Abstract:This Small Business Innovation Research Program Phase I project proposes to develop a handheld Raman optical system for monitoring blood glucose levels noninvasively, continuously, and in real-time. Raman spectroscopy uses laser light scattered by chemical species to distinguish… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project aims to develop a novel research microscope based on coherent Raman scattering (CRS). In contrast to other techniques, CRS is a label-free method that requires excitation with two synchronized laser pulse trains… more
Abstract:… based on chemical phenotyping, which (1) provides quantitative analysis of specific molecular species, (2) has single cell sensitivity, (3) is high throughput, (4) label-free, and (5) non-destructive to living organisms. The proposed system uses coherent Raman scattering… more
Abstract:… devices capable of rapidly detecting, measuring and classifying Chlorinated Organic Solvents (COS) in environmental waters. The proposed sensor technology is based on an innovative adaptation of surface enhanced Ramon spectroscopy that greatly increases the Raman signal… more
Abstract:This Small Business Innovation Research Phase I project will focus on the challenge of reducing the cost of manufacturing Surface-Enhanced Raman Spectroscopy (SERS) substrates. SERS is a powerful analytical technique that is not widely adopted in industry due to the high cost of… more
Abstract:… technology will enable a breakthrough in the detection and identification of single molecules, drastically simplifying the sample preparation by removing the need for labeling. The Phase I work will focus on the use of the nanochannel/nanoantenna system to detect the Raman… more
Abstract:DESCRIPTION (provided by applicant): The use of Surface Enhanced Raman Scattering (SERS) for biomolecule detection has been restricted due to the great difficulty of fabricating ultrasensitive and reproducible surface-plasmonic-resonance (SPR) substrates.Therefore, detecting… more
Abstract:This Small Innovation Research Phase I project aims to demonstrate the feasibility of the Raman Force Microscope (RFM) to provide a new metrology tool for in situ topographic, strain, and chemical analysis with nanometer spatial resolution. Feature size reduction in the… more
Abstract:DESCRIPTION: We propose to develop a new type of monitor to directly and simultaneously identify multiple biomarker metabolites in persons suspected of having been exposed to alcohol. The technology we plan to utilize is surface-enhanced Raman scattering(SERS), based on a… more
Abstract:DESCRIPTION (provided by applicant): Chronic obstructive pulmonary disease (COPD) is a highly and increasingly prevalent disorder characterized by incomplete reversible airflow limitations. It is presently the third leading cause of death in the US, with over 13 million peopl suffering from the… more
Abstract:… analogs will significantly enhance the efficacy of understanding the conditions under which oxytocin is employed by the body. Ionica Sciences will take advantage of recent miniaturization of highly sensitive instrumentation that allows field application of surface enhanced … more
Abstract:… are insufficient to gain important information on side-wall morphology and chemistry to rapidly assess passivation techniques for effectiveness and reliability. Therefore, ACTOPROBE LLC seeks funding to develop an innovative, combined atomic-force/tip-enhanced Raman… more
Abstract:… of aircraft wake vortex. In this NASA SBIR project, we propose to build a lidar instrument that is capable of measuring both the daytime and nighttime atmospheric temperature profile in the lower troposphere. Atmospheric temperature measurement using Raman Lidar… more
Abstract:We propose to develop a device that is capable of rapidly identifying and classifying pollen from a broad sampling base using surface enhanced Raman spectroscopy (SERS). The proposed Raman device is designed to spectroscopically examine, identify and classify… more
Abstract:DESCRIPTION: We propose to build a portable, field-deployable blood test monitor to immediately identify toxic chemical agent buildup in persons suspected of having been exposed to such agents. The technology we plan to utilize is surface- enhanced Raman scattering to look for… more
Abstract:…, such as lubricants and amines formed during the coating process, using a measurement technique that can be adapted to a ship construction environment. The method we have demonstrated in our Phase I program is laser light scattering, specifically standoff Raman scattering,… more
Abstract:… can interfere with normal function and hamper the interpretation of experimental results. Furthermore, the fluorophores themselves are subject to photobleaching which results in limited imaging time and prevents long term studies. Coherent anti-Stokes Raman scattering… more
Abstract:… bases within single or double stranded DNA molecules in vitro. This technology will be capable of identifying and localizing genomic damage, while taking advantage of long read lengths and direct sequencing of unamplified DNA. In particular, this technology will use Raman… more
Abstract:…. This project is anticipated to have far reaching impacts. Infrared spectroscopy is arguably the most widely used technique for chemical characterization, but spatial resolution limits have prevented it from being widely applied at the nanoscale. Scattering SNOM and Raman… more
Abstract:Raman spectroscopy is a highly effective non-contact laser remote sensing method for detecting and identifying chemicals in every-day field environments. Raman spectroscopy is particularly suited for detecting trace surface contaminants that may indicate the presence of… more
Abstract:… to model, if possible, it is much more straightforward to assay for these compounds in the body rather than in the environment. The primary innovations in our approach are that a novel optical micro- to nano-fluidic device will be used along with unique aptamers and Raman… more
Abstract:… of ChromoLogic scientists and collaborators will result in an innovative system that is objective, compact and intuitive to use. In Phase I CL will demonstrate the feasibility of the OCOSMO technology by fabricating a prototype device to demonstrate the concept of Raman… more
Abstract:…, using field-portable, easily deployable, roll-to-roll devices. A low-footprint, low-power, portable roll-to-roll device will be developedbased on the initial prototype built under Phase I supportand ultimately ruggedized and used to fabricate nanocavity-based Raman… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project aims to develop a novel substrate for sensing of biomolecules by Surface Enhanced Raman Spectroscopy (SERS). The substrate is expected to be stable, low cost , reproducible and can be functionalized to improve… more
Abstract:… cells requires a sensitive, high spatial resolution microscopy method based on vibrational resonances that is capable of performing in situ spectroscopy with both frequency and time resolution. In this SBIR/STTR, we will develop a novel self-referencing stimulated Raman… more
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