Abstract:… measurements in the clinic. The broader impact of this project will be the accurate measure of small RNAs, and the clinical utility of such a profile. Products of the same microRNA gene that vary in length by one or two nucleotides are involved in a whole host of diseases,… more
Abstract:DESCRIPTION (provided by applicant): Resistance to chemotherapeutic drugs is an ongoing problem that results in eventual treatment failures or suboptimal patient outcomes. Approximately one-quarter of BCR-ABL(+) leukemia patients demonstrate evidence of resistance to imatinib… more
Abstract:Summary Sleep disordered breathing (SDB) is believed to be a widespread, under-diagnosed condition associated with detrimental health problems, at a high cost to society. The current gold standard for diagnosis of SDB is a time- consuming, expensive, and obtrusive (requiring many attached wires)… more
Abstract:Thermal injury is common in military conflicts due to primarily to the widespread use of explosive devices. Burns can produce scars that are excessive, physically debilitating and functionally damaging. There is a critical need for an effective product that can control bacterial contamination and… more
Abstract:…ing the viscosity of patient derived sputum using state-of-the-art rheometry. Further we will demonstrate that the reduction in viscosity improves mucociliary clearance by assessing activity on monolayers of ciliated cells. We will also determine appropriate dosing and treatment… more
Abstract:…. G-CSF has a short half-life in humans, which necessitates daily dosing for two weeks or more, and may not optimize therapeutic benefits of the protein for patients. Long-acting G-CSF analogs that do not require frequent dosing could provide significant treatment advantages… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will develop a realtime surface energy sensor that can be integrated into existing surface treatment systems to provide process control feedback. This sensor is based on a rapid microwetting measurement that is… more
Abstract:… regions of change in images of the same scene taken at different times is of widespread interest due to a large number of applications in diverse disciplines. Important applications of change detection include video surveillance, remote sensing, medical diagnosis and treatment… more
Abstract:… others to potential customers for beta testing at sites around the country. These beta testers represent a wide range of potential applications of the new instrument: from monitoring of natural surface water, to contaminated groundwater monitoring, to wastewater treatment… more
Abstract:DESCRIPTION (provided by applicant): Diabetes mellitus (DM) leads to a 3-4 fold higher risk of experiencing ischemic stroke. In addition, DM stroke patients are more prone to develop more and earlier white matter (WM) high-intensity lesions than non DM stroke patients. Treatment… more
Abstract:…ch items and are believed to play a role in the transmission of infectious agents. Reducing the number of microorganisms surviving on clothing and furnishings may be an important route to reducing the number of opportunistic infections. Infections lead to increased treatment… more
Abstract:… prioritize chemicals formore extensive toxicological evaluation, support more predictive models of in vivo biological response, and permit assessment of preadipocytes (derived from human inducible pluripotent stem cells from individuals with different genetic or disease… more
Abstract:… Cell Transplantation (HCT), usually in the form of bone marrow transplantation (BMT). Though long recognized experimentally as a means of inducing DSIT, clinical translation has been limited due to the associated complications. A major problem has been the treatment… more
Abstract:DESCRIPTION: Pulmonary drug delivery is increasingly used for both treatment of lung diseases (such as asthma and chronic obstructive pulmonary disease) and in delivering drugs to the systemic circulation. To reach the desired effectiveness and safety… more
Abstract:… and current medications for diabetic retinopathy are unsatisfactory. Therefore, there is a vital medical need to develop alternate therapies for diabetic retinopathy. This project will develop a novel and more effective approach to improve the treatment of this… more
Abstract:…. In this Phase I research, Chemat has successfully prepared a protean glass which is photosensitive. A pattern such as a 3 5 mm line has been made by exposing the masked glass to UV Arc lamp, and the exposed line becomes semi-conductive. Further heat treatment in inert… more
Abstract:DESCRIPTION (provided by applicant): Obstructive Sleep Apnea (OSA) accounts for millions of people not getting adequate or restful sleep and result in loss of productivity, car accidents, and is recognized as a co-morbidity of COPD and other diseases. Snoring, a typical symptom… more
Abstract:… for thefirst time . In 2009, 1/3 o people older than 12 initiated illicit drug use via non-medical use of prescription drugs . Each year the problem results in more morbidity and mortality (often due to accidental overdose). Office-based opioid treatment (OBOT)… more
Abstract:… for the summative study, the project evaluates the CHPD program using a randomized, active control design of OLIVE-based training vs. OpioidRisk.com that compares change in competency, performance, clinical, and communication skills and improved treatment behavior… more
Abstract:… patients with pain, while 2) decreasing the chance of opioid misuse and diversion. For each iPad EMR simulated pain management case, health professional students will collect data, examine the patient, choose the appropriate course of action, outline a treatment plan, and… more
Abstract:Project Goal/Intended Impact: To improve outcomes of in-treatment addicted patients by providing a virtual reality game as part of a regular health care visit with a health care provider. The game can be played with an off- the- shelf commercially available gaming system… more
Abstract:… recent estimates ~33 million people are living with HIV, with 96% residing in the developing world. While antiretroviral therapy is effective and increasingly available, the standard of care requires periodic monitoring of patients' viral load to individualize treatment… more
Abstract:…inement and coarsening operations, (b) a set of algorithms and corresponding numerical software for performing anisotropic mesh adaptation in general, and isotropic adaptation in particular, (c) a robust, order of accuracy preserving, and computationally efficient treatment of… more
Abstract:DESCRIPTION (provided by applicant): Investigational Safety and Toxicity Studies of Subcutaneous COG1410 for Alzheimer's Disease: A Therapeutic Based upon Apolipoprotein-E That is Not Targeted to Amyloid-Beta Background on Alzheimer's Disease: Alzheimer'sDisease… more
Abstract:… leading cause of foot amputation. DPN, characterized by peripheral axonal degeneration and demyelination, can be disabling and extremely painful, causing significant loss of functional abilities and decreasing quality of life. Currently, the only effectve treatments are glucose… more
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