Abstract:This Phase II SBIR involves the testing of a minimally invasive glucose sensor in vivo. Diabetes is an increasingly common lifelong disease and is associated with many complications. It is responsible for an estimated 10-15 percent of all health care expenditures. Effective… more
Abstract:DESCRIPTION (Unedited Applicant's Abstract):When people with diabetes reach
end-stage renal disease they must undergo either dialysis or transplantation.
About 200,000 Americans need artificial kidney machines to stay alive. These
machines rely on sterile… more
Abstract:…,3-dipropyl-xanthine (CPX). Aims 3 and
4 of this proposal are designed to prove that A2B adenosine receptor blockade
improves insulin sensitivity in rat models of insulin resistance. There is a
great need for improved therapies to treat type II diabetes… more
Abstract:… phenomenon in which slight amounts of noise imparted to a system actually increase its sensitivity to weak stimuli. SR has been shown to produce a demonstrable effect in human sensory cells. In both healthy young and clinical subjects - elderly, diabetics, and… more
Abstract:… (SR), a counterintuitive phenomenon in which slight amounts of environmental noise actually increase the discernability of signals or stimuli, produces a demonstrable effect in human sensory cells. In both healthy young and clinical subjects- elderly, diabetics, and stroke… more
Abstract:… phenomenon in which slight amounts of noise imparted to a system actually increase its sensitivity to weak stimuli. SR has been shown to produce a demonstrable effect in human sensory cells. In both healthy young and clinical subjects-elderly, diabetics, and… more
Abstract:… adipose tissues and has an
international reputation in this field. There is an unmet medial need for new
technologies to create implant adipose tissues. Lipodystrophy patients lose
subcutaneous fat, leading to life threatening diabetes. Creating… more
Abstract:DESCRIPTION: Phenotyping involves quantifying the vast array of molecular
components that make up complex organisms. This proposal concerns nanobarcodes,
a potentially revolutionary new technology platform for phenotyping.
Nanobarcodes are free-standing,… more
Abstract:… applications of this project are expected to be immediate and significant. The final refinement in BioHybrid Technologies' microreactor technology is likely to lead to substantial improvements in treatment for a large number of human diseases including diabetes,… more
Abstract:… the mechanical factors leading to pressure ulcers from the operating room environment. Over 40 million surgical procedures are performed annually in the US, of which a significant percentage involves a surgical population at risk of developing pressure ulcers (diabetic,… more
Abstract:Diabetes mellitus is the sixth leading cause of death by disease in the United States, afflicting approximately 16 million people. Currently, there is no cure. The disease is treated by regular, life-long injections of insulin at a large cost to patients, both economically and… more
Abstract:DESCRIPTION (provided by applicant): The goal of this project is to demonstrate
the feasibility of using a novel technology as a dual purpose wound dressing
and drug delivery vehicle for the treatment of wounds associated with early
stage diabetic foot… more
Abstract:… model with spontaneous autoimmune
disease. In Phase 1 we will establish a foundation colony of LEW.1WR1 rats and
begin genetic crosses to introgress traits from BBDR/Wor and LEW.1WR strains.
This should increase the incidence of spontaneous diabetes and may… more
Abstract:Diabetic retinopathy, the leading cause of blindness among working-age
Americans, is characterized by increased retinal microvascular permeability
which results in the formation of lipid exudates, macular edema and blindness.
Abstract:… high costs result from access barriers (physical, convenience,
or genographic), information failure, poor coordination of care, maldistribution of provider
resources, and uneven quality. In addition to high-risk newborns, we believe that patients
with cancer, diabetes,… more
Abstract:Diabetic foot complications result in over 67,000 lower extremity
amputations annually and cause more hospitalizations than any other
single complication of diabetes. Foot wounds precede 84% of these
amputations and usually occur when patients with diabetes have
Abstract:…. Gram-negative pathogens pose a serious health threat as they can be the
causative agents of life-threatening conditions such as septicemia (Escherichia
coli), meningitis (Haemophilus influenzae) or pyrogenic infections in burn
patients and diabetics… more
Abstract:The NIH sponsored Diabetes Control and Complications Trial clearly demonstrates that near normalization of blood glucose dramatically slows the onset of the devastating complications of diabetes. However the continuous long-term tracking of glucose needed to achieve this tight… more
Abstract:DESCRIPTION (Adapted from the Investigator's Abstract): Gastrointestinal (GI)
ulceration and hemorrhage is a major health problem in our country representing
billions of dollars in health care costs and lost revenues from work place.
Despite sophisticated therapeutic agents, the… more
Abstract:…ts and a central control station in addition to the voice communications expected with typical intercoms. Several examples utilizing this digital information are discussed in the proposal. We will specifically study one application associated with tracking the status of diabetic… more
Abstract:DESCRIPTION (Scanned from the Applicant's Abstract): Obesity is a major risk
factor for diabetes mellitus (type 2; NIDDM). Fat cells secrete both diabetes
promoting molecules (fatty acids; TNF-alpha) and at least one molecule that may
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