Abstract:The maintenance of euglycemia should prevent the development of or halt the progression of secondarcomplications of Diabetes Mellitus. Exogenous insulin therapy has been unsuccessful in producing coeuglycemia. Pancreatic tissue replacement has shown encouraging results but is… more
Abstract:Diabetes affects 11,000 people in America and 60,000 new cases are diagnosed every year. The transpencapsulated, immunoprotected islets as a treatment has recently generated much interest. The minuteof glucose achievable by this technique is not possible by conventional… more
Abstract:THE GOAL OF THE RESEARCH IS TO GENERATE DIAGNOSTIC REAGENTS AND/OR THERAPEUTIC REAGENTS FOR DIABETES THROUGH PRODUCTION OF MONOCLONAL ANTIBODIES TO THE PEPTIDE HORMONE, AMYLIN. AMYLIN IS A NEWLY DISCOVERED PEPTIDE HORMONE THAT IS ACTIVE IN THE CONTTROL OF GLUCOSE METABOLISM AND… more
Abstract:… WOULD ENABLE SUCH HOME TESTS. IT IS BASED UPON COMBINING THE TECNOLOGY OF OPTICALLY ACTIVE THROMBIN SUBSTRATES WHICH ENABLE SIMPLE PROTHROMBIN TIME TESTS) WITH THE DRY REAGENT TECHNOLOGY COMMONLY USED TO MAKE LOW-COST STRIP/METER-BASED HOME BLOOD GLUCOSE TESTS FOR DIABETICS.… more
Abstract:A program for the research/development of a reflective, near infrared glucose analyzer isproposed. The design approach allows for an optical computing approach to signal processing andpattern recognition that has the potential for a compact, low-cost instrument for diabetic… more
Abstract:… noise ratio, and building a compact prototype with improved electronics. Anticipated Benefits: Non-invasive measurement of blood glucose concentration. Alternative application to non-invasive measurement of other body chemicals. Use for home glucose monitoring in diabetics.… more
Abstract:The research seeks to establish the feasibility of a microencapsulation device containing isletcells for the treatment of insulin dependent diabetes. The device is a direct application of the spinal fluidflow driven artificial organ invented by the P.I. (U.S. Patent No. 5,222… more
Abstract:Our specific aim is to treat insulin dependent diabetes by porcine pancreatic islet celltransplantation without the use of immunosuppressive agents. In our study, porcine pancreatic isletsare treated with antibody fragments directed against MHC class I antigen, which we in… more
Abstract:Diabetic foot, venous stasis and pressure ulcers are examples of chronic non- healing woundsthat are refractory to standard therapy and represent a major health care problem especially for theincreasing elderly population. Polypeptide growth factors are a class of biological… more
Abstract:This project will design and develop an interactive meal planning program for Hispanics withdiabetes. The Hispanic Health and Nutrition Examination Survey indicated that the prevalence of adultonset diabetes and its complications among Mexican Americans and Puerto Ricans runs… more
Abstract:… are in short supply, the alternative of reconstituting them from cultivatedspecialized cells and extracellular matrix components becomes an important challenge for tissueengineering. Reconstituting a functional endocrine pancreas equivalent capable of rescuing diabetics… more
Abstract:INSULIN-DEPENDENT DIABETES MELLITUS (TYPE I) OCCURS IN ABOUT 0.5% OF CAUCASIANS. THE INCIDENCE INCREASES OVER 20-FOLD IN INDIVIDUALS WITH THE SPEIFIC SUSCEPTIBILITY GENE HLA-DQ3.2. APPROXIMATELY 70% OF INDIVIDUALS WHO BECOME INSULIN-DEPENDENT DIABETICS CARRY THIS GENE, MAKING IT… more
Abstract:…, makes the instrument a practical reality. Phase I of the program will focus on performance analysis and preliminary design of the sensor. One application area to be considered is non-invasive monitoring of blood chemistry, in particular, glucose monitoring in diabetic… more
Abstract:… in a wide variety of tissues: neuronal depolarization, relaxation of smoothmuscle, and positive inotropy in cardiac muscle. The receptor subtypes will serve as drug targets forpotential therapeutic roles in irritable bowel disease, postoperative ileus, diabetic… more
Abstract:The intraperitoneal injection of insulin-producing islets, immunoprotected by an alginate-polyam-ino acid membrane, is a potential method of reversing diabetes without the need for life-longimmunosuppression. Using alginate high in guluronic acid content, we have successfully… more
Abstract:…nt fouling of the sensor in biological fluids and electron transfer mediators which are covalently attached to an insoluble polymer to prevent their diffusion away from the electrode, the development of a reusable in vitro blood glucose monitor (for self-monitoring by diabetic… more
Abstract:… PRODUCED IN BACTERIA OR MAMMALIAN CELLS; ANTIBODIES AGAINST HBEGF) TO ALLOW A MORE DETAILED STUDY OF THE BIOLOGY OF THIS FACTOR. IN ADDITION, AN INITIAL TEST OF THE WOUND HEALING ACTIVITY OF HBEGF WILL BE CONDUCTED IN A FULL-THICKNESS WOUND MODEL IN IMPAIRED (DIABETIC,… more
Abstract:Angiogenesis is a tightly regulated process which plays a role in normal physiological events such as wound healing. Angiogenesis is involved in pathological diseases such as diabetic retinopathy, rheumatoid arthritis, psoriasis, and is a key event in the growth and development… more
Abstract:The long-term goal is to develop a commercial computer- based telecommunications system for monitoring ambulatory patients with serious and complex chronic illnesses. The goal is to adapt the Telephone-Linked Communications (TLC) system to diabetes mellitus; this technology is a… more
Abstract:Diabetic foot, venous stasis and pressure ulcers are examples of chronic non-healing wounds, that are refractory to standard therapy and represent a major health care problem especially for the increasing elderly population. Polypeptide growth factors are a class of biological… more
Abstract:A NUMBER OF POLYUNSATURATED FATTY ACIDS (PUFA) ARE EITHER ESSENTIAL FOR A NORMAL DEVELOPMENT OF THE HUMAN BODY OR POTENTIAL PROPHYLACTIC/THERAPEUTIC AGENTS FOR ATHEROSCLEROSIS, RHEUMATOID ARTHRITIS, CARCINOGENESIS, TYPE I DIABETES, PREMATURE BIRTH AND LOW BIRTH-WEIGHT, AND… more
Abstract:…e channel coil to facilitate imaging both anatomical regions without patient re-positioning. This development is to provide an enhanced signal-to-noise ratio (SNR) and a larger FOV to ascertain the feasibility of imaging and differentiating pathologies associated with diabetes… more
Abstract:… the armamentarium of the health-care providers of those with peripheral nerve involvement. A "shirt-pocket" portable version is available from Connecticut Bioinstruments Inc. Peripheral nerve involvement can arise from many reasons, including metabolic (e. g., Diabetes) and… more
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