Abstract:… This is a Phase II SBIR proposal to increase the throughput of our DNA sequencing instrument to enable whole genome sequencing with high efficiency and accuracy for a cost of under 1000 per genome. In Phase I, we developed a working sequencing assay, a microfluidic… more
Abstract:… (~ 500,000) machines that require dedicated space and staff for their operation. We have invented and patented three techniques that enable the development of a sorting flow cytometer at a fraction of the cost and size of conventional instruments, using microfluidics to… more
Abstract:Cancer is a complex and diverse disease whose treatment can be improved by more sophisticated early detection and monitoring. NanoSort, Inc. proposes to build a lab-on-a-chip microfluidic device platform that can detect and quantify up to 32 multiplexed analytes for the… more
Abstract:… system optimization. Phase 2 (The System): Further development of electronic hardware to fabricate a 80 sensor multiplexed disposable array, automated delivery and clearance of fluid samples to the test sensor using a proprietary design for an electronic microfluidic pump… more
Abstract:… at the patient's side for point-of-emergency clinical decision making. This is in contrast to today's measurement technologies, which require abenchtop instrument and a trained technician. The central hypothesis for this Phase II SBIR effort is this: microfluidic… more
Abstract:… technology widely utilized in newborn screening, but when applied to enzyme assays it is expensive, time consuming, and labor intensive. There is a need for an inexpensive, rapid, and automated technology for performing newborn screening assays. A digital microfluidic… more
Abstract:… suitable for universal bilirubin screening. Therefore, there is an immediate need to develop novel point of care technologies that will meet the AmericanAcademy of Pediatrics recommendation for bilirubin screening. Advanced Liquid Logic's digital microfluidic platform… more
Abstract:DESCRIPTION (provided by applicant): We propose to develop and demonstrate a novel microfluidic device and assay for selection and optimization of delivery vehicles, specifically non-viral vectors for drug delivery to tumors. Tumor drug delivery is a complex phenomenon affected… more
Abstract:DESCRIPTION (provided by applicant): The overall objective of this study is to develop a novel in vitro microfluidic platform to test a drug or delivery vehicle's ability to permeate the Blood-Brain Barrier (BBB). In contrast to current in-vitro models, our proposed… more
Abstract:…. Current methods and devices are time-consuming, labor-intensive, costly, invasive, and consequently, ill-suited for deployment in military and other limited resource settings. To overcome these limitations, we propose to develop and demonstrate a microfluidic impedance… more
Abstract:… in electrochemical power sources, biomicrosystems, bioelectrochemistry, and system design has been assembled to accomplish these goals. BENEFIT: The major outcome of this project will be a completely enzymatic fuel cell coupled with a paper-based microfluidic… more
Abstract:…rated with automation technology developed by the Pacific Northwest National Laboratory (PNNL) to produce a self-contained portable personal exposure sampling unit and a bench-top assay unit. Enertechnix will be responsible for the aerosol sampling and microfluidic components… more
Abstract:Luna Innovations is developing the field-deployable Portable Analysis of Toxic H2O Samples (PATHOS) that utilizes whole cells as extremely sensitive biological detectors of water toxicants via two different metrics (colorimetric and impedance), resulting in increased reliability and sensitivity to a… more
Abstract:… complements our ongoing NIAID Cooperative Agreement, An Integrated Diagnostic Biochip for Point of Care Pathogen Identification (U01 AI082457), for rapid molecular diagnosis urinary tract infections (UTI) using electrochemical biosensors integrated with microfluidics. Since… more
Abstract:… oxidize a mixture of fuels. The cathode complexes facilitate direct electron transfer for oxygen reduction reaction. The configured system does not require exogenous power for fuel delivery, and demonstrates a simple structure and easy operation. This microfluidic… more
Abstract:DESCRIPTION (provided by applicant): We aim to develop a fully integrated microfluidic immunodiagnostic platform utilizing a novel air-liquid cavity acoustic transducer (ALCAT) technology pioneered in the lab of Dr Abe Lee. The diagnosis platform is basedon the well-established… more
Abstract:… year, while adding minimal cost to building infrastructure. The commercialization path for this technology is through the Advanced Flat Glass segment of the Flat Glass market. In addition, this program will enhance scientific innovation at the Ohio Center for Microfluidic… more
Abstract:…ise in lateral flow test strip (LFTS) assays by integrating an LFTS with a cell phone for the quantitative measurement of blood-based biomarkers. Our innovative and extremely cost-effective multi-analyte LFTS approach is imminently suited for space travel. All "… more
Abstract:… disposable reagent cartridge. A key factor enabling this game changing technology is the development of a novel enzyme that converts RNA to DNA and isothermally amplifies it in minutes. These attributes have allowed the design of a device that does not use any microfluidics,… more
Abstract:…. NTI recently achieved expansion from 2-color (2c) to 4-color (4c) ALEX, substantially expanding its multiplexing power. Furthermore, recent work by our consultants Profs. Stephen Quake and Shimon Weiss demonstrates successful merging of microfluidics-based sample… more
Abstract:… power, and demonstrated diagnosticutility for ultrasensitive miRNA quantification at clinically relevant concentrations without amplification. Furthermore, recent work by our consultants Steve Quake and Shimon Weiss shows i) combination of microfluidics-based sample… more
Abstract:… SBIR goal is to develop a rapid, cost-effective, sensitive and specific Ct POC diagnostic system to increase early detection, inform appropriate treatment, reduce the rateof infections, and thereby reduce sequelae. In SBIR Phase I, we developed an initial microfluidic NAAT… more
Abstract:…e in treating sTBI-associated HICP onset. Our proposed SBIR research and commercialization program is to develop a blood and CSF POC neuromonitoring device to predict and identify sTBI patients who will experience delayed HICP onset later. The POC device is based on microfluidic… more
Abstract:…, can work with low sample volumes are typically expensive and have limited sensitivity. Ultra-high sensitivity platforms are also expensive and typically require complex sample prep steps and large sample volumes. Siloam has developed a novel Optimiser microfluidic assay… more
Abstract:DOEs efforts to monitor legacy sites for groundwater contamination would benefit from turn-key systems that can measure metal contaminant concentrations in situ. Southwest Sciences proposes to develop a micro-fluidic sensor for measuring heavy metals in groundwater by measuring… more
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