Abstract:THE GOAL OF THIS PROJECT IS TO DEVELOP A RIBONUCLEASE PROTECTION/MISMATCH ASSAY, WHICH WILL ALLOW THE DETECTION OF ESSENTIALLY ALL SINGLE-BASE MUTATIONS. SUCH AN ASSAY WOULD PROVIDE AN INEXPENSIVE AND WIDELY APPLICABLE METHOD FOR SCREENING FOR GENETIC DISEASES, DETECTING MUTATIONS IN ONCOGENES AND… more
Abstract:USING AN ALTO SAXOPHONE WE WILL DESIGN A BRACKET AND A FRAME SYSTEM UPON WHICH WILL BE MOUNTED A SERIES OF ELECTRO-MECHANICAL SOLENOIDS. THE SOLENOIDS WILL BE MOUNTED OVER THE KEYS ON HALF OF THE SAXOPHONE IN ORDER TO BE ABLE TO OPERATE THE KEYS INDIVIDUALLY OR IN GROUPS. THE SOLENOIDS WILL BE… more
Abstract:RECENT DEVELOPMENTS IN INTERNATIONAL RELATIONS HAVE LED TO THE NECESSITY FOR BATTLE READINESS IN A REGION WHERE CHEMICAL OR BIOLOGICAL WARFARE AGENTS HAVE BEEN EMPLOYED IN THE PAST. AT PRESENT, LITTLE ATTENTION HAS BEEN PAID TO METHODS FOR IDENTIFYING THE CHEMICAL OR BIOLOGICAL CONDITIONS OF FREE… more
Abstract:ONE OF THE MAJOR OBSTACLES TO EDUCATION AND EMPLOYMENT OF INDIVIDUALS WITH SEVERE VISUAL DISABILITIES IS THE INABILITY TO ACCESS VISUAL IMAGES FOUND IN THE EDUCATIONAL SETTING OR REQUIRED FOR SATISFACTORY PERFORMANCE IN THE WORKPLACE. EFFORTS TO PROVIDE ACCESS TO VISUAL IMAGES HAVE INCLUDED… more
Abstract:THE RAPID INCREASE IN WORLD SEAFOOD PRODUCTION BY AQUACULTURAL PROCESSES HAS PLACED A COMPETITIVE BURDEN ON THE UNITED STATES FISHING AND FISH FARMING INDUSTRIES. ECONOMIC PRESSURES HAVE DICTATED THE DEVELOPMENT OF HIGH DENSITY CLOSED-CYCLE AQUACULTURE (HDCCA) UNIT OPERATIONS TO PROVIDE SEAFOOD… more
Abstract:Subsurface corrosion has been implicated in a number of incidents in which aircraft have demonstrated a loss of structural integrity leading to emergency procedures and in one case, the loss of human life. Although several techniques are available to evaluate subsurface corrosion, no method has… more
Abstract:The Air Force has identified a need for more advanced digital control methodologies to make feasible the application of active magnetic bearings to turbine engines. Achieving the goals for enhanced turbine rotor performance necessitates improved bearing control with associated compact size/weight,… more
Abstract:The use of high-temperature laser densification/annealing techniques for enhancing materials surface characteristics has opened new opportunities in material/laser-process diagnostic instrumentation. Important issues in fabrication of reproducible refractory ceramic coating film lies in… more
Abstract:FIBER-OPTIC SENSORS, IN CONJUNCTION WITH FLUORESCENCE SPECTROSCOPY, HAS MANY USES IN BIOCHEMISTRY, IMMUNOASSAYS, AND CLOSED-AQUACULTURE SYSTEMS. THE USE OF IN SITU FLUORESCENCE MEASUREMENT DURING FIELD TESTS IS HAMPERED BY THE PHYSICAL LIMITATIONS OF SPECTROMETERS RELATED TO THEIR SIZE, WEIGHT, AND… more
Abstract:NIAAA has identified the need for education materials which facilitate the training of health professionals and paraprofessionals in the use of various alcoholism assessment techniques and instruments. In response to this need, we will develop a icon-based courseware for alcoholism appraisal… more
Abstract:The objective of this contract is to develop monitoring technology to accurately screen patients on an outpatient basis by monitoring physiologic variables capable of indicating whether or not there is a need for future, more costly, sleep disorder testing. The Contractor shall perform the following… more
Abstract:The National Institute of Child Health and Human Development has identified the need for programs to delay the onset of sexual activity among adolescents and to increase contraceptive protection of the adolescents who are sexually active. In response to this need, we will develop a hypermedia-based… more
Abstract:Simulation provides a means of duplicating the operating environment of a topic of interest in a laboratory setting, but the environment itself is rarely the topic of interest. Providing the simulated environment requires access to personnel with expertise in the environment but without expertise in… more
Abstract:Sickle cell anemia is an inherited disorder of erythrocytes characterized by chronic anemia, recurrent pain, susceptibility to infections, chronic and recurrent organ dysfunction, and diminished life-expectancy. Even among patients having documented homozygous sickle cell anemia (Hb SS), there… more
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