Abstract:… be guided by well- established models of adult learning, the Health Belief Model, and AHRQ's health literacy guidelines for public websites. The second study milestone is the production of a functioning website, which will be pilot tested among older non-treatment seeking… more
Abstract:DESCRIPTION (provided by applicant): Tumor necrosis factor (TNF)-alpha plays a pro-inflammatory role in aging-related neurodegenerative diseases, such as Alzheimer's disease or Parkinson's disease. The biologic TNF inhibitors (TNFI), such as the… more
Abstract:DESCRIPTION (provided by applicant): Metachromatic Leukodystrophy or MLD, is a genetic disease that affects the lysosomal enzyme, arylsulfatase A (ASA). People born with MLD develop extensive lysosomal storage product accumulation in tissues, including thebrain. Children with… more
Abstract:… is an essential component of health care in aging population. Currently,there is no effective tool available to measure hydration status and distinguish those at risk. The reliability and validity o current hydration assessment methods and criteria such as thirst, skin… more
Abstract:… Tactile Imager (VTI) for real time 3-D elasticity imaging and quantitative characterization of pelvic floor tissues. Based on the clinical data VTI has the potential to predict women risk of developing pelvic prolapse, aid in staging and individually optimized treatment… more
Abstract:… monitoring is a common tool for physicians treating patients with acute intracranial hypertension caused by neurological disorders, trauma, and stroke. Knowledge of a patient's ICP progression aids the physician in determining the optimal medical and/or surgical treatment… more
Abstract:This Small Business Research (SBIR) Phase I project tests the application of a thermally responsive biopolymer, simultaneously to deliver breast cancer therapy and to prevent disease recurrence. Encouraging responses to multimodal treatments (surgery, radiotherapy, chemotherapy)… more
Abstract:DESCRIPTION (provided by applicant): Cardiovascular disease (CVD) represents a significant unmet medical need with over 1 million patients in the United States suffering from acute myocardial infarction (AMI) each year. This epidemic of heart attacks alsorepresents a risk factor… more
Abstract:…, hypoxic-ischemic injury, and spinal cord injury among others. Athersys, Inc., and the University ofTexas Medical School at Houston have a collaborative research agreement in place for the development of proof-of-concept studies in vivo and in vitro for the treatment of TBI and… more
Abstract:DESCRIPTION (provided by applicant): The broad long-term goal of this research is to reduce morbidity due to arthritis by developing long-lasting injectable intra-articular drug delivery systems. Intra-articular steroids have been a mainstay of treatment for arthritis for more… more
Abstract:Oral mucositis (OM) is a common side effect in oncology patients receiving radiation treatment. Mucosal breakdown causes pain which leads to increased use of narcotic analgesics and restriction of food intake. OM often progresses to septicemia, increasinghospital stays and costs… more
Abstract:… Array (MEA) technology todeliver the first ever high throughput MEA-based screening system. This development will not only enable rapid advancements in the study of basic network-level electrophysiology, but it will also create new opportunities for CNS disease modeling… more
Abstract:Flying insect vectors and the diseases they transmit continue to be a significant source of concern for United States service members deployed in field operations. In an effort to reduce contact between the vectors and humans, military entomologists are often required to… more
Abstract:DESCRIPTION (provided by applicant): Nicotine addiction poses a serious public health problem in the United States. Cigarette smoking alone has been identified as the cause of numerous diseases, including cancers (e.g., lung, bladder, kidney, and oral cancers, among others),… more
Abstract:… to routinely assessand periodically reassess each patient's risk for falling and to take action to reduce the risk of falling. Furthermore, recent changes to Medicare policy limit and, in some cases, prohibit reimbursement to institutions for the treatment of… more
Abstract:… regulation. In order to compete, catfish producers must become more efficient. Research has shown that hybridization of channel catfish eggs and blue catfish sperm produce progeny that exhibit faster growth, improved feed conversion efficiency, and improved disease resistance… more
Abstract:…e Food and Drug Administration (FDA). Project DescriptionPUBLIC HEALTH RELEVANCE PUBLIC HEALTH RELEVANCE: Improving current methodologies for detecting low levels of hepatitis C virus (HCV) should help public health by allowing early differentiation between healthy and disease… more
Abstract:DESCRIPTION (provided by applicant): Our goal is to develop a new molecular entity with a novel mechanism of action for targeting and eliminating glioblastoma multiforme (GBM, high grade glioma), a deadly and invasive brain tumor with no effective treatment. Of the 12,000… more
Abstract:… change in the structure of a biomolecule such as a protein. For a given protein, different structural changes produce different functionals effect in a biological cell, for example turning biochemical networks on or off. Virtually all biological processes, and all diseases,… more
Abstract:DESCRIPTION (provided by applicant): A key component in any investigation of association and/or cause-effect relationships between the environment (e.g. air pollution, heat waves) and health outcomes (e.g. asthma, heart disease, cancer) is the availabilityof accurate models of… more
Abstract:DESCRIPTION (provided by applicant): Diabetes is a serious, life-threatening disease caused by improper absorption and metabolism of glucose. Increased glucose levels can lead to an accumulation of toxic sugar degradation products, such as methylglyoxal (MG), in the bloodstream.… more
Abstract:… to allow transcriptome profiles to be easily and fairly interrogated. Our proposal to develop technology tostudy the transcriptome in an unbiased, high-throughput manner should make future clinical applications a reality and propel research in comparative tissue disease… more
Abstract:… measurements in the clinic. The broader impact of this project will be the accurate measure of small RNAs, and the clinical utility of such a profile. Products of the same microRNA gene that vary in length by one or two nucleotides are involved in a whole host of diseases,… more
Abstract:DESCRIPTION (provided by applicant): Resistance to chemotherapeutic drugs is an ongoing problem that results in eventual treatment failures or suboptimal patient outcomes. Approximately one-quarter of BCR-ABL(+) leukemia patients demonstrate evidence of resistance to imatinib… more
Abstract:Summary Sleep disordered breathing (SDB) is believed to be a widespread, under-diagnosed condition associated with detrimental health problems, at a high cost to society. The current gold standard for diagnosis of SDB is a time- consuming, expensive, and obtrusive (requiring many attached wires)… more
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