Abstract:…, and this number is heading toward 18 million by 2020.1 Beyond the human costs in lives, productivity, and quality of life, the NIH estimated cancer's direct medical costs t 103 billion in 2010, with total costs being263 billion.1-2 Clearly, adequate drug therapy is… more
Abstract:…. SensoPath Technologies will develop a detailed understanding of the dosimetry of the process, involving the interplay of targeting the receptor on the tumor surface, the delivery of pulsed near infrared (NIR) laser light in the range 800-840 nm, the method of drug… more
Abstract:…FDA-approved sterilization procedures utilizing the Sterigenics gamma radiation facility, and 3) additional biological data providing both a head-to-head comparison of our products to those already on the market while also creating a market "pull" for the … more
Abstract:… ago, but they are very time consuming and troublesome to develop. This project describes a platform that standardizes and automates generation of aptamer reagents. It has to potential to significantly accelerate the development of aptamer tools for use in drug delivery,… more
Abstract:… cell lines, for the applicability of this method. The broader impact/commercial potential of this project, if successful, is a Fluorescent Imaging Kit that can be routinely used with such advanced techniques as high content screening, high throughput screening for … more
Abstract:… sciences. 2D IR spectroscopy provides structural and dynamical information that is difficult to obtain with other techniques, such as at inorganic/organic interfaces that are important in solar cell research or membrane proteins associated with pharmaceutical targets.… more
Abstract:DESCRIPTION (provided by applicant): Project Summary/Abstract Methamphetamine (meth), the fastest-growing illicit drug in the United States, is manufactured in makeshift laboratories using highly flammable and toxic ingredients. Most meth labs are discovered when fires,… more
Abstract:DESCRIPTION (provided by applicant): The absence of a widely accepted commercially available method to measure glomerular filtration rate (GFR) in animal models and in the clinic has had profoundly negative effects on (i) developing methods and drugs for treating kidney disease,… more
Abstract:… during chemotherapy and idiopathic thrombocytopenic purpura. During these situations, close and frequent monitoring of a patient's blood counts is a must to deliver the best care and treatment, whether it be blood transfusions, platelet transfusions, or drug… more
Abstract:… used in the service of clinical or translational research in the social and behavioral sciences. Social and behavioral research plays a critical role in advancing the understanding and prevention of public health problems, both at the individual level (e.g., drug and alcohol… more
Abstract:… HEALTH RELEVANCE: In the United States alone, approximately 7,000 students drop out of school each day. School dropout poses serious individual and societal risks. Dropouts obtain lower skilled and lower paying jobs than high school graduates and are more likely to report drug… more
Abstract:DESCRIPTION (provided by applicant): The objective of this program is to further the development of a novel, stable, non-aqueous glucagon formulation as an integral component of a bi-hormonal (insulin-glucagon) pump system for treatment of persons with diabetes. The addition of glucagon to the… more
Abstract:…, eliminates the risk for amplicon contamination in the assay, and does not require highly trained operators. The PACeR-Gold diagnostic platform will be continuously expanded to include assays to detect nontuberculous mycobacteria, multidrug-resistant-TB, extensively … more
Abstract:…esearch (SBIR) Phase I project will demonstrate that chemical compound activity/binding prediction can be significantly improved by applying geometric mining to the Joint Pharmacophore Space (JPS). Activity/binding prediction is of immense importance to the pharmaceutical… more
Abstract:The goal of this proposal is to discover drug-like retinoid X receptor (RXR) agonists that can halt and reverse the progression of Alzheimer's disease (AD). The research strategy is to target ApoE gene expression through RXR agonists; this has recently been shown to improve… more
Abstract:…l of targeted therapies and monoclonal antibody approaches. The development ofnovel therapy against target critical and specific to the cancer cells but not to the normal tissues is expected to be efficacious and minimize damage to healthy cells. AandG Pharmaceutical Inc. is… more
Abstract:Aromatase Inhibitors (AI) are the preferred hormonal treatment for estrogen receptor positive Breast Cancer (BC) in postmenopausal women and are used to treat approximately 140,000 patients annually in the US. However, ~40% of patients will be, or become resistant to AIs. If sensitivity to AI can be… more
Abstract:DESCRIPTION (provided by applicant): Advances in pharmaceutical drug development and the pioneering use of cell-cultures to produce biologic compounds have the potential to usher in a new era of medicine. There are incredible opportunities for developmentof… more
Abstract:… efficacy in an animal model of EBV lymphomagenesis. In this Phase 1 proposal,we will partner with Fox Chase Chemical Diversity Center to advance a lead compound using medicinal chemistry methods and extensive biochemical and biological analysis to validate mechanism of drug… more
Abstract:…posed novel biological diagnostic platform combines the precision of photonic sensing and nanotechnology with a versatile affinity binding system to make ultrasensitive measurements of biomarkers for a vast array of additional important targets for medical diagnostics, drug… more
Abstract:Advocates for Human Potential, Inc. (AHP) and Carnevale Associates, LLC will develop a plan for the National Drugged Driving Reporting System (DDRS), including a national minimum data set (NMDS) for drugged driving.
Abstract:… Nanotherapeutics (RANT) by combining advanced bioformatics, with DNA-based nanoparticles, peptide nucleic acid (PNA) antisense oligonucleotides, and cell permeating peptides (CPPs). Advanced bioinformatics computing will allow for the identification of essential and drug… more
Abstract:One major cause of the widespread of drug-resistant and virulent bacteria pathogen is the horizontal gene transfer of resistance and virulence genes in the form of plasmids. As proof-of concept for this Phase I effort, Agave BioSystems proposes to develop combinatorial… more
Abstract:Wounds infected with drug-resistant Gram-negative bacteria can increase morbidity, hospital length of stay and cost. Among these Klebsiella pneumoniae and Pseudomonas aeruginosa have become important causes of concern in military personnel wounded in battlefield. New classes of… more
Abstract:… range by using photodetector arrays with built-in drive electronics. The compact, affordable NMIR spectrometer should find many commercial applications in the areas of industry process control and analytical characterization of food, chemicals, and pharmaceuticals… more
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