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Displaying 8451 – 8475 of 9010 Awards
Company: Matrix Pharmaceutical Inc Agency/Program/Year/Phase: HHS / SBIR / 1991 / 1
Abstract: MATRIX PHARMACEUTICAL, INC. IS FOCUSED ON DEVELOPMENT OF THE THERAPEUTIC IMPLANT (TI), A NOVEL INJECTABLE SUSTAINED-RELEASE DRUG PRODUCT. THE TI, A VISCOUS INJECTABLE GEL, IS COMPRISED OF A PROTEIN CARRIER MATRIX, VASOACTIVE TISSUE MODIFIER AND THERAPEUTIC AGENT. THE TI… more
Company: Media Group of CT. Agency/Program/Year/Phase: ED / SBIR / 1991 / 2
Abstract: AS PRODUCERS OF ONE OF THE U.S. DEPARTMENT OF EDUCATION'S EIGHT SUBSTANCE ABUSE PREVENTION VIDEOS DISTRIBUTED TO EVERYSCHOOL IN THE NATION, WE WILL COMBINE OUR EXPERTISE WITH THAT OF PREVENTION AND EVALUATION EXPERTS FROM YALE UNIVERSITY PSYCHOLOGY DEPARTMENT AND THE CONNECTICUT DEPARTMENT OF… more
Company: Micro-med, Inc Agency/Program/Year/Phase: HHS / SBIR / 1991 / 1
Abstract: ERYTHROCYTE MEMBRANE FRAGILITY MAY BE ALTERED BY DISEASE, AGE, AND DRUGS AND PLAYS AN IMPORTANT ROLE IN THE SURVIVAL AND FUNCTION OF THE ERYTHROCYTE. THE ONLY COMMONLY USED TECHNIQUE FOR ASSESSING THIS PARAMETER, THE OSMOTIC FRAGILITY TEST, IS VERY TIME CONSUMING, GIVES AN… more
Company: Epoch Pharmaceuticals, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1991 / 1
Abstract: IN THIS PHASE I STUDY WE WILL IMPROVE THE EFFICIENCY AND DEVELOP THE LINKING CHEMISTRY OF A NOVEL CLASS OF DNA CLEAVAGE REAGENTS. THESE AGENTS, WHICH UNDERGO THERMALLY TRIGGERED RADICAL FORMATION WILL BE MODIFIED WITH AN INTERCALATING GROUP IN ORDER TO INCREASE THE EFFICIENCY OF DNA CLEAVAGE. THE… more
Company: Epoch Pharmaceuticals, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1991 / 1
Abstract: A SECRETABLE ALKALINE PHOSPHATASE (SPAP) REPORTER GENE WILL BE SUBSTITUTED FOR A PORTION OF THE ENV GENE IN AN HIV PROVIRAL DNA CLONE. EXPRESSION OF THE REPORTER GENE WILL BE REGULATED BY A COMPLETE COMPLEMENT OF VIRAL CIS AND TRANS ACTING CONTROL ELEMENTS, SUCH THAT THE LEVEL OF EXTRACELLULAR… more
Company: Epoch Pharmaceuticals, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1991 / 1
Abstract: UNIQUELY MODIFIED ANTI-SENSE OLIGODEOXYNUCLEOTIDES (ODNS) TARGETED TO THE HEPATITIS B SURFACE ANTIGEN TRANSCRIPT WILL BE EVALUATED IN A DIFFERENTIATED HEPATOMA CELL LINE WHICH SUPPORTS THE CONSTITUTIVE PRODUCTION OF INFECTIOUS DANE PARTICLES. INHIBITION OF SURFACE ANTIGEN PRODUCTION WILL BE… more
Company: MOLECULAR DESIGN INTERNATIONAL, INC. Agency/Program/Year/Phase: HHS / SBIR / 1991 / 2
Abstract: … REMISSIONS THAT AREEMOTIONALLY AND PHYSICALLY DEBILITATING. SEVERAL TREATMENTSARE AVAILABLE, BUT IN MANY CASES THESE ARE INADEQUATE. THIS APPLICATION IS BASED ON THE PREMISE THAT TOPICAL ADMINISTRATION OF PRODRUGS SHOULD RESULT IN HIGH CONCENTRATIONS OF THE ACTIVE DRUG AT THE… more
Company: Molecular Oncology Inc Agency/Program/Year/Phase: HHS / SBIR / 1991 / 1
Abstract: …OLOGICALLY ACTIVE TIMP-2 AND 72 KD TYPE IV COLLAGENASE BY RECOMBINANT DNA TECHNOLOGY AND CHARACTERIZE THEIR BIOCHEMICAL AND BIOLOGICAL PROPERTIES. AVAILABILITY OF THESE PROTEINS WILL ALLOW US TO STUDY THEIR ROLE IN DISEASE AND TO DEVELOP ANTIBODIES AND SPECIFIC DRUGS TO BE USED… more
Company: Molecular Solvometrics, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1991 / 1
Abstract: N/A
Company: Moravek Biochemicals, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1991 / 1
Abstract: THE GOAL OF THIS PROJECT IS TO MAINTAIN AND OPERATE A SPECIALIZED LABORATORY FOR THE SYNTHESIS OF SELECTED ANTI-CANCER AND ANTI-AIDS COMPOUNDS LABELED WITH CARBON-14, TRITIUM OR SULFUR-35. IN ADDITION, WE WILL DEVELOP THE RADIOSYNTHESIS OF SUCH DRUGS SELECTED BY NCI. THE LABEL… more
Company: Neurex Corp. Agency/Program/Year/Phase: HHS / SBIR / 1991 / 2
Abstract: OPIOID PEPTIDES AND DRUGS CAUSE MULTIPLE EFFECTS IN THE CENTRAL NERVOUS SYSTEM AND THROUGHOUT THE ENTIRE BODY. SEVERAL DISTINCT OPIOID RECEPTORS HAVE BEEN DESCRIBED BIOCHEMICALLY AND PHARMACOLOGICALLY, BUT THE GENES ENCODING THEM REMAIN UNKNOWN. THIS PROJECT WILL IDENTIFY AND… more
Company: Neuromedical Tech Inc Agency/Program/Year/Phase: HHS / SBIR / 1991 / 1
Abstract: …ORM OF LOW CURRENT TRANS-CRANIAL ELECTROSTIMULATION THERAPY (TCET) ATTENUATES ACUTE OPIATE ABSTINENCE SYNDROME IN MORPHINE ADDICTED RATS. THIS STUDY WILL EXAMINE THE POSSIBILITY THAT TCET ATTENUATES ACUTE AND/OR SECONDARY OPIATE ABSTINENCE SYNDROME IN REHABILITATING DRUG ABUSERS… more
Company: Northwest Toxicology Inc Agency/Program/Year/Phase: HHS / SBIR / 1991 / 1
Abstract: EVIDENCE ABOUNDS THAT LSD CONTINUES TO BE A SIGNIFICANT DRUGOF ABUSE. UNFORTUNATELY, EXISTING GC/MS TESTS FOR LSD ARE GENERALLY UNABLE TO DETECT THE DRUG IN URINE FOR MORE THAN AFEW HOURS AFTER INGESTION. CONSEQUENTLY, THERE IS A CRITICAL NEED FOR DEVELOPMENT OF A MORE SENSITIVE… more
Company: Nova Pharmaceutical Corp Agency/Program/Year/Phase: HHS / SBIR / 1991 / 1
Abstract: STROKE IS THE MOST PROMINENT CNS DISORDER IN THE UNITED STATES AS WELL AS THE LEADING CAUSE OF DISABILITY AND THE THIRD LEADING CAUSE OF DEATH. HOWEVER, THERE ARE NO EFFECTIVE TREATMENTS AVAILABLE TO PREVENT OR REDUCE NEURONAL DAMAGE RESULTING FROM STROKE OR OTHER FORMS OF CEREBRAL ISCHEMIA.… more
Company: Nova Pharmaceutical Corp Agency/Program/Year/Phase: HHS / SBIR / 1991 / 1
Abstract: DOPAMINE (D2) RECEPTOR ANTAGONISTS SUCH AS HALOPERIDOL AND CHLORPROMAZINE ARE MOST COMMONLY USED TO TREAT SCHIZOPHRENIA. HOWEVER, BOTH ACUTE AND CHRONIC ADMINISTRATION OF THESE DRUGS CAN RESULT IN THE APPEARANCE OF EXTRAPYRAMIDAL SIDE EFFECTS (EPS) WHICH, LIKE THE THERAPEUTIC… more
Company: Nova Pharmaceutical Corp Agency/Program/Year/Phase: HHS / SBIR / 1991 / 1
Abstract: ENDOTHELIN-1 (ET-1), A 21 AMINO ACID PEPTIDE, ACTING AT SPECIFIC RECEPTORS IN VASCULAR TISSUES HAS BEEN DEMONSTRATED TO INITIATE SUCH PHYSIOLOGICAL RESPONSES AS: DECREASES/INCREASES IN SYSTEMIC ARTERIAL PRESSURE, ALTERATIONS IN LOCAL BLOOD DISTRIBUTION, RENAL FUNCTION (I. E. FORMATION AND… more
Company: Oculokinetics Inc Agency/Program/Year/Phase: HHS / SBIR / 1991 / 1
Abstract: THE EM/2 ALCOHOL & DRUG SCREENER IS A SIMPLE COMPUTER-BASED TEST WHICH RECORDS A SUBJECTS' OCULAR MOTOR AND PUPILLARY RESPONSES TO DETERMINE IF PHYSIOLOGICAL SYMPTOMS OF DRUG/ALCOHOL INTOXICATION EXIST. THE ADVANTAGES OF THE EM/2 OVER URINE BASED DRUG TESTING INCLUDE IMMEDIATE… more
Company: OPHIDIAN PHARMACEUTICALS, INC. Agency/Program/Year/Phase: DOD / SBIR / 1991 / 1
Abstract: N/A
Company: Organogenesis, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1991 / 1
Abstract: … TO THE RESEARCH NECESSARY FOR THE CONSTRUCTION OF TESTCORNEA\, AN IN VITRO MODEL OF THE HUMAN CORNEA. THIS MODEL WILL BE DESIGNED FOR THREE APPLICATIONS: 1) THE DETERMINATION OF THE OCULAR IRRITANCY AND CYTOTOXIC POTENTIAL OF CHEMICAL, COSMETICS, AND PHARMACEUTICALS; 2) BASIC… more
Company: OXFORD BIOMEDICAL RESEARCH, INC. Agency/Program/Year/Phase: HHS / SBIR / 1991 / 2
Abstract: … OF PGI2 INDICATE AN IMPORTANT ROLE FOR PROSTACYCLIN SYNTHASE IN THE PATHOPHYSIOLOGY OF THROMBOSIS AND CARDIOVASCULAR DISEASES. COMMERCIAL AVAILABILITY OF A PURIFIED PREPARATION OF MAMMALIAN PROSTACYCLIN SYNTHASE SHOULD THEREFORE FACILITATE BASIC AND PHARMACEUTICAL RESEARCH,… more
Company: PHOTONIC BIOSYSTEMS, INC Agency/Program/Year/Phase: HHS / SBIR / 1991 / 1
Abstract: … CONDUCTING BIOASSAYS WITH MICROBES. THIS WILL BE DONE BY PRODUCING SENSOR-ASSAY SAMPLE VESSELS WHICH WILL BE USED TO ANALYZE METABOLISM OF VERSATILE AND USEFUL FOR NUMEROUS APPLICATIONS RANGING FROM CLINICAL ASSAYS, TOXICITY TESTS, MICROBIAL RESEARCH, AND PHARMACEUTICAL… more
Company: Phyton Catalytic, Inc. Agency/Program/Year/Phase: NSF / SBIR / 1991 / 1
Abstract: … LEVEL OF CELLULAR ASSOCIATION. PHASE II INVOLVES INTEGRATION OF OTHER PRODUCTIVITY ENHANCEMENT STRATEGIES WITH THE IMMOBILIZED CELL PROCESS. REACTOR DESIGN AND SCALE-UP STUDIES WILL PRECEDE PILOT SCALE OPERATION. OUR TARGET IS TAXOL, A RARE AND VALUABLE ANT-CANCER DRUG OF VITAL… more
Company: Potomac Photonics Inc Agency/Program/Year/Phase: HHS / SBIR / 1991 / 1
Abstract: … ELECTROPHORESIS. WE INTEND TO DEMONSTRATE \100 TIMES GREATER SENSITIVITY THAN THAT AVAILABLE FROM UV-TRANSMISSION DETECTORS BEING USED FOR HPCE SYSTEMS. SUCH A DETECTOR WILL HAVE A BROAD ARRAY OF APPLICATIONS SUCH AS GENETIC TESTING AND ENGINEERING, PHARMACEUTICAL… more
Company: PROGENICS PHARMACEUTICALS, INC. Agency/Program/Year/Phase: HHS / SBIR / 1991 / 1
Abstract: N/A
Displaying 8451 – 8475 of 9010 Awards
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