Abstract:DESCRIPTION (provided by applicant): Diabetes affects more than 8% of Americans and costs over 174 billion in 2007 in USA. Recently bariatric surgery, such as Roux-en-Y gastric bypass, has been proposed for treating diabetic patients with obesity due to its hypoglycemic effect… more
Abstract:DESCRIPTION (provided by applicant): Diabetes has become a devastating epidemic worldwide. Insulin is commonly used as a treatment to help manage diabetes because of its ability to control blood glucose levels, and is in high demand worldwide, but it facesmultiple challenges… more
Abstract:DESCRIPTION (provided by applicant): An increasing variety of diseases are being shown to be due to immunological processes, including diabetes, and now Alzheimer's disease (AD). AD is the most prevalent age-associated disease and growing evidence suggeststhat aspects of… more
Abstract:…, ease of use, and acceptance and promotion by health care professionals. If successful, we envision that the VR program will serve as a template for interactive VR interventions for children with other chronic conditions requiring self-management, such as asthma, … more
Abstract:…, and engaging interventions for children and their caregivers. Software-based interventions offer an improved means of disseminating empirically-supported treatments for sleep directly to families, just as they have other pediatric conditions such as diabetes, asthma,… more
Abstract:…VANCE PUBLIC HEALTH RELEVANCE: This proposal describes a new software product that enhances the diagnostic capability of optical coherence tomography (OCT), the most commonly performed retinal diagnostic test used in the US for evaluation of macular degeneration and diabetic… more
Abstract:… of exercise, factors which contribute to type 2 diabetes, have led to an increasingly overweight population. According to the International Diabetes Federation, there are 285 million cases of diabetes in the world as of 2010. For the type 2 diabetics, 50% will develop diabetic… more
Abstract:… RELEVANCE: Acute kidney injury (AKI) affects more than 10 million people worldwide per year with 15-60% mortality. However, methods for early diagnosis of AKI are still lacking and consequently this is one of the research topics solicited by the National Institute of … more
Abstract:DESCRIPTION (provided by applicant): Obesity has reached epidemic proportions in the U.S. and plays a major role in the development of type 2 diabetes, dyslipidemia, and cardiovascular disease. There remains a very significant need for better non- surgicaltreatments. While most… more
Abstract:… growth factor cocktail for application to biologic hernia meshes to treat the challenging hernia repair market. CP factors represent a broad spectrum of potent biologic molecules that have demonstrated a benefit in the healing of splinted open wounds in diabetic mice, are… more
Abstract:DESCRIPTION (provided by applicant): We are developing a novel immunomodulatory approach to arrest pancreatic islet injury and restore specific immune tolerance in new-onset Type 1 diabetes mellitus (T1D). Damage of pancreatic islets in T1D may result fromexcess pathogenic… more
Abstract:… from 90% to 50% (plt0.01). In a murine RIRI model, 24 h creatinine elevations were entirely eliminated by a single dose of R-100 prior to reperfusion (plt0.01). Aim #1: Establish the pharmacodynamic (PD) profile of R-100 in models of CIN in healthy and diabetic rodents… more
Abstract:DESCRIPTION (provided by applicant): Annually, 5 to 7 million Americans are treated for chronic wounds that arise from diabetes, lower extremity arterial disease, lower extremity venous disease, pressure ulcers, and traumatic injuries, including burns, demonstrating the need for… more
Abstract:… (ARDTs) are two families of related enzymes that have important medically relevant functions. For example, SIRT3, a mitochondrial sirtuin, controls mitochondrial function, and thereby exerts a strong effect on metabolism, obesity, type 2 diabetes, and… more
Abstract:… the hSlo gene splice variant, called hMaxiK, which codes for the pore forming subunit of the large conductance potassium channel. Prior studies by ICI have shown that hMaxiK improves urogenital pathophysiology in rodent and nonhuman primate models of aging, diabetes and… more
Abstract:… (PARP-1) areuseful neuroprotective agents especially when the neurodegeneration is caused by excitotoxic insult. Inhibitors of PARP-1 have been investigated pre-clinically and clinically for cardiac ischemia, hemorrhagic shock syndrome, stroke, traumatic CNS injury,diabetes,… more
Abstract:DESCRIPTION (provided by applicant): We devised a new generation, highly sensitivity method to diagnosis peripheral neuropathy early, when the probability for reversal is greatest. Cancer chemotherapy and diabetes are the most common causes of neuropathy in the USA. Both cause… more
Abstract:… low micron levels. The objectives are to diagnose peripheral neuropathy near its onset, when the possibility for reversal is highest, and to monitor either progression or reversal of neuropathy during treatment. Target neuropathies are those related to chemotherapy and diabetes… more
Abstract:DESCRIPTION (provided by applicant): According to UnitedHealth14 by 2020 half of all Americans would have either diabetes or pre-diabetes with an annual cost of 500 billion - mainly attributed to diabetes related complications. Diabetes is a growing epidemic… more
Abstract:…esearch will provide breakthroughs needed to advance the discovery of promising new therapies and modulating drugs for neurodegenerative disorders including Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), Parkinson's disease(PD), Type 2 diabetes, Lowe… more
Abstract:… in concentration over time in biological tissues, such as in the interstitial fluid and in the blood. The objectives of this project are to miniaturize an existing Raman bench-top system to one that is wearable, low-cost, and optimized for blood glucose measurement in diabetic… more
Abstract:… impact/commercial potential of this project includes the focus on mobility limitations in persons with lower-limb amputations, which affect twice as many minorities as Caucasians. The commercial potential of this wireless assistive technology is vast: with diabetes as the… more
Abstract:… a number of conditions where vascular dysfunction and inflammation are important pathophysiological mechanisms, for example coronary artery disease or thrombotic microangiopathies. We recently completed apilot study evaluating levels of MPs in patients with diabetes mellitus… more
Abstract:… by applicant): Project Summary Accurate quantification of alcohol and drugs of abuse intoxication in emergency rooms (ERs) is an important screening step for a precise diagnosis and hence for prompt treatment. Some severe emergenciessuch as traumatic head injury, diabetes… more
Abstract:… molecular, cellular and physiological changes of endocrine FGF activity modulation will be verified. This translational research project for therapeutic target validation will lead to the development of potential new drugs against chronic kidney disease, diabetes, obesity… more
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