Abstract:…tly been used to detect shear forces on tires and a means of using the system for predictive maintenance of fleet vehicles is underway. The sensor also has use in biomedical applications include ongoing research for identification and correlation of shear on the foot of … more
Abstract:Peripheral Neuropathy (PN) is a painful debilitating condition caused by progressive subcutaneous nerve damage due to diabetes, chemotherapy or as a result of traumatic combat injuries. Systemic or topical administration of existing therapeutics alleviates pain but does not… more
Abstract:…on-alcoholic steatohepatitis. It is now estimated that 14-24% of the general population and up to 80% of morbidly obese subjects have contracted NAFLD. Untreated disease may progress to cirrhosis and lead to hepatic cancer. Cirrhosis now accounts for 12.5% of diabetes related… more
Abstract:… growth factor cocktail for application to biologic hernia meshes to treat the challenging hernia repair market. CP factors represent a broad spectrum of potent biologic molecules that have demonstrated a benefit in the healing of splinted open wounds in diabetic mice, are… more
Abstract:… in concentration over time in biological tissues, such as in the interstitial fluid and in the blood. The objectives of this project are to miniaturize an existing Raman bench-top system to one that is wearable, low-cost, and optimized for blood glucose measurement in diabetic… more
Abstract:… supply shortage worldwide. Data suggest that omega-3 fatty acids, such as DHA, play important roles in enhancing heart health, brain health, child and infant development and preventing various chronic diseases, such as rheumatoid arthritis, obesity and type-2 diabetes. It is… more
Abstract:… of chronic wounds. Chronic wounds affect 6.5 Million people in the US with an estimated $25 billion spent annually on treatment. This number continues to grow due to increasing health care costs, an aging population, and the rise worldwide in the incidence of diabetes and… more
Abstract:… (HDL) protects from CAD, current methods to assess risk measure the cholesterol content of HDL (HDL-C) as a surrogate indicator of HDL quantity. However, the function of HDL, namely its ability to efflux cholesterol, is what reduces CAD risk. Obesity and diabetes… more
Abstract:…, to a multifunctional health screening kiosk, focusing on riskfactors that disproportionately impact African Americans and Hispanics including high blood pressure, obesity, stress, and diet and exercise behaviors, all important risk factors for heart disease, stroke, diabetes… more
Abstract:DESCRIPTION (provided by applicant): The presence of islet-directed auto-immunity and associated circulating auto-antibodies, previously thought to be primarily characteristic of type-1 diabetes mellitus (T1DM), is now apparent in a proportion of individuals with putative… more
Abstract:DESCRIPTION (provided by applicant): Type 2 diabetes mellitus is one of the most challenging health problems of the 21st century. Global health care expenditures to treat diabetes and its complications are estimated to have been 376 billion in 2010, of which 198 billion was… more
Abstract:… overweight or at risk of becoming overweight. PUBLIC HEALTH RELEVANCE: This project addresses the growing concern over the problem of obesity in children with Intellectual Disabilities. Childhood obesity presents many adverse medical effects, such as diabetes, asthma… more
Abstract:…he relationship between the relative chitin/alginate/additive composition and spinning conditions on mechanical and rheological properties (strength, elasticity, viscosity), water absorption, and additive release rates under simulated conditions as needed for the diabetic skin… more
Abstract:DESCRIPTION (provided by applicant): Diabetic Retinopathy (DR), a vision threatening complication of diabetes, can be managed more effectively if detected early. We propose to enable such early diagnosis by developing a portable retinal imaging instrument-… more
Abstract:… plays a critical role in advancing the understanding and prevention of public health problems, both at the individual level (e.g., drug and alcohol abuse) and at the systems level (e.g., health economics, delivery systems). The treatment and prevention of diabetes, obesity,… more
Abstract:DESCRIPTION (provided by applicant): The objective of this program is to further the development of a novel, stable, non-aqueous glucagon formulation as an integral component of a bi-hormonal (insulin-glucagon) pump system for treatment of persons with diabetes. The addition of… more
Abstract:… conducting DR screening within the EyePACS telemedicine network, administered by UC Berkeley. Based on ongoing LSDC validation study demographics, 92% of the subject population is expected to be from a racial or ethnic minority, and all will have diagnosed diabetic … more
Abstract:… system. Each year in the US, there are 450,000 burns that require medical treatment and 45,000 burns that require hospitalization. One of the most common causes of chronic wounds, venous ulcers, occurs in 600,000 to 1,500,000 US patients; 15% to 20% of patients with … more
Abstract:… SBIR Phase II program goals for which include optimization of ANG-4011 delivery in sustained-release, clinically compatible, biodegradable microspheres, evaluation of ANG-4011 therapy in myocardial-reperfusion models accompanied by co-morbidities (e.g. age and diabetes) and… more
Abstract:… cadaver. We will also demonstrate that low intensity therapeutic ultrasound improves wound healing, as measured by therapy on the rate and extent of epithelialization and granulation tissue formation(the major components in human wound healing) in wild-type and diabetic… more
Abstract:DESCRIPTION (provided by applicant): We seek to develop an ultra-fast insulin analog formulation for the treatment of diabetes mellitus. Ultra-fast pharmacokinetic/dynamic (PK/PD) promises to enable superior performance of pump therapy (continuous subcutaneous insulin infusion;… more
Abstract:DESCRIPTION (provided by applicant): The broad long term goal of this project is to develop an improved treatment for neovascular age-related macular degeneration and for diabetic retinopathy: the two leading causes of blindness in the United States. The… more
Abstract:… simultaneously. The ability to measure oxygen available at specific locations in tissue in addition to measuring oxygen available from the circulation provides a powerful new tool to physicians developing methods to enhance skin healing in patients suffering from diabetes,… more
Abstract:DESCRIPTION (provided by applicant): Significance: Almost 30% of U.S. adults have pre-diabetes. Without weight loss and changes in physical activity and diet, more than 50% of them will eventually develop type 2 diabetes (T2DM), with its increased risk ofcardiovascular disease… more
Abstract:DESCRIPTION (provided by applicant): The objective of the phase I proposal is to demonstrate the feasibility of a new and innovative insulin assay for its integration in a small benchtop device with the focus in clinical diabetes therapy: A) for assessmentof insulin impairment… more
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