Abstract:DESCRIPTION: Androgen action is the net result of opposing pathways of steroid biosynthesis and metabolism. It is now widely recognized that testosterone (T) is an androgenic precursor of the more potent 5 -dihydrotestosterone (DHT), produced by 5 -reductase type 2. Circulating T and DHT also serve… more
Abstract:… and periodontitis are initiated by chronic infection of the gingival crevice with bacteria such as Porphryomonas gingivalis. Risk for gingivitis is universal, but subjects with haplotypes of IL-1B producing higher IL-1 levels in crevicular fluid, diabetics and… more
Abstract:DESCRIPTION (provided by applicant): Acute kidney injury (AKI) is a common, severe complication of cardiopulmonary bypass (CPB) assisted surgeries, and include coronary artery bypass grafts, valve replacements, aortic aneurisms, and organ transplants. Elderly patients, … more
Abstract:… high risk of falling and multiple disease processes. Moreover, the methods evaluated and refined in this study will be used in future web-based applications focused on exercise training in various disease processes that effect mobility and balance, such as stroke, diabetes,… more
Abstract:DESCRIPTION (provided by applicant): The public health problem addressed by this proposal is that inactivity in individuals with chronic disabilities who use a wheelchair results in signifiant and costly secondary complications, such as pressure ulcers, obesity, diabetes,… more
Abstract:… measures for six months. Non-healing wounds affect 6.5 million patients, affecting nearly 2% of the U.S. population, with an annual cost to the healthcare system of 25 billion. These numbers are rising with the aging population and the increasing incidence of diabetes, a… more
Abstract:…tly been used to detect shear forces on tires and a means of using the system for predictive maintenance of fleet vehicles is underway. The sensor also has use in biomedical applications include ongoing research for identification and correlation of shear on the foot of … more
Abstract:…ion and physical activity programs, poor eating habits and sedentary behavior are persistent problems for many college students who are surrounded by numerous unhealthy food choices and physical activity barriers which make them vulnerable to chronic diseases such as diabetes,… more
Abstract:DESCRIPTION (provided by applicant): Diabetes constitutes an enormous public health challenge in USA. About 60 to 70% of people with the disease have mild to severe forms of nervous system damage and there is no effective treatment for diabetic neuropathy.Thus there is a strong… more
Abstract:Peripheral Neuropathy (PN) is a painful debilitating condition caused by progressive subcutaneous nerve damage due to diabetes, chemotherapy or as a result of traumatic combat injuries. Systemic or topical administration of existing therapeutics alleviates pain but does not… more
Abstract:DESCRIPTION (provided by applicant): The long-term objective of the proposed effort is to develop a new anti-HER3 therapeutic for concomitant administration with approved anti-HER2 therapies in HER2+ breast cancer (BCa) patients. Trastuzumab (TZMB), a monoclonal anti-HER2 antibody, and lapatinib, a… more
Abstract:…l derived therapies by removing residual contaminating cells from therapeutic cell formulations. Replacement cells derived from human pluripotent stem cells have the extraordinary potential to treat virtually any condition where cells are lost to injury or disease (i.e. diabetes… more
Abstract:… ultimately seek FDA approval for a novel combination product. PUBLIC HEALTH RELEVANCE PUBLIC HEALTH RELEVANCE: The changing demographics of Western societies include an aging population with a near epidemic of obesity, insulin resistance, and diabetes mellitus,… more
Abstract:… and perform more timely procedures to avoid permanent tissue damage and costly therapies, and eliminate unnecessary additional time in the hospital. Applications include reducing unnecessary wound care procedures such as treatment of bed sores, amputations in diabetic and… more
Abstract:…vel 270 base pair replication origin-antibiotic free selection cassette that we hypothesize will promote long duration gene expression after vector delivery tothe body. The MiniPlasmid platform will be applied to create a wound healing gene therapy product to treat diabetic… more
Abstract:DESCRIPTION (provided by applicant): Age-Related Macular Degeneration is the most common cause of legal blindness in people over 60, affecting an estimated 1.6 million patients. Additionally, over 400,000 diabetic Americans are diagnosed each year with vision-threatening retinal… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will demonstrate a new non-invasive glucose sensor for diabetes patients. Similar in approach to pulse oximetry, the sensor measures the intensity of light scattered by epidermis at two wavelengths to provide a… more
Abstract:… studies in rodent models of RP that would justify initiating development of this novel drug class for clinical use. PUBLIC HEALTH RELEVANCE PUBLIC HEALTH RELEVANCE: Retinitis pigmentosa (RP), is a diverse group of inherited degenerative retinopathies characterized… more
Abstract:DESCRIPTION (provided by applicant): Diabetic nephropathy (DN) is the most common cause of end-stage renal disease (ESRD) in the world and affects about 15-25% of type I diabetes patients and 30-40% of patients with type II diabetes. The development of DNis thought to result… more
Abstract:… hemochromatosis, are typically insidious, causing progressive and sometimes irreversible end-organ injury before clinical symptoms develop. Iron overload in vital organs increases the risk for liver disease (cirrhosis, cancer), heart attack or heart failure, diabetes mellitus… more
Abstract:DESCRIPTION (provided by applicant): Chronic wounds and ulcers are increasing with the growing incidence of diabetes and associated illnesses and have annual costs exceeding 20 billion. These non-healing wounds result in chronic disease, limb amputationsand death and are… more
Abstract:… is approximately 163.8 deaths per 1,000 patient years. Hemodialysis is the leading treatment for more than 341,000 patients in the United States with end-stage renal disease (ESRD), or kidney failure, which can be caused by common chronic conditions such as diabetes and… more
Abstract:DESCRIPTION (provided by applicant): New therapies are desperately needed to relieve patients with Type 1 diabetes from the neuropathy, nephropathy and retinopathy associated with the current standard of treatment, injected insulin. Transplantation of… more
Abstract:DESCRIPTION (provided by applicant): Management of Type 1 diabetes requires vigilant monitoring by patients who often encounter numerous barriers that can impede proper management. Barriers can include educational, psychosocial, and support issues. PolarisHealth Directions, a… more
Abstract:…esearch leading to the submission of a Device Master File (DMF) to the FDA supporting use of Quadrasep as a manufacturing tool for effecting the improved isolation of human pancreatic islets of Langerhans for therapeutic transplantation for the prevention of diabetes in… more
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