Abstract:…mster flank, reduced the size of this organ but only on the ipsilateral side These results suggest that this drug is a soft antiandrogen , expected to be active topically inandrogen-dependent maladies of the skin and scalp, but to be hydrolyzed by plasma or tissue enzymes, thus… more
Abstract:… medicine and drug discovery. To realize the much-heralded promise of personalized medicine, it is necessary to (a) accurately recognize and distinguish disease subtypes, (b) apply these diagnostic signatures at the level of the individual patient (and tissue type) over… more
Abstract:… in Phase I. This platform uses a nuclease protection assay combined with universal PCR to produce targeted sequencing libraries. The lysis-only protocol means there is no need to extract RNA or DNA or to reverse transcribe RNA. Consequently, sequencing from fixed tissue is… more
Abstract:… cells (CDCs), grown from a donor unrelated to the recipient, using a proprietary process exclusively licensed to Capricor. Autologous CDCs have demonstrated their utility as a regenerative agent: able to reduce infarct size (a.k.a scar size), add viable tissue mass, and… more
Abstract:… due to associated toxicities. We have focused on targeting Plasmalemmal Vesicle Associated Protein-1 (Plvap/PV1), an endothelial specific protein with roles in angiogenesis8-10 and diapedesis of leukocytes11. PV1 is expressed on a subset of endothelia in normal … more
Abstract:…. However, prior to initiating clinical studies, Immunomedicswill need to have a required PK/acute toxicity study performed in a relevant animal species (monkeys), an immunohistology study following the Points to Consider, showing the reactivity of the TF10 bsMAb with tissues,… more
Abstract:… (HBV) covalently closed circular DNA (cccDNA) formation and/or maintenance. HBV cccDNA is essential to the virus life cycle and its elimination during chronic infection is considered critical to durable therapy. However, because of the limitations of current HBV tissue… more
Abstract:DESCRIPTION (provided by applicant): Chronic gingival inflammation of the soft tissue surrounding the tooth afflicts over half of all American adults. In the most severely affected, progression of this inflammatory process to the deeper periodontal ligaments and alveolar bone… more
Abstract:DESCRIPTION (provided by applicant): Scleroderma is an autoimmune, connective tissue disorder which causes fibrosis of the skin and internal organs. In the skin, there is overproduction of extracellular matrix, and type 1 and 3 collagen. The disease involves vascular breakdown… more
Abstract:…. Operative Experience, Inc. proposes to meet this requirement through the development of a training program based on an anatomically accurate, vascularized, human body simulator with standardized size and weight, standardized artificial blood vessels and tissues, standardized… more
Abstract:…H RELEVANCE PUBLIC HEALTH RELEVANCE: The goal of this proposal is to develop a compact Selective Cytopheretic Device (cSCD), an extracorporeal membrane device that can sequester activated leukocytes and inhibit their inflammatory activity in order to reduce tissue accumulation… more
Abstract:… will develop a new generation of thermoresponsive cell cultureware that could gain wide market acceptance, and become an enabling technology. The process uses simple equipment, is manufacture-friendly, cost-effective, and is available in formats needed for tissue engineering… more
Abstract:DESCRIPTION (provided by applicant): MALDI tissue imaging, when enabled by Nanoparticulate (NP) Matrix implantation, is maturing into a useful preclinical tool for biomarker and drug discovery in our laboratory and at NIDA-IRP. Quantitatively reproducibleimages from serial… more
Abstract:… extremely low frequency emissions (ELF) influence hair dryer design as well as power-line placement. Cell-phones are scrutinized using measures of radiation absorption. Laser pointers, police traffic radars, and microwave ovens must also be designed using models of the tissues… more
Abstract:… goal is to continue to demonstrate its wide applicability and utility by customizing the method for serial chest CT registration. Second, it is hypothesized that using physically-inspired heuristics to model the patient-specific, inhomogeneous elasticity of lung tissue will… more
Abstract:…vided by applicant): This application addresses Innovations in Biomedical Computational Science and Technology Initiative PAR-09-220. Healthcare is moving towards fully digitized patient records. Surgical pathology represents a challenge inthat high resolution imaging of tissue… more
Abstract:…ce in the presence of an adjuvant. We will demonstrate that this immunization protocol results in the appearance of anti-Borrelia antibodies. Immunized animals will then be challenged with 104 live Borrelia spirochetes. Twenty-one days after challenge we will collect tissue… more
Abstract:DESCRIPTION (provided by applicant): Recent advances in photoacoustic tomography (PAT) have demonstrated its potential for 3D noninvasive high resolution imaging of soft tissues at penetration depths of many centimeters. Further, and perhaps even more importantly, imaging of… more
Abstract:… control of gene expression using long-wavelength (700-750 nm) light. In addition to avoiding the side effects and costs associated with drug-based systems, light-inducible control offers the advantages of precise spatial and temporal targeting of individual tissues and… more
Abstract:DESCRIPTION (provided by applicant): The genetic basis of disease remains a significant research problem, impacting the fields of cancer biology, neurology, cardiology, development, and even microbiology, as recently realized by the Human Microbiome Project. Determination of the genomic sequence… more
Abstract:… for quantitative assessment of 3D and 4D aortic image data from MR and MDCT, the resultsof recent NIH-funded research at the University of Iowa, to clinical applicability. No such analyses are currently commercially available for either assessment of connective tissue… more
Abstract:… destination in the brain). Accordingly, investigators have attempted for more than 30 years to trace, reconstruct, visualize and quantitatively characterize the microscopic three-dimensional (3D) micro-angioarchitecture of the brain in normal and pathological tissue (3D… more
Abstract:DESCRIPTION (provided by applicant): Quantitative characterization of tissue structure and function is one of the most challenging problems in Medical Imaging. Field of view, depth of interrogation, and resolution are critical features that dramatically impact image quality and… more
Abstract:… gained from a given model organism. Specifically, our Specific Aims are: (1) Synthesize four spectrally distinct fixable lipophilic dyes, three for nerve tract tracing andone or blood vessel labeling, that are compatible with standard fixation techniques used in tissue… more
Abstract:… of this project is that multiplex, genetically-encoded assays reporting multiple cell signaling events would expand the depth of knowledge about signal transduction by improving information on the timing, location and pathway cross-talk in physiologically relevant tissues.… more
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