Abstract:… will be expanded from short term VAD implants to the long term ACD, mainly mechanical heart valve (MHV) in close collaboration with JarvikHeart and Meril Life Science. The Phase II goals will address the issues of concern identified in Phase I, e.g., improving adhesion to an… more
Abstract:DESCRIPTION (provided by applicant): As more diverse genetic links are established with cancer, the utility of one-gene-one-test diagnostics is diminished. In addition, biopsies are mixed populations of tumor and normal tissue, requiring deconvolution oftumor and non-tumor… more
Abstract:… used clinically. Both brain perfusion methods, ASL and DSC techniques, involve making images very fast to identify the passage of blood through the capillary compartment. The image signal-to-noise ratio (SNR) is limited by the small (e.g., 3%) fraction of blood in tissue… more
Abstract:… in the integration of a new sensor technology developed by AS & T with a new NDI method, both of which have been independently developed well beyond the conceptual stage. The development of CALIBER will provide an NDI sensor whose output images reveal bondline adhesive… more
Abstract:…egradation in gastric and bile environments. A Phase II plan will be developed to demonstrate the safety of the probiotic and evaluate its efficacy in the treatment of gastrointestinal disease in dolphins. Candidate probiotics will be characterized for colonization and adhesion… more
Abstract:DESCRIPTION (provided by applicant): Intraoperative imaging techniques are used by neurosurgeons in the treatment for primary brain tumors such as gliomas to achieve maximal surgical resection of pathological tissue while leaving essential areas intact. Current imaging… more
Abstract:DESCRIPTION (provided by applicant): For dental and other applications there is a great need for self-filling tissue expanders with the capacity to be reshaped to fit the void by the surgeon at time of implantation. Akina recently completed an initial Phase II study using its… more
Abstract:… to its receptor, CD47, limits NO signaling throughout the vascular system thereby worsening IRI. Blocking the TSP1-CD47 system with anti-CD47 monoclonal antibodies (CD47mAbs) dramatically improves outcomes in models of kidney, liver, brain, hindlimb and soft tissueIRI. In… more
Abstract:… cells on the surface of the glucose sensor. A 12- hour clinical study was completed wherein glucose measurements within interstitial fluid were highly correlated with reference glucose measurements. Moreover, measurements of glucose oscillations within subcutaneous tissue… more
Abstract:…, which is phosphorylated by sphingosine kinases (SK1 and SK2) to produce sphingosine 1-phosphate (S1P). It is established that SK activation and production of S1P are essential for signaling responses to inflammatory cytokines, including their ability to induce adhesion… more
Abstract:… (PTOA). In particular, patients with meniscal tears are at high risk for early PTOA. Chondroprotection of the joint surface is mediated by lubricin, a large glycoprotien which forms a lubricating nanofilm on the cartilage surface and provides anti-adhesion via steric… more
Abstract:… performance of the part. This is due to many reasons including the repair resin rheology and wetting, compatibility and reactivity of the repair resin to the substrate, and mechanical properties. Accordingly, a resin having the necessary viscosity, wetting, and adhesion… more
Abstract:DESCRIPTION (provided by applicant): Metachromatic Leukodystrophy or MLD, is a genetic disease that affects the lysosomal enzyme, arylsulfatase A (ASA). People born with MLD develop extensive lysosomal storage product accumulation in tissues, including thebrain. Children with… more
Abstract:…or (HM) whichis being developed under this grant can objectively quantify changes in the body water content and hydration status. The proprietary patented method implemented in the device is based on the experimental fact that ultrasound velocity through soft tissue isa linear… more
Abstract:… US during their lifetimes. Some loss of utero-vaginal support occurs in most adult women, however, the true etiology of prolapse and differences seen among individuals is not entirely understood. Changes in the elasticity of the vaginal walls, connective support tissues and… more
Abstract:…otherapeutics via Notch signaling pathway inhibitory peptides that are optimized to selectively accumulate within breast tumors, (2) to evaluate in an established, in vivo mouse model of breast cancer this approach?s capacity to reduce breast tumors and spare healthy tissue, and… more
Abstract:… after TBI with both short and long-term GLP toxicity/pathology-necropsy evaluation. The rationale for the proposed groups is that safety must be defined in naive and injured animals, since injury affects biodistribution secondary to chemo-attractant signals from injured tissues… more
Abstract:… of Defense will be the capability to deploy improved computed tomography (CT) algorithms for improving defect detection in solid rocket motor inspection. Commercial applications include automotive components, baggage handling at airports, and micro CT for small animal, … more
Abstract:…nvolves changes in neuronal plasticity t the synapse junction, the exact changes at the protein level leading to the development of dependence and negative responses associated with withdrawal are poorly understood, in large part because of the highly complex cellular and tissue… more
Abstract:… in a way to allow transcriptome profiles to be easily and fairly interrogated. Our proposal to develop technology tostudy the transcriptome in an unbiased, high-throughput manner should make future clinical applications a reality and propel research in comparative … more
Abstract:… that are excessive, physically debilitating and functionally damaging. There is a critical need for an effective product that can control bacterial contamination and prevent colonization, mitigate inflammation, and diffuse to or reach necrotic and damaged tissue resulting… more
Abstract:DESCRIPTION (provided by applicant): Development of radiological/nuclear medical countermeasures to treat Acute Radiation Syndrome (ARS) is a high priority research area for NIAID. Bone marrow is one of the most sensitive tissues to radiation damage and impaired hematopoiesis is… more
Abstract:DESCRIPTION (provided by applicant): Nonlinear optical microscopy techniques (such as two-photon florescence) are being used to acquire volumetric (i.e. three dimensional) images that probe several hundred microns into scattering tissue. These techniques are being combined with… more
Abstract:…mated manufacturing control environments. Scientific and technological understanding will be enhanced by a deeper understanding of the effect of various surface treatment processes on extent and uniformity of surface energy and of the relationship of these properties to adhesion… more
Abstract:… Diabetes mellitus (DM) leads to a 3-4 fold higher risk of experiencing ischemic stroke. In addition, DM stroke patients are more prone to develop more and earlier white matter (WM) high-intensity lesions than non DM stroke patients. Treatment of stroke with tissue… more
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