Abstract:… bone marrow cells to divide and differentiate into neutrophils. Recombinant human G-CSF is widely used to treat chemotherapy-related neutropenia in cancer patients, and recent studies indicate that it improves overall survival in animal models of ARS, although the drug… more
Abstract:…de-offs in manufacturability and cost to develop a variable custom manufacturing process that would including everything from simple marking to 3-D imaging using lens arrays or even constructing full holograms. PUBLIC HEALTH RELEVANCE PUBLIC HEALTH RELEVANCE: Counterfeit … more
Abstract:… used for both treatment of lung diseases (such as asthma and chronic obstructive pulmonary disease) and in delivering drugs to the systemic circulation. To reach the desired effectiveness and safety oforally/nasally inhaled drugs, appropriate deposition of drugs on… more
Abstract:… including VEGF, TNF- , ICAM-1 and CTGF, and inhibits multiple pathological processes of DR such as retinal vascular leakage, inflammation and neovascularization. Based on these observations, we hypothesize that 2F1mab has great potential to become an effective drug for… more
Abstract:… coatings on aircraft carriers, naval ships, and submarines. In the civilian market, CIMOSA could used to detect oxidative corrosion in coatings on commercial airplanes and automobiles, detection of false coatings on counterfeit electrical components, counterfeit drug… more
Abstract:… people reported using prescription pain medications (opioids) non-medically (without a prescription) , and 2 million people reported using prescription painkillers non-medically for thefirst time . In 2009, 1/3 o people older than 12 initiated illicit drug use via… more
Abstract:… by applicant) An epidemic of addiction to prescription pain medications now causes deaths due to overdose that outnumber automobile-related deaths, rising admissions to hospitals, and disrupted lives for both the patient and family.The White House Office of National Drug… more
Abstract:… with HIV, with 96% residing in the developing world. While antiretroviral therapy is effective and increasingly available, the standard of care requires periodic monitoring of patients' viral load to individualize treatment and to control the emergence and spread of drug-… more
Abstract:… population. Work Plan Overview: To translate COG1410 to the clinic and reduce the risks associated with commercialization (please see details in the attached proposal), we are proposing to perform allstudies necessary to receive approval of an Investigational New Drug (IND)… more
Abstract:Oral mucositis is a major complication of radiotherapy for the treatment of head and neck cancer and a major dose-limiting side effect. Our work has shown that intra-esophageal administration of plasmidlliposomes containing the transgene expressing humansuperoxide dismutase 2 (SOD2) (JVRSOD) … more
Abstract:… in collaboration with the group of Professor Robin Rogers at the University of Alabama, will develop new technology for the acid catalyzed conversion of the plant-derived sugar sorbitol to isosorbide, a diol of interest as a chemical intermediate, pharmaceutical… more
Abstract:DESCRIPTION: Summary Enhanced Recovery of Pharmaceutical Solvent driven by EPA Initiative Recent Events: On July 6, 2011 the United States Environmental Protection Agency (EPA) announced plans to establish new safeguards for hazardous secondary materialsrecycling with… more
Abstract:… equipment and to achieve size, performance and safety advantages over existing technologies. Phase I will assess overall feasibility of concept by focusing on design of MOX reactor and identifying requirements to inactivate selection of highly used pharmaceutical … more
Abstract:DESCRIPTION (provided by applicant): The merging of cell culture and microfluidic technology has resulted in improved in vitro models for toxicity studies, drug development, and biomedical research. The reason for which microfluidic approaches provide a more accurate in vitro… more
Abstract:…. In more than one-third ofED visits, patients are unable to provide an accurate list of their medications. Discrepancies and other errors in the documented medication list affect diagnostic and treatment decisions in the ED, and increase the risk of harmful adverse drug… more
Abstract:… conjugated with chelators for radiolabeling with metal radionuclides. Pharmacokinetic, pharmacodynamics, immunogenic and toxicological characteristics of agents will be investigated in animal models to obtain data necessary for filing an Investigational New Drug application.… more
Abstract:… produced complete remissions with long term survival vs. intracranially (IC) implanted human gliomas and breast cancer xenograft and melanoma murine models in mice. In the recentlycompleted Phase I clinical trial (that included patients with CNS involvement), the drug… more
Abstract:… development of the proposed instrument will have wide commercial and scientific applications and benefits. In addition to the Spallation Neutron Source application, the instrument will find applications in oceanographic, biological, chemical, pharmaceutical, energy, and… more
Abstract:…ng and a game changer for automated target recognition". Air Force transition systems include Dismount Detection Radar (DDR) and other next generation Air Force ISR radar systems. Non DoD transitions opportunities exist in border security applications and drug enforcement… more
Abstract:… in our initial in vitro and in vivo studies. However, the oral antimalarial dose needed was approximately 10-fold higher than the intraperitoneal dose. Several factors could be responsible for the observed limited oral absorption. These could include degradation of the … more
Abstract:… project is geared towards developing and demonstrating a crucial component of such an on-line monitoring and control system. If successful, this will provide a tremendous boost to continuous production processes across the food industry. In addition, other pharmaceutical… more
Abstract:… an environment where bacteria can thrive outside the reach of the body's immune system. Currently available infection resistant materials typically rely on the release of antimicrobial substances. Though effective over the short-term, the released drugs can… more
Abstract:… safe and renewable. Unfortunately, the feedstock sorbitol is produced in too small quantities and at too high of a price to be competitive with petroleum-derived phthalates. As a result of the cost, isosorbide is largely restricted to highly specialized uses in pharmaceuticals… more
Abstract:… bioreactor conditions. In the current application, we propose to optimize the fermentation and purification processes and conduct a scaled up production run that will demonstrate proof of concept of the manufacturing process and generate a substantial supply of bulk drug… more
Abstract:…, and are well within the technical capabilities of PSI. The proposed structural studies would be of great value in developing a family of HybridCPG products that could dramatically reduce the manufacturing costs of several important classes of advanced … more
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