Abstract:… and controlled release of sequestered DTX. For newly diagnosed ovarian cancer patients,a majority of whom rapidly progress to a chemoresistant state, NMI's nanomedicine offers a solution that is urgently needed for treating patients with refractory disease, which… more
Abstract:…nt): Age-related macular degeneration (AMD) is the leading cause of vision loss and blindness in people over age 60 in the developed world. Progression of this disease results in the loss of the ability to perform activitieshighly correlaed with quality of life. This disease… more
Abstract:… also demonstrate the efficacy of IOs for orally delivering phytase and probiotics to marine finfish. These efforts will directly address the primary limiting factors of the development of a domestic marine aquaculture industry; nutrient utilization, pollution, and disease… more
Abstract:… association, and to incorporate these methods into existing, widely used software packages that will servethe needs of data analysts in pharmaceuticals, epidemiology, public health, and other fields seeking to better understand the genetic causes of complex disease. The… more
Abstract:DESCRIPTION (provided by applicant): For twenty years prolonged extracorporeal life support (ECLS ECMO) has been standard treatment for infants with severe heart or lung failure unresponsive to other treatment. The healthy survival rate in over 30,000 cases ranges from 40% in… more
Abstract:… percent of adults are affected by SDB, which can lead to daytime sleepiness, impaired cognitive functioning, automobile accidents, stroke, hypertension, and heart failure. Continuous positive airway pressure (CPAP) is currently an effective but expensive treatment, and the… more
Abstract:… defined as born more than 3 months before the expected date of birth, is very high. The current approach of positive pressure gas ventilation carries high risks of mechanical trauma and oxygen toxicity to the lungs. A major paradigm shift in the post-natal treatment of… more
Abstract:DESCRIPTION (provided by applicant): Iron deficiency is frequently encountered in chronic kidney disease (CKD) patients and many other populations. Current oral iron formulations are poorly tolerated. Injectable iron preparations are difficult to administer, costly and have… more
Abstract:… delivering these drugs to the brain and central nervous system (CNS). The promise of plant-made bioproduction has recently been recognized with the FDA approval of Elelyso (taliglucerase), Protalix/Pfizer's plant-made glucocerebrosidase ERT for Gaucher Disease. If… more
Abstract:… and materials, nanopore technology is considered a key piece of attaining the goal of sequencing genomes at low costs and in a rapid manner. This will have significant impacts on human health, including improved understanding of genetic causes of disease,… more
Abstract:… and often fail to be sustained over time. A growing body of literature demonstrates how implementation quality is directly related to the likelihood an EBI will be embedded into everyday practice, as well as the likelihood that the EBI achieves its intended treatment… more
Abstract:… II development and testing plan based on Phase I findings. Phase I research is expected to demonstrate strong support for the proposed product. With this foundation, Phase II full product development will begin followed by a randomized clinical trial examining treatment… more
Abstract:DESCRIPTION (provided by applicant): Obesity is considered the number one health problem in the US and Europe, affecting 10% to 30% of adult populations. Obese individuals are more likely to acquire a variety of secondary diseases including diabetes, heartproblems, immune… more
Abstract:DESCRIPTION (provided by applicant): The program outlined in this application has been designed to accelerate the development and commercialization of a Glucagon Mini-Dose Pen to change the paradigm for treatment of moderate hypoglycemia in insulin-using diabetics. This research… more
Abstract:DESCRIPTION (provided by applicant): The objective of this program is to further the development of a novel, stable, non-aqueous glucagon formulation as an integral component of a bi-hormonal (insulin-glucagon) pump system for treatment of persons with diabetes. The addition of… more
Abstract:…nd betterment of health of these dolphins in captivity is a priority in order to improve the fitness and readiness of these animals for defense missions. Accacia International proposes to develop probiotic pharmaceuticals to treat and prevent gastrointestinal diseases in… more
Abstract:… by applicant): The aim of this innovative proposal is to commercialize a non-invasive topical product that treats uveitis which is safe and easy to administer. Uveitis is the third leading cause of blindness in the United States. Heretofore, the primary treatment of… more
Abstract:We propose to enhance the capability of ASTRAL/ASPM by adding to it a treatment of several physical phenomena. Several methods enabling these new features have been developed and tested in recent years and are mature enough for transition. Efforts will be made to ensure the… more
Abstract:… the threat of lawsuits. The huge oil sand wastewater tailing ponds near Fort McMurray, Alberta, which are representative of vast unconventional US hydrocarbon resources (e.g., Green River, UT), are rendered toxic principally by napthenic acids at<100 ppm. Treatment… more
Abstract:… is at least 10.9 billion based on a recent market survey. Also, a greater understanding of selective sensing would enable alternative applications for the technology, including: low-cost, chronic, in vivo sensors for neurotransmitters, alcohol, metabolites and disease… more
Abstract:… genetic links are established with cancer, the utility of one-gene-one-test diagnostics is diminished. In addition, biopsies are mixed populations of tumor and normal tissue, requiring deconvolution oftumor and non-tumor genoptypes to accurately understand disease etiology… more
Abstract:Impairments to proper cognitive functioning are among the most common problems associated with traumatic brain injury. Treatment for cognitive dysfunction is central to recovery after TBI due to the profound impact cognitive dysfunction can have on an individual’s independence… more
Abstract:… and abroad have found that improved glycemic control benefits people with diabetes. In general, every percentage point drop in A1C blood test results, for example, from 8.0 to 7.0 percent, can reduce the risk of microvascular complications-eye, kidney, and nerve diseases-by… more
Abstract:…, specific, high affinity antipeptide affitnity reagent to be successfully used in mass spec based cancer biomarker detection methods such as SISCAPA, for the analysis of patient plasma. Early detection of cancer is a key to successful and cost effective treatment. Routine… more
Abstract:DESCRIPTION (provided by applicant): MRI cerebral perfusion imaging is a widely disseminated technique on nearly all MRI scanners used for clinical diagnosis of brain disease and for neuroscience research. Over the last five years there has been considerably increased use of… more
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