Abstract:…que to find selective cocaine antagonists or agonist/ antagonists that may be useful in treating cocaine addiction and overdose. Compounds from in vitro binding and uptake studies will be used in in vivo behavior tests to identify potentially useful compounds. $ = TOTAL AWARD… more
Abstract:… long-term care services. The new system will build on Hearthstone's experience in assisted living operations and research, particularly its current SBIR/NIA project is using assessment and outcome measures developed under NIA-funded collaborative studies. $ = TOTAL AWARD AMTS… more
Abstract:…s will be investigated. Information obtained from this Phase 1 research will indicate the feasability of utilizing leptin as a therpeutic agent for the ex vivo expansion of trasnplantable progenitor cells and in vivo to accelerate recovery after transplantation. $ = TOTAL AWARD… more
Abstract:…be made to mGluR subtypes. Antibodies will be screened for their utility in immunohistochemistry and Western blot. The applicant claims that monoclonal antibodies to the mGluRs will be valuable tools for immunolocalization and regulation studies. $ = TOTAL AWARD AMTS & NOT… more
Abstract:…to a proven carrier protein that dramatically enhances immune responses to inserted sequences and conjugated haptens. Rapid production of analytical quantities of hybrid proteins will enable epitope scanning to identify useful antibody reactivities. $ = TOTAL AWARD AMTS & NOT… more
Abstract:… is a combination of such an inhibitor with fluoroquinolone. Given that staphylococcal infections are widespread and rapidly become resistant to antibiotic therapy, the market for this product is likely to be comparable to the market for major antibiotics. $ = TOTAL AWARD AMTS &… more
Abstract:…d from normal and CF patients. These studies will determine the range of tissues that would be appropriate targets for modulation by inositol polyphosphate derivatives and whether they will augment Cl- secretion in diseased as well as in normal epithelia. $ = TOTAL AWARD… more
Abstract:…r. Optical parameters (absorbance combined with fluorescence) will be measured on a cell sorter for selecting repetitively mutagenized bacteria to isolate enzymes with novel catalytic activities from very large mutagenized populations (>106 clones). $ = TOTAL AWARD AMTS & NOT… more
Abstract:…. An improved cell surface display system will allow a greater variety of proteins to be expressed under more manageable conditions, providing an impetus for the advancement of such diverse technologies as antibody development and enzyme evolution. $ = TOTAL AWARD AMTS & NOT… more
Abstract:… of the two small molecular ligands attached through a linker group will then be carried out. It is anticipated that the bifunctional molecule, obtained by tethering the two small ligands, will have a much higher affinity for the Ras protein. $ = TOTAL AWARD AMTS & NOT… more
Abstract:… amenable to a medicinal chemistry program. Arylhydrazones possess structural features that make them less than optimal drug candidates. Structural modifications to increase potency, specificity, and bioavailability, while attenuating toxicity are proposed. $ = TOTAL AWARD… more
Abstract:… feasibility of building an analog library based on candicidin/R-008. The first three modules of the FR-008 PKS gene cluster and genes encoding starter unit synthesis and activation will be functionally expressed in the heterologous streptomyces host. $ = TOTAL AWARD AMTS & NOT… more
Abstract:… of hNT-Neurons in vitro prior to animal studies planned in Phase II. Functional, dopaminergic, human neuronal cells are scientifically promising, technologically superior to other cell systems, and commercially viable as a treatment for Parkinson's disease. $ = TOTAL AWARD… more
Abstract:… including western blots, slot blots and ELISA and to develop an immunological detection assay for Pseudomonas aeruginosa. The applicant plans to commercialize the scanning system and fluorophores for the assay and other biomedical research applications. $ = TOTAL AWARD… more
Abstract:… with a collaboration with key investigator in the area of tick-borne diseases and access to an extensive serum bank accumulated through work on other infectious disease programs should enable the goals and objectives of this proposal to be achieved. $ = TOTAL AWARD AMTS & NOT… more
Abstract:… disruption of the barrier. The aim of the work is to alleviate what are identified as two of the most significant problems with pulsatile blood pumps, namely, diffusion of fluids from the pump system and diffusion of body fluids into the pump system. $ = TOTAL AWARD AMTS &… more
Abstract:… in the elderly, including indication and contraindications to antipsychotic use and also materials covering non- neuromotor side effects. In addition, they will develop materials about antipsychotic drug use in geriatric populations for nonphysician caregivers. $ = TOTAL AWARD… more
Abstract:… genomic DNA from selected unculturable fungi and introduce the cloned DNA into closely related, genetically amenable laboratory strain to express genes from the unculturable fungi and to produce novel secondary metabolites with biological activities. $ = TOTAL AWARD AMTS & NOT… more
Abstract:… of indigenous-type plants. Lingonberries (vitas idaea) were identified for tworeasons: similar species were indigenous to the area, and local surveys substantiated their highmarket value and commercial potential.A Farmer Rancher Project grant (SARE) was awarded testing… more
Abstract:… assay for thyroid peroxidase antibody will be adapted for use with DBS, and its application as a screening assay for hypothyroidism in women during the first four months postpartum investigated. Additional DBS assays will be developed in Phase II. $ = TOTAL AWARD AMTS &… more
Abstract:… be able to uniformly coat up to 2" diameter substrates on both sides. We will evaluate these materials for their microwave transport properties, pattern them into user specified devices, re-evaluate them, and deliver them to the Army for flirther testing. If we are awarded… more
Abstract:… such as apodization, array geometries, acousto-optic resonance enhancement and novel fabrication methods involving transducer cutting. The objective is to improve the capabilities of acousto-optic tunable filters by at least an order of magnitude. $ = TOTAL AWARD AMTS & NOT… more
Abstract:… cultural, and inner city populations. This battery will be useful to a wide variety of agencies which deal directly or indirectly with these populations, including hospitals, clinics, and local, state, and federal health and human services agencies. $ = TOTAL AWARD AMTS &… more
Abstract:… The advantage of using handwriting movements rather than arm movements, gait, speech, or eye movements is that most individuals have a well-trained repertoire of handwriting patterns that can be recorded easily. There is no comparable system on the market. $ = TOTAL AWARD AMTS… more
Abstract:… chip would be designed to fit in the CD port of a laptop computer which could be used in clinical labs, offices, and in the field. If successful, the unit would cost about $5,000. For comparison, the Affymetrix scanner will soon be marketed for $80,000. $ = TOTAL AWARD… more
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