Abstract:Our objective is to create a female rat model which exhibits Non-Insulin Dependent Diabetes Mellitus (NIDDM). Literature supports that our diabetic, fatty male rat as superior to other available rat models in the onset and level of diabetes expressed. Characteristics such as… more
Abstract:We will develop methods that will permit the application of genomic mismatch scanning (GMS) to thegenome. If GMS can be applied to humans, it will rapidly identify the sub-chromosomal locations of cdisorders, such as non-insulin dependent diabetes mellitus, facilitating the… more
Abstract:… adults, so a quantitative degree of obesity (body fat fraction) may be deduced. Such routine measurements should result in improved weight control programs with consequent reduction in the health risks associated with hypertension, cardio vascular disease, cancer, diabetes, and… more
Abstract:Preliminary studies indicate that use of low-dose insulin therapy may prevent the onset of insulin-diabetes mellitus (IDDM) in certain high-risk individuals. This hypothesis is currently being testedmulticenter clinical trial, Diabetes Prevention Trial- 1 (DPT-1). Should the… more
Abstract:…velop an interactive, multimedia product that will assist physicianprofessionals in helping appropriately selected patients with IDDM adopt individualized intensive thproduct will provide guidance for achieving, as optimally as possible for a given individual, the trDiabetes… more
Abstract:We will develop and pilot test an innovative approach to enhancing the dietary knowledge of peopleparticularly those who either have or are at risk for Type II diabetes, the type which affects peoploverweight and accounts for 90% of the 14,000,000 Americans who have diabetes.… more
Abstract:…een objects and between points in space and 3D objects. Pimplementation will be tested on two experimental models: 1) spatial relationships between nerve celterminal synaptic fibers; 2) characterization of the 3D branching geometry of sensory and sudomotornormal and diabetic… more
Abstract:…rushing patterns will compliment in vitro studies and lead to theimportant brushing characteristics. This approach to enhancing toothbrush efficacy may provide highoral health for both the general population and those with periodontal disease.National Institute of Diabetes and… more
Abstract:The Diabetes Control and Complications Trial (DCCT) has shown that tight metabolic control can reduterm complications of diabetes. Blood glucose monitoring at home, combined with frequent communicatiinformation to health care providers, can help improve patients' diabetes… more
Abstract:…ifications will involve an external "plug-in" module to avoid damage to the imager and to expedite the animal experiments. This innovation will revolutionize many areas of medical diagnosis. These areas will range from retinal blood flow imaging to characterization of diabetic… more
Abstract:Diabetic patients with peripheral sensory neuropathy are at high risk for the development of foot uulcerations remain unnoticed in the absence of pain or "protective sensation" and often develop intothat can lead to amputation. Fifty to seventy percent of all lower extremity… more
Abstract:… is to inhibit the angiogenic process through the specific antagonism of a growth finteraction. Although an absolute requirement for the proper development of a growing fetus, angiogebeen associated with numerous disease states, including the growth of solid tumors, diabetic… more
Abstract:…AN TO COMPLETE DEVELOPMENT OF THE SYSTEM AND DEMONSTRATE ITS USABILITY AND "USER FRIENDLINESS". A PHASE II APPLICATION IS PLANNED IN WHICH THE PROJECT WILL BE TESTED ON A GROUP OF FORTY PATIENTS WHO HAVE OPTED TO LEARN HOME GLUCOSE MONITORING AND HAVE ENROLLED IN THE DIABETES… more
Abstract:… in thehydrocolloid dressings. Current research shows that the presence of such NO releasing polymers in thenhancement of wound repair. Evidence also exists that enhanced NO production, occurring in normal awounding, is suppressed in diabetic or otherwise… more
Abstract:The maintenance of euglycemia should prevent the development of or halt the progression of secondarcomplications of Diabetes Mellitus. Exogenous insulin therapy has been unsuccessful in producing coeuglycemia. Pancreatic tissue replacement has shown encouraging results but is… more
Abstract:Diabetes affects 11,000 people in America and 60,000 new cases are diagnosed every year. The transpencapsulated, immunoprotected islets as a treatment has recently generated much interest. The minuteof glucose achievable by this technique is not possible by conventional… more
Abstract:THE GOAL OF THE RESEARCH IS TO GENERATE DIAGNOSTIC REAGENTS AND/OR THERAPEUTIC REAGENTS FOR DIABETES THROUGH PRODUCTION OF MONOCLONAL ANTIBODIES TO THE PEPTIDE HORMONE, AMYLIN. AMYLIN IS A NEWLY DISCOVERED PEPTIDE HORMONE THAT IS ACTIVE IN THE CONTTROL OF GLUCOSE METABOLISM AND… more
Abstract:… WOULD ENABLE SUCH HOME TESTS. IT IS BASED UPON COMBINING THE TECNOLOGY OF OPTICALLY ACTIVE THROMBIN SUBSTRATES WHICH ENABLE SIMPLE PROTHROMBIN TIME TESTS) WITH THE DRY REAGENT TECHNOLOGY COMMONLY USED TO MAKE LOW-COST STRIP/METER-BASED HOME BLOOD GLUCOSE TESTS FOR DIABETICS.… more
Abstract:A program for the research/development of a reflective, near infrared glucose analyzer isproposed. The design approach allows for an optical computing approach to signal processing andpattern recognition that has the potential for a compact, low-cost instrument for diabetic… more
Abstract:… noise ratio, and building a compact prototype with improved electronics. Anticipated Benefits: Non-invasive measurement of blood glucose concentration. Alternative application to non-invasive measurement of other body chemicals. Use for home glucose monitoring in diabetics.… more
Abstract:The research seeks to establish the feasibility of a microencapsulation device containing isletcells for the treatment of insulin dependent diabetes. The device is a direct application of the spinal fluidflow driven artificial organ invented by the P.I. (U.S. Patent No. 5,222… more
Abstract:Our specific aim is to treat insulin dependent diabetes by porcine pancreatic islet celltransplantation without the use of immunosuppressive agents. In our study, porcine pancreatic isletsare treated with antibody fragments directed against MHC class I antigen, which we in… more
Abstract:Diabetic foot, venous stasis and pressure ulcers are examples of chronic non- healing woundsthat are refractory to standard therapy and represent a major health care problem especially for theincreasing elderly population. Polypeptide growth factors are a class of biological… more
Abstract:This project will design and develop an interactive meal planning program for Hispanics withdiabetes. The Hispanic Health and Nutrition Examination Survey indicated that the prevalence of adultonset diabetes and its complications among Mexican Americans and Puerto Ricans runs… more
Abstract:… are in short supply, the alternative of reconstituting them from cultivatedspecialized cells and extracellular matrix components becomes an important challenge for tissueengineering. Reconstituting a functional endocrine pancreas equivalent capable of rescuing diabetics… more
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