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Displaying 26 – 50 of 53 Awards
Company: MARVAL BIOSCIENCES, INC. Agency/Program/Year/Phase: HHS / SBIR / 2005 / 1
Abstract: …e increased at least 3-5 fold. Our Phase 2 proposal (to be submitted upon completion of phase 1) we will test our agents in CT angiography studies in animal models. The novelty and significance of this work lies in the ability to perform these studies 1) without bolus tracking… more
Company: PARADIGM PHARMACEUTICALS, LLC Agency/Program/Year/Phase: HHS / SBIR / 2005 / 1
Abstract: …olar to low nanomolar concentrations. Orally administered STAMP exhibited significant and dose-dependent in vivo anti-HIV activity in Hu-PBL-SCID mice against a genotypically and phenotypically NRTI-resistant clinical HIV-1 isolate (BR/92/019). A single 50 mg/kg oral bolus dose… more
Company: AVANIR PHARMACEUTICALS Agency/Program/Year/Phase: HHS / SBIR / 2004 / 1
Abstract: … protective antigen (PA) and lethal factor (LF). We will evaluate and characterize Mabs for affinity (using BiaCore and KinExA) and toxin neutralization (using an in vitro cell-based assay). Selected candidates will be further evaluated in a rodent animal model, using bolus… more
Company: EIC LABORATORIES, INC. Agency/Program/Year/Phase: HHS / SBIR / 2004 / 1
Abstract: …sess the effects of the polymer on the relevant electrochemical properties of electrodes, evaluate the effects of plasmin on polymer degradation, and assess the effects of NGF elution by quantifying the response of PC12 ceils in a culture containing a NGF-eluting bolus of the… more
Company: Inotek Pharmaceuticals Corporation Agency/Program/Year/Phase: HHS / SBIR / 2004 / 1
Abstract: …, pharmacokinetics, and safety in a population with acute stroke. Based on clinical studies of INO-1001 in healthy subjects, we expect that INO-1001 will be Well-tolerated and safe, and maintain therapeutic drug plasma concentrations for 24 hours after a single bolus.… more
Company: PEAK PERFORMANCE TECHNOLOGIES, INC. Agency/Program/Year/Phase: HHS / SBIR / 2004 / 1
Abstract: …, and (d) demonstrate the feasibility of applying the tracking algorithms to an actual videofluoroscopic data set. 2) Develop and test algorithms for performing specific temporal and spatial measurements of normal VFS swallowing behaviors based on tracked bolus… more
Company: PROTEOMTECH, INC. Agency/Program/Year/Phase: HHS / SBIR / 2004 / 1
Abstract: …es of proUK which we have targeted for improvement: (a) increased fibrin specificity, (b) increased resistance to natural inhibitors such as plasminogen activator inhibitor (PAI), (c) reduced nonspecific systemic bleeding, (d) increased half life, and (e) single bolus… more
Company: BIONIX DEVELOPMENT CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 2003 / 1
Abstract: … test the above hypothesis will require three specific aims: (1) Design and Construction of Combination Applicator (2) Study of Radiation Dosimetry (3) Evaluation of Combination Applicator Performance. The design of the applicator will integrate the CMA, water bolus and… more
Company: CHRYSALIS BIOTECHNOLOGY, INC. Agency/Program/Year/Phase: HHS / SBIR / 2003 / 1
Abstract: … helps reduce infection when live Pseudomonas are added to the wounds; and (3) determine if hNTP15 has major safety or stability issues that would prevent it from moving forward as a drug candidate. For these studies intravenous (I.V.) and Intraperitoneal (I.P.) bolus… more
Company: PARADIGM PHARMACEUTICALS, LLC Agency/Program/Year/Phase: HHS / SBIR / 2003 / 1
Abstract: … subacute toxicity in mice at dose levels tested (12.5 - 100 mg/kg). Therapeutic plasma concentrations greater than or equal to 5muM, which are highly cytotoxic against human cancer cells, can be rapidly achieved and maintained in mice for at least 24 h after i.p. bolus… more
Company: Radiation Monitoring Devices, Inc. Agency/Program/Year/Phase: HHS / SBIR / 2002 / 1
Abstract: … existing CT systems provide high-resolution images with excellent sensitivity to skeletal tissue and soft tissue, particularly when contrast-enhancing media are employed. However, use of this powerful modality for many important functional studies such as first pass … more
Company: ICHOR MEDICAL SYSTEMS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2002 / 1
Abstract: … a year. Recent studies have demonstrated that long-term maintenance IFN-a therapy can slow progression of HCV-related liver inflammation and fibrosis, which often lead to chronic liver disease. Unfortunately, the cost, inconvenience, and side effects associated with bolus… more
Company: INTRAGENE SCIENCES, INC. Agency/Program/Year/Phase: HHS / SBIR / 2002 / 1
Abstract: …nt problems with systemic administration of this peptide have been encountered, including difficulty in producing adequate amounts of functional protein for in vivo use, and instability resulting in a very short circulating half-life, which necessitates high-dose bolus or… more
Company: DIRECT THERAPEUTICS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2001 / 1
Abstract: … perfusion tracer HMPAO. The regional distribution of DTI-015 may be observed with the use of MR through: 1) local trapping of infused intravascular MR contrast in the affected vascular bed; 2) arterial spin-labeling perfusion imaging; 3) bolus… more
Company: T & B BIOCLONE, INC. Agency/Program/Year/Phase: HHS / SBIR / 2001 / 1
Abstract: The cytokine Interleukin-10 (IL-10) has shown promise in clinical trials for the treatment of inflammatory bowel disease (IBD). Currently IL-10 is administered to IBD patients systemically either by bolus intravenous or subcutaneous injections. Due to the short in vivo half-life… more
Company: ARADIGM CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 1998 / 2
Abstract: … drug reservoir form an integral disposable part that avoids potentially toxic or incompatible stabilizers. Because the medicament is in its native form and enters the nozzle only once, the probability of damage to gene vectors is vastly reduced. The aerosol 'bolus' is… more
Company: ARADIGM CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 1997 / 1
Abstract: … drug reservoir form an integral disposable part that avoids potentially toxic or incompatible stabilizers. Because the medicament is in its native form and enters the nozzle only once, the probability of damage to gene vectors is vastly reduced. The aerosol 'bolus' is… more
Company: Engineering Partnership, Ltd Agency/Program/Year/Phase: HHS / SBIR / 1997 / 2
Abstract: … to other thermodilution methods, the heater will be locatand will apply energy to the blood to cause heating. A thermistor located at the end of the catheterwill measure the resulting temperature rise of the blood and use that measure to predict cardiac outnot use bolus… more
Company: Bsd Medical Corp. Agency/Program/Year/Phase: HHS / SBIR / 1995 / 2
Abstract: …nal dynamic electronic steering capability; 3) the applicator will have the ability to reduce localized superficial heating without significantly altering the central heating focus; and 4) the applicator will have an elliptical shape in order to reduce the amount of bolus water… more
Company: Thermal Technologies, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1995 / 1
Abstract: … output measurement system to correctly scale the instantaneous velocity waveforms over a givinterval so as to produce instantaneous flow waveforms. Cardiac output is the fundamental performancassessing the status of the heart. In the USA, the 1.3 million Swan-Ganz … more
Company: BIOCHEMANALYSIS CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 1994 / 1
Abstract: … limitation prevents widespread use of this otherwise desirable approach. The investigatorspropose to combine the recent development of Dy as a nonabsorbable fecal marker with the traditionalbalance approach, using both unlabeled continuous feeding and labeled bolus… more
Company: Collaborative Laboratorytor Agency/Program/Year/Phase: HHS / SBIR / 1994 / 1
Abstract: … Respiratory Distress Syndrome, whilesimultaneously achieving greater cost-effectiveness of the dosage form. Current surfactant preparationsare too viscous for aerosolization and must be delivered to the lung by intratracheal instillation of a large,potentially obstructive bolus… more
Company: Lifequest Medical, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1994 / 1
Abstract: …. LifeQuest Medical has developed an IO auto-injector (the First-Med System) foremergency delivery of diazepam in pediatric seizures and epilepsy. A needle -- drug cartridge -- springassembly generates sufficient force to puncture skin and bone, delivering a drug bolus into… more
Company: Rocky Mountain Research, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1994 / 1
Abstract: … method used for determining cardiac output, is highlytechnique dependant and yields results that may be off as much as +/- 2O%. To reduce error, theprocedure is often repeated a number of times and the average of all of the readings taken. Each readingrequires a bolus… more
Company: CANDELA CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 1993 / 1
Abstract: … prior to each laser burn to selectively enhance absorption of laser light in the designated target area during laser irradiation. In contrast to previous studies, dye concentration is monitored precisely. Laser energy is delivered during the transit of a dye bolus or when… more
Displaying 26 – 50 of 53 Awards
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