Abstract:…ess Innovation Research (SBIR) Phase I will focus on development of novel biopolymers obtained by covalently attaching peptide side chains to hyaluronic acid (HA) backbone polymer chains through carefully controlled chemistry. The resulting material can be used for soft tissue… more
Abstract:Wolf Technical Services, Inc. (Wolf) is developing a Modular Anthropomorphic Test Device (ATD) that is specifically designed for use in blast and ballistic testing. The ATD offers improved biofidelity compared to existing ATDs, with a frangible skeletal system and soft-tissue… more
Abstract:… blown insulations. This product will reduce energy consumption and peak-hour power loads, while significantly improving space savings compared to other retrofit solutions. To eliminate settling of the insulation, the aerogel will be designed to have adhesive properties… more
Abstract:… Non-subjective Testing (PATIENT). PATIENT uses complementary technologies to present the most realistic model for modern training requirements for organs, vasculature, instrumentation, and controls. With the right components, the physical configuration of a proper tissue… more
Abstract:… an approach to provide high-fidelity anatomical models that can be used for medical simulation and training. Current 3D printing systems do not provide a method for various materials to be simultaneously deposited to represent the various properties of tissue, bone, muscle… more
Abstract:…dications by delivering a greater concentration of medication to a local area with a very low systemic dose. The result is a noninvasive drug delivery method with high patient acceptability. Nano-formulated compositions are promising means for transdermal tissue specific drug… more
Abstract:… savings projected for masking, postcure machining, and extension of the system to gap fill, fuel tank sealant application, and hard shim forming. Beyond meeting the Air Force manufacturing needs, the ILSAS has the potential to become the new standard in advanced adhesive… more
Abstract:…, rapid, automatic, easy-to-use NDI of large honeycomb sandwich structures used in aircraft and other military platforms. With minor modification, the IMHOS system can also be used for NDI of parts containing light, heterogeneous, materials (e.g., explosives, adhesives,… more
Abstract:…To address the Army"s need for a topical wound treatment with recombinant heat shock proteins (rHSPs) that can be applied to wounds to promote wound healing and skin graft survival, Physical Optics Corporation (POC) proposes to develop a new topical soft tissue treatment… more
Abstract:This Small Business Innovation Research Program (SBIR) Phase I project aims to develop and demonstrate a superpenetration multiphoton microscope (S-MPM) that will more than double the imaging depth achievable in highly scattering biological tissue. MPM technology has… more
Abstract:…ic and highly refractory with a melting point of>1000 & #176;C which will improve the thermal resistance of mat materials to be able to withstand 650 & #176;F minimum for 20 minutes minimum. We"ve developed a series of methods to provide excellent adhesion of our… more
Abstract:… to review the novice"s actions subjectively. In an ideal system, extensive data on the performance of the user could be fed into realistic overall systemic models. In this work we propose a method of incorporating force sensors heterogeneously with synthetic tissue by… more
Abstract:The DOD and commercial markets have a distinct need for low cost anatomically accurate, complex synthetic human tissue in order to improve training and improve surgical precision. In this project a novel multiple material print-head is developed using a 3D printer capable of… more
Abstract:This Small Business Innovation Research (SBIR) Phase I Project continues the development of the choroid plexus (CP) growth factor cocktail for application to biologic hernia meshes to treat the challenging hernia repair market. CP factors represent a broad spectrum of potent biologic molecules that… more
Abstract:Wound infections that result in bacteremia and even mortality are a significant problem among soldiers with soft tissue/burn injuries. Overall morbidity associated with such wounds could be reduced substantially if the infectious etiology of these infections was clarified… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will investigate the application of a novel tissue engineering approach to the fabrication of animal products, in particular leather. The approach relies on the automated deposition of conveniently prepared… more
Abstract:… light scattered by chemical species to distinguish, identify, and quantify them based on the shifted spectrum found in their optical fingerprint. The fingerprint of glucose can be used to key in and register its changes in concentration over time in biological tissues, such… more
Abstract:…, which is the leading cause of death (~90%) for bleeding-related trauma. The foam material is based on the biopolymer chitosan; a modification to this polymer with novel hydrophobic grafts allows the material to clot blood much more rapidly and adhere to tissue more… more
Abstract:… replacement to PVC in the flooring market. A novel process to continuously create sheet materials has also been determined. To complete the development of this technology and disrupt incumbent products, the new technology needs to be advanced to improve the adhesive bonding… more
Abstract:… Applications and Other Benefits: If successful, this technology will enable scaling of low energy capillary separation to address dewatering, harvesting and water purification in a wide array of industries. Capillary separation exploits the principals of liquid … more
Abstract:… interrogate complex cell cultures is important since it is believed that many diseases, drug side effects, and environmental phenotypes are the result of multi-cellular interactions that have been disrupted, leading to physical changes at the complex cell/tissue level.… more
Abstract:… cellular neurotoxicological events by been demonstrated in vivo using rodents. For example, both Me-Hg and Pb acetate can affect neurons indirectly through compromising the developing astrocytes. This human co-culture cell assay should be more representative of neural tissue… more
Abstract:…, so that they do not generate bubbles/pores in the laminate. Initial work yielded a decrease in porosity from 3% to 1%. A new technology has been demonstrated for rapidly coating the Al tooling with a microstructured release layer. During phase II, the topography, adhesion,… more
Abstract:…t cohesive failure from an unacceptable value of 863% to an acceptable value of 981%. These results indicate that automated atmospheric pressure plasma treatment of organic matrix composites is a viable technology for surface preparation prior to structural adhesive bonding. … more
Abstract:… protective coating systems which show improved performance at elevated temperatures, will result in improving the current tooling life and efficiency thereby improving overall productivity. The crystal-chemical approach can be used to predict the extent of adhesive… more
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