Abstract:…translation modifications in proteins analyzed in tandem mass spectrometers. The source can be easily incorporated into a design of a varietyof tandem mass spectrometers. This will allow much better detection of disease-specific biomarkers from biological fluids or tissues… more
Abstract:…e plan to develop a novel detection system that will improve sensitivity and dynamic range of the FTMS systems by a factor of 10or more, which will allow much better characterization of disease-specific biomarkers in the FTMS-based analysis of biological fluids or tissues… more
Abstract:The objective is to develop approaches are sought for sample preservation of nucleic acids from blood products or other sample for storage at room temperature conditions. The goals of the project are to: 1) determine preferable tissue for nucleic acid archiving; 2) investigate… more
Abstract:… MPSI in humans: (i) Which AAV serotype is most effective in mediating gene transfer into human neuronal cells? To address this question, we will compare the effectiveness of AAV8, AAV9 and AAVrh.10 for gene transfer efficiency in human neuronal primary cultures and brain … more
Abstract:…na. The gene delivery vector belongs to a new family of adeno-associated virus (AAV) serotypes that we identified and which perform substantially better than previously available gene transfer technologies. Recombinant AAV gives stable gene expressionin non-dividing tissues… more
Abstract:…, to establish protocols for the procedure and to gather preliminary clinical data. Breast cancer patients will receive a 14C-oxaliplatin microdose a few hours prior to normal biopsy. DNA will be isolated from white blood cells and left over tumor biopsy tissue. Drug-DNA… more
Abstract:… non-vital endodontic use to make the clinical procedures shorter and more consistent, of benefit to the patient and clinician,and enhance the probability for a positive outcome. The new material should promote regeneration of the periodontal ligament and cemental tissues that… more
Abstract:… by applicant): Dental implants have very high survival rates and are the fastest growing field in dentistry. But, high complication rates result in significant morbidit, cost, and disappointment. Better pre-operative knowledge of softtissue thickness and hard tissue… more
Abstract:…imultaneous and continuous detection of multiple pesticides. Part of this work will be preservation and shelf life testing of thesensor and optimization for automated use in waste water and food processing plants. We will use computational physics to predict adhesion strength of… more
Abstract:… of metal I-125 or Cs-131 seeds, originally designed for prostate cancer, sewn to a bio-absorbable vicryl mesh. The device is not optimal for treating lung cancer. The device emits radiation in all directions and delivers radiation to otherwise healthy tissue. It is… more
Abstract:DESCRIPTION (provided by applicant): Approximately 25% of the products being developed by the biotechnology industry are antibodies and many of these antibodies are directed to epitopes on human cells and tissues. We are proposing a novel concept for the production of antibodies… more
Abstract:… that block HIV infection could potentially be used therapeutically in HIV+ individuals to reduce viral load and disease progression, and could also be used prophylactic ally to reduce transmission between individuals if present in the appropriate mucosal tissues. An… more
Abstract:… independent of petroleum sources is a key goal of the emerging bio-based economy. Lastly, many protein polymers (including silk) are biocompatible and biodegradable and thus can form the basis for new classes of medical materials used to replace or re-grow connective tissues… more
Abstract:…. Image-guided TPPDT, in which the irradiation of the tumor is controlled by its digitized image throughout the 3D volume of the tumor, will define and incorporate optical tumor margins to ensure that the entire tumor is treated. Planned image-defined tumor treatment in tissue… more
Abstract:… Phase II project seeks to address the unmet need for high-throughput, cost effective tools to model the metastasis of brain cancer cells. The proposed Phase II work will achieve three key objectives necessary for broad adoption: 1) eliminating the use of adhesive during… more
Abstract:… of the abrasive treatments characteristic of cell proliferation assays currently on the market. The company plans to develop new methods for the usage of its technology with Fluorescently Activated Cell Sorting (FACS) protocols and testing different formats, such as tissues and… more
Abstract:…ort lived. The object of this project is t produce a product that can occlude patent dentinal tubules (the causeof DH) and adhere to the wet interior surface of the dentinal tubules. The research goal of this study is to optimize the fluorapatite (FA) crystal/polymer of adhesive… more
Abstract:…nd bacterial adherence; Phase 2 will scale up manufacturing and evaluate toxicity in preparation for human trials. The rationale for this research is to mimic the function of the endothelium.Low levels of NO released by the normal endothelium inhibit platelet adhesion and… more
Abstract:… (PVD) processes and to Atomic Layer Deposition. This deposition process allows virtually any arbitrary metal oxide to be easily deposited with high quality allowing different high-k dielectrics to be straightforwardly evaluated. The coatings have high adhesion, are… more
Abstract:… is an important molecular diagnostic tool in the differential diagnosis that includes lymphoid hyperplasia, atypical lymphoid hyperplasia, chronic inflammation, and B cell neoplasms. Current methods of LCR identification in formalin fixed paraffin embedded (FFPE) tissue… more
Abstract:… strategies often increasemorbidity and mortality following hemorrhage. Augmenting negative intrathoracic pressure, even without fluid resuscitation, improves hemodynamic parameters and outcome in adult porcine hemorrhagic shock. Vascular biology, physiology, and tissue… more
Abstract:… screening tests. Phase II testing validates the Zn-Ni IZ-C17+ with IZ-264 post treatment process in comparison to LHE cad utilizing industry accepted requirements for threaded fasteners / components for process installation, corrosion, thickness, fatigue, adhesion, hydrogen… more
Abstract:…ovel therapeutic options. The use of anti-EGF-R and anti v-EGF therapies has proven the potential of targeted therapies and monoclonal antibody approaches. The development ofnovel therapy against target critical and specific to the cancer cells but not to the normal tissues is… more
Abstract:… the behavior of pristine, degraded, defective, and damaged bonded joints in composites structures. The tool will include a multi-physics module with numerical formulations for describing the process-driven and environmentally-impacted behaviors of the adhesive and the… more
Abstract:DESCRIPTION (provided by applicant): Neuropathic pain is a complex, chronic pain state that is usually initiated by tissue injury and maintained, in part, by subsequent dysfunction of damaged peripheral nerve fibers or fibers that innervate that injured tissue. The impact of… more
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