Abstract:… was observed with a therapeutic index (TI) of at least 40 in high fat high carbohydrate (HFHC) fed rats. We are submitting this SBIR Phase II proposal to develop our compound to the IND stage. Obesity and excess fat is a major risk factor for cardiovascular disease, diabetes… more
Abstract:DESCRIPTION (provided by applicant): The prevalence of Type 2 diabetes is expected to reach 20%-30% by 2050. In the last 8 years, a new class of drugs, called incretin mimetics, has been used successfully for the treatment of the disease. Incretin mimetics(including exenatide)… more
Abstract:…, and quality control dimensions and accelerate development of new drugs while making existing ones safer and more efficiently produced. The technology can be used wherever proteins are under development for fighting diseases such as cancer, Alzheimer's, diabetes, and… more
Abstract:DESCRIPTION (provided by applicant): Type 2 diabetes is a particularly debilitating disease and is endemic for a large proportion of the world's population. The unmet challenges in disease management are the lack of long-term efficacy in reducing hyperglycemia and the… more
Abstract:… and continues to grow. Automated solid phase peptide synthesis (SPPS) is a mainstay of modern medicinal research, and has been used on micromole up tometric ton industrial scale. Peptide drugs such as Exenatide, a GLP-1 analogue and a life-saver to many type-2 diabetes… more
Abstract:… leading to complication such as septicaemia and osteomyelitis, in addition to causing significant pain and suffering, compromised quality of life, financial burden, and morbidity/mortality. In conjunction with an aging population, particularly those with diabetes, kidney… more
Abstract:? DESCRIPTION (provided by applicant): Approximately 3 million Americans and around 24 million people worldwide are affected by Type 1 Diabetes (T1D). Glucose monitoring followed by exogenous insulin injection, allogeneic whole organ pancreas transplantation, and allogeneic… more
Abstract:In a large portion of the population the strong desire to eat sweet foods is a major contributing factor leading to overweightness and obesity, and the concomitant predisposition to diabetes diseases. Low calorie sweeteners like Saccharin, Aspartame, Cyclamate and Acesulfame K… more
Abstract:DESCRIPTION (provided by applicant): The long term objective of diabetes treatment is to create an artificial pancreas to substitute for the role of the biological pancreas in patients. This artificial pancreas must constantly measure glucose and respondwith an appropriate… more
Abstract:The broader impact/commercial potential of this Small Business Technology Transfer (STTR) Phase I project is to develop an intelligent self-management tool for the 25 million diabetes patients in the US and the 200 million diabetes patients in the world. The proposed study is… more
Abstract:… for diagnosis, monitoring and management of disease in primary care environments, especially relevant for the aging population that may have restricted mobility. Diseases that are thought to show vascular symptoms or manifestations in the retina include … more
Abstract:… hypertrophic scarring or graft rejection, and multiply the number of operative procedures. Meanwhile, venous ulcers occur in 600,000 to 1,500,000 US patients, and 35-45% of these patients will not respond to current treatments. In addition, 15% to 20% of patients with diabetes… more
Abstract:…a large proportion of the general population. The burden of painful conditions on the individuals and the society follow a rising trajectory because of the paucity of effectiveand reasonably safe pharmaceuticals that are needed globally. Aging population and diabetes epidemic… more
Abstract:… in human cells and impact virtually all aspects of cellular physiology, from the coordination of the cell cycle and cell division to apoptosis. The deregulation of kinase mediated signaling is now known to be involved in a variety of human diseases that include, diabetes… more
Abstract:DESCRIPTION (provided by applicant): Skeletal muscle atrophy is a widespread and serious medical problem. Frequent causes of skeletal muscle atrophy include orthopedic injuries, bed rest, advanced age, cancer, heart failure, COPD, diabetes, stroke, renalfailure, critical… more
Abstract:DESCRIPTION (provided by applicant): In the United States, 25.8 million children and adults have diabetes and 79 million have pre-diabetes. Insulin therapy is critical in Type 1 Diabetes and now understood to be an inevitable therapeutic… more
Abstract:DESCRIPTION (provided by applicant): Pre-mixed formulations of soluble prandial insulin analogs and NPH micro-crystalline suspensions provide a simplified and cost-effective basal-bolus regimen for patients with Type 2 diabetes mellitus (T2DM) not effectively controlled by basal… more
Abstract:… I studies to exhibit rapid-acting PK/PD properties irrespective of protein concentration in the range 0.6 - 3.0 mM, i.e., from U-100 to U-500 strengths. We anticipate that a U-500 formulation of Fluorolog will be of particular benefit tothe treatment of Type 2 diabetes… more
Abstract:? DESCRIPTION (provided by applicant): Diabetes represents one of the most serious health crises worldwide. It is estimated by the American Diabetes Association that one person is diagnosed with diabetes every 17 seconds, while the International Diabetes Federation states… more
Abstract:… Ge-based SWIR sensors proposed here are low-power, high-resolution and dramatically lower cost. When incorporated into handheld devices, such as smartphones, SWIR image sensors may allow non-invasive, real-time biological monitoring. For example, they may enable diabetic… more
Abstract:ABSTRACT The Specific Aim of this proposal is to test the feasibility of developing a web-based peer mentor training and mentor-mentee matching system to help patients better manage their diabetes through mentoring. Effective self-management of diabetesis the key to improving… more
Abstract:ABSTRACT The Specific Aim of this proposal is to test the feasibility of developing, utilizing, and evaluating a web-based diabetes self-management support (DSMS) training program that is culturally tailored for the African American community. Effectiveself-management is the… more
Abstract:… ppb) inthe United States likely underestimates the health risk of human arsenic consumption. Prolonged exposure to even low ppb levels of arsenic is known to substantially increase risks of lung, bladder and kidney cancers, cardiovascular disease, type II diabetes, and a… more
Abstract:DESCRIPTION (provided by applicant): The goals of this project are to develop a biomarker for MLR-1023 in order to validate Lyn kinase as a molecular target for treatment of Type II diabetes (T2D) and use the biomarker to understand the pharmacokinetic/pharmacodynamic (PK/PD)… more
Abstract:… screening as well as follow-up assessment in the healthcare domain. Administered via blood draw in the clinical setting, the metabolic panel consists of assessing 14 unique blood-borne analytes indicative of renal and hepatic function, electrolyte and fluid balance, diabetes… more
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