Abstract:… in Phase I. This platform uses a nuclease protection assay combined with universal PCR to produce targeted sequencing libraries. The lysis-only protocol means there is no need to extract RNA or DNA or to reverse transcribe RNA. Consequently, sequencing from fixed tissue is… more
Abstract:… cells (CDCs), grown from a donor unrelated to the recipient, using a proprietary process exclusively licensed to Capricor. Autologous CDCs have demonstrated their utility as a regenerative agent: able to reduce infarct size (a.k.a scar size), add viable tissue mass, and… more
Abstract:… due to associated toxicities. We have focused on targeting Plasmalemmal Vesicle Associated Protein-1 (Plvap/PV1), an endothelial specific protein with roles in angiogenesis8-10 and diapedesis of leukocytes11. PV1 is expressed on a subset of endothelia in normal … more
Abstract:…. However, prior to initiating clinical studies, Immunomedicswill need to have a required PK/acute toxicity study performed in a relevant animal species (monkeys), an immunohistology study following the Points to Consider, showing the reactivity of the TF10 bsMAb with tissues,… more
Abstract:… (HBV) covalently closed circular DNA (cccDNA) formation and/or maintenance. HBV cccDNA is essential to the virus life cycle and its elimination during chronic infection is considered critical to durable therapy. However, because of the limitations of current HBV tissue… more
Abstract:DESCRIPTION (provided by applicant): Chronic gingival inflammation of the soft tissue surrounding the tooth afflicts over half of all American adults. In the most severely affected, progression of this inflammatory process to the deeper periodontal ligaments and alveolar bone… more
Abstract:… robust to dynamic motion in moist environments and under constant mechanical stresses. MC10 & UIUC jointly propose Mechanically-iNvisible electronic Tattoo (Mentat), an ultra-lightweight evolution of MC10"s existing conformal (flexible & stretchable), adhesive… more
Abstract:…. Robots are also employed with tasks that are too dangerous for humans or when movement could affect the results and success of a task. The following proposal applies nanoGrip's expertise in design, fabrication, and characterization of gecko-inspired microfiber adhesives… more
Abstract:…ap shear strength performance as control hook and loop closures while demonstrating several magnitude order better resistance to vapor permeation such systems. This will be accomplished through a new closure system proposed to be based on polymer microfiber adhesives inspired by… more
Abstract:DESCRIPTION (provided by applicant): Scleroderma is an autoimmune, connective tissue disorder which causes fibrosis of the skin and internal organs. In the skin, there is overproduction of extracellular matrix, and type 1 and 3 collagen. The disease involves vascular breakdown… more
Abstract:… with other organic wastes in the on-board waste processing equipment and marine biodegradable as defined by ASTM D7081 standard. As part of Phase I, NTIC investigated (1) three classes of biobased, non-plastic materials that function as a coating or as an adhesive depending… more
Abstract:…. Operative Experience, Inc. proposes to meet this requirement through the development of a training program based on an anatomically accurate, vascularized, human body simulator with standardized size and weight, standardized artificial blood vessels and tissues, standardized… more
Abstract:…H RELEVANCE PUBLIC HEALTH RELEVANCE: The goal of this proposal is to develop a compact Selective Cytopheretic Device (cSCD), an extracorporeal membrane device that can sequester activated leukocytes and inhibit their inflammatory activity in order to reduce tissue accumulation… more
Abstract:… by providing novel polymer brush-like architectures to the culture surface to reduce protein adsorption, and allow efficient hydration to release the strongly adherent cells. Moreover, addition of functionalities to polymer brush-like architectures will increase the adhesive… more
Abstract:…differing thermal conductivity characteristics.
The objective of this project is to achieve a revolutionary improvement of the bonding process between highly dissimilar materials used in various industrial applications. The proposed technology is applicable to both adhesive and… more
Abstract:DESCRIPTION (provided by applicant): MALDI tissue imaging, when enabled by Nanoparticulate (NP) Matrix implantation, is maturing into a useful preclinical tool for biomarker and drug discovery in our laboratory and at NIDA-IRP. Quantitatively reproducibleimages from serial… more
Abstract:… extremely low frequency emissions (ELF) influence hair dryer design as well as power-line placement. Cell-phones are scrutinized using measures of radiation absorption. Laser pointers, police traffic radars, and microwave ovens must also be designed using models of the tissues… more
Abstract:… goal is to continue to demonstrate its wide applicability and utility by customizing the method for serial chest CT registration. Second, it is hypothesized that using physically-inspired heuristics to model the patient-specific, inhomogeneous elasticity of lung tissue will… more
Abstract:…vided by applicant): This application addresses Innovations in Biomedical Computational Science and Technology Initiative PAR-09-220. Healthcare is moving towards fully digitized patient records. Surgical pathology represents a challenge inthat high resolution imaging of tissue… more
Abstract:…ce in the presence of an adjuvant. We will demonstrate that this immunization protocol results in the appearance of anti-Borrelia antibodies. Immunized animals will then be challenged with 104 live Borrelia spirochetes. Twenty-one days after challenge we will collect tissue… more
Abstract:DESCRIPTION (provided by applicant): Recent advances in photoacoustic tomography (PAT) have demonstrated its potential for 3D noninvasive high resolution imaging of soft tissues at penetration depths of many centimeters. Further, and perhaps even more importantly, imaging of… more
Abstract:… They reduce weight and improve fuel efficiency. Composite structures are now incorporated into aircraft by all major aerospace manufacturers. Many composite structures are assembled with fasteners, but, to meet future design requirements, manufacturers need adhesive bonding… more
Abstract:… control of gene expression using long-wavelength (700-750 nm) light. In addition to avoiding the side effects and costs associated with drug-based systems, light-inducible control offers the advantages of precise spatial and temporal targeting of individual tissues and… more
Abstract:DESCRIPTION (provided by applicant): The genetic basis of disease remains a significant research problem, impacting the fields of cancer biology, neurology, cardiology, development, and even microbiology, as recently realized by the Human Microbiome Project. Determination of the genomic sequence… more
Abstract:… new type of anti-corrosion coating has been devised to address the problem. The proposed coating utilizes the characteristic of self-assembly, to achieve extremely even coatings on complex geometries. The coating is applicable to multiple surface types with good adhesion and… more
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