Abstract:DESCRIPTION (provided by applicant): One of the hallmarks of type 2 diabetes (T2D) is an inadequate number of functional pancreatic beta cells that results in insufficient insulin leading to hyperglycemia. Our preliminary work using various mouse models identified a novel target… more
Abstract:DESCRIPTION (provided by applicant): Type 2 diabetes (T2D) is a devastating disease that has undergone a striking increase in prevalence in the U.S. and worldwide. Although a number of different drugs exist to help manage this condition, unfortunately morethan 1/3 of affected… more
Abstract:DESCRIPTION (provided by applicant): Type I diabetes is an autoimmune disease where auto-immunity leads to slow, progressive destruction of pancreatic -cells and development of overt diabetes. Currently, there is no cure for type I diabetes, which is treated with insulin… more
Abstract:DESCRIPTION (provided by applicant): Healing of Diabetic Ulcers with Gaseous Nitric Oxide Generated from Room Air Diabetic foot ulcers (DFUs) are a frequent and debilitating complication of diabetes, and affect 1-2.5 million patients in the US. Many DFUs remain unhealed, leading… more
Abstract:DESCRIPTION (provided by applicant): About 28.3 million Americans have type II diabetes (T2D) and over 40.1% of middle-aged adults have prediabetes, a condition characterized by impaired glucose tolerance and insulin resistance. Current antidiabetic medications are effective in… more
Abstract:DESCRIPTION (provided by applicant): Type 1 Diabetes (T1D) is thought to result from a breakdown of self-tolerance that is characterized by T cell-mediated destruction of the insulin-producing -cells in the pancreas. Ultimately, glucose metabolism is interrupted, resulting in… more
Abstract:… treatment. In Phase II, Aggamin will initiate cGMP manufacturing, produce a prototype device and conduct studies in a baboon PE model for efficacy and safety. PE affects 3-8% of all pregnancies and disease incidence is rising as risk factors such as obesity, diabetes,… more
Abstract:…agnostic test because accurately identifying and treating MDD would reduce the high medical costs arising from medical service delivery to patients with untreated depression, as well as improving outcomes for patients with comorbid medical conditions such as diabetes or heart… more
Abstract:… EEG analysis for further confirmation.The current system for classifying sleep vs. wake is essentially as good as EEG/EMG; REM/NREM would be extremely valuable as a first pass screen. Medical targets of interest are sleep/circadian disorders, sleep apnea, obesity/… more
Abstract:… gave a major improvement in NASH activity scores (NAS) in mice, which corresponded to suppression of histologic disease-progression. PZ-235 also significantly protected against severe pancreatitis, a common sequela seen with several of the newly approved type-II diabetes… more
Abstract:DESCRIPTION: Therapeutic peptides are used to treat human diseases ranging from HIV to diabetes and have some of the best features of small molecule and recombinant protein drugs. Therapeutic peptides account for 13 billion of annual pharmaceutical salesand are part of a… more
Abstract:…, are now commonly observed in children. Dietary supplementation or amendment of deficient foods with ingredients that are high in fiber and plant antioxidants may be a cost-effective means of managing weight and decreasing risk factors for heart disease and diabetes. Defatted… more
Abstract:…, to a multifunctional health screening kiosk, focusing on riskfactors that disproportionately impact African Americans and Hispanics including high blood pressure, obesity, stress, and diet and exercise behaviors, all important risk factors for heart disease, stroke, diabetes… more
Abstract:DESCRIPTION (provided by applicant): The presence of islet-directed auto-immunity and associated circulating auto-antibodies, previously thought to be primarily characteristic of type-1 diabetes mellitus (T1DM), is now apparent in a proportion of individuals with putative… more
Abstract:… severe consequences to society and to the individual, resulting in pain that can interfere with school attendance, learning, and play. Poor oral health often continues into adulthood, and research shows linkages between poor oral health and heart and lung disease, diabetes,… more
Abstract:DESCRIPTION (provided by applicant): Type 2 diabetes mellitus is one of the most challenging health problems of the 21st century. Global health care expenditures to treat diabetes and its complications are estimated to have been 376 billion in 2010, of which 198 billion was… more
Abstract:… overweight or at risk of becoming overweight. PUBLIC HEALTH RELEVANCE: This project addresses the growing concern over the problem of obesity in children with Intellectual Disabilities. Childhood obesity presents many adverse medical effects, such as diabetes, asthma… more
Abstract:…he relationship between the relative chitin/alginate/additive composition and spinning conditions on mechanical and rheological properties (strength, elasticity, viscosity), water absorption, and additive release rates under simulated conditions as needed for the diabetic skin… more
Abstract:DESCRIPTION (provided by applicant): The purpose of this SBIR study is to develop and evaluate a real-time speech translation system to facilitate Medication Therapy Management (MTM) of patients with diabetes who primarily speak Spanish. We plan to accomplish this by (1)… more
Abstract:DESCRIPTION (provided by applicant): Diabetic Retinopathy (DR), a vision threatening complication of diabetes, can be managed more effectively if detected early. We propose to enable such early diagnosis by developing a portable retinal imaging instrument- LSC EYE - that will,… more
Abstract:… plays a critical role in advancing the understanding and prevention of public health problems, both at the individual level (e.g., drug and alcohol abuse) and at the systems level (e.g., health economics, delivery systems). The treatment and prevention of diabetes, obesity,… more
Abstract:DESCRIPTION (provided by applicant): The objective of this program is to further the development of a novel, stable, non-aqueous glucagon formulation as an integral component of a bi-hormonal (insulin-glucagon) pump system for treatment of persons with diabetes. The addition of… more
Abstract:DESCRIPTION (provided by applicant): The prevalence of nutrition-related conditions (overweight/obesity, cancer, diabetes, heart disease, etc.) among Americans is widely documented. During the last twenty years, the frequency of dining out has increased, with Americans currently… more
Abstract:DESCRIPTION (provided by applicant): The overall goal of the proposed SBIR program is to implement and evaluate a low cost portable retinal camera, the DLP-Cam, in a community-based system for diabetic retinopathy (DR) screening and treatment. Untreated DRhas reached epidemic… more
Abstract:… in the DRG neurons of rats after peripheral nerve injury and CGRP accumulates in experimentally-induced neuromas in rats as well as in human neuromas. Furthermore, excessive release of CGRP into the skin of rats was demonstrated in experimentally-induced diabetic… more
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