Abstract:DESCRIPTION (provided by applicant): Dramatic increases in the incidence of obesity, diabetes, and the metabolic syndrome are increasing the prevalence of chronic liver diseases. Liver fibrosis arising from an excessive deposition of type I collagen in theparenchyma, occurs in… more
Abstract:… and quality control dimensions and accelerate development of new drugs while making existing ones safer and more efficiently produced. The technology can be used wherever proteins are under development for fighting diseases such as cancer, Alzheimer's, diabetes, and… more
Abstract:The United States is facing increasing levels of childhood obesity that have more than tripled in the past thirty years. With obesity comes a higher risk of related health issues such as diabetes. This project is focused on the development of novel wheat varieties for the… more
Abstract:DESCRIPTION (provided by applicant): Approximately 32% of Medicare spending is attributed to diabetic populations, and the prevalence of diabetes is growing at an alarming rate. Approximately 79 million Americans have prediabetes. The landmark 2002 Diabetes… more
Abstract:… [R43/R44]). Chronic wounds affect 6.5 million people in the USeach year, and 1-2% of the population in all developed countries, with treatment costs in the US alone reaching 25 billion annually. The increasing elderly population, in addition to the rising rates of diabetes… more
Abstract:… are not based on -amyloid supply side or removal but address its toxic effects on critical neuronal survival, metabolic and plasticity pathways. There is widening recognition that AD is an insulin resistant state affecting the brain, a so-called 'type II diabetes'… more
Abstract:… DiscoveryBioMed, Inc. (DBM) has launched an innovative and automation-friendly drug discovery program to screen synthetic organic small molecule collections on differentiated human adipocyte platforms to discover a newclass of therapeutic drugs for type 2 diabetes mellitus… more
Abstract:… of chronic wounds. Chronic wounds affect 6.5 Million people in the US with an estimated $25 billion spent annually on treatment. This number continues to grow due to increasing health care costs, an aging population, and the rise worldwide in the incidence of diabetes and… more
Abstract:… (HDL) protects from CAD, current methods to assess risk measure the cholesterol content of HDL (HDL-C) as a surrogate indicator of HDL quantity. However, the function of HDL, namely its ability to efflux cholesterol, is what reduces CAD risk. Obesity and diabetes… more
Abstract:… (STTR) Phase I Project aims to optimize and test prototypes of continuous, multi-analyte sensors based on stimuli-responsive hydrogels. The proposed sensor array will be capable of monitoring multiple biomarkers relevant to several common human diseases such as diabetes,… more
Abstract:…, which accounts for the significant complications and mortalty among the population with chronic liver diseases. The medical and financial burden of cirrhosis to the USA is substantial, as it is associated with Hepatitis B and C, fatty liver of obesity and diabetes and… more
Abstract:… patients, our product will provide an integrated system of quantitative and longitudinal tracking of CV injury. In the future, this product can be scaled toinclude other patient populations in need of surveillance for cardiomyopathy such as, other cancer survivors, diabetics,… more
Abstract:DESCRIPTION (provided by applicant): We seek to develop a rapid-acting U-500 insulin analog formulation for patients with Type 2 and Type 1 diabetes mellitus (T2DM and T1DM). Such a novel product would improve treatment in two contexts: (i) for T2DM patients with marked insulin… more
Abstract:DESCRIPTION (provided by applicant): Close-loop systems of insulin delivery-comprising an insulin pump, continuous glucose monitor, and feedback-based control algorithm-provide a promising technology to enable tight glycemic control in Type 1 diabetes mellitus with improved… more
Abstract:DESCRIPTION (provided by applicant): Despite years of development, currently available continuous glucose monitors (CGMs) still lack good accuracy and reliability for short-term and particularly, long-term use in diabetes management. While insulin pumps work well, CGM remains… more
Abstract:… is the leading cause of morbidity and mortality in the United States and is an emerging epidemic world-wide. In particular, atherosclerosis is a life-threatening disease strongly associated with risk factors such as elevated cholesterol levels, high blood pressure and diabetes… more
Abstract:…as systems. The technology and business objectives outlined in this proposal will have a direct impact on basic research and clinical applications to enhance the current state of glycemicmanagement and thereby will improve the well-being of the population with diabetes. … more
Abstract:Diabetes is an epidemic disease in the United States and worldwide. Diabetes care accounts for 10% of all U.S. healthcare costs, most of which is consumed in the care of complications from diabetes, but also includes lost economic productivity from illness,… more
Abstract:… this project will expand the application of the TiO2 nanotube sensing platform to other diseases beyond TB and other fields. For example VOBs are known to be associated with heart transplant rejection, lung cancer, ischemic heart disease, preeclampsia of pregnancy, diabetes… more
Abstract:…, is to develop and evaluate the School TIME Toolkit (Toolkit) to support parents and teachers of elementary school-aged children who have a chronic illness and intermittent school attendance (CICISA). Children with chronic illnesses, such as asthma, cancer, diabetes and other… more
Abstract:DESCRIPTION (provided by applicant): Type 1 diabetes often leads to short-term and long-term complications which impair quality of life. Though many research groups are developing versions of an artificial endocrine pancreas (AP) system, current systems require at least one… more
Abstract:… hygiene. The antimicrobial and safety benefits iodine vapor perfusion may have wide ranging applications for the Federal Government and commercially for use in protecting water supplies, vegetable and fruit surfaces, animal carcasses, medical uses such as diabetic ulcerations… more
Abstract:DESCRIPTION (provided by applicant): Type 2 Diabetes (T2D) is an inflammatory disease affecting 26 million people in the US (11%) and is predicted to affect more than 30% of adults in the US by 2050. The economic cost of T2D is over 200 billion a year. People with T2D suffer… more
Abstract:DESCRIPTION (provided by applicant): One of the hallmarks of type 2 diabetes (T2D) is an inadequate number of functional pancreatic beta cells that results in insufficient insulin leading to hyperglycemia. Our preliminary work using various mouse models identified a novel target… more
Abstract:DESCRIPTION (provided by applicant): Type 2 diabetes (T2D) is a devastating disease that has undergone a striking increase in prevalence in the U.S. and worldwide. Although a number of different drugs exist to help manage this condition, unfortunately morethan 1/3 of affected… more
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