Abstract:…, and physically connecting the affinity binder genotype and phenotype. These requirements can limit the effectiveness of the screen. In contrast, this project will develop a novel proprietary technology that screens for affinity binders in solution using microfluidic in vitro… more
Abstract:This SBIR Phase I project will develop a microfluidic in-situ TEM specimen holder with accurate environmental parameter monitoring capabilities; The inability to dynamically image materials at atomic resolutions in changing liquid environments is a significant impediment to the… more
Abstract:Espira has developed a Biohazard Water Analyzer (BWA) for field-based rapid pathogen detection. BWA employs advanced technologies including microfluidic sample preparation for nucleotide analysis and highly sensitive carbon nanotube-based electrochemical sensing for rapid… more
Abstract:…r is embedded within theapertures of an array of hollow microneedles, the on-body biosensor is able to perform various bioanalytical functions directly at the microneedle-transdermal fluid interface and does not require sophisticated microelectromechanical or microfluidic… more
Abstract:… PUBLIC HEALTH RELEVANCE PUBLIC HEALTH RELEVANCE: A next generation label-free drug discovery platform tailored for applications from early stage to later stage drug discovery will be developed. The proposed platform combines multiple enhancements in optics, … more
Abstract:…ionic nanopore current measurements. The long-term objective is to couple the control method with a single-nucleotide sensor for a reusable and chemistry-free platform for sequencing long single-stranded DNA. There are three aims: Aim 1.Develop a dual-pore microfluidic chip and… more
Abstract:… and transported from any number of low-resource settings, expanding the reach of blood diagnostic methods. To achieve this project, Tasso is uniquely positioned through three key collaborations: 1) Professor David Beebe as an expert consultant for simple microfluidic… more
Abstract:… and is typically orders of magnitude worse than the transducercapabilities. This bottleneck will always exist in architectures where the volume concentration of a target molecule or cell is detected along a wall of a fluid-filled compartment - as is customary with … more
Abstract:… CTCs for molecular and functional analysis of cancer patient blood. This proposal is led by Dr. Garcia (PI), who has extensiveexperience in early-stage development of the TR-NanoVelcro CTC Assay and has a background in nanomaterials, surface chemistry, microfluidics, and in… more
Abstract:…pe as a 'pre-defined CDR' (PDC) library. This novel library system will have properties that will also enable it to greatly facilitate both the downstream affinity-reagent selection and the maturation processes. Methods for testing this library using microfluidics and… more
Abstract:… rate. Innovation: Our patent-pending SpinDxTM system uniquely addresses this need by achieving rapid (~15 minute), multiplexed quantitation of protein and cellular biomarkersfrom small volume (~30 L) whole blood samples. All assays are packaged on one disposable microfluidic… more
Abstract:DESCRIPTION (provided by applicant): Cardiac arrhythmias affect more than 5 million people nationwide, resulting in more than 1.2 million hospitalizations and 400,000 deaths yearly. The development of cardiac ablation has significantly improved treatment outcomes. Ablation traditionally has relied… more
Abstract:DESCRIPTION (provided by applicant): Neuron-cell culture is widely used for studies in basic research, drug discovery, and toxicity testing. Traditional random cultures allow limited access to subcellular compartments (axons, dendrites, synapses) due to extensive and haphazard growth of neurons. Our… more
Abstract:… to current techniques. The project will develop this sensor by exploiting the connection between the MP magnetic orientation, fluid behavior and volume characteristics. Functionally coated MPs will be combined with a salmonella aptamer biomarker in a microfluidic channel. A… more
Abstract:… This is a Phase II SBIR proposal to increase the throughput of our DNA sequencing instrument to enable whole genome sequencing with high efficiency and accuracy for a cost of under 1000 per genome. In Phase I, we developed a working sequencing assay, a microfluidic… more
Abstract:… (~ 500,000) machines that require dedicated space and staff for their operation. We have invented and patented three techniques that enable the development of a sorting flow cytometer at a fraction of the cost and size of conventional instruments, using microfluidics to… more
Abstract:Cancer is a complex and diverse disease whose treatment can be improved by more sophisticated early detection and monitoring. NanoSort, Inc. proposes to build a lab-on-a-chip microfluidic device platform that can detect and quantify up to 32 multiplexed analytes for the… more
Abstract:… system optimization. Phase 2 (The System): Further development of electronic hardware to fabricate a 80 sensor multiplexed disposable array, automated delivery and clearance of fluid samples to the test sensor using a proprietary design for an electronic microfluidic pump… more
Abstract:… at the patient's side for point-of-emergency clinical decision making. This is in contrast to today's measurement technologies, which require abenchtop instrument and a trained technician. The central hypothesis for this Phase II SBIR effort is this: microfluidic… more
Abstract:… technology widely utilized in newborn screening, but when applied to enzyme assays it is expensive, time consuming, and labor intensive. There is a need for an inexpensive, rapid, and automated technology for performing newborn screening assays. A digital microfluidic… more
Abstract:… suitable for universal bilirubin screening. Therefore, there is an immediate need to develop novel point of care technologies that will meet the AmericanAcademy of Pediatrics recommendation for bilirubin screening. Advanced Liquid Logic's digital microfluidic platform… more
Abstract:DESCRIPTION (provided by applicant): We propose to develop and demonstrate a novel microfluidic device and assay for selection and optimization of delivery vehicles, specifically non-viral vectors for drug delivery to tumors. Tumor drug delivery is a complex phenomenon affected… more
Abstract:DESCRIPTION (provided by applicant): The overall objective of this study is to develop a novel in vitro microfluidic platform to test a drug or delivery vehicle's ability to permeate the Blood-Brain Barrier (BBB). In contrast to current in-vitro models, our proposed… more
Abstract:…. Current methods and devices are time-consuming, labor-intensive, costly, invasive, and consequently, ill-suited for deployment in military and other limited resource settings. To overcome these limitations, we propose to develop and demonstrate a microfluidic impedance… more
Abstract:… in electrochemical power sources, biomicrosystems, bioelectrochemistry, and system design has been assembled to accomplish these goals. BENEFIT: The major outcome of this project will be a completely enzymatic fuel cell coupled with a paper-based microfluidic… more
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