Abstract:DESCRIPTION (provided by applicant): Extreme insulin resistance in patients with diabetes is defined as insulin dose requirement of greater than 200 units daily. Currently, U-500 regular insulin is frequently used to treat these patients, however, the slowabsorption and… more
Abstract:DESCRIPTION (provided by applicant): With 500,000 Americans in the final stage of chronic kidney disease (CKD) and another 40 million at risk for developing CKD due to obesity, diabetes and hypertension renal disease is a modem epidemic. Serum phosphorus (Pi) levels are thought… more
Abstract:DESCRIPTION (provided by applicant): Mesodissection Device Microscopic analysis of tissue mounted on glass slides is commonly used to study cancer, nonneoplastic entities such as heart disease and diabetes, and normal cell function. At a growing rate, researchers are utilizing… more
Abstract:DESCRIPTION (provided by applicant): The goal of this application is to develop a test kit to quickly and accurately diagnose type 1diabetes; differentiate it from type 2 diabetes and screen for pre-diabetes . Current screening methods… more
Abstract:…and translation of a medical technology to reduce health disparities within the priority area of chroni disease through the development and testing of an innovative web-based technology, Cookin' Up Health, for the self-management of diet related to hypertension and diabetes… more
Abstract:… engine and clinical trials directory and accompanying widget that can be embedded online by third parties. The purpose is to enable individuals to quickly identify geographically close trials, which they may be qualifiedfor. The current focus is on Type 2 diabetes (T2D) but… more
Abstract:DESCRIPTION (provided by applicant): Of the 24 million patients diagnosed with diabetes in the US, 6.5 million (27%) depend on a strict regime of insulin administration. Limited or unreliable patient reporting of critical diabetes care parameters (blood glucose measurements,… more
Abstract:DESCRIPTION (provided by applicant): Dramatic increases in the incidence of obesity, diabetes, and the metabolic syndrome are increasing the prevalence of chronic liver diseases. Liver fibrosis arising from an excessive deposition of type I collagen in theparenchyma, occurs in… more
Abstract:… function or mental retardation. Our proprietary thrombin-derived TP508 peptide mitigates effects of whole-body nuclear radiation in mice, protecting endothelium, delaying bacteremia, and restoring normal wound healing. TP508 has shown positive results in diabetic foot… more
Abstract:… be monitored and recommendations made from automated systems, caregivers or physicians directlyor through social networking solutions. 3) If successful, MobileMedMinder can be extended as a mobile platform for chronic disease management system, such as diabetes, depression,… more
Abstract:… important needs in the areas of membrane protein function and drug screening and characterization. The membrane protein arrays will be useful in thedevelopment of effective and safe therapeutic agents for the treatment of wide range diseases such as cancer, diabetes,… more
Abstract:… limited quantity nucleic acid samples. These advancements will enable various long desired and needed studies, open new research frontiers and provide a comprehensive understanding of the biological mechanisms underlying disease states, such as cancer, heart disease, diabetes,… more
Abstract:… systems by applying human-derived hemodynamic shear stress forces to primary human cells in co-culture. Our initial system replicates the human vascular system and enables the creation of disease conditions including vascular inflammation, early atherogenesis and diabetic… more
Abstract:… selective small molecule inhibitors of FABP4 and FABP5 for the treatment of metabolic diseases The Western diet and lifestyle has brought an epidemic of health problems collectively referredto as metabolic syndrome. Obesity plays a central role, contributing to type 2 diabetes… more
Abstract:… by applicant): People with intellectual disabilities (ID) have rates of obesity greater than the general population. They often have poor energy dense diets and tend to be inactive. This group also experiences a high prevalence of health related problems: cancer, diabetes,… more
Abstract:… to an aqueous-reconstituted glucagon. Meeting thesebenchmarks will justify advancing the product into an NDA-enabling bioequivalency study. PUBLIC HEALTH RELEVANCE: The current standard of care for hypoglycemic emergencies?the Glucagon Emergency Kit requires a … more
Abstract:… the healthier kids' selections are purchased. As a result, children will be selecting menu items that are lower in calories, fat, saturated fat and sodium, leading to reduced risks of such nutrition-related conditions as obesity, heart disease, cancer, and diabetes… more
Abstract:… will harness the popularity and ubiquity of mobile microgames on hand-held devices for educating children on self-management of chronic health conditions. Millions of children suffer from chronic conditions which require regular management, including asthma, diabetes,… more
Abstract:…, multiple layers of sunglasses, put on/taken off rapidly. (2) Very slow-switching (2 - 5 minutes) photochromic lenses which need UV light for activation. Light-adapting remedies for persons with ARMD wouldalso assist persons with other, age-related diseases, e.g. diabetic … more
Abstract:DESCRIPTION (provided by applicant): We seek to develop an ultra-fast, zinc-free insulin analog formulation for the treatment of diabetes mellitus. An ultra-fast pharmacokinetic-dynamic (PK/PD) profile promises to enable superior performance of pump therapy (continuous… more
Abstract:… affect 3.5% of the U.S. population and will afflict 15% of the population over their lifetime. Despite the development of many new therapies, they are all limited by serious side effects, including extrapyramidal effects (uncontrolled movements), obesity and diabetes. These… more
Abstract:DESCRIPTION (provided by applicant): Significance: Almost 30% of U.S. adults have pre-diabetes. Without weight loss and changes in physical activity and diet, more than 50% of them will eventually develop type 2 diabetes (T2DM), with its increased risk ofcardiovascular disease… more
Abstract:DESCRIPTION (provided by applicant): Foot ulcers are a prevalent complication in the diabetic population, and despite that, the exact causation of plantar ulcers is still unknown. Research suggests that vertical pressure and horizontal shear play an integral role, but the… more
Abstract:DESCRIPTION (provided by applicant): There is a worldwide consensus that islet transplantation may be considered a viable option for the treatment of insulin-dependent diabetes mellitus, and clinical trials are underway at many centers around the world. Asthis approach for… more
Abstract:… that will apply to native islets as well as islets differentiated from mesenchymal stem cells and other stem cell sources. The human health consequence of this research will be to improve the isolation, handling and transfusionof human islets used for treating … more
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