Abstract:This Small Business Innovation Research (SBIR) Phase I project proposes to implement a low-cost compact, wide-band, and high-resolution on-chip spectrometer and other components for Raman spectroscopy applications. The proposed architecture consists of silicon-nitride (SiN)… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project aims to develop a laser source for label-free microscopy technique, in particular coherent Raman scattering (CRS) microscopy. In contrast to other techniques, CRS requires excitation with two synchronized laser pulse… more
Abstract:…. The high power laser can be applied to ophthalmology, refractive surgery, photocoagulation, general surgery, therapeutic, imaging, and cosmetic applications. Biomedical instruments include those involved in cells or proteins, cytometry, and DNA sequencing; laser Raman… more
Abstract:… laboratory. However, in some settings, the availability of a rapid test would improve the timing of the public health response to an outbreak. Rapid response to measles outbreaks is critical. Argent Diagnostics has developed a bench top assay using surface enhanced raman… more
Abstract:…, the instrument will enable routine near-field tip-enhanced optical imaging with spatial resolutions in the range of 10-50nm along with topographic and transport (scanning tunneling microscopy) determinations. Furthermore, it will allow vibrational spectroscopy (Raman… more
Abstract:… assistance missions. These scenarios can place soldiers in direct contact with harmful biological and chemical warfare organisms and agents, toxic industrial chemicals, and explosives. Current portable sensor technology solutions rely on visible and near-IR Raman or… more
Abstract:…vided by applicant): The combination of high toxicity and widespread occurrence has created a pressing need for effective monitoring of arsenic in groundwater. Through this program Agiltron will develop a field deployable monitoring tool based on surface enhanced Raman… more
Abstract:Leveraging Agiltron"s industrial leading developments and production of Raman instruments, external cavity laser and nonlinear optical components, we propose to develop a new class of high performance compact deep ultraviolet (UV) laser for Raman spectroscopy. The approach… more
Abstract:Applied Quantum Technologies proposes the development of a snapshot Raman spectral imager for chemical imaging applications with a 1-5 meter standoff. Standoff chemical imaging methods are typically point-based, making scan times impractical for situations where a wide area… more
Abstract:Raman spectroscopy is a highly effective non-contact laser remote sensing method for detecting and identifying chemicals in every-day field environments. Raman spectroscopy is particularly suited for detecting trace surface contaminants that may indicate the presence of… more
Abstract:DESCRIPTION (provided by applicant): Raman spectroscopy is a potentially important clinical tool for real-time diagnosis of diseases and in situ evaluation of living tissues. However, the application of Raman spectroscopy for tissue evaluation has been limited by the strong… more
Abstract:… on Mars remains a key objective for future missions. However current instruments for detailed organic analysis require complex sample handling and can process only a limited number of samples. To allow for rapid sample characterization, the in situ non-destructive … more
Abstract:High throughput, fast detection and characterization of organic and inorganic materials have become important challenge for future planetary robotic rover exploration and planetary missions. Crystal Research, Inc. (CRI) proposes to develop a compact resonance-enhanced Raman… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project proposes to develop an entirely new platform for the molecular diagnostics of cancer exploiting a new Surface Enhanced Raman Scattering (SERS) enhanced Ligase Detection Reaction (LDR) and an optically active… more
Abstract:… developments in quantum mechanics and digital electronics onto a mature and proven platform. The Pulsed Optically Pumped Maser is an obvious choice directly traceable to existing, spaceflight-worthy clocks while exploiting the unique advantages of a"pulsed"(… more
Abstract:This proposed project is concerned with the design, fabrication, and demonstration of a new class of plasmonic nanostructures for single molecule surface-enhanced Raman spectroscopy for biological and chemical sensing applications. A complete design of the plasmonic… more
Abstract:NP Photonics proposes to develop an ultra-stable, compact, and highly reliable deep ultraviolet (UV) laser source for Raman spectroscopy. For this, we will draw on NP Photonics"long experience with the commercialization of single-frequency fiber lasers and amplifiers. In… more
Abstract:… of detecting vapor phase agents at 10-7g/m3 in less than 1 minute. This will be accomplished by developing a method to produce novel localized surface plasmon resonance (LSPR) nanostructures, supported by theory, that produce a minimum surface-enhanced Raman scattering… more
Abstract:…00 B. anthracis spores or 50µg of ricin per liter water) within 10 minutes. During the Phase I program feasibility was demonstrated by successfully detecting the capture of less than 10 Bacillus anthracis-Sterne (BAS) spores in under 15 minutes by surface-enhanced Raman… more
Abstract:… brightness will enable the use of NSOM for many other applications not currently possible. For example, higher power will enable higher scanning speed or larger scanning area. It will also enable application to high-spatial-resolution molecular spectroscopy or Raman… more
Abstract:This proposal addresses the need to increase the probability of detection (PD) and reduce the probability of false alarm (Pfa) for non-contact, real-time sensors for trace levels of biological and chemical targets using simultaneous detection of Raman and fluorescence emissions.… more
Abstract:…t-weight and power efficient instruments that enable elemental and/or mineralogy analysis, Q-Peak, together with Firestar Technology and the Colorado School of Mines, proposes to develop a compact, robust and efficient, instrument capable of performing, Laser-Raman Spectroscopy… more
Abstract:Systems & Processes Engineering Corporation (SPEC) proposes a miniature class 1 eye-safe LADAR to provide explosive detection and classification through use of Raman scattering spectroscopy. The system is a hand held device interfacing to a tough book computer, allowing… more
Abstract:The University of Arizona has demonstrated high-average-power all-solid-state ultraviolet (UV) lasers based on harmonic generation in borate crystals. TIPD is proposing the development of a compact, stable high power UV laser source based on the University"s exsisting CsLiB6O10 laser,… more
Abstract:… robotic spacecrafts with instrumental payloads for scientific measurements of lunar surface features such as rocks, soil, and minerals. These instrument payloads will be helpful in identifying lunar resources that can be used in establishing extended human presence. Raman… more
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