Abstract:…. Prompt treatment in the first hours after a burn injury is essential to prevent ischemia, hyperemia and necrosis, which progressively enlarge the wound and increase the risk of permanent scarring, contractures, disfigurement and loss of function. Applied Tissue… more
Abstract:This project (technology transfer opportunity) is aimed at significant improving both the efficiency and performance of the ambient pressure nanoDESI ionization source for the comprehensive analysis of aerosol particles and surfaces including biological tissues by tandem mass… more
Abstract:Tissue Genesis (TGI) is proposing to develop a highly portable, easy to use, low-cost, point-of-care, adipose-derived stem cell (ASC) isolation device that fully integrates the process from fat extraction to cell product. This next generation system addresses current technology… more
Abstract:… to a full torso. In order to make effective use of IO devices in training, the Phase I device will be constructed to satisfy the following requirements: Ability to incorrectly/correctly palpate a realistic-feeling humerus underneath the skin/muscle tissue layers … more
Abstract:… shell. When the device is opened and installed, the treated textile is released/unrolled and the vapor shield activated by airflow. The device could be attached to the ceiling or beam of either a tent or other temporary or permanent structure with the self-adhesive strip. … more
Abstract:… announcement given the prevalence of the IED which often creates complex burn wounds on the face and skin that often form hypertrophic scars that often contract over time. Burn wound healing is a complex process that includes phases of inflammation, granulation tissue… more
Abstract:DESCRIPTION: Significant increase in the efficiency and speed of MS-based tissue imaging (IMS) performed at atmospheric conditions using high-resolution mass spectrometer will have a profound impact on method applications to the entire analytical field ofcharacterization of… more
Abstract:…, if applied to infants and young children, only have a 20% chance of success. Capsule tears hinder lens removal and affect the mechanical stability and performance of artificial lens implants. Currently, pediatric cataract surgeons mustmake do using devices with tissue… more
Abstract:…, ... and peripheral vascular diseases. Humaycte has developed a novel vascular graft that has shown excellent function in large animal models. The graft is made by culturing allogeneic human smooth muscle cells in a bioreactor to produce an engineered vascular tissue, which… more
Abstract:… mitochondrial dysfunction due to environmental stressors. Diverse acute insults from surgery, trauma, ischemia/reperfusion (I/R) and drug andenvironmental chemical toxicity lead to mitochondrial dysfunction and result in cell injury and death in many organs/tissues (e.g. heart… more
Abstract:DESCRIPTION (provided by applicant): The most common malignancy in American women is breast cancer. Breast reconstruction for mastectomy currently involves two choices, implant or autologous tissue flap. Implant reconstruction is relatively simpler but istemporary, whereas flap … more
Abstract:…fort aims to enhance these functions and add to them a material "immune response" capable of local detection of oxygen intrusion, followed by automatic compositional changes which resist further oxygen ingress, and finally the creation of "scar tissue" that… more
Abstract:…illator coupled to a color PIN diode detector via an optical fiber. Small field radiotherapy techniques such as stereotactic radiosurgery (SRS) or stereotactic body radiation therapy (SBRT) enable delivery of high radiation doses to tumors while sparing healthy tissue and organs… more
Abstract:… lymphoma and is directly activated by several cancer-associated mutations. NF-kB is also a key signaling node in the communication between tumors and the inflammatory microenvironment by promoting inflammation, cell survival, cell proliferation, angiogenesis, and tissue… more
Abstract:… necrosis factor-alpha and hyaluronic acid were able to reduce secondary necrosis in a partial-thickness rat burn model by 70%. This SBIR Phase I will focus on treating partial-thickness burns to test of the safety and efficacy of the technology in preventing extensive tissue… more
Abstract:… situ therapeutic vaccine which incorporatesbiological cofactors and patient-specific cell lysate, attracts dendritic cells (DCs), exposes them to the tumor specific antigens, and then releases them to direct a strong, targeted immune response against malignant tissue. Phase… more
Abstract:… the results of this project will not only save the lives of patients with tracheal lesions that currently have no other viable options, but it will advance the field of regenerative medicine and have significant benefits on the commercial development of other tissue engineered… more
Abstract:… NMI's long circulating nanocolloid technology developed for encapsulating poorly soluble drugs, such as DTX. Integrin targeting is highly applicable for ovarian cancer because most of ovarian cancers differentially express integrins compared to other adult tissues.… more
Abstract:…elerator user facilities consist of a stainless steel base material (for thermal isolation) and a thin Cu film (for RF conductivity). The electro- chemical deposition techniques presently used to apply the Cu to the stainless steel have several draw backs. To encourage … more
Abstract:…gs on flexible metal bellows. This superconducting layer leads to a decrease in the surface resistance at cryogenic temperatures and a decrease in the power consumption of the bellows. AASC will further engineer this superconducting layer by improving the film adhesion to the… more
Abstract:… and there are few safe alternative treatments. There are no treatments that take advantage of modern molecular medicine's advances in immunotherapy. Therapeutic applications of monoclonal antibodies (mAbs) offer a way to target treatments to specific tissues. However,… more
Abstract:… exhaust recovery systems, which are inefficiently designed, in three aspects: 1) heat extraction; 2) heat conversion; and 3) heat rejection. The proposed technology will address these shortcomings with innovative heat transfer components, unique thermoelectric module adhesion… more
Abstract:… will be expanded from short term VAD implants to the long term ACD, mainly mechanical heart valve (MHV) in close collaboration with JarvikHeart and Meril Life Science. The Phase II goals will address the issues of concern identified in Phase I, e.g., improving adhesion to an… more
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