Abstract:… year, while adding minimal cost to building infrastructure. The commercialization path for this technology is through the Advanced Flat Glass segment of the Flat Glass market. In addition, this program will enhance scientific innovation at the Ohio Center for Microfluidic… more
Abstract:… disposable reagent cartridge. A key factor enabling this game changing technology is the development of a novel enzyme that converts RNA to DNA and isothermally amplifies it in minutes. These attributes have allowed the design of a device that does not use any microfluidics,… more
Abstract:… able to analyze a variety of both organic and metallic contaminants in environmental samples. A multiplicity of innovative components and designs for sample pre-concentration, separation, fluid transfer and detection were introduced, with emphasis on microfluidic… more
Abstract:…. NTI recently achieved expansion from 2-color (2c) to 4-color (4c) ALEX, substantially expanding its multiplexing power. Furthermore, recent work by our consultants Profs. Stephen Quake and Shimon Weiss demonstrates successful merging of microfluidics-based sample… more
Abstract:… power, and demonstrated diagnosticutility for ultrasensitive miRNA quantification at clinically relevant concentrations without amplification. Furthermore, recent work by our consultants Steve Quake and Shimon Weiss shows i) combination of microfluidics-based sample… more
Abstract:… SBIR goal is to develop a rapid, cost-effective, sensitive and specific Ct POC diagnostic system to increase early detection, inform appropriate treatment, reduce the rateof infections, and thereby reduce sequelae. In SBIR Phase I, we developed an initial microfluidic NAAT… more
Abstract:…e in treating sTBI-associated HICP onset. Our proposed SBIR research and commercialization program is to develop a blood and CSF POC neuromonitoring device to predict and identify sTBI patients who will experience delayed HICP onset later. The POC device is based on microfluidic… more
Abstract:…, can work with low sample volumes are typically expensive and have limited sensitivity. Ultra-high sensitivity platforms are also expensive and typically require complex sample prep steps and large sample volumes. Siloam has developed a novel Optimiser microfluidic assay… more
Abstract:DOEs efforts to monitor legacy sites for groundwater contamination would benefit from turn-key systems that can measure metal contaminant concentrations in situ. Southwest Sciences proposes to develop a micro-fluidic sensor for measuring heavy metals in groundwater by measuring… more
Abstract:… flight qualified processing payloads to extract experiment samples via a needle-less septum and then allows transfer of those samples into a number of different on-orbit analytical devices, including such instrumentation as the Light Microscopy Module, the Microfluidic Flow… more
Abstract:… in the LMM, which could lead to new advanced materials with exciting commercial potential. Capitalizing on Techshot's rapid progress with the LMM-DS, as well as the company's vast array of separations technologies and extensive experience with microfluidic systems… more
Abstract:… design that can reliably measure both quantities with the required accuracy and precision.
We will investigate two innovations that will significantly simplify and reduce the cost of our current sensors. First, we will combine the optics and flow cell using microfluidics… more
Abstract:Translume, in collaboration with Dr. Joseph Needoba, Oregon Health and Science University, proposes to develop a microfluidic colorimetric sensor for the quantitative measurement of important inorganic nutrients in estuaries, coastal waters, and oceans. The technology will… more
Abstract:…vided by applicant): The goal of this Phase I SBIR project is to develop a device for automated array printing of lipids and membrane proteins onto submerged microtiter plate surfaces in a way that maintains their activity and function. Ourproprietary 3D microfluidic printing… more
Abstract:…evelopment in September 2009 by NIAIDfor use in differentiating between true infection and vaccine-induced seropositivity in future HIV vaccine trials and is now entering the verification and validation stage of development. The EOSCAPE-T1D will combine proprietary micro-fluidic… more
Abstract:… puts the USA at a disadvantage in developing exportable products. The proposed DOE project aims to take advantage of recent technological advances developed for lab-on-a-chip (LOC) applications. Based on our experiences constructing such devices, the proposed … more
Abstract:… concern due to their known toxic and carcinogenic effects. To address the Army"s need for a field-portable test to detect and quantify chlorinated organic compounds in water samples, Physical Optics Corporation (POC) proposes to develop a novel Microfluidics-Based… more
Abstract:ABSTRACT: In response to the Air Force need for a nutplate installation process that requires no preparation of the nutplate before installation, Physical Optics Corporation (POC) has developed a new Pull and Stick Nutplate Process (PASN) based on an innovative micro-fluid… more
Abstract:…ise in lateral flow test strip (LFTS) assays by integrating an LFTS with a cell phone for the quantitative measurement of blood-based biomarkers. Our innovative and extremely cost-effective multi-analyte LFTS approach is imminently suited for space travel. All "… more
Abstract:…, similar to the transition from electron tubes to integrated circuits in electronics. The spectrometer is an optical chip just a few millimeters in size; it can be implemented to detect any desired substance. The spectrometer can potentially be integrated with microfluidic… more
Abstract:… has the potential to unlock the complexity inherent to cell populations. However, conventional techniques for cell isolation are very low-throughput. The goal of this DOE-SBIR grant proposal is to develop GigaGens patent-pending GigaLink microfluidic … more
Abstract:… cells. In Phase I, our objective is to build a proof-of-concept method for single sperm capture and intermolecular linkage between two nucleic acid targets. We propose to conduct a thorough optimization of overlap extension primersand then build a custom microfluidics… more
Abstract:… high throughput and scalable. Unlike standard photolithography, this technique is capable of manufacturing parts with 3D resolved feature. Among the many diverse applications of this 3D microfabrication process, FemtoFab Inc. has identified the manufacturing of microfluidic… more
Abstract:… determination of at least two chiral molecules in both polar and nonpolar solvents; and 3) Investigate design parameter tradeoffs including voltage and frequency dependence and throughput up to gram per day scale. We will use rotating electric fields, microfluidics and chiral… more
Abstract:…rch are: (1) to develop SELP liquid embolic injection solution formulations; (2) to determine the gelation rate and gel strength of SELP fluidsat their maximum injectable viscosity; (3) to assess their occlusion of simulated arterial channels in-vitro using a microfluidic… more
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