Abstract:DESCRIPTION (provided by applicant): Type I diabetes is a widespread disease in which insulin producing pancreatic islets are lost, leading to unstable glucose levels. If the islets can be replaced, as with transplantation, then diabetes can be reversed.Human islets have… more
Abstract:DESCRIPTION (provided by applicant): Diabetes and diabetes-related co-morbidities are at epidemic proportions and an enormous burden to our healthcare system. Although there has been significant progress in defining the causative factors and molecular… more
Abstract:Obesity and its associated metabolic complications including diabetes are becoming increasingly prevalent in the general population as well as in military personnel. Brown adipose tissue (BAT) is a major site of energy expenditure through thermogenesis, which is mediated by the… more
Abstract:…aluate the capability of AOSLO retinal images to serve as a clinically useful surrogates for visual acuity in eyes with center-involved diabetic macular edema, and to evaluate correlations between quantified AOSLO image metrics and the state of retinal disease in diabetic … more
Abstract:… consumption, and low maintenance operation. The broader/commercial impact of this work targets improved air pollution monitoring for public health. This will be greatly beneficial to society since illnesses such as asthma, heart disease, autism, diabetes, and cancer… more
Abstract:DESCRIPTION (provided by applicant): Radikal Therapeutics (RTX) is developing a novel K+-ATP channel opener (R-801) for the prevention of radiocontrast media (CM) induced nephropathy (CIN), a devastating complication developing in gt 25% of diabetics withsignificant preexisting… more
Abstract:…E: Radiocontrast imaging is an invaluable and frequently used diagnostic modality for but its use is complicated by the subsequent development of kidney injury, often to the extent of requiring dialysis, particularly in populations at greatest risk, suh as the elderly, diabetic… more
Abstract:This application directly addresses Agriculturally-related Manufacturing Technology cross-cutting priority for USDA. The Nutrasorb technology enables manufacture of a new generation of science-based, efficacious, shelf-stable, and tasty anti-diabetic / anti-obesity functional… more
Abstract:DESCRIPTION (provided by applicant): Twenty-six million people in America have chronic kidney disease (CKD). Diabetes is by far the leading cause of CKD (diabetic nephropathy), accounting for 44% of new cases of dialysis (in 2005). Current treatments… more
Abstract:… the hSlo gene splice variant, called hMaxiK, which codes for the pore forming subunit of the large conductance potassium channel. Prior studies by ICI have shown that hMaxiK improves urogenital pathophysiology in rodent and nonhuman primate models of aging, diabetes and… more
Abstract:…n in less than 3 minutes. This sensitivity exceeds that of current tests and allows early detection of nerve damage. In Phase I we will build a new prototype Bumps device and show feasibility by measuring tactile thresholds of small cohorts of patients with diabetes (because of… more
Abstract:DESCRIPTION (provided by applicant): Genalyte will demonstrate the feasibility of our bio-sensing instrument platform for rapid sensitive high- throughput and low cost multiplexed panels to identify and monitor immune status for Type 1 Diabetes (T1D) auto-antibodies. The key to… more
Abstract:… and fluctuates in response to cellular stimuli. O-GlcNAc often competes with protein phosphorylation, and these two modifications have extensive crosstalk in the regulation of signaling, transcription, and the functions of oncogenes and tumor suppressors. Diabetes,… more
Abstract:DESCRIPTION (provided by applicant): Type 1 diabetes often leads to short-term and long-term complications which impair quality of life. Many research groups, including ours, are developing an artificial endocrine pancreas (AP), which combines continuous glucose sensing with… more
Abstract:… dermal elements including vasculature, skin appendages such as hair follicles, as well as epithelial and dermal differentiation. The ultimate product for development will be a gel for treating burns and other wounds such as decubitus ulcers, venous ulcers and diabetic… more
Abstract:… are hexavalent Cr (Cr+6, which is associated with industrial exposure and toxicity) and trivalent Cr (Cr+3, which is stable and a biologically active form). Cr+3 is an essential nutrient for humans and shortages may cause heart conditions and metabolic disruptions or diabetes;… more
Abstract:DESCRIPTION (provided by applicant): In this STTR project, we present EyeMark, a set of tools for automated computation of biomarkers for diabetic retinopathy using retinal image photographs. Specifically, we will develop tools for computation of… more
Abstract:DESCRIPTION (provided by applicant): Abstract In this small business innovations research (SBIR) project, we present aiArt: Advanced Image Analysis Tools for Diabetic Retinopathy Telemedicine applications. aiArt (pronounced eye-art), with its automated image… more
Abstract:… when radiation is combined with injury (RCI). Agents to mitigate effects of radiation and RCI must therefore be developed and stockpiledfor emergency use. We proposed that TP508 (rousalatide acetate), a novel peptide drug currently in clinical trials for healing diabetic… more
Abstract:… cellbiology. This is a rapidly expanding market that includes clinical uses (islet transplantation), active in vitro research on adult/fetal islets of several species, and pre-clinicl stem cell research with the potential to revolutionize the treatment of diabetes… more
Abstract:… are not met by current healthcare delivery models. As an emerging technology, telemedicine is an efficient, cost-effective way to deliver healthcare services to rural, health disparity communities. Hubble Telemedical currently provides remote management of diabetic … more
Abstract:… between the socket and skin. The volume changes may be due to inactivity, weight gain or loss, medications, vascular conditions, or other medical complications. Additionally, the residual limb may have reduced sensation due to neuropathy related to diabetes. This project… more
Abstract:…vided by applicant): The product that will result from the proposed SBIR program, a consortium collaboration between BioPancreate (a small business) and Cornell University, will be an orally-administered insulin-replacement therapy for bothtype-1 and type-2 diabetes mellitus,… more
Abstract:… of this proposal is to examine the efficacy of novel adeno-associated virus (AAV) variants expressing soluble FLT-1, a potent inhibitor of VEGF-mediated neovascularization and vascular permeability, to treat diabetic macular edema (DME). DME is an advanced form of diabetic… more
Abstract:…, with a potential $3 billion global market. The use of this sweetener will improve taste profiles and expand adoption of low-calorie beverages, confectionaries, baked goods, dairy products, and so on, thus benefitting public health by reducing incidence of diabetes and… more
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