Abstract:… materials complicate the adaptation of existing experimental approaches and require new instruments to perform basic measurements. This project will incorporate a fully-functional scanned-probe system into a sample holder for transmission electron microscopy (TEM), thereby… more
Abstract:The addition of continuous fluid flow through a set of electron transparent windows in a transmission electron microscope (TEM) or scanning transmission electron microscope (STEM) will provide the ability to image reactions that occur at the nanoscale. In particular, liquid STEM… more
Abstract:Friction and wear are energy-robbing processes that represent a tremendous burden to the national economy, especially in this time of record oil/fuel prices. Unfortunately, the field of tribology (the science of friction, lubrication, and wear of interacting surfaces in relative motion) lags many… more
Abstract:In situ tensile testing in the transmission electron microscope (TEM) has been a powerful tool for revealing underlying physical mechanisms at the nano or even atomic scale when materials are subjected to an applied stress. However, all commercially available in situ TEM… more
Abstract:… that cont
rols access to opioid medications with limited-use passcodes. These passcodes can be obtained using several commonly available server-based technologies, including interactive voice response, short message service, email, or web-based applications. The sys
Abstract:… of hardware and
software designed to measure thermal pain sensitivity of rodents (rats and mice) based upon learned (cortically mediated) escape behaviors that are induced by thermal stimuli (hot or cold) to the paws. The apparatus features a testing chamber with two … more
the new system which will be evaluated in vitro and in vivo to demonstrate that the new crimping system has not compromised the physical or biological integrity of the PLS. We will successfully design a new crimping method for the current PLS delivery sys
tem that will… more
Abstract:…, via post-synthesis thermo-diffusion of dopants into the powder, or by laser ablation of doped crystals. Micro-nano-scale powders will be further reduced into nano-scale by means of mechanical grinding and laser ablation in liquid and gaseous environments. XRD, TEM, and… more
Abstract:… of cardiovascul
ar disease. High-throughput systems under development aim to measure heart rate but do not address other critical parameters of cardiovascular function such as blood velocity, stroke volume and ejection fraction. We propose to develop a high-throughput sys
Abstract:…, to a large extent, on the development of new blood vessels to supply food and oxygen to rapidly growing and dividing cells. Proteins involved in angiogenesis are attractive t
argets for new cancer therapeutics. One protein in particular, tumor endothelial marker 8 (TEM8),… more
Abstract:…e highly porous 3D
non-woven scaffolds on an industrial scale suitable for biomedical applications. (3) The multiple-jet electrospinning/electroblowing format in combination with coaxial spinning capability can allow the processing of delicate bioactive materials at low … more
Abstract:DESCRIPTION (provided by applicant): Using a method of retroviral gene transduction we have been able to generate conditionally immortalized long-term hematopoietic stem cell lines from mouse bone marrow stem cells, fetal cord blood and adult bone marrow s
tem cells. Phase I of… more
Abstract:… and update the software modules robustly. Most importantly, there needs to be a framework to integrate heterogeneous subsystems in order to perform various experiments. This project will develop a reference Service-Oriented Architecture (SOA) for ILC control sysÂ¬tems. A… more
Abstract:Low temperature (550 C) SOFC will be developed and characterized with a combination of impedance spectroscopy and high resolution microscopy (FIB, SEM, TEM, XEDS, EELS, SAED, CBED methods). Initial focus will be on a low temperature samarium doped ceria electrolyte and low… more
Abstract:… by Dr. Dav
id Goldfarb, an AFrame adviser) (4) Blood Chemistries (5) GPS or Cell-Based Location (E911) (6) Non-Invasive Blood Glucose Monitor. As future sensors or other devices are developed they can be integrated into AFrame's innovative, open health monitoring sys
Abstract:… does not
easily detect subpopulations of drug-resistant strains below 20%. It is also difficult to link specific mutations to individual viral species. The principal objective of this proposal is to develop a highly sensitive, cost-effective and high throughput sys
Abstract:… samples, and sam
ples becoming lost, mislabeled, or contaminated with significant frequency. The goal of this project is to develop and commercialize a system for long term storage of precious liquids that eliminates or significantly reduces all of these problems. This sys
Abstract:… by r
educing human errors and catching dangerous counterfeit medicines at the point of sale. Centice proposes to develop a fast, accurate and affordable system for spectroscopically identifying and verifying prescription medicines at the point of sale. This sys
tem will reduce… more
tion is known to break down, such as highly charged biomolecules in multivalent salt environments. In Phase II, this model will be further refined, incorporated into an electrostatics modeling software package and used to study biologically significant sys
microbeam research facility. The cost and size of the facility would be comparable to an electron microscope. To develop the microbeam source, the photon energy will be raised to the 1 KeV to 3 KeV range by exploiting optical transitions in helium-like sys
tems such as neon… more
Abstract:Instead of being sent to flare which contributes to energy loses and greenhouse gas emissions, many refinery off-gases could be converted into valuable chemicals such as hydrogen. However, the refinery off-gases contain large concentrations of sulfur that must be removed to prevent the poisoning of… more
Abstract:The Department of Energy supports collaborative research centers for electron beam microcharacterization of materials. Within these facilities, in situ transmission-electron-microscopy (TEM) tensile testing has been a powerful tool for revealing underlying physical mechanisms… more
Abstract:…osites (CMCs) The performance of the advanced strike fighters can be im-proved by reducing the weight of the propulsion system. The jet engines of interest are Pratt & Whitney's F135 engine or General Electric's F136 engine. Both engines use a common exhaust sys-tem produced… more
Abstract:…, water disse
ction, and microwave tissue coagulation. Pluromed has developed a biocompatible gel in which the blood vessel is filled with and occluded by the gel. The gel's working principle is based on the reverse thermosensitive properties of the polymer. At low … more
Abstract:… laboratory scal
e, as well as process-scale purification of pharmaceutical proteins. This technology was developed as a result of NIH-funded studies on the prodomain- mediated folding reaction of the Bacillus protease subtilisin. The two fundamental components of this sys
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