Abstract:… and is typically coupled with low levels of physical activity (i.e. sedentary lifestyles). The combination of obesit and inactivity has resulted in increased morbidity and mortality from hypertension, stroke, coronary artery disease, dyslipidemia, type 2 diabetes,… more
Abstract:…o detect shear forces on tires and a means of using the system for predictive maintenance of fleet vehicles is underway. The sensor also has use in biomedical applications include ongoing research for identification and correlation of shear on the foot of diabetics. The… more
Abstract:…, is to develop and evaluate the School TIME Toolkit (Toolkit) to support parents and teachers of elementary school-aged children who have a chronic illness and intermittent school attendance (CICISA). Children with chronic illnesses, such as asthma, cancer, diabetes and other… more
Abstract:DESCRIPTION (provided by applicant): All forms of diabetes are characterized by the death of insulin producing cells. In Type 1 diabetes (T1D), this leads to the reliance on exogenous insulin for survival. In addition, there is cell loss in T2D and inindividuals who lose… more
Abstract:DESCRIPTION (provided by applicant): Type 1 Diabetes (T1D) affects an estimated one in three hundred young people in the U.S., with increasing annual incidence. It is primarily an autoimmune disease and is often associated with other serious autoimmune conditions such as… more
Abstract:DESCRIPTION (provided by applicant): Diabetes mellitus affected 285 million adults worldwide in 2010 and is expected to increase in prevalence to 439 million people by the year 2030. Foot ulceration continues to be a major comorbidity of diabetes and afflicts as many as 15 to… more
Abstract:… studies of animals including development, infection, immune response, cardiac studies, tissue injury and healing. The iodinated contrast agents cause contrast induced reactions (CIRs) in many patients, including those with allergies, asthma, kidney diseases and diabetes.… more
Abstract:…ess Innovation Research (SBIR) Phase II project aims to develop the process and engineering controls necessary to scale up the manufacturing of a nitric-oxide-releasing active pharmaceutical ingredient (API). One of the applications is a wound-healing product for diabetic foot… more
Abstract:… each year. The only effective treatment is tight control of blood glucose levels, though even best practices provide incomplete protection from hyperglycemia. Long term diabetes is frequently associated with microvascular complications: approx 5% of diabetics develop… more
Abstract:DESCRIPTION (provided by applicant): Physical activity plays a critical role in public health. Unfortunately, the prevalence of sedentary lifestyles is extremely high in the U.S., and there are well-established links between sedentariness and health riskssuch as obesity, … more
Abstract:… is approximately 163.8 deaths per 1,000 patient years. Hemodialysis is the leading treatment for more than 341,000 patients in the United States with end-stage renal disease (ESRD), or kidney failure, which can be caused by common chronic conditions such as diabetes and… more
Abstract:DESCRIPTION (provided by applicant): With the growing prevalence of diabetes, the ability to accurately and reliably diagnose diabetes in its earliest stages has become a public health priority. Early identification of T1D risk and the onset of autoimmunity provide the basis for… more
Abstract:DESCRIPTION (provided by applicant): An estimated 23.6 million people (7 percent of the population) in the United States have diabetes; 90 to 95 percent of all diagnosed cases are type 2 diabetes (CDC, 2007). Obesity and metabolic syndrome are the… more
Abstract:…TH RELEVANCE: The last two decades have seen an overwhelming amount of basic and preclinicalresearch demonstrating the therapeutic promise of human mesenchymal stem cells (hMSCs) for neurodegenerative diseases, spinal cord and brain injuries, cardiovascular diseases, diabetes… more
Abstract:… composite tissue, and islet transplantationcurrently require nonspecific immunosuppressive agents indefinitely for graft maintenance. These agents have significant toxicities, including nephrotoxicity, opportunistic infections, increased rate of malignancy, diabetes, and… more
Abstract:… rate (GFR) estimates as well as tests for urine albumin. This should result is a more reliable and earlier identification of CKD. n addition, our CKD-Assay would give physicians the ability to evaluate patients that have been recently diagnosed with hypertension or diabetes… more
Abstract:…ntegrity of large portions of the skin as a result of wounds and wound-related infection may lead to major disability or even death. Every year in the United States more than 1.25 million people suffer burns and 6.5 million have chronic skin ulcers caused by diabetes and other… more
Abstract:DESCRIPTION (provided by applicant): The growing populations of the elderly and those with type-II diabetes are at high risk for developing chronic wounds that are slow to heal. Effective therapeutics to promote wound healing can significantly improve thelives of those faced… more
Abstract:DESCRIPTION (provided by applicant): Modifiable behavioral risk factors for diabetes and cardiovascular disease, two of the most costly diseases in both human and monetary terms, include obesity, lack of physical activity, smoking tobacco and excess alcohol consumption. Despite… more
Abstract:… to other fields. PUBLIC HEALTH RELEVANCE: Patient controlled self-therapy is an enticing factor for packaging drugs in single-dose prefilled syringe formats which treat chronic ailments, such as rheumatoid arthritis, multiple sclerosis, and diabetes. Other… more
Abstract:DESCRIPTION (provided by applicant): The long-term objective of the proposed study is to develop a monoclonal antibody that inhibits the progression of diabetic retinopathy. Insulin-like growth factor-I (IGF-I) has been implicated in both endothelial… more
Abstract:…because a large amount of blood that must be transported and handled. The Virogenomics platform will use just a drop of blood and will provide results while the patient is still in the doctor?s office. This diagnostic test works similar to the blood-glucose monitors diabetics… more
Abstract:DESCRIPTION (provided by applicant): The objective of this Phase II competitive renewal project is to implement a clinical study to collect data to validate EyeStar(tm), a software system as the basis for comprehensive telescreening for all stages of diabetic … more
Abstract:DESCRIPTION (provided by applicant): This proposed project is motivated by the fact that comprehensive, broad-scale screening for eye diseases such as age-related macular degeneration (AMD), glaucoma, and diabetic retinopathy (DR), including advanced stages,… more
Abstract:… characteristics found in cellular membranes and enable the investigation of protein-ligand and protein-membrane interactions in a multiplexed fashion. Such a tool would enable novel lipid-based research and diagnostic assays in a multitude of areas including cancer, diabetes,… more
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