eventual treatment failures or suboptimal patient outcomes. Approximately one-quarter of BCR-ABL(+) leukemia patients demonstrate evidence of resistance to imatinib… more
Abstract:… bone marrow cells to divide and differentiate into neutrophils. Recombinant human G-CSF is widely used to treat chemotherapy-related neutropenia in cancer patients, and recent studies indicate that it improves overall survival in animal models of ARS, although the drug… more
Abstract:…de-offs in manufacturability and cost to develop a variable custom manufacturing process that would including everything from simple marking to 3-D imaging using lens arrays or even constructing full holograms. PUBLIC HEALTH RELEVANCE PUBLIC HEALTH RELEVANCE: Counterfeit … more
Abstract:… used for both treatment of lung diseases (such as asthma and chronic obstructive pulmonary disease) and in delivering drugs to the systemic circulation. To reach the desired effectiveness and safety oforally/nasally inhaled drugs, appropriate deposition of drugs on… more
Abstract:… including VEGF, TNF- , ICAM-1 and CTGF, and inhibits multiple pathological processes of DR such as retinal vascular leakage, inflammation and neovascularization. Based on these observations, we hypothesize that 2F1mab has great potential to become an effective drug for… more
Abstract:… coatings on aircraft carriers, naval ships, and submarines. In the civilian market, CIMOSA could used to detect oxidative corrosion in coatings on commercial airplanes and automobiles, detection of false coatings on counterfeit electrical components, counterfeit drug… more
Abstract:… people reported using prescription pain medications (opioids) non-medically (without a prescription) , and 2 million people reported using prescription painkillers non-medically for thefirst time . In 2009, 1/3 o people older than 12 initiated illicit drug use via… more
Abstract:… by applicant) An epidemic of addiction to prescription pain medications now causes deaths due to overdose that outnumber automobile-related deaths, rising admissions to hospitals, and disrupted lives for both the patient and family.The White House Office of National Drug… more
Abstract:… with HIV, with 96% residing in the developing world. While antiretroviral therapy is effective and increasingly available, the standard of care requires periodic monitoring of patients' viral load to individualize treatment and to control the emergence and spread of drug-… more
Abstract:… population. Work Plan Overview: To translate COG1410 to the clinic and reduce the risks associated with commercialization (please see details in the attached proposal), we are proposing to perform allstudies necessary to receive approval of an Investigational New Drug (IND)… more
Abstract:Oral mucositis is a major complication of radiotherapy for the treatment of head and neck cancer and a major dose-limiting side effect. Our work has shown that intra-esophageal administration of plasmidlliposomes containing the transgene expressing humansuperoxide dismutase 2 (SOD2) (JVRSOD) … more
Abstract:… in collaboration with the group of Professor Robin Rogers at the University of Alabama, will develop new technology for the acid catalyzed conversion of the plant-derived sugar sorbitol to isosorbide, a diol of interest as a chemical intermediate, pharmaceutical… more
Abstract:DESCRIPTION: Summary Enhanced Recovery of Pharmaceutical Solvent driven by EPA Initiative Recent Events: On July 6, 2011 the United States Environmental Protection Agency (EPA) announced plans to establish new safeguards for hazardous secondary materialsrecycling with… more
Abstract:… equipment and to achieve size, performance and safety advantages over existing technologies. Phase I will assess overall feasibility of concept by focusing on design of MOX reactor and identifying requirements to inactivate selection of highly used pharmaceutical … more
Abstract:DESCRIPTION (provided by applicant): The merging of cell culture and microfluidic technology has resulted in improved in vitro models for toxicity studies, drug development, and biomedical research. The reason for which microfluidic approaches provide a more accurate in vitro… more
Abstract:…. In more than one-third ofED visits, patients are unable to provide an accurate list of their medications. Discrepancies and other errors in the documented medication list affect diagnostic and treatment decisions in the ED, and increase the risk of harmful adverse drug… more
Abstract:… conjugated with chelators for radiolabeling with metal radionuclides. Pharmacokinetic, pharmacodynamics, immunogenic and toxicological characteristics of agents will be investigated in animal models to obtain data necessary for filing an Investigational New Drug application.… more
Abstract:… produced complete remissions with long term survival vs. intracranially (IC) implanted human gliomas and breast cancer xenograft and melanoma murine models in mice. In the recentlycompleted Phase I clinical trial (that included patients with CNS involvement), the drug… more
Abstract:… development of the proposed instrument will have wide commercial and scientific applications and benefits. In addition to the Spallation Neutron Source application, the instrument will find applications in oceanographic, biological, chemical, pharmaceutical, energy, and… more
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