Abstract:… that are excessive, physically debilitating and functionally damaging. There is a critical need for an effective product that can control bacterial contamination and prevent colonization, mitigate inflammation, and diffuse to or reach necrotic and damaged tissue resulting… more
Abstract:DESCRIPTION (provided by applicant): Development of radiological/nuclear medical countermeasures to treat Acute Radiation Syndrome (ARS) is a high priority research area for NIAID. Bone marrow is one of the most sensitive tissues to radiation damage and impaired hematopoiesis is… more
Abstract:DESCRIPTION (provided by applicant): Nonlinear optical microscopy techniques (such as two-photon florescence) are being used to acquire volumetric (i.e. three dimensional) images that probe several hundred microns into scattering tissue. These techniques are being combined with… more
Abstract:…mated manufacturing control environments. Scientific and technological understanding will be enhanced by a deeper understanding of the effect of various surface treatment processes on extent and uniformity of surface energy and of the relationship of these properties to adhesion… more
Abstract:… Diabetes mellitus (DM) leads to a 3-4 fold higher risk of experiencing ischemic stroke. In addition, DM stroke patients are more prone to develop more and earlier white matter (WM) high-intensity lesions than non DM stroke patients. Treatment of stroke with tissue… more
Abstract:…ed articular cartilage is accepted as one of the determinants of outcome following osteochondral allograft transplantation. Refrigerated storage methods used for cartilage storage prior to clinical cartilage utilization need to be carefully evaluated because the tissue may be… more
Abstract:… will include 1) cell viability and proliferation, 2) base line adipogenic differentiation, and 3) response to obesogen(s). Feasibility for progression to Phase II will be demonstration of gt70% viability, cell survival with retention of attachment to the tissue culture… more
Abstract:…, security, and defense, among others. To study safety and potential health hazards of EM devices, high-fidelity voxelized anatomical body models have been used in conjunction with sophisticated EM and thermal solvers to predict energy absorption rates and tissue… more
Abstract:… disease. The Wnt pathway mediates multiple pathological processes, including angiogenesis, vascular permeability, inflammation and fibrosis, as it regulates many pathogenic factors, such as VEGF, tumor necrosis factor-alpha(TNF- ), intercellular adhesion… more
Abstract:…reproducibility and homogeneity. Commercial Applications and Other Benefits: Diamonds radiation hardness and many other unique properties are propelling it to important roles in DOE & apos;s discovery efforts in fundamental physics. Diamond is promising as a tissue… more
Abstract:DESCRIPTION (provided by applicant): Seroma formation (fluid accumulation in the wound) is among the most common post-surgical complications, occurring in up to 50% of certain surgical procedures. TissuGlu(R) Surgical Adhesive is designed to adhere flaps of… more
Abstract:… for 50% of the recipients. However, widespread clinical application of for T1D is hindered by two critical barriers: 1) the need for systemic immunosuppression for the current intraportal liver transplant site; and 2) by the finite and low supply of human islet tissue (a… more
Abstract:…, at 1 week, 2 weeks, 6 weeks, and 12 weeks in the live animals, and at the 12 and 24-week sacrifice dates. Following necropsy joints will be evaluated byCT and gross and histological semi- quantitative scoring. In addition, mechanical properties of repair tissue, the… more
Abstract:DESCRIPTION (provided by applicant): The overall goal of this study is to develop a tissue-engineered total joint replacement from an engineered biomaterial scaffold combined with adult bone marrow-derived mesenchymal stem cells (MSCs) for regeneration ofthe entire femoral… more
Abstract:… would benefit from a less invasive procedure. Expanded use of TAVI devices will also have a positive economic impact on the healthcare system, with decreased O.R. times, shorter hospital stays, and reduced complication rates. We have developed a technology called '… more
Abstract:…, monitor pharmacodynamics and toxicities. 2) Monitor tumor responses to DM-CHOC-PEN per imaging/examinations using RECIST guidelines. 3) Electronically store/analyze clinical data for toxicity, responses and tumor-organrelationships. 4) Continue to bank tumor tissue from pre-… more
Abstract:ABSTRACT: Deployable Space Systems, Inc. (DSS), in partnership with Emcore Photovoltaics (EMCORE), proposes the development and TRL 5/6 validation of an adhesive-less photovoltaic panel assembly, termed"HSA"for High Survivability Array. Space solar array adhesives… more
Abstract:DESCRIPTION (provided by applicant): The ability to accurately detect the developing lesions at early stage in dental practice and to quantify the lesions will provide dentists with the opportunity of initiating early prophylactic treatment; correct diagnosis of a fractured tooth in is earliest… more
Abstract:…, blocks the development of HF when given prophylactically. This project attempts to confirm and expand the preclinical feasibility data and potential for IRS954 to be a novel therapy for HF with the following Specific Aims: Aim 1: Evaluate the pharmacokinetics and tissue… more
Abstract:…, but all attempts have still fallen short of an ideal ‘bio-plastic’. §The proposed concept is to demonstrate an ideal bio-plastic by using mycelium as the polymer, resin, or structural matrix. Preliminary studies have shown basidiomycete stipe tissue offers… more
Abstract:…ic and highly refractory with a melting point of>1000 & #176;C which will improve the thermal resistance of mat materials to be able to withstand 650 & #176;F minimum for 20 minutes minimum. We"ve developed a series of methods to provide excellent adhesion of our… more
Abstract:… proposes development of an infection resistant surface designed to promote normal healing for application to the transcutaneous drivelines of ventricular assist devices. Theproposed surface will incorporate a three-pronged approach to infection resistance; a low adhesion… more
Abstract:… that enable rapid measurements without significant compromise to the analytical data. Herein, we propose to develop arobust mass spectrometry (MS) based surface sampling device that enables direct analysis of a variety of materials including biological tissue and live… more
Abstract:DESCRIPTION: The ultimate goal of the Phase I SBIR project is to establish the feasibility of using ion mobility spectrometry (IMS) or liquid chromatography-IMS (LC-IMS) as a fast, selective and sensitive method for rapid monitoring of bio manufacturing processes for on-line use to improve the… more
Abstract:DESCRIPTION (provided by applicant): Adhesion formation after intra-abdominal surgery poses a significant health risk, cited as a leading cause of small bowel obstruction and female infertility. Methods to prevent these adhesions are currently limited to barrier films which are… more
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