Abstract:… mitochondrial dysfunction due to environmental stressors. Diverse acute insults from surgery, trauma, ischemia/reperfusion (I/R) and drug andenvironmental chemical toxicity lead to mitochondrial dysfunction and result in cell injury and death in many organs/tissues (e.g. heart… more
Abstract:DESCRIPTION (provided by applicant): The most common malignancy in American women is breast cancer. Breast reconstruction for mastectomy currently involves two choices, implant or autologous tissue flap. Implant reconstruction is relatively simpler but istemporary, whereas flap … more
Abstract:…fort aims to enhance these functions and add to them a material "immune response" capable of local detection of oxygen intrusion, followed by automatic compositional changes which resist further oxygen ingress, and finally the creation of "scar tissue" that… more
Abstract:…illator coupled to a color PIN diode detector via an optical fiber. Small field radiotherapy techniques such as stereotactic radiosurgery (SRS) or stereotactic body radiation therapy (SBRT) enable delivery of high radiation doses to tumors while sparing healthy tissue and organs… more
Abstract:… lymphoma and is directly activated by several cancer-associated mutations. NF-kB is also a key signaling node in the communication between tumors and the inflammatory microenvironment by promoting inflammation, cell survival, cell proliferation, angiogenesis, and tissue… more
Abstract:… necrosis factor-alpha and hyaluronic acid were able to reduce secondary necrosis in a partial-thickness rat burn model by 70%. This SBIR Phase I will focus on treating partial-thickness burns to test of the safety and efficacy of the technology in preventing extensive tissue… more
Abstract:… situ therapeutic vaccine which incorporatesbiological cofactors and patient-specific cell lysate, attracts dendritic cells (DCs), exposes them to the tumor specific antigens, and then releases them to direct a strong, targeted immune response against malignant tissue. Phase… more
Abstract:… the results of this project will not only save the lives of patients with tracheal lesions that currently have no other viable options, but it will advance the field of regenerative medicine and have significant benefits on the commercial development of other tissue engineered… more
Abstract:… NMI's long circulating nanocolloid technology developed for encapsulating poorly soluble drugs, such as DTX. Integrin targeting is highly applicable for ovarian cancer because most of ovarian cancers differentially express integrins compared to other adult tissues.… more
Abstract:…elerator user facilities consist of a stainless steel base material (for thermal isolation) and a thin Cu film (for RF conductivity). The electro- chemical deposition techniques presently used to apply the Cu to the stainless steel have several draw backs. To encourage … more
Abstract:…gs on flexible metal bellows. This superconducting layer leads to a decrease in the surface resistance at cryogenic temperatures and a decrease in the power consumption of the bellows. AASC will further engineer this superconducting layer by improving the film adhesion to the… more
Abstract:… and there are few safe alternative treatments. There are no treatments that take advantage of modern molecular medicine's advances in immunotherapy. Therapeutic applications of monoclonal antibodies (mAbs) offer a way to target treatments to specific tissues. However,… more
Abstract:… exhaust recovery systems, which are inefficiently designed, in three aspects: 1) heat extraction; 2) heat conversion; and 3) heat rejection. The proposed technology will address these shortcomings with innovative heat transfer components, unique thermoelectric module adhesion… more
Abstract:… will be expanded from short term VAD implants to the long term ACD, mainly mechanical heart valve (MHV) in close collaboration with JarvikHeart and Meril Life Science. The Phase II goals will address the issues of concern identified in Phase I, e.g., improving adhesion to an… more
Abstract:DESCRIPTION (provided by applicant): As more diverse genetic links are established with cancer, the utility of one-gene-one-test diagnostics is diminished. In addition, biopsies are mixed populations of tumor and normal tissue, requiring deconvolution oftumor and non-tumor… more
Abstract:… used clinically. Both brain perfusion methods, ASL and DSC techniques, involve making images very fast to identify the passage of blood through the capillary compartment. The image signal-to-noise ratio (SNR) is limited by the small (e.g., 3%) fraction of blood in tissue… more
Abstract:… in the integration of a new sensor technology developed by AS & T with a new NDI method, both of which have been independently developed well beyond the conceptual stage. The development of CALIBER will provide an NDI sensor whose output images reveal bondline adhesive… more
Abstract:…egradation in gastric and bile environments. A Phase II plan will be developed to demonstrate the safety of the probiotic and evaluate its efficacy in the treatment of gastrointestinal disease in dolphins. Candidate probiotics will be characterized for colonization and adhesion… more
Abstract:DESCRIPTION (provided by applicant): Intraoperative imaging techniques are used by neurosurgeons in the treatment for primary brain tumors such as gliomas to achieve maximal surgical resection of pathological tissue while leaving essential areas intact. Current imaging… more
Abstract:DESCRIPTION (provided by applicant): For dental and other applications there is a great need for self-filling tissue expanders with the capacity to be reshaped to fit the void by the surgeon at time of implantation. Akina recently completed an initial Phase II study using its… more
Abstract:… to its receptor, CD47, limits NO signaling throughout the vascular system thereby worsening IRI. Blocking the TSP1-CD47 system with anti-CD47 monoclonal antibodies (CD47mAbs) dramatically improves outcomes in models of kidney, liver, brain, hindlimb and soft tissueIRI. In… more
Abstract:… cells on the surface of the glucose sensor. A 12- hour clinical study was completed wherein glucose measurements within interstitial fluid were highly correlated with reference glucose measurements. Moreover, measurements of glucose oscillations within subcutaneous tissue… more
Abstract:…, which is phosphorylated by sphingosine kinases (SK1 and SK2) to produce sphingosine 1-phosphate (S1P). It is established that SK activation and production of S1P are essential for signaling responses to inflammatory cytokines, including their ability to induce adhesion… more
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