Abstract:DESCRIPTION (provided by applicant): The overall goal of this study is to develop a tissue-engineered total joint replacement from an engineered biomaterial scaffold combined with adult bone marrow-derived mesenchymal stem cells (MSCs) for regeneration ofthe entire femoral… more
Abstract:… would benefit from a less invasive procedure. Expanded use of TAVI devices will also have a positive economic impact on the healthcare system, with decreased O.R. times, shorter hospital stays, and reduced complication rates. We have developed a technology called '… more
Abstract:…, monitor pharmacodynamics and toxicities. 2) Monitor tumor responses to DM-CHOC-PEN per imaging/examinations using RECIST guidelines. 3) Electronically store/analyze clinical data for toxicity, responses and tumor-organrelationships. 4) Continue to bank tumor tissue from pre-… more
Abstract:ABSTRACT: Deployable Space Systems, Inc. (DSS), in partnership with Emcore Photovoltaics (EMCORE), proposes the development and TRL 5/6 validation of an adhesive-less photovoltaic panel assembly, termed"HSA"for High Survivability Array. Space solar array adhesives… more
Abstract:DESCRIPTION (provided by applicant): The ability to accurately detect the developing lesions at early stage in dental practice and to quantify the lesions will provide dentists with the opportunity of initiating early prophylactic treatment; correct diagnosis of a fractured tooth in is earliest… more
Abstract:…, blocks the development of HF when given prophylactically. This project attempts to confirm and expand the preclinical feasibility data and potential for IRS954 to be a novel therapy for HF with the following Specific Aims: Aim 1: Evaluate the pharmacokinetics and tissue… more
Abstract:…, but all attempts have still fallen short of an ideal ‘bio-plastic’. §The proposed concept is to demonstrate an ideal bio-plastic by using mycelium as the polymer, resin, or structural matrix. Preliminary studies have shown basidiomycete stipe tissue offers… more
Abstract:…ic and highly refractory with a melting point of>1000 & #176;C which will improve the thermal resistance of mat materials to be able to withstand 650 & #176;F minimum for 20 minutes minimum. We"ve developed a series of methods to provide excellent adhesion of our… more
Abstract:… proposes development of an infection resistant surface designed to promote normal healing for application to the transcutaneous drivelines of ventricular assist devices. Theproposed surface will incorporate a three-pronged approach to infection resistance; a low adhesion… more
Abstract:… that enable rapid measurements without significant compromise to the analytical data. Herein, we propose to develop arobust mass spectrometry (MS) based surface sampling device that enables direct analysis of a variety of materials including biological tissue and live… more
Abstract:DESCRIPTION: The ultimate goal of the Phase I SBIR project is to establish the feasibility of using ion mobility spectrometry (IMS) or liquid chromatography-IMS (LC-IMS) as a fast, selective and sensitive method for rapid monitoring of bio manufacturing processes for on-line use to improve the… more
Abstract:DESCRIPTION (provided by applicant): Adhesion formation after intra-abdominal surgery poses a significant health risk, cited as a leading cause of small bowel obstruction and female infertility. Methods to prevent these adhesions are currently limited to barrier films which are… more
Abstract:…cing conditions are encountered to perform de-icing of the wing leading edge. Ultrasonic de-icing is achieved by driving the actuators to create ultrasonic shear stresses at the substrate/ice interface such that the ultrasonic stresses are greater than the adhesion strength of… more
Abstract:… also enables destructive biochemical processes. While numerousadjunctive therapies for acute myocardial infarctions (AMI) have been studied, innovative combination therapies are needed. Both hypothermia and gradual reperfusion have shown benefit in terms of saving heart tissue… more
Abstract:… prototype (microarrays, PCR reagents, Hybridization Reagents, Specialized Software) for subsequent Beta Testing. This kit will be prepared under manufacturing control (ISO 13845) similar to the HLA-Chip products from GenUSA which are currently being launched into tissue… more
Abstract:…mster flank, reduced the size of this organ but only on the ipsilateral side These results suggest that this drug is a soft antiandrogen , expected to be active topically inandrogen-dependent maladies of the skin and scalp, but to be hydrolyzed by plasma or tissue enzymes, thus… more
Abstract:… medicine and drug discovery. To realize the much-heralded promise of personalized medicine, it is necessary to (a) accurately recognize and distinguish disease subtypes, (b) apply these diagnostic signatures at the level of the individual patient (and tissue type) over… more
Abstract:… Chemical Vapor Deposition (iCVD) process. In this solvent-free process, GVD creates the pure PTFE fluoropolymer from reactive precursor vapors and deposits the PTFE as a uniform coating at the same time. Using iCVD, GVD and optimize PTFE’s surface energy, adhesion, and… more
Abstract:… in Phase I. This platform uses a nuclease protection assay combined with universal PCR to produce targeted sequencing libraries. The lysis-only protocol means there is no need to extract RNA or DNA or to reverse transcribe RNA. Consequently, sequencing from fixed tissue is… more
Abstract:… cells (CDCs), grown from a donor unrelated to the recipient, using a proprietary process exclusively licensed to Capricor. Autologous CDCs have demonstrated their utility as a regenerative agent: able to reduce infarct size (a.k.a scar size), add viable tissue mass, and… more
Abstract:… due to associated toxicities. We have focused on targeting Plasmalemmal Vesicle Associated Protein-1 (Plvap/PV1), an endothelial specific protein with roles in angiogenesis8-10 and diapedesis of leukocytes11. PV1 is expressed on a subset of endothelia in normal … more
Abstract:…. However, prior to initiating clinical studies, Immunomedicswill need to have a required PK/acute toxicity study performed in a relevant animal species (monkeys), an immunohistology study following the Points to Consider, showing the reactivity of the TF10 bsMAb with tissues,… more
Abstract:… (HBV) covalently closed circular DNA (cccDNA) formation and/or maintenance. HBV cccDNA is essential to the virus life cycle and its elimination during chronic infection is considered critical to durable therapy. However, because of the limitations of current HBV tissue… more
Abstract:DESCRIPTION (provided by applicant): Chronic gingival inflammation of the soft tissue surrounding the tooth afflicts over half of all American adults. In the most severely affected, progression of this inflammatory process to the deeper periodontal ligaments and alveolar bone… more
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