Abstract:… information from the user, on the food and insulin intakdevice will have the capability to communicate to the user the expected glycemic index at several tiequipment will have the capability of determining the patient-specific parameters of the model. Theclosely with diabetes… more
Abstract:The overall objective of this research program is to develop implantable microreactors containingislets for treatment of diabetic patients. We will focus on development of technology required tofabricate these microreactors, and on in vitro studies of islet viability and… more
Abstract:Insulin-dependent diabetes mellitus affects millions of persons in the U.S. Despite years of intenseffectiveness of current therapeutic regimens remains limited due to the difficulty of duplicating thealthy pancreas. A potential method of treating this disease is the… more
Abstract:… need and a large commercial opportunity. A non-invasive glucose monitor btechnology will be small and inexpensive, since it does not use a detector. Even though recent reseadiabetics are able to forestall the debilitating and often fatal complications of diabetes by frequeonly… more
Abstract:There are more than 8,000,000 diabetics in the United States and 500,000 new cases are diagnosed eaDiabetics are at high risk for serious foot problems due to vascular and neurological deficiencies.injuries occur frequently, and lower extremity amputations… more
Abstract:Blood glucose monitoring is a technique that is widely applied in current diabetes care. It gives testimate of blood glucose upon which changes in their management can be made. The current method, whsource of lancet induced blood sample, is somewhat inconvenient and entails… more
Abstract:Our objective is to create a female rat model which exhibits Non-Insulin Dependent Diabetes Mellitus (NIDDM). Literature supports that our diabetic, fatty male rat as superior to other available rat models in the onset and level of diabetes expressed. Characteristics such as… more
Abstract:We will develop methods that will permit the application of genomic mismatch scanning (GMS) to thegenome. If GMS can be applied to humans, it will rapidly identify the sub-chromosomal locations of cdisorders, such as non-insulin dependent diabetes mellitus, facilitating the… more
Abstract:… adults, so a quantitative degree of obesity (body fat fraction) may be deduced. Such routine measurements should result in improved weight control programs with consequent reduction in the health risks associated with hypertension, cardio vascular disease, cancer, diabetes, and… more
Abstract:Preliminary studies indicate that use of low-dose insulin therapy may prevent the onset of insulin-diabetes mellitus (IDDM) in certain high-risk individuals. This hypothesis is currently being testedmulticenter clinical trial, Diabetes Prevention Trial- 1 (DPT-1). Should the… more
Abstract:…velop an interactive, multimedia product that will assist physicianprofessionals in helping appropriately selected patients with IDDM adopt individualized intensive thproduct will provide guidance for achieving, as optimally as possible for a given individual, the trDiabetes… more
Abstract:We will develop and pilot test an innovative approach to enhancing the dietary knowledge of peopleparticularly those who either have or are at risk for Type II diabetes, the type which affects peoploverweight and accounts for 90% of the 14,000,000 Americans who have diabetes.… more
Abstract:…een objects and between points in space and 3D objects. Pimplementation will be tested on two experimental models: 1) spatial relationships between nerve celterminal synaptic fibers; 2) characterization of the 3D branching geometry of sensory and sudomotornormal and diabetic… more
Abstract:…rushing patterns will compliment in vitro studies and lead to theimportant brushing characteristics. This approach to enhancing toothbrush efficacy may provide highoral health for both the general population and those with periodontal disease.National Institute of Diabetes and… more
Abstract:The Diabetes Control and Complications Trial (DCCT) has shown that tight metabolic control can reduterm complications of diabetes. Blood glucose monitoring at home, combined with frequent communicatiinformation to health care providers, can help improve patients' diabetes… more
Abstract:…ifications will involve an external "plug-in" module to avoid damage to the imager and to expedite the animal experiments. This innovation will revolutionize many areas of medical diagnosis. These areas will range from retinal blood flow imaging to characterization of diabetic… more
Abstract:Diabetic patients with peripheral sensory neuropathy are at high risk for the development of foot uulcerations remain unnoticed in the absence of pain or "protective sensation" and often develop intothat can lead to amputation. Fifty to seventy percent of all lower extremity… more
Abstract:… is to inhibit the angiogenic process through the specific antagonism of a growth finteraction. Although an absolute requirement for the proper development of a growing fetus, angiogebeen associated with numerous disease states, including the growth of solid tumors, diabetic… more
Abstract:…AN TO COMPLETE DEVELOPMENT OF THE SYSTEM AND DEMONSTRATE ITS USABILITY AND "USER FRIENDLINESS". A PHASE II APPLICATION IS PLANNED IN WHICH THE PROJECT WILL BE TESTED ON A GROUP OF FORTY PATIENTS WHO HAVE OPTED TO LEARN HOME GLUCOSE MONITORING AND HAVE ENROLLED IN THE DIABETES… more
Abstract:… in thehydrocolloid dressings. Current research shows that the presence of such NO releasing polymers in thenhancement of wound repair. Evidence also exists that enhanced NO production, occurring in normal awounding, is suppressed in diabetic or otherwise… more
Abstract:The maintenance of euglycemia should prevent the development of or halt the progression of secondarcomplications of Diabetes Mellitus. Exogenous insulin therapy has been unsuccessful in producing coeuglycemia. Pancreatic tissue replacement has shown encouraging results but is… more
Abstract:Diabetes affects 11,000 people in America and 60,000 new cases are diagnosed every year. The transpencapsulated, immunoprotected islets as a treatment has recently generated much interest. The minuteof glucose achievable by this technique is not possible by conventional… more
Abstract:THE GOAL OF THE RESEARCH IS TO GENERATE DIAGNOSTIC REAGENTS AND/OR THERAPEUTIC REAGENTS FOR DIABETES THROUGH PRODUCTION OF MONOCLONAL ANTIBODIES TO THE PEPTIDE HORMONE, AMYLIN. AMYLIN IS A NEWLY DISCOVERED PEPTIDE HORMONE THAT IS ACTIVE IN THE CONTTROL OF GLUCOSE METABOLISM AND… more
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