Abstract:…cess for encapsulation of probiotic candidates will be developed to extend shelf life and confer resistance to degradation in gastric and bile environments. A Phase II plan will be developed to demonstrate the safety of the probiotic and evaluate its efficacy in the treatment of… more
Abstract:DESCRIPTION (provided by applicant): Intraoperative imaging techniques are used by neurosurgeons in the treatment for primary brain tumors such as gliomas to achieve maximal surgical resection of pathological tissue while leaving essential areas intact. Current imaging… more
Abstract:…to fit the void by the surgeon at time of implantation. Akina recently completed an initial Phase II study using its hydrogel-based reshapable swelling tissue expanders (Restiex(R)). The study validated the function of Restiex to generate additional tissue of rat skin as well as… more
Abstract:DESCRIPTION (provided by applicant): Of all diseases, tuberculosis (TB) represents one of, if not, the greatest health disparity between whites and minorities . For every TB-infected white person in the United States, there are an estimated 9 African- Americans, 8 Latinos, 6… more
Abstract:"Measles is a highly contagious, human disease that is spread by the respiratory route, and, in the developing world, remains a leading cause of death due to vaccine-preventable infectious diseases in children younger than 5 years. The most recent estimates are that there were… more
Abstract:…and societal problems. The result is significantly decreased health and well-being and increased education and healthcare costs. The U.S. Department of Health and Human Services has established an ambitious goal of eliminating lead poisoning in children. The Centers for Disease… more
Abstract:… iPSCs and expose them to methamphetamine and withdrawal in order to analyze the electrophysiological properties of patient-specific neurons versus controls, etc. Even though it is considered a technology with great potential in studies of addiction or other diseases,… more
Abstract:… in human blood. CD4 cell counts are needed to stage and monitor HIV-infected patients. In adults, the absolute number of CD4+ T cells per microlitre of blood has critical prognostic and therapeutic implications, and is used for both HIV staging and treatment… more
Abstract:… is a portable, low-cost sensor product which meets the needs from the water quality monitoring market, a growing sector with a compounded annual growth rate of 4.6%. The implementation of chlorination disinfection systems has virtually eliminated waterborne diseases in the… more
Abstract:DESCRIPTION (provided by applicant): Organ transplantation is a lifesaving option for those with end stage renal disease. In spite of many improvements in organ procurement, transplant procedures and immune suppression, the damage done by ischemia-reperfusion injury (IRI)… more
Abstract:… RNA-based therapeutics. PUBLIC HEALTH RELEVANCE PUBLIC HEALTH RELEVANCE: Functional RNA molecules such as aptamers, miRNAs, and siRNAs have exciting potential as therapeutics in areas such as viral infections, cancer, genetic disorders, and neurological diseases.… more
Abstract:… utilized animal model of MS. If successful, this project will provide the basis for further testing ASC-101 technology in additional animal models of MS using NSCs.PUBLIC HEALTH RELEVANCE PUBLIC HEALTH RELEVANCE: Neural stem cells (NSCs) have the potential for treatment of… more
Abstract:… imaging based on AFM based tip enhanced IR ablation (nanoIR-MS). b) to apply this technique towards the application ofSingle cell imaging. Information on the chemical composition within a cell has implications in the understanding of cell metabolism, division, disease… more
Abstract:DESCRIPTION (provided by applicant): Liver fibrosis is a form of scar formation that is found in almost all patients with chronic injury to the liver. Over time it frequently progresses to cirrhosis, an end-stage lethal disease which is the seventh leadingcause of death in the… more
Abstract:…nt): The renin-angiotensin-aldosterone system (RAAS) plays a critical role in renal physiology. Inhibitors of angiotensin-converting enzyme (ACE) or angiotensin receptor blockers (ARB) are the mainstay in the clinical management of renal disorders such as chronic kidney disease… more
Abstract:… inhibitors with activity in vitro and in vivo. The lead SK2 inhibitor, designated as ABC294640, has antitumor and anti-inflammatory activitiesin several in vivo models, while exhibiting very low toxicity to the animal. Our Preliminary Studies indicate that treatment of mice … more
Abstract:… in patients following traumatic joint injuries. This observation, coupled with the rapid joint surface disruption in lubricin null mice, suggest that preserving or restoring the lubricant could play a major role in mitigating the risk of degenerative joint disease in patients… more
Abstract:…llowing: (1) refinement of grain size; (2) reduced propensity to form porosity; and (3) promote fracture toughness. Its processing parameters will be targeted to maximize basketweave microstructure throughout the deposit and to eliminate the need for post process HIP treatment.… more
Abstract:… desensitization in a compelling manner. The intention is to generate three potential vaccine candidates for evaluation by an external advisory board. In addition to new innovative allergy products, this work will help us understand the mechanisms of IgE-mediated disease… more
Abstract:…ial sea salt mixtures or transport of saltwater from offshore sites. The direct filtration process is a simplified strategy for implementing a coagulation/flocculation process. Coagulation and flocculation aids have long been used in the drinking water and wastewater treatment… more
Abstract:DESCRIPTION (provided by applicant): Lung infections by Mycobacterium avium and Mycobacterium abscessus are increasing in incidence. Diseases caused by both Mycobacteria are common in patients with chronic lung conditions, such as cystic fibrosis (CF), non-CF bronchiectasis and… more
Abstract:DESCRIPTION (provided by applicant): Although recurrent microaspiration of refluxed gastric fluid ( GER with microaspiration ) is suspected in the onset and course of many diseases of the lungs and airways, the lack of a non-invasive, direct test for its occurrence has hampered… more
Abstract:… countries, Pap testing has not been implemented, mostly due to the high degree of medical infrastructure needed. In many rural low-resource settings, it proves difficult to relocate women with a positive cytology result and bring them back for follow-up treatment to the… more
Abstract:DESCRIPTION (provided by applicant): Higher vegetable intake has been related to lower risks of diabetes, cardiovascular disease, several cancers, and obesity/adiposity later in life. Yet, children are eating vegetables well below recommended amounts. Parents are important… more
Abstract:… 500,000 cases annually of active infection in the US. The currently-used triple therapy is a combination of a proton pump inhibitor and broad spectrum antimicrobials, usually amoxicillin and clarithromycin. A recent meta-analysis of clinical data showed that treatment failure… more
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