Abstract:… Type II Mucopolysaccharidosis (MPS), also known as Hunter's syndrome, is a genetic disease that affects the lysosomal enzyme, iduronate-2-sulfatase (IDS). Consequently, patients with MPS-II develop extensive lysosomal storage product accumulation in tissues, including… more
Abstract:…alized elderly. We propose to develop the Hydration Monitor (HM) that can objectively quantify changes in the body water content and hydration status. The method implemented in the device is based on the experimental fact that ultrasound velocity through soft tissue is a linear… more
Abstract:…roxidase MPO as a treatment forAlzheimer's disease. MPO is an abundant enzyme in leukocytes but its expression can be induced inastrocytes in Alzheimer's disease. This abnormal expression of MPO can lead to the oxidation of lipids and proteins leading to tissue damage… more
Abstract:… after TBI with both short and long-term GLP toxicity/pathology-necropsy evaluation. The rationale for the proposed groups is that safety must be defined in naive and injured animals, since injury affects biodistribution secondary to chemo-attractant signals from injured tissues… more
Abstract:The objective of Phase I is the preliminary design, prototype and testing of a 3D spectral imaging system for the characterization and evaluation of viability of engineered tissue for treating war injuries. The purpose is in ensuring tissue viability, maturity, vascularity to… more
Abstract:… is applying for a Phase II SBIR to continue that work and carry out the studies necessary to file for an IND. Specifically, the goals of the current application are: 1.) to develop the necessary assays for IND-enabling studies and to verify the proposed tissue-level… more
Abstract:… subdermal PO2 and hemoglobin oxygen saturation in skin. The product, Oxyspheres , will find wide use in the development of healing therapies for skin grafts, skin ulcers, and amputations. The capability to measure PO2 at the interface between skin and underlying tissues… more
Abstract:… commercially viable, self-contained single-tube assays with minimum hands-on time and no requirement for sophisticated instrument. PUBLIC HEALTH RELEVANCE: Staphylococcus aureus, particularly MRSA, is a major cause of infections ranging from skin and soft tissue… more
Abstract:… partly because such systems often produce responses that are not relevant to the actual human disease state, high throughput screening has not historically delivered a strong return on investment. More representative primary cell models are often available for tissues and… more
Abstract:… primary cause of death on the battlefield. Over 40% of the trauma cases admitted at hospitals inthe United States is due to road traffic accidents. The vast majority of these deaths occur before the injured could be transported to a treatment facility. Various types of tissue… more
Abstract:… microRNA (miRNA) concentrations in cells that have shown to be associated with normal physiological processes, as well as diseases, including cancer. Currently there are no rapid, quantitative methods available to measure miRNA expression in living cells or tumor tissue. All… more
Abstract:…fy novel small molecule disruptors of the viral inhibitor from compound libraries. We will also identify novel RNA-disrupting compounds using computer modeling techniques. The novel drugs identified will be synthesized and tested using flavivirus-infected cells in tissue culture… more
Abstract:… states, the capabilitiesof spectral domain optical coherence tomography have yet to define a role. The objective of this proposal is to develop an imaging handpiece that is more suited to clinically useful imaging of the cornea, the tear film, and the tissue… more
Abstract:… lesions can have a dramatic impact on cervical cancer mortality rates, increasing five- year survival rates from 70% to about 100%. This project focuses on development of a novel imaging system for improving diagnosis and characterization of cervical tissue. The… more
Abstract:…, current pump technologies do not provide any means to quantify the amount of insulin entering the blood stream. This can pose major risk to the health of the users in cases where the insertion needle may not deliver insulin due to improper placement, or scar tissue. In… more
Abstract:…treatment of Epilepsy. PUBLIC HEALTH RELEVANCE: RELEVANCE Current medical therapy leaves 30 percent of Epilepsy patients without adequate control of their seizures. Developmentof a minimally invasive surgical option for thermally destroying the tissue in the brain… more
Abstract:… leak and unnecessary ostomy diversion through the creation of an objective, repeatable means by which to screen patients intra-operatively. Patients at low risk will avoid an unnecessary ostomy. Patients at high risk of leak, despite efforts to improve tissue viability,… more
Abstract:DESCRIPTION (provided by applicant): In modern day medicine, cellular therapies, regenerative medicine and tissue engineering all involve technologies for harvesting, expanding, modifying and re-implanting live viable cells and tissues. Processes for preparing the therapeutic… more
Abstract:DESCRIPTION (provided by applicant): Autologous regenerative medicine tissue therapy costs are very high because when individual tissues are manufactured all the costs fall on a single patient. Allogeneic tissues are cheaper because large tissue batches can be made and the costs… more
Abstract:… such an approach will eventually become part of a standard ofcare. The most promising route for the delivery of such materials is direct LV injection (DLVI). Thus far, the utility of DLVI has been hampered by the lack methods for accurate spatial targeting of affected tissue.… more
Abstract:Rapid and accurate characterization and/or identification of the differentiation state of the stem cells is critical to the development of regenerative medicine technologies as well as tissue engineering solutions. Current methods and devices are time-consuming, labor-intensive,… more
Abstract:… effects in humans. Unfortunately, high resolution thermal simulations are computationally very expensive. The goal of this project is to develop fast anatomy- and physiology-based computational tools for predicting whole-body and localized thermal response of tissue due to… more
Abstract:…e and overall deposition rates. Diamonds radiation hardness and many other unique properties are propelling it to be utilized in increasingly important roles in DOE & apos;s discovery efforts in fundamental particle physics. Diamond also has important potential as a tissue… more
Abstract:…y in patients with ALI/ARDS ranges from 30-60% and recovery often is associated with long term pulmonary and non-pulmonary morbidity. ALI/ARDS is characterized by an intense systemic inflammatory response leading to neutrophil infiltration of the lungs and lung tissue damage.… more
Abstract:… are dry and chemically stable from cryogenic to elevated temperatures, simplifying installation and preventing thermal pump-out. Assembly, integration, and test time (AI & T) for CNT TIMs can be significantly reduced in comparison to liquid or adhesive TIMs. In… more
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