Abstract:…, such as lubricants and amines formed during the coating process, using a measurement technique that can be adapted to a ship construction environment. The method we have demonstrated in our Phase I program is laser light scattering, specifically standoff Raman scattering,… more
Abstract:… can interfere with normal function and hamper the interpretation of experimental results. Furthermore, the fluorophores themselves are subject to photobleaching which results in limited imaging time and prevents long term studies. Coherent anti-Stokes Raman scattering… more
Abstract:… bases within single or double stranded DNA molecules in vitro. This technology will be capable of identifying and localizing genomic damage, while taking advantage of long read lengths and direct sequencing of unamplified DNA. In particular, this technology will use Raman… more
Abstract:…. This project is anticipated to have far reaching impacts. Infrared spectroscopy is arguably the most widely used technique for chemical characterization, but spatial resolution limits have prevented it from being widely applied at the nanoscale. Scattering SNOM and Raman… more
Abstract:Raman spectroscopy is a highly effective non-contact laser remote sensing method for detecting and identifying chemicals in every-day field environments. Raman spectroscopy is particularly suited for detecting trace surface contaminants that may indicate the presence of… more
Abstract:… to model, if possible, it is much more straightforward to assay for these compounds in the body rather than in the environment. The primary innovations in our approach are that a novel optical micro- to nano-fluidic device will be used along with unique aptamers and Raman… more
Abstract:… of ChromoLogic scientists and collaborators will result in an innovative system that is objective, compact and intuitive to use. In Phase I CL will demonstrate the feasibility of the OCOSMO technology by fabricating a prototype device to demonstrate the concept of Raman… more
Abstract:…, using field-portable, easily deployable, roll-to-roll devices. A low-footprint, low-power, portable roll-to-roll device will be developedbased on the initial prototype built under Phase I supportand ultimately ruggedized and used to fabricate nanocavity-based Raman… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project aims to develop a novel substrate for sensing of biomolecules by Surface Enhanced Raman Spectroscopy (SERS). The substrate is expected to be stable, low cost , reproducible and can be functionalized to improve… more
Abstract:… cells requires a sensitive, high spatial resolution microscopy method based on vibrational resonances that is capable of performing in situ spectroscopy with both frequency and time resolution. In this SBIR/STTR, we will develop a novel self-referencing stimulated Raman… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project aims to develop Surface Enhanced Raman Scattering (SERS) nanotags for diagnostic and security applications. A novel class of SERS tags that exhibit much higher performance than other tag formulations were… more
Abstract:DESCRIPTION (provided by applicant): The overall aim of this SBIR program is to develop a surface-enhanced Raman spectroscopy (SERS) based device for on-site analysis of drugs in saliva. This device will allow immediate assessment of both medicinal and illicit drug use by… more
Abstract:… recently gained interest due to their ability to focus and enhance electric fields around the star surface features. Field enhancement has been estimated to be as large as 10,000 times greater than that observed for spherical gold particles. In fact, single nanostar Raman… more
Abstract:… primitive bodies.?COSOM provides a broad organic and inorganic compound measurement capability without the need for sample handling or reagents. It will excite sub-ppb levels of organic compounds on rocks, soil, or other surfaces at 235 nm and simultaneously measure Raman… more
Abstract:… approach for in vitro characterization of engineered tissue constructs. Optical coherence tomography (OCT) imaging will be used for gross assessment of tissue morphology and birefringence properties, while reflectance confocal microscopy (RCM) and Raman spectroscopy… more
Abstract:… amplifier/laser can be applied to ophthalmology, refractive surgery, photocoagulation, general surgery, therapeutic, imaging, and cosmetic applications. Biomedical instruments include those involved in cells or proteins, cytometry, and DNA sequencing; laser Raman… more
Abstract:For lightweight and power-efficient instruments that enable elemental and/or mineralogy analysis, Q-Peak proposes to develop a compact, robust, and efficient instrument capable of performing imaging spectroscopy, Laser-Raman Spectroscopy (LRS) and Laser Induced Breakdown… more
Abstract:… false positive readings, provide"smart"sensor functionality, and facilitate logistically advantageous data transfer. The objective of the proposed work is to develop such a sensing module, based on the combination of a miniaturized surface enhanced Raman… more
Abstract:… laser which required an external water chiller, nitrogen purges, and consume more than 5 cu. ft. of lab space. The FQ-OPSL will provide 100 mW of power at 244 nm comparable to the larger footprint gas lasers. The FQ-OPSL will provide an ideal laser source for Raman… more
Abstract:Alakai proposes to develop a Standoff Explosive Raman AIT Upgrade Module (SERAUM) which utilizes, Eye-safe, deep UV Raman scanning/imager
to detect explosives and their precursors, for short standoff trace explosive detection. This system is designed for integration into DHS's… more
Abstract:…y"s need for a field-portable test to detect and quantify chlorinated organic compounds in water samples, Physical Optics Corporation (POC) proposes to develop a novel Microfluidics-Based Organic Compounds Analysis (MOCA) device based on surface-enhanced Raman spectroscopy… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project proposes to implement a low-cost compact, wide-band, and high-resolution on-chip spectrometer and other components for Raman spectroscopy applications. The proposed architecture consists of silicon-nitride (SiN)… more
Abstract:… miniaturizing the sizes of sensors, decreasing their cost, and improving their sensitivity. The first targeted application will be the handheld, low-cost Laser Induced Breakdown Spectroscopy system. It will then be expanded into other areas of spectrometers, such as Raman… more
Abstract:…, and 5) eliminate the source through targeted public educating on proper use and disposal. This system combines a portable instrument with consumable analysis cartridge designed to measure compounds in aqueous solution at one part per billion using surface-enhanced Raman… more
Abstract:… exposure to Mycobacterium tuberculosis (M.tb) given their deployments to endemic areas. Rapid screening/diagnostics tests are therefore necessary for both active and latent TB, but current tests have important limitations. We have developed a new technique based on Raman… more
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