Abstract:…e of where limbs are in space- that has been impaired by disability. Active cueing (in contrast to current reactive cueing methods) will provide a more proprioceptive feedback that will better enable persons with amputations due to systemic complications (e.g. diabetes) to… more
Abstract:… our goals are: 1) develop the STAMP prototype visualizations and system architecture; 2) evaluate the feasibility of STAMP in enabling education and shared medical decision-making. Long term goals for STAMP include its extension to other chronic conditions, e.g., diabetes… more
Abstract:…ypothesis that adipose-derived stromal/stem cell (ASC) therapy will accelerate and improve pressure ulcer healing in the elderly. Studies will be conducted in young (3-4 month) and old (24 month) C57Bl/6 male mice using leptin receptor deficient (db/db) obese diabetic mice (3-4… more
Abstract:…tion to wound cavities prior to surgical closure could significantly reduce the number of superficial and deep incisional SSIs and organ-space SSIs. Amicrobe's hydrogel product may also help prevent infections in traumatic wounds and chronic wounds such as diabetic foot… more
Abstract:DESCRIPTION: In 2010, more than 875,000 Americans with diabetes were diagnosed with a lower extremity ulcer. Failed closure of these wounds results in more than 73,500 lower extremity amputations annually. Valitor, Inc. is developing protein-polymer therapeutics to overcome the… more
Abstract:DESCRIPTION (provided by applicant): Medikine will use SBIR funding to develop a novel therapeutic approach for treating diabetic nephropathy (DN) - a major life-threatening complication of diabetes, and the leading cause of chronic kidney disease and kidney… more
Abstract:… to continuously sensed glucose concentration data represents a modern attempt to mechanically simulate normal beta cell physiology and solve many of the problems associated with intensive insulin therapy today, including improving the quality of life for patients with diabetes… more
Abstract:DESCRIPTION (provided by applicant): Extreme insulin resistance in patients with diabetes is defined as insulin dose requirement of greater than 200 units daily. Currently, U-500 regular insulin is frequently used to treat these patients, however, the slowabsorption and… more
Abstract:DESCRIPTION (provided by applicant): With 500,000 Americans in the final stage of chronic kidney disease (CKD) and another 40 million at risk for developing CKD due to obesity, diabetes and hypertension renal disease is a modem epidemic. Serum phosphorus (Pi) levels are thought… more
Abstract:DESCRIPTION (provided by applicant): Mesodissection Device Microscopic analysis of tissue mounted on glass slides is commonly used to study cancer, nonneoplastic entities such as heart disease and diabetes, and normal cell function. At a growing rate, researchers are utilizing… more
Abstract:DESCRIPTION (provided by applicant): The goal of this application is to develop a test kit to quickly and accurately diagnose type 1diabetes; differentiate it from type 2 diabetes and screen for pre-diabetes . Current screening methods… more
Abstract:…and translation of a medical technology to reduce health disparities within the priority area of chroni disease through the development and testing of an innovative web-based technology, Cookin' Up Health, for the self-management of diet related to hypertension and diabetes… more
Abstract:… engine and clinical trials directory and accompanying widget that can be embedded online by third parties. The purpose is to enable individuals to quickly identify geographically close trials, which they may be qualifiedfor. The current focus is on Type 2 diabetes (T2D) but… more
Abstract:DESCRIPTION (provided by applicant): Of the 24 million patients diagnosed with diabetes in the US, 6.5 million (27%) depend on a strict regime of insulin administration. Limited or unreliable patient reporting of critical diabetes care parameters (blood glucose measurements,… more
Abstract:DESCRIPTION (provided by applicant): Dramatic increases in the incidence of obesity, diabetes, and the metabolic syndrome are increasing the prevalence of chronic liver diseases. Liver fibrosis arising from an excessive deposition of type I collagen in theparenchyma, occurs in… more
Abstract:… function or mental retardation. Our proprietary thrombin-derived TP508 peptide mitigates effects of whole-body nuclear radiation in mice, protecting endothelium, delaying bacteremia, and restoring normal wound healing. TP508 has shown positive results in diabetic foot… more
Abstract:… be monitored and recommendations made from automated systems, caregivers or physicians directlyor through social networking solutions. 3) If successful, MobileMedMinder can be extended as a mobile platform for chronic disease management system, such as diabetes, depression,… more
Abstract:… important needs in the areas of membrane protein function and drug screening and characterization. The membrane protein arrays will be useful in thedevelopment of effective and safe therapeutic agents for the treatment of wide range diseases such as cancer, diabetes,… more
Abstract:… limited quantity nucleic acid samples. These advancements will enable various long desired and needed studies, open new research frontiers and provide a comprehensive understanding of the biological mechanisms underlying disease states, such as cancer, heart disease, diabetes,… more
Abstract:… systems by applying human-derived hemodynamic shear stress forces to primary human cells in co-culture. Our initial system replicates the human vascular system and enables the creation of disease conditions including vascular inflammation, early atherogenesis and diabetic… more
Abstract:… selective small molecule inhibitors of FABP4 and FABP5 for the treatment of metabolic diseases The Western diet and lifestyle has brought an epidemic of health problems collectively referredto as metabolic syndrome. Obesity plays a central role, contributing to type 2 diabetes… more
Abstract:… by applicant): People with intellectual disabilities (ID) have rates of obesity greater than the general population. They often have poor energy dense diets and tend to be inactive. This group also experiences a high prevalence of health related problems: cancer, diabetes,… more
Abstract:… to an aqueous-reconstituted glucagon. Meeting thesebenchmarks will justify advancing the product into an NDA-enabling bioequivalency study. PUBLIC HEALTH RELEVANCE: The current standard of care for hypoglycemic emergencies?the Glucagon Emergency Kit requires a … more
Abstract:… the healthier kids' selections are purchased. As a result, children will be selecting menu items that are lower in calories, fat, saturated fat and sodium, leading to reduced risks of such nutrition-related conditions as obesity, heart disease, cancer, and diabetes… more
Abstract:… will harness the popularity and ubiquity of mobile microgames on hand-held devices for educating children on self-management of chronic health conditions. Millions of children suffer from chronic conditions which require regular management, including asthma, diabetes,… more
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