Abstract:DESCRIPTION (provided by applicant): Raman spectroscopy is a potentially important clinical tool for real-time diagnosis of diseases and in situ evaluation of living tissues. However, the application of Raman spectroscopy for tissue evaluation has been limited by the strong… more
Abstract:… on Mars remains a key objective for future missions. However current instruments for detailed organic analysis require complex sample handling and can process only a limited number of samples. To allow for rapid sample characterization, the in situ non-destructive … more
Abstract:High throughput, fast detection and characterization of organic and inorganic materials have become important challenge for future planetary robotic rover exploration and planetary missions. Crystal Research, Inc. (CRI) proposes to develop a compact resonance-enhanced Raman… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project proposes to develop an entirely new platform for the molecular diagnostics of cancer exploiting a new Surface Enhanced Raman Scattering (SERS) enhanced Ligase Detection Reaction (LDR) and an optically active… more
Abstract:… developments in quantum mechanics and digital electronics onto a mature and proven platform. The Pulsed Optically Pumped Maser is an obvious choice directly traceable to existing, spaceflight-worthy clocks while exploiting the unique advantages of a"pulsed"(… more
Abstract:This proposed project is concerned with the design, fabrication, and demonstration of a new class of plasmonic nanostructures for single molecule surface-enhanced Raman spectroscopy for biological and chemical sensing applications. A complete design of the plasmonic… more
Abstract:NP Photonics proposes to develop an ultra-stable, compact, and highly reliable deep ultraviolet (UV) laser source for Raman spectroscopy. For this, we will draw on NP Photonics"long experience with the commercialization of single-frequency fiber lasers and amplifiers. In… more
Abstract:… of detecting vapor phase agents at 10-7g/m3 in less than 1 minute. This will be accomplished by developing a method to produce novel localized surface plasmon resonance (LSPR) nanostructures, supported by theory, that produce a minimum surface-enhanced Raman scattering… more
Abstract:…00 B. anthracis spores or 50µg of ricin per liter water) within 10 minutes. During the Phase I program feasibility was demonstrated by successfully detecting the capture of less than 10 Bacillus anthracis-Sterne (BAS) spores in under 15 minutes by surface-enhanced Raman… more
Abstract:… brightness will enable the use of NSOM for many other applications not currently possible. For example, higher power will enable higher scanning speed or larger scanning area. It will also enable application to high-spatial-resolution molecular spectroscopy or Raman… more
Abstract:This proposal addresses the need to increase the probability of detection (PD) and reduce the probability of false alarm (Pfa) for non-contact, real-time sensors for trace levels of biological and chemical targets using simultaneous detection of Raman and fluorescence emissions.… more
Abstract:…t-weight and power efficient instruments that enable elemental and/or mineralogy analysis, Q-Peak, together with Firestar Technology and the Colorado School of Mines, proposes to develop a compact, robust and efficient, instrument capable of performing, Laser-Raman Spectroscopy… more
Abstract:Systems & Processes Engineering Corporation (SPEC) proposes a miniature class 1 eye-safe LADAR to provide explosive detection and classification through use of Raman scattering spectroscopy. The system is a hand held device interfacing to a tough book computer, allowing… more
Abstract:The University of Arizona has demonstrated high-average-power all-solid-state ultraviolet (UV) lasers based on harmonic generation in borate crystals. TIPD is proposing the development of a compact, stable high power UV laser source based on the University"s exsisting CsLiB6O10 laser,… more
Abstract:… robotic spacecrafts with instrumental payloads for scientific measurements of lunar surface features such as rocks, soil, and minerals. These instrument payloads will be helpful in identifying lunar resources that can be used in establishing extended human presence. Raman… more
Abstract:To support a variety of applications in environmental chemical sensingincluding homeland security, defense, and commercial applicationswe will develop a UV-enhanced Raman spectroscopy system which demonstrates improved SNR by up to 5 orders of magnitude and spectral resolution… more
Abstract:Alakai proposes to breadboard and design the Chemical Explosives Detection Scanner (CEDS), an Eye-safe, deep UV Raman Scanner/imager to detect
explosives chemicals and their precursors, for short standoff trace explosive detection. This system could eventually be integrated into… more
Abstract:…. DHS is seeking stand off detection of trace explosive particle without the need for collecting the particles in an IMS (or Time of Flight
Mass Spectrometer) sensor.
To respond to this situation SLI is proposing an innovative exploitation of the Coherent Anti-Stokes Raman… more
Abstract:… miniaturizing the sizes of sensors, decreasing their cost, and improving their sensitivity. The first targeted application will be the handheld, low-cost Laser Induced Breakdown Spectroscopy system. It will then be expanded into other areas of spectrometers, such as Raman… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project aims to develop an innovative Raman-based real-time microalgal biofuel analyzer. Although microalgae are popular feedstock with great potential for biofuel production, there is currently no suitable, fast and… more
Abstract:… uses its innovations to manufacture devices that provide near real-time, precise water analysis in the field. Our Phase I SBIR project goal was to prove the feasibility of detecting 100 part-per-billion-level water contamination using an embedded surface-enhanced Raman… more
Abstract:…, new and faster techniques based on molecular biology principles have emerged during the last 10 years to supplement traditional methodology. This project will assess the feasibility to develop multi-layered nanoparticles that can be integrated into a Surface Enhanced Raman… more
Abstract:This topic addresses the need for compact efficient solid-state deep ultraviolet (UV) lasers operating in the wavelength range of 220-250 nm, for use in Raman systems for chemical and biological detection. The laser to be developed would also be very useful in the detection of… more
Abstract:…or this method will be presented along with trace detection of blister agents. It is also clear that a potent SERS material for chemical warfare agent detection is not the only piece of the puzzle required to meet the objectives expressed by the Army; a portable Raman reader… more
Abstract:…. The most accurate systems utilize PCR technology and are therefore bulky, cannot be easily miniaturized, and generally are not suitable for detection in more remote locations. Smaller systems, such as those based on the detection of spores via standard Raman… more
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