Abstract:… that is faster and less expensive than traditional methods. Improved capability of monitoring exposure will have positive public health outcomes, as long- term exposure to arsenic is associated with health problems including cancer and cardiovascular disease. The phase… more
Abstract:DESCRIPTION (provided by applicant): Electrochemical Home Monitoring System for Lithium Blood Level Over the past 50 years, pharmaceutical lithium has been one of the most widely-used and prescribed drugs for the effective treatment of bipolar disorder andother manic disorders.… more
Abstract:? DESCRIPTION (provided by applicant): Diabetes is a major health care problem that has reached crisis proportions. The disease accounts for gt14% of total national health care expenditures in the US and untold losses of precious human resources, and new therapies are… more
Abstract:DESCRIPTION (provided by applicant): Guild proposes to develop an antisense oligomer-based antifungal effective against the human pathogen Aspergillus fumigatus. With a 40%-60% mortality rate, invasive aspergillosis (IA) due to A. fumigatus now surpasses invasive candidiasis as the most frequent… more
Abstract:… (provided by applicant): Non-variceal upper gastrointestinal bleeding (NVUGIB) is a major cause of morbidity and mortality worldwide. Incidence of NVUGIB in the US is 53 events per 100,000 adults, with approximately 160,000 hospital admissions annually. US treatment and… more
Abstract:ABSTRACT: Aircraft engine and structural components are being produced from forgings with increasingly complex geometries in a wide range of aerospace alloys. The forging process involves a number of steps required to attain favorable material properties (e.g., heat treatment,… more
Abstract:…ding the mechanical stimulus required to lessen the burden of osteoporosis. The near-term goal of the project is to address a select subset of unilateral knee muscle weakness pathologies while creating the framework that can be used with a broad spectrum of diseases and injuries… more
Abstract:? DESCRIPTION (provided by applicant): This NIH Bridge Grant will result in a conduction cooled, liquid helium free, MRI background magnet for a commercial image guided radiation treatment (IGRT) for cancer treatment. The program will ensure the successful continued… more
Abstract:… not destroy the HIV-1 provirus. In addition, ARV does not impact the large reservoir of latent HIV-infected cells present in lymphoid tissues and in the gut of infected patients. Moreover, patients must remain on ARV for life, or viral replication will resume once treatment… more
Abstract:DESCRIPTION (provided by applicant): Today, systemic sclerosis (SSc) clinical trials generally include all subsets; some may benefit, others do not, confounding measures of efficacy. Because each expression subset has a different underlying deregulated molecular pathway, no single drug is expected… more
Abstract:DESCRIPTION (provided by applicant): Recent research on the treatment of first-episode psychosis has documented positive results and hope for better long-term outcomes for consumers and their families. In particular, the NIMH-funded RISE study (Recovery after an Initial… more
Abstract:… the product's feasibility and the need for a large-scale randomized trial to determine the tool's effectiveness. During Phase I, participants in the Simulator group showed significant improvements in MI skills as measured by Motivational Interviewing Treatment… more
Abstract:… keep actuators functioning at a high availability rate. In order to provide improved wear and damage tolerance of stainless steel and steel ball screws/jack screws for aircraft subsystems, IBC Materials and Technologies Inc. will develop a novel dual-layer surface … more
Abstract:Modern aircraft make extensive use of fasteners made of steel, titanium, nickel and other alloys mated with aluminum and composite airframe materials. This coupling of dissimilar materials yields galvanic corrosion issues, which degrades mechanical integrity, is costly to inspect, and poses a safety… more
Abstract:DESCRIPTION (provided by applicant): Malaria can be a life-threatening disease, especially in children, if left untreated. According to WHO, 525,000 to 2.0 million African children die from Malaria every year. The current gold standard for diagnosis is examination of Giemsa… more
Abstract:…ffusion of vorticity in the vortical flow regions. The remaining challenge is to remove the tuning of model parameters to make the method truly predictive and robust. We will develop a fully adaptive VC (AVC) method based on a new formulation. Auxiliary numerical treatments… more
Abstract:DESCRIPTION (provided by applicant): HIV-1 causes the largest number of deaths from a single infectious agent in the world today. Despite considerable advances in treatment of HIV-1 infection and AIDS, which it causes, there is an urgent need for better methods of prevention and… more
Abstract:DESCRIPTION (provided by applicant): Lyme disease is the most prevalent vector-borne disease in the U.S., with about 30,000 cases per year reported by CDC and a range now covering 24 states. Early diagnosis and treatment of Lyme disease is important to… more
Abstract:… areas are expanding. Melioidosis is difficult to trea and diagnose due to the fact that B. pseudomallei is resistant to common antibiotics and symptoms are non-specific. Mortality rates reach 45% and 20% in Thailand and Australia respectively, even with antibiotic treatment.… more
Abstract:… (King et al., 2011). As headaches become more frequent and severe,the negative impact on happiness increases and adolescents report less satisfaction with their health and with their life (Sillampaa, 1983). There are a number of challenges associated with treatment, including… more
Abstract:… predominately lack sufficient ability to prevent unintended actions on cohabitating species. Using proven embedded sensor and signal processing technology, traditional and emerging baiting and bioagent delivery techniques can be augmented to prevent inadvertent treatment to… more
Abstract:Significant challenges remain for the designers of life support equipment for spacecraft?primarily for the processing of aqueous fluids: oxygen supply, air revitalization, thermal management systems, water reclamation, medical fluids, and others. The main problem is that failure-prone processes are… more
Abstract:DESCRIPTION (provided by applicant): Over 5 million Americans are currently believed to have Alzheimer's disease (AD), the most common form of dementia. This number could reach 16 million by 2050. AD is a terminal, progressive brain disorder with no knowncause or cure. AD… more
Abstract:… human health due to its toxicity and bioaccumulation via the food chain. Elevated exposure to Hg can affect the liver, kidneys, and cardiovascular, gastro-intestinal, and neurological systems of the human body. Inorganic Hg (Hg2+) can cause chronic kidney disease (CKD) and… more
Abstract:… infrared microbolometer technology. The iREyes will also identify hot spots associated with repetitive stress to reduce ulceration risk. Diabetic foot wounds are common, complex and costly. Foot areas that are likely to ulcerate are associated with increased local skin… more
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