Abstract:… cells. In Phase I, our objective is to build a proof-of-concept method for single sperm capture and intermolecular linkage between two nucleic acid targets. We propose to conduct a thorough optimization of overlap extension primersand then build a custom microfluidics… more
Abstract:… high throughput and scalable. Unlike standard photolithography, this technique is capable of manufacturing parts with 3D resolved feature. Among the many diverse applications of this 3D microfabrication process, FemtoFab Inc. has identified the manufacturing of microfluidic… more
Abstract:… determination of at least two chiral molecules in both polar and nonpolar solvents; and 3) Investigate design parameter tradeoffs including voltage and frequency dependence and throughput up to gram per day scale. We will use rotating electric fields, microfluidics and chiral… more
Abstract:…rch are: (1) to develop SELP liquid embolic injection solution formulations; (2) to determine the gelation rate and gel strength of SELP fluidsat their maximum injectable viscosity; (3) to assess their occlusion of simulated arterial channels in-vitro using a microfluidic… more
Abstract:…, decentralized approach to PET probe development is required to give scientists the freedom to determine what probes they want to use to best solve the problems of their interest. This goal can be achieved by building a benchtop, computer-controlled, microfluidic… more
Abstract:… biomarkers. A decentralized approach to PET probe development is required to give scientists the freedom to determinewhat probes they want to use to best solve the problems of their interest. This goal can be achieved by building a benchtop, PC-controlled, microfluidic… more
Abstract:HJ Science & Technology, Inc. proposes to develop a novel high pressure "pump-on-a-chip" and "valve-on-a-chip" microfluidic technology for NASA planetary science applications including on-chip sample manipulation and analysis. In particular, we will… more
Abstract:HJ Science & Technology, Inc. proposes to demonstrate the feasibility of an integrated "lab-on-a-chip" technology capable of in-situ, high throughput, and real time identification and characterization of a variety of toxic metals, organics, and bacteria biomarkers in spacecraft water… more
Abstract:… of the components of basic metabolic and blood gas panels. Using wireless optode sensors, which can reduced in size to the nanoscale, and fluorescence signal detection removes the need for wired connection of the sensors, sample preprocessing and microfluidics for… more
Abstract:… complements our ongoing NIAID Cooperative Agreement, An Integrated Diagnostic Biochip for Point of Care Pathogen Identification (U01 AI082457), for rapid molecular diagnosis urinary tract infections (UTI) using electrochemical biosensors integrated with microfluidics. Since… more
Abstract:… relatively slowly. Annotating genes by quickly connecting large-scale functions of interest to their genetic circuits and catabolic pathways is a difficult task that requires new tools that do not currently exist. We propose a high-throughput, microfluidic platform… more
Abstract:… of Michigan. To develop procedures to utilize the 384 array hanging drop plate to form co-culture spheroids of PCa cells, marrow stromal cells (MSCs), and human bone marrow endothelial cells (HBMECs) similar to those prepared previously in low throughput microfluidic… more
Abstract:DESCRIPTION (provided by applicant): Microfluidic Processing of Leukocytes for Diagnostics Testing Summary/Abstract: New tests to quantify the numbers and functional states of key leukocyte types from blood samples offer enhanced determination and personalization of clinical… more
Abstract:… of this STTR project is to improve stem cell banking and transplantation by marketing an efficient and robust processing system that results in superior recoveries of viable leukocytes and HSPCs, focusing on UCB as an immediate objective but involving a microfluidic cell… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project proposes to develop a highly innovative, thermoelectric, microfluidic DNA sequencing method for mutation detection (e.g., SNPs) for applications in personalized medicine. The overall objective is to optimize… more
Abstract:… and conventional assay technology (based on microtiter plates) does not have the degree of miniaturization needed to reduce cell usage to levels that enable extensive drug screening. This project?s objective is to develop novel ultraminiaturized assays using microfluidics that… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project is aimed at developing optofluidic technology for medical diagnostics. Optofluidics describes the combination of integrated optics with microfluidics in a single chip scale system. As such, optofluidic devices have… more
Abstract:… specific instruments that provide repeated testing of disease biomarkers at low cost and low complexity. The long-term goal of LiquiLume Diagnostics Inc. is to develop solutions to these challenges based on optofluidics - the combination of integrated optics and microfluidics… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project propose to use a highly effective microfluidic based process to clean and disinfect contaminated water. Veloctron will build the portable water treatment unit and test the efficiency in killing pathogens and removing… more
Abstract:… assays. Currently, lengthy and laborious derivation processes hinder the large-scale production of uniform and reliable hiPSC and hiPSC-derived neural cell populations. Thus, the goal of this project is to establish the feasibility of using a novel microfluidic-based… more
Abstract:… cell sorting and magnetic-activated cell sorting require exogenous labeling or genetic modification, neither of which is ideal for such clinical applications. Therefore, Biopico System teams with the University of California, Irvine for their expertise in microfluidic… more
Abstract:…. PUBLIC HEALTH RELEVANCE: Biopico System and UC Irvine propose a Multiplexed Onchip Nanomagnetic Immunoassay for TOxin Reporting (MONITOR) to detect multiple toxins accumulated in blood. This MONITOR system combines immunoassay, serum separation microfluidics,… more
Abstract:… extremely low concentrations of target analytes. This renders them impractical for population studies of multiple analytes where very small volumes of blood are collected. In response to RFA-ES-12-004, Newomics Inc. proposes to develop fully- integrated microfluidic chips, as… more
Abstract:DESCRIPTION (provided by applicant): A Microfluidic Single Molecule Free Solution Hydrodynamic Separation Platform Despite the power of modern methods such as microarrays, digital PCR, and deep sequencing, gel electrophoresis remains the workhorse of molecular biology. While… more
Abstract:…or miRNA profiling called Ligo-miR will be developed. Hybridization and ligation of locked nucleic acid probes will be used to generate miRNA specific ligation products encoded by length. The ligation products will then be directly identified and quantified using microfluidic… more
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