Abstract:…, which is phosphorylated by sphingosine kinases (SK1 and SK2) to produce sphingosine 1-phosphate (S1P). It is established that SK activation and production of S1P are essential for signaling responses to inflammatory cytokines, including their ability to induce adhesion… more
Abstract:… (PTOA). In particular, patients with meniscal tears are at high risk for early PTOA. Chondroprotection of the joint surface is mediated by lubricin, a large glycoprotien which forms a lubricating nanofilm on the cartilage surface and provides anti-adhesion via steric… more
Abstract:… performance of the part. This is due to many reasons including the repair resin rheology and wetting, compatibility and reactivity of the repair resin to the substrate, and mechanical properties. Accordingly, a resin having the necessary viscosity, wetting, and adhesion… more
Abstract:DESCRIPTION (provided by applicant): Metachromatic Leukodystrophy or MLD, is a genetic disease that affects the lysosomal enzyme, arylsulfatase A (ASA). People born with MLD develop extensive lysosomal storage product accumulation in tissues, including thebrain. Children with… more
Abstract:…or (HM) whichis being developed under this grant can objectively quantify changes in the body water content and hydration status. The proprietary patented method implemented in the device is based on the experimental fact that ultrasound velocity through soft tissue isa linear… more
Abstract:… US during their lifetimes. Some loss of utero-vaginal support occurs in most adult women, however, the true etiology of prolapse and differences seen among individuals is not entirely understood. Changes in the elasticity of the vaginal walls, connective support tissues and… more
Abstract:…otherapeutics via Notch signaling pathway inhibitory peptides that are optimized to selectively accumulate within breast tumors, (2) to evaluate in an established, in vivo mouse model of breast cancer this approach?s capacity to reduce breast tumors and spare healthy tissue, and… more
Abstract:… after TBI with both short and long-term GLP toxicity/pathology-necropsy evaluation. The rationale for the proposed groups is that safety must be defined in naive and injured animals, since injury affects biodistribution secondary to chemo-attractant signals from injured tissues… more
Abstract:… of Defense will be the capability to deploy improved computed tomography (CT) algorithms for improving defect detection in solid rocket motor inspection. Commercial applications include automotive components, baggage handling at airports, and micro CT for small animal, … more
Abstract:…nvolves changes in neuronal plasticity t the synapse junction, the exact changes at the protein level leading to the development of dependence and negative responses associated with withdrawal are poorly understood, in large part because of the highly complex cellular and tissue… more
Abstract:… in a way to allow transcriptome profiles to be easily and fairly interrogated. Our proposal to develop technology tostudy the transcriptome in an unbiased, high-throughput manner should make future clinical applications a reality and propel research in comparative … more
Abstract:… that are excessive, physically debilitating and functionally damaging. There is a critical need for an effective product that can control bacterial contamination and prevent colonization, mitigate inflammation, and diffuse to or reach necrotic and damaged tissue resulting… more
Abstract:DESCRIPTION (provided by applicant): Development of radiological/nuclear medical countermeasures to treat Acute Radiation Syndrome (ARS) is a high priority research area for NIAID. Bone marrow is one of the most sensitive tissues to radiation damage and impaired hematopoiesis is… more
Abstract:DESCRIPTION (provided by applicant): Nonlinear optical microscopy techniques (such as two-photon florescence) are being used to acquire volumetric (i.e. three dimensional) images that probe several hundred microns into scattering tissue. These techniques are being combined with… more
Abstract:…mated manufacturing control environments. Scientific and technological understanding will be enhanced by a deeper understanding of the effect of various surface treatment processes on extent and uniformity of surface energy and of the relationship of these properties to adhesion… more
Abstract:… Diabetes mellitus (DM) leads to a 3-4 fold higher risk of experiencing ischemic stroke. In addition, DM stroke patients are more prone to develop more and earlier white matter (WM) high-intensity lesions than non DM stroke patients. Treatment of stroke with tissue… more
Abstract:…ed articular cartilage is accepted as one of the determinants of outcome following osteochondral allograft transplantation. Refrigerated storage methods used for cartilage storage prior to clinical cartilage utilization need to be carefully evaluated because the tissue may be… more
Abstract:… will include 1) cell viability and proliferation, 2) base line adipogenic differentiation, and 3) response to obesogen(s). Feasibility for progression to Phase II will be demonstration of gt70% viability, cell survival with retention of attachment to the tissue culture… more
Abstract:…, security, and defense, among others. To study safety and potential health hazards of EM devices, high-fidelity voxelized anatomical body models have been used in conjunction with sophisticated EM and thermal solvers to predict energy absorption rates and tissue… more
Abstract:… disease. The Wnt pathway mediates multiple pathological processes, including angiogenesis, vascular permeability, inflammation and fibrosis, as it regulates many pathogenic factors, such as VEGF, tumor necrosis factor-alpha(TNF- ), intercellular adhesion… more
Abstract:…reproducibility and homogeneity. Commercial Applications and Other Benefits: Diamonds radiation hardness and many other unique properties are propelling it to important roles in DOE & apos;s discovery efforts in fundamental physics. Diamond is promising as a tissue… more
Abstract:DESCRIPTION (provided by applicant): Seroma formation (fluid accumulation in the wound) is among the most common post-surgical complications, occurring in up to 50% of certain surgical procedures. TissuGlu(R) Surgical Adhesive is designed to adhere flaps of… more
Abstract:… for 50% of the recipients. However, widespread clinical application of for T1D is hindered by two critical barriers: 1) the need for systemic immunosuppression for the current intraportal liver transplant site; and 2) by the finite and low supply of human islet tissue (a… more
Abstract:…, at 1 week, 2 weeks, 6 weeks, and 12 weeks in the live animals, and at the 12 and 24-week sacrifice dates. Following necropsy joints will be evaluated byCT and gross and histological semi- quantitative scoring. In addition, mechanical properties of repair tissue, the… more
Abstract:DESCRIPTION (provided by applicant): The overall goal of this study is to develop a tissue-engineered total joint replacement from an engineered biomaterial scaffold combined with adult bone marrow-derived mesenchymal stem cells (MSCs) for regeneration ofthe entire femoral… more
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