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Displaying 101 – 125 of 126 Awards
Company: Cytopro, Inc. Agency/Program/Year/Phase: HHS / SBIR / 2005 / 1
Abstract: …in retina-serived cells. We believe that objectives of phase I studies will be to accrue sufficient data for phase II studies that lenti-Cyto-PO vector system will be used in the retina of mice as a vehicle to transfer transgenes encoding anti-angiogenic peptides and siRNA to… more
Company: Excellin Life Sciences, Inc. Agency/Program/Year/Phase: HHS / SBIR / 2005 / 1
Abstract: … can hardly be achieved by the existing techniques. The immediate application of this project will be in the area of gene transfer, which currently has a market of $ 200M in US alone. As this product permits effective transfection of other molecules (e.g., siRNA and… more
Company: GENESEGUES, INC. Agency/Program/Year/Phase: DOD / SBIR / 2005 / 1
Abstract: …, by comparing the biodistribution of three nanocapsule coating proteins for tumor-targeting in a syngeneic, orthotopic model of prostate cancer. We will select the most promising coating for future testing with a transposon plasmid being developed to generate siRNA against… more
Company: GENVEC, INC. Agency/Program/Year/Phase: HHS / SBIR / 2005 / 1
Abstract: … expression, transcriptional and post-transcriptional, will be tested. Aim 1 will optimize a transcriptional repressor, incorporate it into a cell line and demonstrate its functionality on AdVectors with inhibitory genes. Aim 2 will test the hypothesis that a single … more
Company: Intradigm Corporation Agency/Program/Year/Phase: HHS / SBIR / 2005 / 1
Abstract: DESCRIPTION (provided by applicant): We are proposing this project to develop and commercialize a novel, histidine/lysine (HK) polymer based, siRNA transfection reagent. The goal of the phase I study of this project is to evaluate the feasibility of using PT88, a member of the… more
Company: ORIGENE TECHNOLOGIES, INC. Agency/Program/Year/Phase: HHS / SBIR / 2005 / 1
Abstract: DESCRIPTION (provided by applicant): siRNA has emerged as a powerful genomics tool for functional analysis of human genes and potential drug discovery. This technology holds great promise for genome-wide functional genetic screens in mammalian cells. However, such screens have… more
Company: SYSTEM BIOSCIENCES, LLC (SBI) Agency/Program/Year/Phase: HHS / SBIR / 2005 / 2
Abstract: … tools are critical for genome-wide discovery and validation of drug targets, and to open avenues for newer concepts in drug therapy and diagnostics of complex human diseases. The recent introduction of gene knockdown technology based on small interfering RNAs (siRNA) holds… more
Company: Galenea Corporation Agency/Program/Year/Phase: HHS / SBIR / 2005 / 1
Abstract: …fense research. RNA interference (RNAi) is a process by which double-stranded RNA directs sequence-specific degradation of messenger RNA in animal and plant cells. RNAi appears to be ideal for interfering with influenza virus infection because 1) short interfering (si) … more
Company: AMBION DIAGNOSTICS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2004 / 1
Abstract: … during development and disease progression. Unfortunately biomedical researchers lack rapid, quantitative assays to detect small RNAs in clinical samples. The proposed research will result in the development of kits and reagents to rapidly detect and quantify siRNA or… more
Company: COMPARATIVE BIOSCIENCES, INC. Agency/Program/Year/Phase: HHS / SBIR / 2004 / 1
Abstract: …ntisense oligonucleotide with known activity for blocking Idl expression and angiogenesis to duplicate the anti-angiogenic phenotype of the Id1/Id3 knockout mouse, (2) Use in vitro/in vivo Matrigel studies and the mouse hyperoxia model to test the activity of siRNA… more
Company: CYNTELLECT, INC. Agency/Program/Year/Phase: HHS / SBIR / 2004 / 2
Abstract: …cluding difficult cell types; (ii) evaluate impact of optoinjection on cell physiology and compare to existing methods; and (iii) implement functional genomics assays on LEAP. Phase II will demonstrate broad utility of LEAP for in situ gene silencing by optoinjection of siRNA in… more
Company: DHARMACON, INC. Agency/Program/Year/Phase: HHS / SBIR / 2004 / 1
Abstract: DESCRIPTION (provided by applicant): RNA interference (RNAi) is the most efficient, natural reverse genetic tool discovered to date. The potency of RNAi is based on a mechanism, where a pre-existing highly complex protein machinery is guided by short interfering RNA (siRNA)… more
Company: Intradigm Corporation Agency/Program/Year/Phase: HHS / SBIR / 2004 / 1
Abstract: … targeting ligand layer on its surface. This layered particle provides tumor targeted delivery of nucleic acid from iv administration through tail vein. Recently, RNA interference has been demonstrated to be very effective in gene down regulation. Short double stranded RNA (… more
Company: Intradigm Corporation Agency/Program/Year/Phase: HHS / SBIR / 2004 / 1
Abstract: DESCRIPTION (provided by applicant): The objective of this proposal is to evaluate using siRNA agent to knockdown pro-angiogenic genes as a treatment for HSV infection of eyes that can result the blinding lesions of stromal keratitis (SK). Recurrence of herpes simplex virus… more
Company: SOMAGENICS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2004 / 1
Abstract: The discovery and development of RNA interference and especially the breakthrough of using small interfering RNAs (siRNA) to inhibit gene expression is revolutionizingbiology and opening new avenues for developing novel therapeutics. Despite the current usefulness of the… more
Company: SYSTEM BIOSCIENCES, LLC (SBI) Agency/Program/Year/Phase: HHS / SBIR / 2004 / 1
Abstract: … genomics studies will speed up the discovery and validation of drug targets, and open avenues for new concepts in drug therapy and diagnostics of complex human diseases. Recent innovations in gene knockdown technology based on small interfering RNA (siRNA) have… more
Company: SYSTEM BIOSCIENCES, LLC (SBI) Agency/Program/Year/Phase: HHS / SBIR / 2004 / 1
Abstract: … of novel high throughput functional genomics tools is critical for a genome-wide discovery of a gene's functions and for linking their products into signaling pathways. The recent introduction of gene knockdown technology, based on small interfering RNAs (siRNA),… more
Company: SYSTEM BIOSCIENCES, LLC (SBI) Agency/Program/Year/Phase: HHS / SBIR / 2004 / 1
Abstract: … sequencing and gene expression projects, there is an urgent need to develop novel bioinformatic tools and technologies to uncover the functions of each gene in the human genome. Recent innovations in gene knockdown technology, based on small interfering RNA (siRNA), have… more
Company: ALLELE BIOTECHNOLOGY AND PHARMACEUTICALS Agency/Program/Year/Phase: HHS / SBIR / 2003 / 1
Abstract: … tool for gene function studies and drug development. Currently, application of this technology is largely limited by the efficiency of delivering RNAi-inducing reagents into mammalian cells. The aim of this proposal is to establish techniques to efficiently transfect … more
Company: AMBION DIAGNOSTICS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2003 / 1
Abstract: DESCRIPTION (provided by applicant): The proposed research will enable mammalian cells to be used in mutation/selection experiments to identify genes involved in cellular processes. The objective of the proposal is to develop procedures for preparing siRNA libraries using… more
Company: Dharmacon Research, Inc Agency/Program/Year/Phase: NSF / SBIR / 2003 / 1
Abstract: … (RNAi) gene silencing in mammalian cells. Sequence-specific RNAi is achieved by introducing homologous, short interfering RNA duplexes (siRNAs) into cells. siRNAs are generated by several methods of which the most popular are (1) chemically synthesized siRNA duplexes,… more
Company: IMGENEX Agency/Program/Year/Phase: HHS / SBIR / 2003 / 1
Abstract: … that gene's expression through a process known as RNA interference (RNAi); this process post-transcriptionally silences a gene through mRNA inhibition or degradation, siRNAs appear to suppress gene expression without producing a non-specific cytotoxic response. The siRNA… more
Company: MIRUS BIO CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 2003 / 2
Abstract: …. The overall objective of the studies proposed in this SBIR Fast Track grant application is to develop the use of RNAi for the purposes of drug target validation in mammalian cells in vitro and in vivo. In Phase I studies, we will develop reagents for delivery of siRNA and… more
Company: MIRUS BIO CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 2003 / 1
Abstract: … to develop and utilize RNA interference (RNAi) technology to treat smallpox. RNAi is accomplished by the introduction of double-stranded RNA into the cell, resulting in sequence specific degradation of the target mRNA. Application of short (21-25 bp) double stranded RNA (… more
Company: AMBION DIAGNOSTICS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2002 / 1
Abstract: … function, but may one day be used for human therapeutics. The RNAi phenomenon was only recently demonstrated to be present in mammalian cells and in mammalian cells occur specifically in response to short double stranded RNA molecules termed small interfering RNAs (siRNA). In… more
Displaying 101 – 125 of 126 Awards
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