Abstract:… and is typically orders of magnitude worse than the transducercapabilities. This bottleneck will always exist in architectures where the volume concentration of a target molecule or cell is detected along a wall of a fluid-filled compartment - as is customary with … more
Abstract:… CTCs for molecular and functional analysis of cancer patient blood. This proposal is led by Dr. Garcia (PI), who has extensiveexperience in early-stage development of the TR-NanoVelcro CTC Assay and has a background in nanomaterials, surface chemistry, microfluidics, and in… more
Abstract:…pe as a 'pre-defined CDR' (PDC) library. This novel library system will have properties that will also enable it to greatly facilitate both the downstream affinity-reagent selection and the maturation processes. Methods for testing this library using microfluidics and… more
Abstract:… rate. Innovation: Our patent-pending SpinDxTM system uniquely addresses this need by achieving rapid (~15 minute), multiplexed quantitation of protein and cellular biomarkersfrom small volume (~30 L) whole blood samples. All assays are packaged on one disposable microfluidic… more
Abstract:DESCRIPTION (provided by applicant): Cardiac arrhythmias affect more than 5 million people nationwide, resulting in more than 1.2 million hospitalizations and 400,000 deaths yearly. The development of cardiac ablation has significantly improved treatment outcomes. Ablation traditionally has relied… more
Abstract:DESCRIPTION (provided by applicant): Neuron-cell culture is widely used for studies in basic research, drug discovery, and toxicity testing. Traditional random cultures allow limited access to subcellular compartments (axons, dendrites, synapses) due to extensive and haphazard growth of neurons. Our… more
Abstract:… to current techniques. The project will develop this sensor by exploiting the connection between the MP magnetic orientation, fluid behavior and volume characteristics. Functionally coated MPs will be combined with a salmonella aptamer biomarker in a microfluidic channel. A… more
Abstract:… This is a Phase II SBIR proposal to increase the throughput of our DNA sequencing instrument to enable whole genome sequencing with high efficiency and accuracy for a cost of under 1000 per genome. In Phase I, we developed a working sequencing assay, a microfluidic… more
Abstract:… (~ 500,000) machines that require dedicated space and staff for their operation. We have invented and patented three techniques that enable the development of a sorting flow cytometer at a fraction of the cost and size of conventional instruments, using microfluidics to… more
Abstract:Cancer is a complex and diverse disease whose treatment can be improved by more sophisticated early detection and monitoring. NanoSort, Inc. proposes to build a lab-on-a-chip microfluidic device platform that can detect and quantify up to 32 multiplexed analytes for the… more
Abstract:… system optimization. Phase 2 (The System): Further development of electronic hardware to fabricate a 80 sensor multiplexed disposable array, automated delivery and clearance of fluid samples to the test sensor using a proprietary design for an electronic microfluidic pump… more
Abstract:… at the patient's side for point-of-emergency clinical decision making. This is in contrast to today's measurement technologies, which require abenchtop instrument and a trained technician. The central hypothesis for this Phase II SBIR effort is this: microfluidic… more
Abstract:… technology widely utilized in newborn screening, but when applied to enzyme assays it is expensive, time consuming, and labor intensive. There is a need for an inexpensive, rapid, and automated technology for performing newborn screening assays. A digital microfluidic… more
Abstract:… suitable for universal bilirubin screening. Therefore, there is an immediate need to develop novel point of care technologies that will meet the AmericanAcademy of Pediatrics recommendation for bilirubin screening. Advanced Liquid Logic's digital microfluidic platform… more
Abstract:DESCRIPTION (provided by applicant): We propose to develop and demonstrate a novel microfluidic device and assay for selection and optimization of delivery vehicles, specifically non-viral vectors for drug delivery to tumors. Tumor drug delivery is a complex phenomenon affected… more
Abstract:DESCRIPTION (provided by applicant): The overall objective of this study is to develop a novel in vitro microfluidic platform to test a drug or delivery vehicle's ability to permeate the Blood-Brain Barrier (BBB). In contrast to current in-vitro models, our proposed… more
Abstract:…. Current methods and devices are time-consuming, labor-intensive, costly, invasive, and consequently, ill-suited for deployment in military and other limited resource settings. To overcome these limitations, we propose to develop and demonstrate a microfluidic impedance… more
Abstract:… in electrochemical power sources, biomicrosystems, bioelectrochemistry, and system design has been assembled to accomplish these goals. BENEFIT: The major outcome of this project will be a completely enzymatic fuel cell coupled with a paper-based microfluidic… more
Abstract:…rated with automation technology developed by the Pacific Northwest National Laboratory (PNNL) to produce a self-contained portable personal exposure sampling unit and a bench-top assay unit. Enertechnix will be responsible for the aerosol sampling and microfluidic components… more
Abstract:Luna Innovations is developing the field-deployable Portable Analysis of Toxic H2O Samples (PATHOS) that utilizes whole cells as extremely sensitive biological detectors of water toxicants via two different metrics (colorimetric and impedance), resulting in increased reliability and sensitivity to a… more
Abstract:… oxidize a mixture of fuels. The cathode complexes facilitate direct electron transfer for oxygen reduction reaction. The configured system does not require exogenous power for fuel delivery, and demonstrates a simple structure and easy operation. This microfluidic… more
Abstract:DESCRIPTION (provided by applicant): We aim to develop a fully integrated microfluidic immunodiagnostic platform utilizing a novel air-liquid cavity acoustic transducer (ALCAT) technology pioneered in the lab of Dr Abe Lee. The diagnosis platform is basedon the well-established… more
Abstract:… year, while adding minimal cost to building infrastructure. The commercialization path for this technology is through the Advanced Flat Glass segment of the Flat Glass market. In addition, this program will enhance scientific innovation at the Ohio Center for Microfluidic… more
Abstract:… disposable reagent cartridge. A key factor enabling this game changing technology is the development of a novel enzyme that converts RNA to DNA and isothermally amplifies it in minutes. These attributes have allowed the design of a device that does not use any microfluidics,… more
Abstract:… able to analyze a variety of both organic and metallic contaminants in environmental samples. A multiplicity of innovative components and designs for sample pre-concentration, separation, fluid transfer and detection were introduced, with emphasis on microfluidic… more
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