Abstract:…ng and a game changer for automated target recognition". Air Force transition systems include Dismount Detection Radar (DDR) and other next generation Air Force ISR radar systems. Non DoD transitions opportunities exist in border security applications and drug enforcement… more
Abstract:… in our initial in vitro and in vivo studies. However, the oral antimalarial dose needed was approximately 10-fold higher than the intraperitoneal dose. Several factors could be responsible for the observed limited oral absorption. These could include degradation of the … more
Abstract:… project is geared towards developing and demonstrating a crucial component of such an on-line monitoring and control system. If successful, this will provide a tremendous boost to continuous production processes across the food industry. In addition, other pharmaceutical… more
Abstract:… an environment where bacteria can thrive outside the reach of the body's immune system. Currently available infection resistant materials typically rely on the release of antimicrobial substances. Though effective over the short-term, the released drugs can… more
Abstract:… safe and renewable. Unfortunately, the feedstock sorbitol is produced in too small quantities and at too high of a price to be competitive with petroleum-derived phthalates. As a result of the cost, isosorbide is largely restricted to highly specialized uses in pharmaceuticals… more
Abstract:… bioreactor conditions. In the current application, we propose to optimize the fermentation and purification processes and conduct a scaled up production run that will demonstrate proof of concept of the manufacturing process and generate a substantial supply of bulk drug… more
Abstract:…, and are well within the technical capabilities of PSI. The proposed structural studies would be of great value in developing a family of HybridCPG products that could dramatically reduce the manufacturing costs of several important classes of advanced … more
Abstract:… by applicant): Crystallization, followed by subsequent structure determination, is a major step in understanding the structure- function relationship of macromolecules. Understanding macromolecule structure has become a key part in the development of new pharmaceuticals,… more
Abstract:Project Summary/Abstract Ocular pharmaceuticals predominantly use the topical route of administration, which involves a number of benefits and limitations when compared to systemic drug routes. A major limitation of the ocular topical route is the rapid loss of drug via tearing… more
Abstract:DESCRIPTION (provided by applicant): Treating patients infected with Human Immunodeficiency Virus-1 (HIV-1) is a substantial clinical challenge with evolving pharmaceutical drug and dosing options. Treatments should improve the health and quality of life for… more
Abstract:… for mycotoxin exposure in either the acute or chronic setting, and the lack of an effective therapeutic could be catastrophic. In order to protec the safety and health of military personnel and civilians, there is a need to develop a therapeutic and prophylactic drug,… more
Abstract:DESCRIPTION (provided by applicant): Drug toxicity due to either overdose or abusive use represents a major healthcare problem. According to the Toxic Exposure Surveillance System data pharmaceuticals are implicated in 42% of all poisoning cases with gt123,000 annual cases… more
Abstract:… approach to prevent adhesions, which account for over 960,000 hospital care days and more than 2.3 billion in inpatient expenditures per year the product also has the potential to be adapted for use in a number of other biomedical applications including drug delivery… more
Abstract:… and easy to use by scientists and clinicians in academiaand industry. PUBLIC HEALTH RELEVANCE PUBLIC HEALTH RELEVANCE: The ability to treat brain disorders relies on accurately finding targets in the brain, that can serve as targets for novel drugs, or for… more
Abstract:DESCRIPTION (provided by applicant): This project will establish proof-of-concept for a powerful and versatile implementation of live-cell assays in a true high-throughput screening (HTS) format for small-molecule drug discovery. The technological basis isfluorescence lifetime… more
Abstract:… potential of this project is the need to replace PEG-based personal care additives, driven by reports that these materials contain toxic side products left after the manufacturing process, such as 1,4-dioxane, among others. The United States Food and Drug… more
Abstract:The design, fabrication, characterization, and preclinical evaluation of novel nanoparticle-based drug formulations capable of delivering candidate RNAi therapeutics for the treatment of cancer. PUBLIC HEALTH RELEVANCE
Abstract:… activity in cell cultures. In contrast, its hydrolysis product - (S)-HYG-441 - is devoid of both activities. (S)-HYG-440, applied topically to one hamster flank, reduced the size of this organ but only on the ipsilateral side These results suggest that this drug is a … more
Abstract:… common pathologies or interventions. Arterial thrombosis and the acute ischemic events that follow, such as myocardial infarction and stroke, are among the leading causes of death, incapacitation, and rising health care costs in the developed world. Therefore antiplatelet … more
Abstract:… (e.g., SPIA in Bioconductor and Pathway Express) and are the basis for Advaita's recently-introduced Pathway Guide. In the presently proposed work, we will apply and extend this systembiology approach to critical problems in personalized medicine and drug discovery.… more
Abstract:DESCRIPTION (provided by applicant): Medical drugs and devices are regulated by the U.S. Food and Drug Administration (FDA) based on data from multicenter clinical trials. In 2010, U.S. spending on clinical trials was approximately 25 billion. Over the past decade the… more
Abstract:… targeted sequencing libraries. The lysis-only protocol means there is no need to extract RNA or DNA or to reverse transcribe RNA. Consequently, sequencing from fixed tissue is as sensitive and accurate as sequencing unfixed tissue, addressing an unmet need for drug… more
Abstract:… in the acute MI setting, adjunctive to the gold-standard treatment(i.e. PCI [percutaneous coronary intervention]), rapidly after restoration of blood flow (or reperfusion), as a cardioprotective agent. Capricor has an approved IND (Investigational New Drug… more
Abstract:…in combination with state of the art therapies for melanoma and demonstrate synergistic efficacy of anti-PV1 combination therapies in a genetic murine melanoma model that closely mimics human disease. PUBLIC HEALTH RELEVANCE PUBLIC HEALTH RELEVANCE: Two new drugs for… more
Abstract:… and social constraints. BENEFIT: The completion of this project will result in the creation of a secure alert dispatch system for mobile devices that can be used with confidence in adverse communications and hostile environments, including warfighting, peace-keeping, drug… more
There are several categories such as “By Agency”, “By Year”, “By State” etc.
Select a checkbox within a category to refine your search results.
Each of your selections is listed in the “Narrow Search Filters” bar. You can uncheck these selections to remove them.
Search for Either Criteria
When you select multiple values within a category, the results will include values that match either of the selections.
For example, selecting “2005” and “2007” in the “By Year” category will display results that include either 2005 OR 2007 in the results.
Narrowing the Search Results
You can refine your search results across categories. To narrow down your results, select multiple values across different categories. The results will only include values that match the selections across the categories.
For example, selecting “2005” in the “By Year” category and “NASA” in the “By Agency” category will only display the results that contain both “2005” AND “NASA” in the results.