Abstract:…ability. We propose to combine the best elements from both systems into the BioPrism. The BioPrism will use nanoscale optical devices (photonics) developed in the Erickson Lab at Cornell University and currently being commercialized by Optofluidics. Using a microfluidic flow… more
Abstract:DESCRIPTION (provided by applicant): Invasive aspergillosis (IA), caused by the fungus Aspergillus fumigatus, is associated with mortality rates of 40- 50%. In response to the lack of effective treatments, the Infectious Diseases Society of America highlighted A. fumigatus as one of only six… more
Abstract:… imaging modalities spanning a range of spatial scales and frequencies. This powerful and versatile correlative microscopy specimen holder platform will enable environmental LM and EM, allow accurate temperature regulation (from below 0 C to 100 C), and empower microfluidic… more
Abstract:… biomarkers. A decentralized approach to PET probe development is required to give scientists the freedom to determine what probes they want to use to best solve the problems of their interest. This goal can be achieved by building a benchtop, PC-controlled, microfluidic… more
Abstract:… species, therefore has the potential to be widely applicable for general use as a Molecular Interaction Photometer (MIP). BSI is a prime candidate to become an MIP because it has a simple and inexpensive optical train comprised of a He-Ne laser, a microfluidic… more
Abstract:… monitoring technologies for chlorinated organic compounds are still lacking both in terms of selectivity and sensitivity. In collaboration with Texas Tech University, HJ Science & amp; Technology, Inc. proposes to demonstrate the feasibility of an integrated microfluidic… more
Abstract:… sensors. Specifically, it is designed to perform rapid detections of multiple toxins with sensitivity and specificity that are only currently achievable with laboratory based instruments. We will transfer enzyme linked immunosorbent assay (ELISA) to our microfluidic format… more
Abstract:… of HPPOC chips and successfully demonstrating the required maximum pressures and flow rates. In addition, we have also established a novel HPPOC actuated VOC platform. In Phase II, we will construct, test, and deliver a high performance and low power consumption … more
Abstract:…, and simultaneous identification and characterization of universal classes of ions, molecules, and biomolecules for NASA in-situ planetary compositional analysis, and planetary and small body surface chemistry studies. The technology combines programmable microfluidic… more
Abstract:… Institute (JBEI) propose to develop an automated, software-controlled, programmable, low-cost, and compact platform capable of running rapid and complex bioengineering processes and optimization of new biomanufacturing systems. Our approach combines the microfluidic… more
Abstract:… shellfish industry and the aquaculture industry in general. In addition to brevetoxins, the same technology has clear potential to be subsequently developed to permit the diagnostics of toxins produced by a wide range of other pathogens. In particular, the same microfluidic… more
Abstract:This Small Business Innovation Research Phase I project proposes to develop a state-of-the-art microfluidic technology for pathogen and toxin diagnostics in drinking water. The innovation stems from our ability to transfer enzyme linked immunosorbent assay (ELISA) to an… more
Abstract:… biotechnology applications. However, gene identification currently requires both large sequencing efforts and massive screens of recombinant bacterial cells using slow and labor-intensive plate based assays. This platform technology uses an innovative microfluidic… more
Abstract:… biology research and the development of personalized medicine applications. This project will enhance the scientific and technological understanding of fundamental electroporation mechanisms and single cell analysis techniques by combining nanofabrication, microfluidics,… more
Abstract:… of cells required thereby increasing throughput per batch of differentiated hepatocytes, and it also decreases costs through reduced usage ofexpensive reagents. To address this issue, Euveda Biosciences has developed a novel cell-based assay platform based on microfluidic… more
Abstract:… have been limited to the research setting as previous tools have lacked the throughput to examine the heterogeneity of complex clinical samples effectively. The proposed work builds upon the deformability cytometry platform, which employs inertial microfluidic principles… more
Abstract:… 003, Newomics Inc. proposes to develop high-throughput Omics-based assays to evaluate the effects of chemical toxicants on proliferation and differentiation of human MSC. The core technology platform will be based on Newomics' breakthrough silicon-microfluidic-chip,… more
Abstract:…project proposes to demonstrate and develop a prototype of a minimally-invasive drug delivery technology to address the need for a more practical and effective transtympanic drug delivery system. The technology combines a proprietary trocar catheter with a MEMS-based … more
Abstract:This Small Business Technology Transfer (STTR) Phase I project proposes to develop a simulation and design software for droplet-based microfluidic devices. Designing microfluidic platforms for biological and biochemistry applications is a laborious process… more
Abstract:… at home. To address this important unmet need, we propose a unique and innovative device for patient-administered neutrophil testing at home. Our neutrophil counting device takes advantage of cellular properties manifested specifically when flowing through microfluidic… more
Abstract:… hardware profile of the traditional ultrasound systems, to result in a safe, portable, low cost medical imaging device for screening and early detection of breast and other cancers. While optical microscopy continues to evolve through integration of optics with microfluidics… more
Abstract:…, and physically connecting the affinity binder genotype and phenotype. These requirements can limit the effectiveness of the screen. In contrast, this project will develop a novel proprietary technology that screens for affinity binders in solution using microfluidic in vitro… more
Abstract:This SBIR Phase I project will develop a microfluidic in-situ TEM specimen holder with accurate environmental parameter monitoring capabilities; The inability to dynamically image materials at atomic resolutions in changing liquid environments is a significant impediment to the… more
Abstract:Espira has developed a Biohazard Water Analyzer (BWA) for field-based rapid pathogen detection. BWA employs advanced technologies including microfluidic sample preparation for nucleotide analysis and highly sensitive carbon nanotube-based electrochemical sensing for rapid… more
Abstract:…r is embedded within theapertures of an array of hollow microneedles, the on-body biosensor is able to perform various bioanalytical functions directly at the microneedle-transdermal fluid interface and does not require sophisticated microelectromechanical or microfluidic… more
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