Abstract:… (CTCs) using engineered adenoviruses and sophisticated flow cytometry. Current techniques for detection of CTCs include reverse transcriptase-polymerase chain reaction (RT-PCR), flow cytometry, fluorescence in situ hybridization, and, more recently, microfluidics.… more
Abstract:… sufficient technology been developed to even begin exploring human applications. A key breakthrough was the discovery of the stem cell as a significant element for regeneration. Previous work has suggested that stem cells can be targeted and captured in a synthetic microfluidic… more
Abstract:…ells released into the bloodstream by the primary tumor - for molecular analysis offers an attractive strategy for genotyping patient-specific tumors and mutations. The goal of this project is to demonstrate and validate a procedure that marries high efficiency microfluidic… more
Abstract:… preparation of viral and bacterial sample and obtaining PCR-ready nucleic acids and immuno-reactive content from a variety of sample matrices such as water, whole blood and plasma (virtually any biological matrix). The platform consist a low cost, disposable, … more
Abstract:DESCRIPTION (provided by applicant): The overall goal of this research collaboration is to develop a high-throughput digital microfluidic instrument capable of screening dozens of newborns simultaneously for severe combined immunodeficiency (SCID). There is a significant need at… more
Abstract:…tions requires significant expenditure of time and effort with currently available techniques. The goal of this project is to develop an automated and low-cost DNA quality control solution for use in biobanks. The proposed device will combine droplet-based Digital Microfluidic … more
Abstract:… use in these countries. Building upon successful results from phase I, we propose to build a laboratory prototype of a highly distributable low cost newborn screening platform suitable for use in India and China (Aim 1). We will design a low cost digital microfluidic cartridge… more
Abstract:…vided by applicant): The ultimate goal of this project is to develop an extremely compact and inexpensive DNA sequence for applications in laboratory and clinical settings. The device will implement pyrosequencing on a disposable droplet based digital microfluidic cartridge… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will develop a prototype online ion monitor for more efficient and cost effective management of water resources in the power industry. The industry currently lacks instrumentation that can both monitor ions below 10 g/L concentrations… more
Abstract:… sensors for measuring the displacement and gap in the NIST micro-rheometer. No electrical connections are required to the moving parts. All electronics and optics are removed from the chip so that it is inexpensive and disposable. A fixed, simple micro-fluidic… more
Abstract:… concentration spiked into the raw sample) that can be amplified by the same primers as the analyte, but detected separately; henceallowing us to detect amplification inhibitors in direct clinical samples. The objectives of Phase I are to: 1) modify the BU microfluidic device… more
Abstract:…, current assays are poorly sensitive especially in early disease and cannot discriminate between the early and late stages of LD. New assays are needed and we plan to fill this unmet need. In this Phase I proposal our main objective is to use ultrasensitive microfluidics… more
Abstract:DESCRIPTION (provided by applicant): The goal of this proposal is to complete development of a Microfluidic Liver Array (MLA) platform for improved and lower cost in vitro toxicity screening targeting the human liver. This funding will directly lead tothe commercialization… more
Abstract:… of the proposed technology. In Phase 2, efforts will focus along two lines. First, component design optimization will be carried out with fabrication enhancements and extended testing and characterization for technology validation. Second, an integrated microfluidic… more
Abstract:…, require minimal user training, and universal. We propose to develop a general purpose BioPrep cartridge for universal bio-sample preparation for detection of biowarfare agents. The cartridge will be based on CFDRC"s EMUS platform a suite of microfluidic… more
Abstract:… high price tag for these instruments, ranging from several hundred thousand to millions of dollars, and there is a clear need for alternate solutions for a label-free, low-cost, high-throughput enzyme screening platform. We propose to develop a novel, microfluidic,… more
Abstract:… animal trials and oversimplified in vitro models. Results obtained from in vitro models are not predictive of in vivo toxicity owing to significant difference from the in vivo physiological conditions. In this context, we propose to develop and demonstrate a novel microfluidic… more
Abstract:… ambient conditions, ChromoLogic (CL) has developed a novel Fluid Preservation System (FPS). FPS is based on collecting and sealing fluids in a sterile, hermetically sealed volume, with automatic separation of supernatant fluid where necessary. The unique microfluidic and… more
Abstract:…rated with automation technology developed by the Pacific Northwest National Laboratory (PNNL) to produce a self-contained portable personal exposure sampling unit and a bench-top assay unit. Enertechnix will be responsible for the aerosol sampling and microfluidic components… more
Abstract:This Small Business Innovation Research Phase I project will develop a microfluidic in-situ Transmission Electron Microscope (TEM) specimen holder with accurate temperature and pressure measurement and control abilities. The inability to dynamically image materials at atomic… more
Abstract:…ess Innovation Research (SBIR) Phase I project proposes to develop an entirely new platform for the molecular diagnostics of cancer exploiting a new Surface Enhanced Raman Scattering (SERS) enhanced Ligase Detection Reaction (LDR) and an optically active microfluidic chip. Since… more
Abstract:… sensor fabrication and sensor evaluation, including sensitivity, specificity,detection limit, linearity, accuracy, dynamic range, repeatability, precision, accuracy, interference, cross-reactivity, drift, and sensor calibration. Second is the development of microfluidic… more
Abstract:…, as well as in high throughput applications for target validation in pharmaceutical industry. Specific aims of this SBIR proposal include: 1) Design andmanufacture miniaturized circuits for impedance measurements, 2) Design and manufacture CO2- impervious microfluidic… more
Abstract:… single sensing endpoint (impedance). With the advances in lab-on-a-chip technologies, cell maintenance systems that are integrated into the chip become possible. Therefore, it is highly desirable to merge advances in label-free multiparametric cellular sensing with … more
Abstract:DESCRIPTION (provided by applicant): Microfluidic systems are emerging as critically important tools for high throughput cell based analysis for applications including genotyping, sequencing, gene expression analysis, nucleic acid amplification, and diagnostics. Lab-on-a-chip… more
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