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Displaying 6001 – 6025 of 6438 Awards
Company: Houston Biotechnology, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1989 / 1
Abstract: …NOID AND/OR TYROSINE METABOLITE (MEHPLA) HAS BEEN IDENTIFIED AS THE NATURAL LIGAND FOR NUCLEAR TYPE II BINDINGSITES. MEHPLA INHIBITS ESTROGEN STIMULATION OF UTERINE CELLULAR HYPERPLASIA AND DNA SYNTHESIS IN THE RAT AND MCF-7 HUMAN BREAST CANCER CELL PROLIFERATION IN TISSUE… more
Company: Infrared Fiber Systems, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1989 / 2
Abstract: THIS PROJECT IS INTENDED TO RESULT IN AN INFRARED FIBER LASER CATHETER FOR USE IN LASER ANGIOPLASTY, OPHTHALMIC SURGERY, NEUROSURGERY, AND ENDOSCOPIC MICROSURGERY WHERE PRECISION OF TISSUE REMOVAL IS A NECESSITY. THE FIBER WILL BE MADE FROM ZIRCONIUM FLUORIDE GLASS, WHICH HAS… more
Company: Inova Diagnostics Inc Agency/Program/Year/Phase: HHS / SBIR / 1989 / 1
Abstract: … IN DIAGNOSIS OF VARIOUS AUTOIMMUNE DISEASES. THE BASIC TECHNOLOGY EXPLORED WILL BE AN ENZYME-LINKED IMMUNOSORBENT ASSAY UTILIZING VARIOUS TYPES OF PROTEIN- AND NUCLEIC-ACID-BINDING MEMBRANES AS A SOLID-PHASE SUPPORT. CLINICALLY RELEVANT AUTOANTIGENS, EITHER FROM CRUDE TISSUE… more
Company: Integrated Genetics Inc Agency/Program/Year/Phase: HHS / SBIR / 1989 / 1
Abstract: TISSUE PLASMINOGEN ACTIVATOR (TPA) IS A THROMBOLYTIC AGENT THAT HAS BEEN DEMONSTRATED TO BE EFFICACIOUS FOR CLOTS THAT CAUSE MYOCARDIAL INFARCTION AND PULMONARY EMBOLISM. THE AGENT, HOWEVER, MUST BE ADMINISTERED AT HIGH DOSES OVER SEVERAL HOURS. MAJOR AND MINOR BLEEDING MAY… more
Company: International Tech Tran Inc Agency/Program/Year/Phase: HHS / SBIR / 1989 / 1
Abstract: THE DEVELOPMENT OF A FAST, FLEXIBLE, TEMPORAL, SPATIAL, AND SPECTRALLY RESOLVED CAMERA FOR MEDICAL ENDOSCOPIC USE OFFERSTHE PROMISE OF A QUANTUM ADVANCEMENT IN LASER ENDOSCOPIC SURGERY. SUCH A CAMERA WOULD HELP ADVANCE SPECTROSCOPIC RESEARCH IN DISCRIMINATING HEALTHY TISSUE FROM… more
Company: Jcl Clinical Research Corp Agency/Program/Year/Phase: HHS / SBIR / 1989 / 1
Abstract: … FOR INVASIVE CANDIDIASIS IS AVAILABLE BUT IS DEPENDENT ON TIMELY DIAGNOSIS. THIS PROJECT WILL DEVELOP A SENSITIVE, DOUBLE-ANTIBODY ANTIGEN-CAPTURE ENZYME IMMUNOASSAY (EIA) THAT WILL DETECT CANDIDA ANTIGENS IN THE SERUM OF PATIENTS WITH CANDIDA INFECTIONS OF DEEP TISSUES.… more
Company: Kawamoto Research Services Agency/Program/Year/Phase: HHS / SBIR / 1989 / 1
Abstract: ALTHOUGH MOST IN VITRO STUDIES OF CENTRAL NERVOUS SYSTEM (CNS) DEVELOPMENT, TRANSPLANTATION, REGENERATION, NEUROPATHOLOGY, OR ELECTROPHYSIOLOGY REQUIRE ONLY SMALL AMOUNTS OF NEURAL TISSUE, HUGE AMOUNTS ARE WASTED BECAUSE OF THE DIFFICULTY OF CULTURING ANY BUT THE YOUNGEST FETAL… more
Company: L.VAD TECHNOLOGY, INC. Agency/Program/Year/Phase: HHS / SBIR / 1989 / 2
Abstract: …AL INVASION OF THE SITE WHERE THE CATHETER GIVING ACCESS TO THEPERITONEAL CAVITY PASSES THROUGH THE SKIN. L.VAD'S NEW APPROACH TO THE DESIGN OF A PERCUTANEOUS ACCESS DEVICE (PAD)RELIABLY CREATES A BIOLOGICAL SEAL AT THE JUNCTION OF THE IMPLANT AND THE SURROUNDING TISSUES THAT IS… more
Company: Lasersurge Inc Agency/Program/Year/Phase: HHS / SBIR / 1989 / 2
Abstract: THE USE OF LASER ENERGY TO WELD TISSUE AND TO CREATE SUTURELESS ANASTOMOSES HAS GREAT POTENTIAL. MANY LASER-WELDED TISSUES CAN WITHSTAND PHYSIOLOGIC STRESS WITHOUT WEAKENING AND HEAL WITH GOOD RESTORATION OF FUNCTION. INVESTIGATORS HAVE WELDED BOWEL IN RABBITS AND RATS.… more
Company: Loats Associates, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1989 / 1
Abstract: … AT APPROXIMATELY 8 TO 10 PERCENT OF THE COST OF A PET SCANNER, MAKING IT A VIABLE SUPPLEMENT OR REPLACEMENT FOR PET IN MANYTYPES OF STUDIES. IT HAS APPLICATION AS A MONITORING INSTRUMENT IN THE TREATMENT OF TUMORS WHERE IT IS OFTEN NECESSARY TO OBSERVE TISSUE CONDITION… more
Company: Marrow Tech Inc Agency/Program/Year/Phase: DOD / SBIR / 1989 / 1
Abstract: A THREE-DIMENSIONAL HUMAN SKIN MODEL HAS BEEN DEVELOPED IN OUR LABORATORY AND IS BEING CHARACTERIZED AND MODIFIED FOR USE IN CYTOTOXICITY ASSAYS, CHEMICAL PENETRATION STUDIES, AND ENGRAFTMENT STUDIES, AS A TARGET TISSUE IN DRUG MECHANISM STUDIES, AND AS A SOURCE FOR VARIOUS… more
Company: Marrow Tech Inc Agency/Program/Year/Phase: HHS / SBIR / 1989 / 1
Abstract: A THREE-DIMENSIONAL SYSTEM FOR THE GROWTH OF HUMAN TISSUES IN VITRO HAS BEEN DEVELOPED AT MARROW-TECH, INC. IN THIS PHYSIOLOGICAL METHOD, STROMAL CELLS ARE ESTABLISHED ON A SUPPORT MATRIX AND ACT TO PROVIDE A FOUNDATION FOR THE CONTINUED GROWTH AND DIFFERENTIATION OF CELLS.… more
Company: Mdr Group Inc Agency/Program/Year/Phase: HHS / SBIR / 1989 / 1
Abstract: CLEAR, VISCOUS, AND ELASTIC FLUIDS ARE USED INTRAOCULARLY INOPHTHALMIC SURGERY TO PROTECT AND COAT CELL LAYERS AND TO MANIPULATE EYE TISSUE AND STRUCTURES. MDR GROUP, INC., IS DEVELOPING A SYSTEM OF SYNTHETIC, CLEAR VISCOELASTIC OPHTHALMIC SURGICAL FLUIDS WITH VARIED RHEOLOGIC… more
Company: Med/graphics Div Agency/Program/Year/Phase: HHS / SBIR / 1989 / 1
Abstract: … CODE UNDER ADVERSE CONDITIONS ON SMALL DIAMETERS IS THE MAJOR FOCUS OF THE RESEARCH EFFORTS. PRELIMINARY ON-SITE INTERVIEWS WILL BE CONDUCTED AND FOLLOWUP IN-SERVICE WILL BE PROVIDED. SAMPLINGS AND TESTS WILL BE PERFORMED TO DETERMINE SOFTWARE NEEDS, LABEL ADHESION… more
Company: MEDICAL PHYSICS, INC. Agency/Program/Year/Phase: HHS / SBIR / 1989 / 1
Abstract: FREE TISSUE TRANSFER HAS REVOLUTIONIZED MANY AREAS OF RECONSTRUCTIVE SURGERY. AS FREE TISSUE TRANSFER IS NOW BEING DONE ROUTINELY AT INSTITUTIONS WHERE INEXPERIENCED STAFF ARE UNABLE TO ADEQUATELY MONITOR VIABILITY, THE NEED FOR A RELIABLE METHOD TO MONITOR… more
Company: Medimatrix Inc. Agency/Program/Year/Phase: HHS / SBIR / 1989 / 2
Abstract: …, LASTING AT MOST 18 MONTHS; REGULAR REAPPLICATION OF SOLUBLE COLLAGEN IS NECESSARY TO RETAIN THE AUGMENTATION. IN THIS PROPOSAL, A FEASIBILITY STUDY IS DESIGNED TO TEST THE USE OF AN INJECTABLE COLLAGEN MATRIX BEAD, COMBINED WITH HYALURONIC ACID, FOR USE IN SOFT TISSUE… more
Company: Medimatrix Inc. Agency/Program/Year/Phase: HHS / SBIR / 1989 / 1
Abstract: … DACRON FIBERS, FOLLOWED BY THE ESTABLISHMENT OF A COLLAGEN MATRIX AROUND THE DACRON FIBERS. IT IS ANTICIPATED THAT THIS MATERIAL WILL BE HIGHLY BIOCOMPATIBLE, WILL PRODUCE AT LEAST TEMPORARY MECHANICAL INTEGRITY, AND WILL SUBSEQUENTLY STRENGTHEN DUE TO NEW TISSUE INGROWTH TO… more
Company: MicroFab Technologies Inc Agency/Program/Year/Phase: NSF / SBIR / 1989 / 1
Abstract: N/A
Company: Epoch Pharmaceuticals, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1989 / 2
Abstract: … RESTRICTION FRAGMENTS. SUCH ANTISENSE, CROSS-LINKABLE OLIGONUCLEOTIDES, DESIGNED TO MINIMIZE HOST TOXICITY, MAY BE USEFUL AS CHEMOTHERAPEUTIC AGENTS FOR INFECTIOUS DISEASESAND CANCER. THEY WILL BE TARGETED AT THE MRNA OR DNA OF MICROORGANISMS OR OF ANY CANCER TISSUE… more
Company: Moana Bioproducts Inc Agency/Program/Year/Phase: DOC / SBIR / 1989 / 1
Abstract: …ED CIGUATOXIN CONJUGATED TO PROTEIN CARRIERS. THE MAB-CTX THUS OBTAINED IS CONJUGATED TO COLLOIDAL GOLD (< 0.45 UM DIAMETER) OR COLORED LATEX PARTICLES. THIS WILL BE THE SPECIFIC DETECTION REAGENT. TOXINS IN FISH SAMPLES WILL BE DETECTED BY TOUCHING THE FISH TISSUE WITH BAMBOO… more
Company: Molecular Diagnostic Systems Agency/Program/Year/Phase: HHS / SBIR / 1989 / 1
Abstract: …DEFINE THE EPITOPES RECOGNIZED BY THE MONOCLONAL ANTIBODIES TO EA-D AND EBNA-1, (2) DEVELOP PURIFICATION METHODS FOR EA-D AND EBNA-1 USING MONOCLONAL ANTIBODIES, AND (3) EVALUATE MONOCLONAL ANTIBODY PURIFICATION METHODS FOR THE ISOLATION OF AUTHENTIC EA-D AND EBNA-1 FROM TISSUE… more
Company: MOLECULES FOR HEALTH, INC. Agency/Program/Year/Phase: HHS / SBIR / 1989 / 1
Abstract: … A DEGRADABLE SPACER GROUP. THE DRUG-POLYMER ADDUCTS WILL BE CHARACTERIZED, AND STUDIES WILL BE PERFORMED TO DETERMINE WHETHER THEY INHIBIT MAMMALIAN RIBONUCLEOTIDE REDUCTASE BEFORE AND AFTER TREATMENT WITH MICROSOMAL AND LYSOSOMAL ENZYMES. CYTOTOXICITY AGAINST TISSUE… more
Company: NANOPTICS, INC. Agency/Program/Year/Phase: HHS / SBIR / 1989 / 1
Abstract: N/A
Company: Neurex Corp. Agency/Program/Year/Phase: HHS / SBIR / 1989 / 1
Abstract: MUSCARINIC ACETYLCHOLINE RECEPTORS ARE THE PRIMARY MEDIATORS OF CHOLINERGIC NERVOUS INPUTS CONTROLLED BY THE PARASYMPATHETIC NERVOUS SYSTEM. STRUCTURAL HETEROGENEITY IN THIS RECEPTOR FAMILY HAS BEEN LONG SUSPECTED ON THE BASISOF THE BINDING CHARACTERISTICS OF VARIOUS TISSUES TO… more
Company: Nova Pharmaceutical Corp Agency/Program/Year/Phase: HHS / SBIR / 1989 / 1
Abstract: … DISEASE MODELS, THERE APPEARS IN VASCULAR SMOOTH MUSCLE A DIFFERENT RECEPTOR ON WHICH DES-ARG(9)-BK IS AN AGONIST. EVIDENCE SUGGESTS THAT INTERLEUKIN-1 (IL-1) IS RESPONSIBLE FOR INDUCING THESE B1 RECEPTORS. SIMILARLY, IN SEVERAL MODELS OF HUMAN PATHOLOGY AND IN TISSUE FROM… more
Displaying 6001 – 6025 of 6438 Awards
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