Abstract:… comprised of these basic subunits. These current methods include immunoassays or PCR, both of which require expensive equipment and reagents with limited shelf life and restrictive environmental conditions for storage and use. Current optical methods such as Raman… more
Abstract:… provides a broad organic and inorganic compound measurement capability without the need for sample handling or reagents.It will excite sub-ppb levels of organic compounds on rocks, soil, or other surfaces in the deep UV below 250 nm and simultaneously measure Raman… more
Abstract:…t are designed to remove nitrogen through Simultaneous Nitrification and DeNitrification (SNdN). This is an example of a major source of potential environmental contamination. The technology of the proposed innovative sensor is deep ultraviolet excited resonance Raman (DUV-RR)… more
Abstract:Recent work by several groups has resulted in the recognition of the potential for Arctic tundral regions to become a significant net source of carbon greenhouse gases from thawing permafrost. As the Arctic region responds to climate forcings, monitoring how aerosol distributions respond and modify… more
Abstract:…, microstructure, and overall tissue state and maturity for transplantation. In a Phase I study, Physical Sciences Inc. (PSI) in collaboration with the Center for Regenerative Medicine at the Massachusetts General Hospital (MGH), investigated the use of combined Raman… more
Abstract:…chanical design and subjecting it to thermoelastic analysis. The Phase II program will fabricate an engineering prototype and demonstrate it at the DoE Southern Great Plains site for several months. It will be intercompared with balloon-borne radiosondes and with the sites … more
Abstract:DESCRIPTION (provided by applicant): Physical Sciences, Inc. (PSI), in collaboration with The Forsyth Institute, Cambridge, MA proposes to investigate the use of combined Raman microspectroscopy-Optical Coherence Tomography (OCT) imaging for in vivo diagnosis of tooth decay,… more
Abstract:…. We will accomplish this by (i) adopting the appropriate method of generating a pump laser composed of spike trains of uneven duration and delay (STUD pulses), (ii) adopting the appropriate method of detecting and diagnosing the amplified transmission of a stimulated Raman… more
Abstract:…d two photon laser induced fluorescence (fs-TPLIF) technique; (ii) The development of 1-D imaging of electric field distribution, and rotational/translational temperature and vibrational distribution function, using fs coherent Anti-Stokes Raman scattering… more
Abstract:… visual alarm indicator, and an electronic output signal that can interface with an aircraft's caution and warning system. The objective of the proposed work is to develop such a sensing module, based on the combination of a miniaturized surface enhanced Raman scattering… more
Abstract:… than the state of the art. Under Phase I, we have established the feasibility of realizing a superluminal ring laser gyroscope (SRLG) and a superluminal ring laser accelerometer (SRLA), based on diode-pumped alkali lasers (DPALs), augmented by a fast-light Raman cells. … more
Abstract:… time. Technologies that can assess the integrity of LWR structures and provide means to mitigate the degradation of reactor structures will help prolong reactor life and diminish the risks of structural failure. A portable, nondestructive assessment (NDA) Raman… more
Abstract:… during sample collection, transport and storage. Also, current requirements for surrounding aquifer contamination requires a more frequent sampling intervals that will be hard to be met by current methods because of cost and sampling time. A novel portable Raman… more
Abstract:… planetary surfaces, guided by robotic vehicles. These instruments should be highly reliable and compact, be remotely operable and require minimal operating resources. To meet this challenge, the goal of the proposed Phase I program is to develop a combined Raman and… more
Abstract:This project will develop an integrated nanoplasmonic sensor Raman device to detect chemical warfare agents. The Raman device will be designed and produced by MKS Technology and will be cell-phone sized for portability. The device will: operate from 2-AA batteries; have a… more
Abstract:…an detect bacteria at clinically relevant concentrations. We demonstrated the efficacy of this biomarker by accurately characterizing the presence/absence of bacteria in the plasma of blood obtained from hospitalized febrile patients. We also demonstrated a UV Raman modulation… more
Abstract:This Small Business Innovation Research Program Phase I project proposes to develop a handheld Raman optical system for monitoring blood glucose levels noninvasively, continuously, and in real-time. Raman spectroscopy uses laser light scattered by chemical species to distinguish… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project aims to develop a novel research microscope based on coherent Raman scattering (CRS). In contrast to other techniques, CRS is a label-free method that requires excitation with two synchronized laser pulse trains… more
Abstract:… based on chemical phenotyping, which (1) provides quantitative analysis of specific molecular species, (2) has single cell sensitivity, (3) is high throughput, (4) label-free, and (5) non-destructive to living organisms. The proposed system uses coherent Raman scattering… more
Abstract:… devices capable of rapidly detecting, measuring and classifying Chlorinated Organic Solvents (COS) in environmental waters. The proposed sensor technology is based on an innovative adaptation of surface enhanced Ramon spectroscopy that greatly increases the Raman signal… more
Abstract:This Small Business Innovation Research Phase I project will focus on the challenge of reducing the cost of manufacturing Surface-Enhanced Raman Spectroscopy (SERS) substrates. SERS is a powerful analytical technique that is not widely adopted in industry due to the high cost of… more
Abstract:… technology will enable a breakthrough in the detection and identification of single molecules, drastically simplifying the sample preparation by removing the need for labeling. The Phase I work will focus on the use of the nanochannel/nanoantenna system to detect the Raman… more
Abstract:DESCRIPTION (provided by applicant): The use of Surface Enhanced Raman Scattering (SERS) for biomolecule detection has been restricted due to the great difficulty of fabricating ultrasensitive and reproducible surface-plasmonic-resonance (SPR) substrates.Therefore, detecting… more
Abstract:This Small Innovation Research Phase I project aims to demonstrate the feasibility of the Raman Force Microscope (RFM) to provide a new metrology tool for in situ topographic, strain, and chemical analysis with nanometer spatial resolution. Feature size reduction in the… more
Abstract:DESCRIPTION: We propose to develop a new type of monitor to directly and simultaneously identify multiple biomarker metabolites in persons suspected of having been exposed to alcohol. The technology we plan to utilize is surface-enhanced Raman scattering(SERS), based on a… more
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