Abstract:This Small Business Innovation Research (SBIR) Phase I project aims to develop an innovative Raman-based real-time microalgal biofuel analyzer. Although microalgae are popular feedstock with great potential for biofuel production, there is currently no suitable, fast and… more
Abstract:… uses its innovations to manufacture devices that provide near real-time, precise water analysis in the field. Our Phase I SBIR project goal was to prove the feasibility of detecting 100 part-per-billion-level water contamination using an embedded surface-enhanced Raman… more
Abstract:…, new and faster techniques based on molecular biology principles have emerged during the last 10 years to supplement traditional methodology. This project will assess the feasibility to develop multi-layered nanoparticles that can be integrated into a Surface Enhanced Raman… more
Abstract:This topic addresses the need for compact efficient solid-state deep ultraviolet (UV) lasers operating in the wavelength range of 220-250 nm, for use in Raman systems for chemical and biological detection. The laser to be developed would also be very useful in the detection of… more
Abstract:…or this method will be presented along with trace detection of blister agents. It is also clear that a potent SERS material for chemical warfare agent detection is not the only piece of the puzzle required to meet the objectives expressed by the Army; a portable Raman reader… more
Abstract:…. The most accurate systems utilize PCR technology and are therefore bulky, cannot be easily miniaturized, and generally are not suitable for detection in more remote locations. Smaller systems, such as those based on the detection of spores via standard Raman… more
Abstract:…ent delivering routine near-field tip-enhanced optical imaging with spatial resolutions in the range of 10-50nm along with topographic (Atomic Force Microscopy) and transport (Scanning Tunneling Microscopy) determinations. It will allow vibrational spectroscopy (Raman… more
Abstract:… assistance missions. These scenarios can place soldiers in direct contact with harmful biological and chemical warfare organisms and agents, toxic industrial chemicals, and explosives. Current portable sensor technology solutions rely on visible and near-IR Raman or… more
Abstract:…, or with needed precision, resolution and sensitivity. Products which do have these characteristics tend to be fairly large and not readily transportable. Current research and development in this area generally involves spectroscopic methods including Raman, FTIR and… more
Abstract:… a scaled up synthesis of nitrogen-doped boron nanotubes (BNTs) and boron nanofibers (BNFs) will be developed which will be optimized by a design-of-experiment approach during Phase II. Characterization of the BNTs/BNFs by scanning electron microscopy, Raman spectroscopy… more
Abstract:This Small Business Technology Transfer Phase I project will develop a new type of nanostructured substrate for applications in arsenide detection using surface enhanced Raman spectroscopy (SERS). Arsenic is a well known toxic chemical which exists in both nature and industrial… more
Abstract:This Small Business Technology Transfer (STTR) Phase II project focuses on the commercialization of a new low-cost and compact low-resolution (~1 nm) Raman spectroscopy (LRRS) technique for medical diagnostics. Current Raman spectroscopy systems are bulky and expensive and have… more
Abstract:In Phase I, Aerius Photonics demonstrated Raman spectroscopy at 785 nm, 980 nm, and 1064 nm, with only 1064 nm-based excitation showing a reduction in fluorescence. In addition, Aerius Photonics and partner Ahura Scientific, demonstrated a breadboard version of an InGaAs-based… more
Abstract:… actual exposure problems. We propose to build a portable, field- deployable blood test monitor to immediately identify toxic chemical agent buildup in persons suspected of having been exposed t
o such agents. The technology we plan to utilize is surface-enhanced Raman… more
Abstract:We propose to develop a compact, marine-deployable chemical sensor for the underwater detection of explosives using surface enhanced Raman spectroscopy (SERS). SERS is a well known tool for chemical identification, down to the single molecule level of sensitivity that provides… more
Abstract:… identify hull surface contamination, such as lubricants and amines formed during the coating process, using a measurement technique that can be adapted to a ship construction environment. The method we propose is laser light scattering, specifically standoff Raman scattering,… more
Abstract:We propose to develop a combination Tip-Enhanced Raman Scattering and Shear-Force Microscopy (TERS-SFM) instrument to study the composition and morphology of nanoparticles, surfaces, and biofilms on any substrate material. The instrument developed during Phase I will rely upon… more
Abstract:Mutation of genetic DNA is a major factor causing cancer. Locating these changes in the DNA sequence of single molecules is difficult because they cannot be assayed by conventional sequencing techniques. This project will demonstrate sequencing capabilities for single stranded DNA and RNA… more
Abstract:… for hazardous substances, such as heavy metals, radionuclides and chlorinated solvents on the surface and in the subsurface. This dual sensor instrument will be equipped to monitor soils, sludge, slurries, groundwater and surface water using a fusion of LIBS and Raman… more
Abstract:… will be delivered to DoD Labs for evaluation and demonstration. Noise and detectivity D* will be characterized in detail. During Phase III, we will manufacture and market the proposed camera to defense contractors for incorporation into military systems and for our own … more
Abstract:…ng the acoustic signatures emitted by the target molecules, the proposed PAS technology offers better detection sensitivity in identifying the presence and concentrations of targeted molecules compared to conventional photo-spectroscopic techniques like LIBS, Raman spectroscopy,… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project continues the development of an innovative diagnostic technology based on surface-enhanced Raman scattering (SERS) through its combination with gold nanoparticle labels, high-speed fluid handling, and sandwich-based… more
Abstract:… fast detection and characterization of inorganic and organic biomarkers have become important challenge for future lunar robotic rover exploration and planetary missions. To allow for rapid sample characterization on the Moon and Mars, the in situ non-destructive Raman… more
Abstract:… proper safety precautions can be implemented during the retrieval process. In addition, there is a need for active monitoring of the dynamic chemistry of the waste during storage since the composition of the waste can become highly corrosive. A novel fiber optic Raman… more
Abstract:… products and serve as an on-site quality control monitor is proposed. This sensor, coupled to a battery operated reader, will serve a specific surety control needed in the marketplace after the China milk contamination of 2008. The sensor is based on Surface-Enhanced Raman… more
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