Abstract:…, to a multifunctional health screening kiosk, focusing on riskfactors that disproportionately impact African Americans and Hispanics including high blood pressure, obesity, stress, and diet and exercise behaviors, all important risk factors for heart disease, stroke, diabetes… more
Abstract:DESCRIPTION (provided by applicant): The presence of islet-directed auto-immunity and associated circulating auto-antibodies, previously thought to be primarily characteristic of type-1 diabetes mellitus (T1DM), is now apparent in a proportion of individuals with putative… more
Abstract:… severe consequences to society and to the individual, resulting in pain that can interfere with school attendance, learning, and play. Poor oral health often continues into adulthood, and research shows linkages between poor oral health and heart and lung disease, diabetes,… more
Abstract:DESCRIPTION (provided by applicant): Type 2 diabetes mellitus is one of the most challenging health problems of the 21st century. Global health care expenditures to treat diabetes and its complications are estimated to have been 376 billion in 2010, of which 198 billion was… more
Abstract:… overweight or at risk of becoming overweight. PUBLIC HEALTH RELEVANCE: This project addresses the growing concern over the problem of obesity in children with Intellectual Disabilities. Childhood obesity presents many adverse medical effects, such as diabetes, asthma… more
Abstract:…he relationship between the relative chitin/alginate/additive composition and spinning conditions on mechanical and rheological properties (strength, elasticity, viscosity), water absorption, and additive release rates under simulated conditions as needed for the diabetic skin… more
Abstract:DESCRIPTION (provided by applicant): The purpose of this SBIR study is to develop and evaluate a real-time speech translation system to facilitate Medication Therapy Management (MTM) of patients with diabetes who primarily speak Spanish. We plan to accomplish this by (1)… more
Abstract:DESCRIPTION (provided by applicant): Diabetic Retinopathy (DR), a vision threatening complication of diabetes, can be managed more effectively if detected early. We propose to enable such early diagnosis by developing a portable retinal imaging instrument-… more
Abstract:… plays a critical role in advancing the understanding and prevention of public health problems, both at the individual level (e.g., drug and alcohol abuse) and at the systems level (e.g., health economics, delivery systems). The treatment and prevention of diabetes, obesity,… more
Abstract:DESCRIPTION (provided by applicant): The objective of this program is to further the development of a novel, stable, non-aqueous glucagon formulation as an integral component of a bi-hormonal (insulin-glucagon) pump system for treatment of persons with diabetes. The addition of… more
Abstract:DESCRIPTION (provided by applicant): The prevalence of nutrition-related conditions (overweight/obesity, cancer, diabetes, heart disease, etc.) among Americans is widely documented. During the last twenty years, the frequency of dining out has increased, with Americans currently… more
Abstract:… conducting DR screening within the EyePACS telemedicine network, administered by UC Berkeley. Based on ongoing LSDC validation study demographics, 92% of the subject population is expected to be from a racial or ethnic minority, and all will have diagnosed diabetic … more
Abstract:… in the DRG neurons of rats after peripheral nerve injury and CGRP accumulates in experimentally-induced neuromas in rats as well as in human neuromas. Furthermore, excessive release of CGRP into the skin of rats was demonstrated in experimentally-induced diabetic… more
Abstract:… system. Each year in the US, there are 450,000 burns that require medical treatment and 45,000 burns that require hospitalization. One of the most common causes of chronic wounds, venous ulcers, occurs in 600,000 to 1,500,000 US patients; 15% to 20% of patients with … more
Abstract:… SBIR Phase II program goals for which include optimization of ANG-4011 delivery in sustained-release, clinically compatible, biodegradable microspheres, evaluation of ANG-4011 therapy in myocardial-reperfusion models accompanied by co-morbidities (e.g. age and diabetes) and… more
Abstract:… cadaver. We will also demonstrate that low intensity therapeutic ultrasound improves wound healing, as measured by therapy on the rate and extent of epithelialization and granulation tissue formation(the major components in human wound healing) in wild-type and diabetic… more
Abstract:… a phase 1a clamp study of healthy volunteers. The present application thus provides a logical bridge between highly promising in vitro and animal data, as generated in the Phase 1 SBIR program, and key pre-IND milestones. PUBLIC HEALTH RELEVANCE: Diabetes is increasing… more
Abstract:DESCRIPTION (provided by applicant): We seek to develop an ultra-fast insulin analog formulation for the treatment of diabetes mellitus. Ultra-fast pharmacokinetic/dynamic (PK/PD) promises to enable superior performance of pump therapy (continuous subcutaneous insulin infusion;… more
Abstract:DESCRIPTION (provided by applicant): The broad long term goal of this project is to develop an improved treatment for neovascular age-related macular degeneration and for diabetic retinopathy: the two leading causes of blindness in the United States. The… more
Abstract:… simultaneously. The ability to measure oxygen available at specific locations in tissue in addition to measuring oxygen available from the circulation provides a powerful new tool to physicians developing methods to enhance skin healing in patients suffering from diabetes,… more
Abstract:DESCRIPTION (provided by applicant): Significance: Almost 30% of U.S. adults have pre-diabetes. Without weight loss and changes in physical activity and diet, more than 50% of them will eventually develop type 2 diabetes (T2DM), with its increased risk ofcardiovascular disease… more
Abstract:… are the most expensive of all the ESRD treatments for Medicare, costing about 77,000/person/year, a cost that can be avoided by immediate access through a permanent arteriovenous graft. With the increase in aging population of ESRD patients, higher occurrence of diabetes… more
Abstract:DESCRIPTION (provided by applicant): The objective of the phase I proposal is to demonstrate the feasibility of a new and innovative insulin assay for its integration in a small benchtop device with the focus in clinical diabetes therapy: A) for assessmentof insulin impairment… more
Abstract:DESCRIPTION (provided by applicant): The World Health Organization estimates that diabetes affects about 185 million people worldwide, with approx. 20 million individuals (approx. 6 percent by population) afflicted in the US (approx. 10 percent of this type 1 diabetes). Tighter… more
Abstract:… of those have apps on their phones. Although our project will focus on tobacco cessation medication, this app would have broad applicability beyond tobacco cessation treatment. Non-adherence to treatment for chronic conditions such as hypertension, hyperlipidemia, and diabetes… more
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