Abstract:… represent a technology that would enhance the protection of existing donors, expand the time window for surgical implementation, and potentially resuscitate marginal organs which could then be transplanted. The goal of this application is to examine the use of a tissue repair… more
Abstract:This project (technology transfer opportunity) is aimed at significant improving both the efficiency and performance of the ambient pressure nanoDESI ionization source for the comprehensive analysis of aerosol particles and surfaces including biological tissues by tandem mass… more
Abstract:… SBIR application is to develop a non-cell-based means of inhibiting coagulation and platelet activation on engineered vascular grafts, so that small-diameter arterial grafts may be available off the shelf. This arterial graft will consist of human engineered tissue that is… more
Abstract:…n) is a theranostic isotope that is suitable for both diagnostic and therapeutic applications. Its low energy gamma rays can be imaged using standard gamma cameras. For therapy its short-range ( & lt;300 micron) conversion electrons minimize damage to healthy tissue. … more
Abstract:The broader impact/commercial potential of this Small Business Innovation Research (SBIR) project is the development of a screening method to reliably identify binding agents that can be used to target drugs to specific tissues or cell types. Targeting drugs can increase their… more
Abstract:DESCRIPTION (provided by applicant): This proposal involves the incorporation of a proprietary nitric oxide (NO) releasing polymer material (NORL) into a venous catheter to reduce infection and clotting. Low levels of NO released by the normal endotheliuminhibit platelet … more
Abstract:… differential diagnosis that includes lymphoid hyperplasia, atypical lymphoid hyperplasia, chronic inflammation, and B cell neoplasms. LCR can be detected by flow cytometry (FCM) as an abnormal kappa:lambda ratio on the cell surface. However, FCM requires fresh (unfixed) … more
Abstract:Abstract Persistent injury to the liver can cause chronic inflammation and dysregulated deposition of extracellular matrix (ECM), leading to accumulation of fibrotic scar tissue and eventually cirrhosis. While fibrosis is a normal wound healing response, in excess, it can… more
Abstract:…. This nanocomposite coating is highly transparent, easy to apply via spray coating over large areas and containing no volatile organic compounds. In Phase I, we will develop, produce and characterize durable anti-icing and ice-phobic surfaces, including ice adhesion strength… more
Abstract:… have developed two patent-pending methods for improving sensitivity in detection of breast cancer using (DWI): (1) Analyzing ADC gradient at the lesion border, and (2) Enhancing diffusion images to improve differentiation of lesion from background tissue. In the… more
Abstract:… a rad hard beta particle detector that can operate at elevated temperatures. Bore hole logging is another application suited to diamond detectors. Due to its high density of nuclei, diamond is promising for fast neutron detection. Because the effective atomic number of tissue… more
Abstract:…. Prior work of our collaborator and consultant, Dr. George Perry at University of Texas San Antonio and Dr. Xiongwei Zhu at Case Western Reserve University,demonstrated increased oxidative damage to nucleic acid in vulnerable neurons in the hippocampal tissues from… more
Abstract:…vided by applicant): Devastating and disfiguring facial injuries can result from gunshot wounds and motor vehicle accidents as well as from cancer surgeries of the head and neck or breast. The most advanced reconstructive procedures involvedistant transfer of tissue including… more
Abstract:Project Summary / Abstract There are 4 parathyroid glands in the neck and they are responsible for the production of parathyroid hormone which maintains calcium homeostasis throughout the body. They are difficult to identify relative to the other tissues in the neck such as… more
Abstract:…hardening of the organ and a gradual decline in organ function. The proposed microscaffold brings together on one single platform two drugs with very different actions. One drug is aspirin that reduces inflammation and the other drug is Relaxin which can soften hardened tissue… more
Abstract:… partner with a leading thin-silicon solar cell manufacturer to develop highly flexible, dielectric backplane materials. ANI and its partner will take advantage of the flexibility of thin-silicon and work to provide support solutions that have excellent adhesion and do suffer… more
Abstract:… process. The CNF-enhanced coatings will be evaluated for level of dispersion, to ensure optimum improvement in mechanical properties and surface finish. The coatings will then be applied to composite panels and will be characterized for flexibility, adhesion, abrasion… more
Abstract:ABSTRACT: Arteriocyte intends to develop and commercialize an innovative wound dressing. This SMART Bandage will incorporate an optical oxygen sensor and provide oxygen measurements of underlying wounded tissue, enabling assessment of the extent of injury and likelihood for… more
Abstract:… utilizes antibody-antigen surface binding as its core sensor technology. Our proposed SCAN tool is designed to provide an on-orbit analysis of suspension samples to support studies of bone and muscle loss, multi-generational species studies and cell and plant tissue per… more
Abstract:… machine. This proposed "smart" material will ultimately enable the cost-effective manufacture of large, lightweight core-stiffened composite cryogenic pressure vessels. Carbon nanotubes (CNTs) will be transferred either directly onto the prepreg, or onto adhesive… more
Abstract:ABSTRACT: This project will deliver software that integrates information from repeated experiments, disparate imaging and functional sensing to study the physiological response of ocular tissue to laser damage. Imaging and functional testing modalities include the fundus… more
Abstract:ABSTRACT: This proposal entitled A dual acting drug for enhancing radiotherapeutic benefit is designed to provide proof of concept evidence that the novel compound EWA001 can protect normal lung tissue from radiation-induced damage within an in vivo model without appreciably… more
Abstract:DESCRIPTION (provided by applicant): Cancers selected for the NIH's The Cancer Genome Atlas (TCGA) project have been chosen because of their poor prognosis and overall public health impact. Select tissue samples have been profiled for gene and miRNA expression, promoter… more
Abstract:This Small Business Technology Transfer Research (STTR) Phase I project is seeking to develop a novel cost-effective strategy to modify dental implants with biomimetic nanofibers for controlled regeneration of gingival tissue. In order to seal the dental implants from bacteria… more
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