Abstract:… amenable to a medicinal chemistry program. Arylhydrazones possess structural features that make them less than optimal drug candidates. Structural modifications to increase potency, specificity, and bioavailability, while attenuating toxicity are proposed. $ = TOTAL AWARD… more
Abstract:… feasibility of building an analog library based on candicidin/R-008. The first three modules of the FR-008 PKS gene cluster and genes encoding starter unit synthesis and activation will be functionally expressed in the heterologous streptomyces host. $ = TOTAL AWARD AMTS & NOT… more
Abstract:… of hNT-Neurons in vitro prior to animal studies planned in Phase II. Functional, dopaminergic, human neuronal cells are scientifically promising, technologically superior to other cell systems, and commercially viable as a treatment for Parkinson's disease. $ = TOTAL AWARD… more
Abstract:… including western blots, slot blots and ELISA and to develop an immunological detection assay for Pseudomonas aeruginosa. The applicant plans to commercialize the scanning system and fluorophores for the assay and other biomedical research applications. $ = TOTAL AWARD… more
Abstract:… with a collaboration with key investigator in the area of tick-borne diseases and access to an extensive serum bank accumulated through work on other infectious disease programs should enable the goals and objectives of this proposal to be achieved. $ = TOTAL AWARD AMTS & NOT… more
Abstract:… disruption of the barrier. The aim of the work is to alleviate what are identified as two of the most significant problems with pulsatile blood pumps, namely, diffusion of fluids from the pump system and diffusion of body fluids into the pump system. $ = TOTAL AWARD AMTS &… more
Abstract:… in the elderly, including indication and contraindications to antipsychotic use and also materials covering non- neuromotor side effects. In addition, they will develop materials about antipsychotic drug use in geriatric populations for nonphysician caregivers. $ = TOTAL AWARD… more
Abstract:… genomic DNA from selected unculturable fungi and introduce the cloned DNA into closely related, genetically amenable laboratory strain to express genes from the unculturable fungi and to produce novel secondary metabolites with biological activities. $ = TOTAL AWARD AMTS & NOT… more
Abstract:… of indigenous-type plants. Lingonberries (vitas idaea) were identified for tworeasons: similar species were indigenous to the area, and local surveys substantiated their highmarket value and commercial potential.A Farmer Rancher Project grant (SARE) was awarded testing… more
Abstract:… assay for thyroid peroxidase antibody will be adapted for use with DBS, and its application as a screening assay for hypothyroidism in women during the first four months postpartum investigated. Additional DBS assays will be developed in Phase II. $ = TOTAL AWARD AMTS &… more
Abstract:… be able to uniformly coat up to 2" diameter substrates on both sides. We will evaluate these materials for their microwave transport properties, pattern them into user specified devices, re-evaluate them, and deliver them to the Army for flirther testing. If we are awarded… more
Abstract:… such as apodization, array geometries, acousto-optic resonance enhancement and novel fabrication methods involving transducer cutting. The objective is to improve the capabilities of acousto-optic tunable filters by at least an order of magnitude. $ = TOTAL AWARD AMTS & NOT… more
Abstract:… cultural, and inner city populations. This battery will be useful to a wide variety of agencies which deal directly or indirectly with these populations, including hospitals, clinics, and local, state, and federal health and human services agencies. $ = TOTAL AWARD AMTS &… more
Abstract:… The advantage of using handwriting movements rather than arm movements, gait, speech, or eye movements is that most individuals have a well-trained repertoire of handwriting patterns that can be recorded easily. There is no comparable system on the market. $ = TOTAL AWARD AMTS… more
Abstract:… chip would be designed to fit in the CD port of a laptop computer which could be used in clinical labs, offices, and in the field. If successful, the unit would cost about $5,000. For comparison, the Affymetrix scanner will soon be marketed for $80,000. $ = TOTAL AWARD… more
Abstract:…E will be recorded. Theoretical analysis will be performed to estimate temperature increases which can be expected for various system configurations. Temperature increases will be correlated with appropriate application times to estimate risk of thermal injury. $ = TOTAL AWARD… more
Abstract:… of these play an important role in various diseases, including neurological diseases e.g. Parkinsonism. We propose to characterize and study the role of a novel antioxidant-lutein. Neurobiological, neurochemical and biochemical techniques will be employed. $ = TOTAL AWARD… more
Abstract:…. Our long-range goal is to further develop and improve the molecular staging assay to increase throughput and cost-effectiveness. This sensitive assay has enormous potential as a rapid, low-cost, safe screening tool for early and recurrent bladder cancer. $ = TOTAL AWARD… more
Abstract:…ng inhibitors to provide a heretofore unprecedented control over the types of N- glycans added to newly synthesized glycoproteins OGS will evaluate how well these processing inhibitors block the production of infectious HB virus I chronically infected hepatocytes. $ = TOTAL … more
Abstract:… of human promyelocytic leukemia cells, 20-50-fold increase in the in vitro differentiation of HL-60 cells, etc. This higher activity may be due to the longer half-life of ST-630 or due to the fact that its major metabolite, ST-232, is both stable and active. $ = TOTAL AWARD… more
Abstract:…toxicity; and (3) further explore structure-activity relationships and mechanisms of these compounds. The goal of this Phase I proposal is to synthesize one or more lead compounds which maximize anti-seizure potency while minimizing adverse effects. $ = TOTAL AWARD AMTS & NOT… more
Abstract:…ustors. The development and demonstration experiments will be conducted in an optically-accessible combustor designed to operate at up to 50 atm with 1-2 lb/s of pre-heated air. This air supply system will be provided by PSI at no cost if the program is awarded. In… more
Abstract:…turbine combustors. The development and demonstration experiments will be conducted in an optically-accessible combustor designed to operate at up to 50 atm with 1-2 lb/s of pre-heated air. This air supply system will be provided by PSI at no cost if the program is awarded. … more
Abstract:… are a combination of software and equipment used to customize substrates to specific circuit designs. This collection of equipment and software is known as the programming station and currently occupies two full laboratory benches.With research funds from a Phase I award,… more
Abstract:… recently invented at Iowa State University, to achieve sub-diffraction optical resolution for studies of living cells. The longer term objective (Phases I and II) is to develop an integrated near-field confocal microscope for biological applications. $ = TOTAL AWARD AMTS & NOT… more
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