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Displaying 6001 – 6025 of 6427 Awards
Company: Marrow Tech Inc Agency/Program/Year/Phase: HHS / SBIR / 1989 / 1
Abstract: A THREE-DIMENSIONAL SYSTEM FOR THE GROWTH OF HUMAN TISSUES IN VITRO HAS BEEN DEVELOPED AT MARROW-TECH, INC. IN THIS PHYSIOLOGICAL METHOD, STROMAL CELLS ARE ESTABLISHED ON A SUPPORT MATRIX AND ACT TO PROVIDE A FOUNDATION FOR THE CONTINUED GROWTH AND DIFFERENTIATION OF CELLS.… more
Company: Mdr Group Inc Agency/Program/Year/Phase: HHS / SBIR / 1989 / 1
Abstract: CLEAR, VISCOUS, AND ELASTIC FLUIDS ARE USED INTRAOCULARLY INOPHTHALMIC SURGERY TO PROTECT AND COAT CELL LAYERS AND TO MANIPULATE EYE TISSUE AND STRUCTURES. MDR GROUP, INC., IS DEVELOPING A SYSTEM OF SYNTHETIC, CLEAR VISCOELASTIC OPHTHALMIC SURGICAL FLUIDS WITH VARIED RHEOLOGIC… more
Company: Med/graphics Div Agency/Program/Year/Phase: HHS / SBIR / 1989 / 1
Abstract: … CODE UNDER ADVERSE CONDITIONS ON SMALL DIAMETERS IS THE MAJOR FOCUS OF THE RESEARCH EFFORTS. PRELIMINARY ON-SITE INTERVIEWS WILL BE CONDUCTED AND FOLLOWUP IN-SERVICE WILL BE PROVIDED. SAMPLINGS AND TESTS WILL BE PERFORMED TO DETERMINE SOFTWARE NEEDS, LABEL ADHESION… more
Company: MEDICAL PHYSICS, INC. Agency/Program/Year/Phase: HHS / SBIR / 1989 / 1
Abstract: FREE TISSUE TRANSFER HAS REVOLUTIONIZED MANY AREAS OF RECONSTRUCTIVE SURGERY. AS FREE TISSUE TRANSFER IS NOW BEING DONE ROUTINELY AT INSTITUTIONS WHERE INEXPERIENCED STAFF ARE UNABLE TO ADEQUATELY MONITOR VIABILITY, THE NEED FOR A RELIABLE METHOD TO MONITOR… more
Company: Medimatrix Inc. Agency/Program/Year/Phase: HHS / SBIR / 1989 / 2
Abstract: …, LASTING AT MOST 18 MONTHS; REGULAR REAPPLICATION OF SOLUBLE COLLAGEN IS NECESSARY TO RETAIN THE AUGMENTATION. IN THIS PROPOSAL, A FEASIBILITY STUDY IS DESIGNED TO TEST THE USE OF AN INJECTABLE COLLAGEN MATRIX BEAD, COMBINED WITH HYALURONIC ACID, FOR USE IN SOFT TISSUE… more
Company: Medimatrix Inc. Agency/Program/Year/Phase: HHS / SBIR / 1989 / 1
Abstract: … DACRON FIBERS, FOLLOWED BY THE ESTABLISHMENT OF A COLLAGEN MATRIX AROUND THE DACRON FIBERS. IT IS ANTICIPATED THAT THIS MATERIAL WILL BE HIGHLY BIOCOMPATIBLE, WILL PRODUCE AT LEAST TEMPORARY MECHANICAL INTEGRITY, AND WILL SUBSEQUENTLY STRENGTHEN DUE TO NEW TISSUE INGROWTH TO… more
Company: MicroFab Technologies Inc Agency/Program/Year/Phase: NSF / SBIR / 1989 / 1
Abstract: N/A
Company: Epoch Pharmaceuticals, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1989 / 2
Abstract: … RESTRICTION FRAGMENTS. SUCH ANTISENSE, CROSS-LINKABLE OLIGONUCLEOTIDES, DESIGNED TO MINIMIZE HOST TOXICITY, MAY BE USEFUL AS CHEMOTHERAPEUTIC AGENTS FOR INFECTIOUS DISEASESAND CANCER. THEY WILL BE TARGETED AT THE MRNA OR DNA OF MICROORGANISMS OR OF ANY CANCER TISSUE… more
Company: Moana Bioproducts Inc Agency/Program/Year/Phase: DOC / SBIR / 1989 / 1
Abstract: …ED CIGUATOXIN CONJUGATED TO PROTEIN CARRIERS. THE MAB-CTX THUS OBTAINED IS CONJUGATED TO COLLOIDAL GOLD (< 0.45 UM DIAMETER) OR COLORED LATEX PARTICLES. THIS WILL BE THE SPECIFIC DETECTION REAGENT. TOXINS IN FISH SAMPLES WILL BE DETECTED BY TOUCHING THE FISH TISSUE WITH BAMBOO… more
Company: Molecular Diagnostic Systems Agency/Program/Year/Phase: HHS / SBIR / 1989 / 1
Abstract: …DEFINE THE EPITOPES RECOGNIZED BY THE MONOCLONAL ANTIBODIES TO EA-D AND EBNA-1, (2) DEVELOP PURIFICATION METHODS FOR EA-D AND EBNA-1 USING MONOCLONAL ANTIBODIES, AND (3) EVALUATE MONOCLONAL ANTIBODY PURIFICATION METHODS FOR THE ISOLATION OF AUTHENTIC EA-D AND EBNA-1 FROM TISSUE… more
Company: MOLECULES FOR HEALTH, INC. Agency/Program/Year/Phase: HHS / SBIR / 1989 / 1
Abstract: … A DEGRADABLE SPACER GROUP. THE DRUG-POLYMER ADDUCTS WILL BE CHARACTERIZED, AND STUDIES WILL BE PERFORMED TO DETERMINE WHETHER THEY INHIBIT MAMMALIAN RIBONUCLEOTIDE REDUCTASE BEFORE AND AFTER TREATMENT WITH MICROSOMAL AND LYSOSOMAL ENZYMES. CYTOTOXICITY AGAINST TISSUE… more
Company: NANOPTICS, INC. Agency/Program/Year/Phase: HHS / SBIR / 1989 / 1
Abstract: N/A
Company: Neurex Corp. Agency/Program/Year/Phase: HHS / SBIR / 1989 / 1
Abstract: MUSCARINIC ACETYLCHOLINE RECEPTORS ARE THE PRIMARY MEDIATORS OF CHOLINERGIC NERVOUS INPUTS CONTROLLED BY THE PARASYMPATHETIC NERVOUS SYSTEM. STRUCTURAL HETEROGENEITY IN THIS RECEPTOR FAMILY HAS BEEN LONG SUSPECTED ON THE BASISOF THE BINDING CHARACTERISTICS OF VARIOUS TISSUES TO… more
Company: Nova Pharmaceutical Corp Agency/Program/Year/Phase: HHS / SBIR / 1989 / 1
Abstract: … DISEASE MODELS, THERE APPEARS IN VASCULAR SMOOTH MUSCLE A DIFFERENT RECEPTOR ON WHICH DES-ARG(9)-BK IS AN AGONIST. EVIDENCE SUGGESTS THAT INTERLEUKIN-1 (IL-1) IS RESPONSIBLE FOR INDUCING THESE B1 RECEPTORS. SIMILARLY, IN SEVERAL MODELS OF HUMAN PATHOLOGY AND IN TISSUE FROM… more
Company: Oread Laboratories Inc Agency/Program/Year/Phase: HHS / SBIR / 1989 / 1
Abstract: THE AIM OF THIS PROJECT IS TO EVALUATE THE FEASIBILITY OF DEVELOPING ANALYTICAL TECHNOLOGY APPLICABLE TO THE DETERMINATION OF DESMOSINE (DMS) IN THE SYSTEMATIC CIRCULATORY SYSTEM AND IN OTHER PHYSIOLOGICAL SAMPLES. IN VIVO HYDROLYTIC DEGRADATION OF THE CONNECTIVE TISSUE… more
Company: Paravax Inc. Agency/Program/Year/Phase: HHS / SBIR / 1989 / 1
Abstract: THE SPECIFIC AIM OF THIS PROJECT IS TO IMPROVE THE SURVIVAL AND PROLIFERATIVE ABILITY OF TICK CELL LINES. DRAWING UPON RECENT IMPROVEMENTS IN THE TISSUE CULTURE OF INSECT CELLS THAT HAVE LED TO THE COMMERCIAL SCALE-UP OF RECOMBINANT PROTEINS EXPRESSED IN INSECT CELLS,… more
Company: Creare Agency/Program/Year/Phase: HHS / SBIR / 1989 / 2
Abstract: … CONTROLLED-TEMPERATURE DISTRIBUTION OF A GIVEN MAGNITUDE IS CRITICAL TO THE SUCCESS OF HYPERTHERMIA TREATMENT. RECENT ADVANCES IN COMPUTER TECHNOLOGY HAVE MADE NUMERICAL MODELING OF HYPERTHERMIA TREATMENT A VIABLE ALTERNATIVE FOR PREDICTING THE TEMPERATURE DISTRIBUTION IN … more
Company: FOSTER-MILLER, INC. Agency/Program/Year/Phase: NASA / SBIR / 1989 / 2
Abstract: BTBA IS A THERMOPLASTIC POLYIMIDE EXHIBITING A COMBINATION OF GOOD PROCESSABILITY AND HIGH PERFORMANCE (CHEMICAL RESISTANCE, HIGH MECHANICAL, ADHESIVE, THERMOMECHANICAL, ANDTHERMO-OXIDATIVE PROPERTIES) DUE TO THE PRESENCE OF CRYSTALLIZABLE GROUPS WITHIN THE POLYMER WHICH… more
Company: FOSTER-MILLER, INC. Agency/Program/Year/Phase: DOD / SBIR / 1989 / 2
Abstract: GLASS FIBER-REINFORCED THERMOPLASTIC RESIN COMPOSITES CURRENTLY SHOW UNSATISFACTORY PERFORMANCE AS A RESULT OF INADEQUATE ADHESION AT THE FIBER/RESIN INTERFACE. INTERFACE MODIFICATION BY APPLICATION OF HIGH TEMPERATURE POLYIMIDE RESIN COATINGS TO GLASS FIBERS WILL GREATLY… more
Company: FOSTER-MILLER, INC. Agency/Program/Year/Phase: DOD / SBIR / 1989 / 1
Abstract: …CURRENT MATERILS AND HIGH TENSILE STRENGTH). WE WILL USE INNOVATIVE POLYMER PROCESSING TO MAKE A BIAXIALLY ORIENTED LCP COATING WHICH WILL ACTUALLY CARRY TENSILE AND SHEAR LOADS ALONG WITH THE GLASS FIBER. THE LCP COATINGS WILL BE STRIPPABLE AND PROVIDE GOOD ADHESION TO THE… more
Company: Plant Genetics Inc Agency/Program/Year/Phase: USDA / SBIR / 1989 / 1
Abstract: COATED SOMATIC EMBRYOS OR "SOMATIC SEEDS" PROVIDE A METHOD TO DIRECTLY DELIVER PLANT MATERIAL FROM TISSUE CULTURE TO THE GREENHOUSE OR FIELD WITHOUT THE LABORIOUS AND EXPENSIVE STEP OF FORMING TRANSPLANTS. DESICCATED SOMATIC SEEDS WOULD HAVE MANY ADVANTAGES OVER HYDRATED SOMATIC… more
Company: Precision Optics Corpon Agency/Program/Year/Phase: HHS / SBIR / 1989 / 1
Abstract: … AT TWO OR MORE DIFFERENT WAVELENGTHS) CAN BE MADE WILL ADD AN IMPORTANT NEWDIMENSION TO GASTROINTESTINAL FIBEROPTIC DIAGNOSES. SUCH PROCESSING OF SPECTRAL IMAGES WILL ENABLE THE DIAGNOSTICIAN,DURING ROUTINE ENDOSCOPIC EXAMINATIONS, TO DETECT LOCATIONS IN TISSUE WHERE… more
Company: Proteins International Inc Agency/Program/Year/Phase: HHS / SBIR / 1989 / 2
Abstract: … CONTAMINANTS OF THE HUMAN ENVIRONMENT. THE SIMPLEST EXAMPLES OF SUCH COMPOUNDS ARE MALONDIALDEHYDE, ACROLEIN, AND METHYL GLYOXAL. MALONDIALDEHYDE IS A PRODUCT OF LIPID PEROXIDATION AND PROSTAGLANDIN BIOSYNTHESIS AND IS PRESENT IN VIRTUALLY ALL MAMMALIAN TISSUES. METHYL… more
Company: Research Biochemicals, Agency/Program/Year/Phase: NSF / SBIR / 1989 / 2
Abstract: …OUNDS WILL BE COUPLED TO DOPAMINE AGONISTS (THERAPEUTIC DRUGS FOR PARKINSON'S DISEASE) AND ANTAGONISTS (THERAPEUTIC AGENTS FOR SCHIZOPHRENIA). WE WILL TEST THE AFFINITY AND SELECTIVITY OF THESE COMPOUNDS FOR DOPAMINE RECEPTORS. NEURAL MEMBRANES AT VARIOUS LEVELS OF TISSUE… more
Company: Research Biochemicals, Agency/Program/Year/Phase: HHS / SBIR / 1989 / 2
Abstract: …OUNDS WILL BE COUPLED TO DOPAMINE AGONISTS (THERAPEUTIC DRUGS FOR PARKINSON'S DISEASE) AND ANTAGONISTS (THERAPEUTIC AGENTS FOR SCHIZOPHRENIA). WE WILL TEST THE AFFINITY AND SELECTIVITY OF THESE COMPOUNDS FOR DOPAMINE RECEPTORS. NEURAL MEMBRANES AT VARIOUS LEVELS OF TISSUE… more
Displaying 6001 – 6025 of 6427 Awards
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