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Displaying 5626 – 5650 of 6425 Awards
Company: ADVANCED MAGNETICS, INC. Agency/Program/Year/Phase: HHS / SBIR / 1992 / 1
Abstract: THE ULTIMATE GOAL OF THIS RESEARCH IS THE DEVELOPMENT OF TISSUE SPECIFIC, OR DIRECTED MAGNETIC RESONANCE UMAGING (MRI) CONTRAST AGENTS. THESE AGENTS WILL CONSIST OF PEPTIDES ATTACHED TO SMALL, BIODEGRADABLE SUPERPARAMAGNETIC IRON OXIDE COLLOIDS. THE BIODISTRIBUTION OF THE… more
Company: Advanced Scientific Concepts, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1992 / 1
Abstract: … LINEAR OVER THE FULL DYNAMIC RANGE. THE ADI IS HIGH-SPEED AND, THEREFORE, DETECTS INDIVIDUAL DISINTEGRATIONS WITH HIGH SENSITIVITY. BECAUSE OF ITS HIGH SPEED AND ENERGY RESOLUTION CAPABILITY, IT CAN DISTINGUISH MORE THAN ONE RADIOPHARMACEUTICAL IN A SINGLE TISSUE SPECIMEN.… more
Company: Radiation Monitoring Devices, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1992 / 1
Abstract: TO BE EFFECTIVE, A RADIATION THERPAY PORTOCOL SHOULD CONTROL THE CUMULATIVE DOSE DELIVERD TO A TUMOR TO BETTERN THAN 5%, WHILE MINIMIZING THE DOSE TO THE SURROUNDING TISSUE. PRESENTLY, THERE EXISTS NO PRACTICAL MEANS FOR ACUTALLY MEASURING IN VIVO, THE CUMULATIVE DOSE RECEIVED… more
Company: AMERINEX APPLIED IMAGING, INC. Agency/Program/Year/Phase: HHS / SBIR / 1992 / 1
Abstract: … BRAIN, OBTAINED FROM THE INVERSE SOLUTION, WILL THEN BE OVERLAID UPON THE 3-D RENDERING OF THE HEAD FOR VISUAL DISPLAY. A VARIETY OF MENU-DRIVEN FEATURES WILL BE PROVIDED FOR THE RAPID, INTERACTIVE DISPLAY OF THIS COMBINED MEG/MRI DATA, INCLUDING HEAD ROTATION, TISSUE… more
Company: ANTICANCER, INC. Agency/Program/Year/Phase: HHS / SBIR / 1992 / 1
Abstract: … SPECIMENS. THUS, THIS MODEL GIVES US THE POSSIBILITY OF STUDYING THE ABILITY OF A GIVEN MAB TO TARGET, BOTH THE PRIMARY TUMOR (LOCALLY GORWING) AND DISTANT METASTASES. THE CONCOMITANT USE OF AN IN VITRO TEST TO SCREEN THE REACTIVITY OF THE MAB ON LIVING TUMOR TISSUES GROWING IN… more
Company: Applied Sciences, Inc. Agency/Program/Year/Phase: DOD / SBIR / 1992 / 1
Abstract: …, low density, and great thermal properties. They would be great for a number of applications such as fins for spacecraft radiators. So why aren't they used more on spacecraft thermal systems? One reason is joining technology. Although many methods such as brazing and … more
Company: ATOM SCIENCES, INC. Agency/Program/Year/Phase: HHS / SBIR / 1992 / 1
Abstract: N/A
Company: AUTOMATION, INFORMATION AND Agency/Program/Year/Phase: HHS / SBIR / 1992 / 1
Abstract: THE LONG-TERM OBJECTIVE OF THIS RESEARCH IS TO DESIGN, BUILD AND COMMERCIALIZE A MEDICAL IMAGING SYSTEM BASED ON ELECTRICAL IMPEDANCE TOMOGRAPHY (EIT). EIT IS AN ATTRACTIVE DIAGNOSTIC TOOL DUE IN PART TO ITS LOW-COST BUT MORE SO BECAUSE IT DIFFERENTIATES TISSUE ACCORDING TO ITS… more
Company: BEND RESEARCH, INC. Agency/Program/Year/Phase: HHS / SBIR / 1992 / 1
Abstract: … AND SUITABLE FOR LARGE-SCALE PRODUCTION. SUCCESS IN PHASE I WOULD LEAD TO A PHASE II PROGRAM FOCUSED ON (1)CHARACTERIZING THE TECHNOLOGY (2) EXPANDING IT TO A WIDER RANGE OF CHIRAL CYANOHYDRINS, (3) DEVELOPING OPTIMIZATION STRATEGIES, (4) IDENTIFYING SCALE-UP TISSUES… more
Company: BIOELASTICS RESEARCH, LTD. Agency/Program/Year/Phase: HHS / SBIR / 1992 / 1
Abstract: … POLYPEPTIDES, THAT CAN BE CROSS-LINKED TO FORM BIOCOMPATIBLE, ELASTOMERIC MATRICES. THE METHODOLOGIES INVOLVE PEPTIDE SYNTHESIS, FABRICATION OF ELASTOMERIC MATRICES, INCORPORATION OF CELL ATTACHMENT SITES AND CYTOKINES, CELL CULTURE TESTING FOR MESOTHELIAL CELL ADHESION,… more
Company: SURMODICS, INC. Agency/Program/Year/Phase: HHS / SBIR / 1992 / 2
Abstract: THE LONG-TERM OBJECTIVE OF THIS PROJECT IS TO IMPROVE THE SURFACE PROPERTIES OF ARTIFICIAL CORNEA OVERLAY IMPLANTS FORUSE IN REFRACTIVE SURGICAL PROCEDURES. THIS WILL BE DONE BYCOVALENTLY IMMOBILIZING CELL ADHESION PROTEINS TO THESE LENSES TO PROMOTE EPITHELIALIZATION OVER THE… more
Company: SURMODICS, INC. Agency/Program/Year/Phase: NSF / SBIR / 1992 / 1
Abstract: THE SELECTION OF A POLYMER FOR USE IN A BIOMEDICAL APPLICATION IS BASED UPON THE PHYSICAL CHARACTERISTICS OF THE POLYMER SUCH AS STRENGTH AND FLEXIBILITY AND UPON THE BIOCOMPATIBILITY OF THE MATERIAL WITH TISSUE. IT IS FREQUENTLY THE CASE THAT COMPROMISES MUST BE MADE BETWEEN… more
Company: SURMODICS, INC. Agency/Program/Year/Phase: HHS / SBIR / 1992 / 1
Abstract: … OF THE BREAST SHAPE. THIS PHASE I PROJECT WILL COMBINE TWO TYPES OF PROSTHESIS SURFACE MODIFICATIONS TO REDUCE CAPSULE FORMATION AND CONTRACTURE. FIRST, THE PROSTHESIS TO BE USED WILL HAVE A TEXTURE (POROUS) SILICONE RUBBER SURFACE. POROUS POLYMERS ARE REPORTED TO IMPROVE … more
Company: Biomol Research Laboratoryt Agency/Program/Year/Phase: HHS / SBIR / 1992 / 1
Abstract: … USEFUL INHIBITOR OF GLYCOSPHINGOLIPID (GSL) BIOSYNTHESIS. GSLS PLAY IMPORTANT ROLES IN (1) CANCER CELL METASTASIS, PROLIFERATION, AND RESISTANCE AGAINST THE HOST'S IMMUNOSURVEILLANCE SYSTEM, (2) THE BINDING AND ACTIVATION OF PATHOGENIC ORGANISMS AND TOXINS TO TISSUES, AND (3)… more
Company: BIOPURE CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 1992 / 1
Abstract: … OR A RED BLOOD CELL SUBSTITUTE MADE UP OF ULTRAPURE POLYMERIZED BOVINE HEMOGLOBIN. DONOR LIVERS, OBTAINED FROM NORMAL FED RATS, WILL BE ASSESSED FOR BILIARY EXCRETION, O2 UTILIZATION, PRODUCTION OF GLUCOSE, LACTATE, AMINO ACID N, UREA N, RELEASE OF K+ AND TISSUE INJURY… more
Company: Biosynthesis Inc Agency/Program/Year/Phase: HHS / SBIR / 1992 / 1
Abstract: …DIABETES IN THE UNITED STATES ALONE IS STAGGERING. THE MAINTENANCE OF EUGLYCEMIA SHOULD PREVENT THE DEVLOPMENT OF OR HALT THE PROGRESSION OF THE SECONDARY DIABETIC COMPLICATIONS. EXOGENOUS INSULIN TERAPY HAS BEEN SUCCESSFUL IN PRODUCING LONG-TERM EUGLYCEMIA. PANCREATIC TISSUE… more
Company: BIOTEK, INC. Agency/Program/Year/Phase: DOD / SBIR / 1992 / 1
Abstract: … INSUFFICIENT SUPPLY OF DONOR BONE, THE POSSIBILITY OF TRANSMISSION OF PATHOGENS SUCH AS HEPATITIS B OR HUMAN IMMUNODEFICIENCY VIRUS (HIV). DEMINERALIZED BONE MATRIX, ALTHOUGH SUCCESSFUL, DO NOT PROVIDE IMMEDIATE STRUCTURAL STABILITY OR ABILITY TO SUPPORT SOFT TISSUE.… more
Company: BORON BIOLOGICALS, INC. Agency/Program/Year/Phase: DOE / SBIR / 1992 / 2
Abstract: … (BPA), CAN ALSO SELECTIVELY LOCALIZE IN SKIN CANCERS SUCH ASMALIGNANT MELANOMA. UPON IRRADIATION BY A THERMAL OR EPITHERMAL NEUTRON BEAM, THE COMPOUND PRODUCES LOCALIZED RADIATION OF ONLY ONE OR TWO CELL WIDTHS THAT KILLS CANCER CELLS WITHOUT DAMAGE TO HEALTHY TISSUE AND… more
Company: Boston Advanced Tech Inc. Agency/Program/Year/Phase: NASA / SBIR / 1992 / 2
Abstract: … ANALYSIS WILL BE PERFORMED DIRECTLY THROUGH THE SKIN BY USING LIGHT FROM A LASER DIODE ARRAY THAT IS REFLECTED FROM A PROMINENT VEIN NEAR THE SKIN SURFACE, IN EITHER THE WRIST OR ANKLE REGION OF THE BODY. THE LASER DIODES WILL OPERATE AT LOW POWER, CAUSING NO TISSUE INJURY,… more
Company: Bozeman Bio-tech Inc. Agency/Program/Year/Phase: USDA / SBIR / 1992 / 1
Abstract: … PERSISTENT AGENT, ACTS TOO SLOWLY, REQUIRING ABOUT 3 WEEKS TO BEGIN KILLING. IN PRELIMINARY USDA TESTS, NOSEMA ACRIDOPHAGUS HENRY (NA), ANOTHER MICROSPORIDIAN, DEMONSTRATED SPEED AND VIRULENCE, ACTING IN ONE-THIRD THE TIME OF NL, AND ATTACKED A MUCH BROADER TISSUE RANGE. NA… more
Company: Brewer Science Incorporated Agency/Program/Year/Phase: NSF / SBIR / 1992 / 1
Abstract: … TECHNIQUE KNOWN AS LIGA MICROFORMING. THE ULTIMATE GOAL OF THIS PROGRAM (PHASES I AND II) IS THE DIRECT FABRICATION OF WAVE GUIDE STRUCTURES BY X-RAY OR DEEP-UV LITHOGRAPHY. NEW RESIST MATERIALS WITH OUTSTANDING SENSITIVITY, CONTRAST,RESOLUTION, AND ADHESION ARE REQUIRED… more
Company: Brookwood Biomedical Agency/Program/Year/Phase: HHS / SBIR / 1992 / 1
Abstract: …XPAND HEMATOPOIETIC STEM CELL POPULATIONS IN VITRO WOULD BE OF OBVIOUS ADVANTAGE IN BOTH AUTOLOGOUS AND ALLOGENEIC BONE MARROW TRANSPLANTATION. STEM CELL PROPAGATION REQUIRES INTERACTION WITH ADHERENT STROMAL SUPPORT CELLS AND CAN BE PERFORMED IN CONVENTIONAL TISSUE CULTURE AND… more
Company: CALBIOMARINE TECHNOLOGIES, INC. Agency/Program/Year/Phase: HHS / SBIR / 1992 / 1
Abstract: … ECTEINASCIDIA TURBINATA. THE PHASE I STUDY WILL EXAMINE THE EFFECTS OF 6 ENVIRONMENTAL FACTORS ON ECTEINASCIDIN PRODUCTION: LIGHT INTENSITY, TEMPERATURE, FEEDING RATE, INORGANIC NITROGEN CONENTRATION, INORGANIC PHOSPHATE CONCENTRATION AND SIMULATED PREDATION TISSUE DAMAGE.… more
Company: Cape Cod Research Agency/Program/Year/Phase: DOD / SBIR / 1992 / 1
Abstract: N/A
Company: Ceramed Corporation Agency/Program/Year/Phase: HHS / SBIR / 1992 / 1
Abstract: FACILITATING THE IMMIGRATION OF OSTEOGENIC CELLS FROM THE SURROUND HOST TISSUE WITH SUBSEQUENT INCREASE IN BONE INGROWTH INTO A MORE BIOLOGICALLY ACTIVE NATURAL SCAFFOLD IS OF CLINICAL SIGNIFICANCE. OF PARTICULAR IMPORTANT IS ITS APPLICATION TO THE ELDERLY POPULATION WHO REQUIRE… more
Displaying 5626 – 5650 of 6425 Awards
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