Abstract:Three areas of research on low cost, reliable, folding aero surfaces will be conducted. First, different types of fin deployment and flight control actuators will be examined. These include conventional fin actuators, shape-memory-alloy, piezoelectric, magnetostrictive, and electrostrictive… more
Abstract:The vibration signatures (mechanical, acoustic, and electromagnetic) produced by machine components may be used for machinery diagnostics. By regularly measuring vibration levels, defects can be detected and diagnosed before causing extensive damage or failure, a process known as predictive… more
Abstract:The position control of aircraft is inherently a two-point boundary-value problem, and aircraft rate and attitude control are desirably treated as such. The aircraft maneuvers from an initial state vector at a given initial time to a final state vector at a given or optimiized final time. The final… more
Abstract:The Phase I research effort will identify candidate glass compositions suitable for drawing useable fibers for delivery of 3 micron laser radiation for medical procedures. The goal of a biocompatible, low loss, high laser damage threshold, sterilizable, flexible, thermally stable fiber, with good… more
Abstract:A CRITICAL NEED EXISTS FOR A DIAGNOSTIC INSTRUMENT TO MEASURE THE ENERGY DISTRIBUTIONS AND DENSITIES OF CONFINED ENERGETIC ION COMPONENTS IN DEUTERIUM-TRITUIM (D-T) BURNING FUSION TOKAMAKS (E.G., CONFINED ALPHA-PARTICLES WITH 3.5 MEV BIRTH ENERGY). COLLECTIVE THOMSON SCATTERING (CTS) IS RECOGNIZED… more
Abstract:THIS PROJECT ADDRESSES THE PROBLEM OF DEVELOPING A NOVEL, SEALED, SOURCE OF 14 MEV NEUTRONS WHICH CAN OPERATE AT HIGH OUTPUT FLUX WITH LONG LIFE. THE MULTIPLE-ROD ANODE NEUTRON SOURCE (MRANS) USES A SIMPLE COLD-CATHODE PLASMA GENERATOR COMBINED WITH A MULTIPOLE MAGNETIC FIELD AND A DISTRIBUTED ION… more
Abstract:This is part of a program to develop gene medicines for treatment of dermatoses such as psoriasis. We will utilize a novel DNA expression vector (HK1) capable of directing high-level tissue-specific expression from keratinocytes in the epidermis. The HK1 vector contains transcription and translation… more
Abstract:THIS PROPOSAL ENCOMPASSES A NEW TECHNOLOGICAL IDEA. THIS IDEA IS BASED ON A PATENTED WORKING OPTICAL BACKPLANE TECHNOLOGY WITHOUT FIBEROPTICS. PROJECT ENGINEERS THROUGHOUT THE U.S. HAVE LONG SOUGHT AFTER A REPLACEMENT FOR COMPLEX, UNRELIABLE MATRIX SWITCHING. THIS TECHNOLOGY ELIMINATES ALL RELAY… more
Abstract:THE PRIMARY OBJECTIVE OF THIS PROJECT IS TO DEVELOP NEW SOFTWARE TOOLS THAT UTILIZE LASER GRAPHICS TO HELP THE CLINICAL INVESTIGATOR PERCEIVE SIGNIFICANT INFORMATION IN STUDY DATASETS. THE FIRST STEP, IN PHASE I, IS TO IDENTIFY GRAPHICAL DATA VISUALIZATION TECHNIQUES SUITABLE FOR CLINICAL DATA, TO… more
Abstract:THE PRINCIPAL OBJECTIVE OF THIS PROJECT IS TO SPECIFY, DESIGN AND DEVELOP NEW COMPUTER SOFTWARE TOOLS TO PROVIDE IMPROVED DATA MANAGEMENT AND ANALYSIS SUPPORT TO THE CLINICAL RESEARCH PROCESS. THE PROJECT WILL USE TWO MAJOR NCRR-SPONSORED RESOURCES; THE GENERAL CLINICAL RESEARCH CENTERS AS A SOURCE… more
Abstract:THE OBJECTIVE OF THIS PROJECT IS TO DEVELOP, WITHIN THE CONTEXT OF THE PROPHET II SYSTEM, POWERFUL NEW DATA VISUALIZATION SOFTWARE TO ENHANCE THE ABILITY OF THE BIOLOGIAL SCIENTIST TO PERCEIVE AND COMMUNICATE SIGNIFICANT INFORMATION IN DNA AND PROTEIN SEQUENCE DATA. PHASE I OF THE PROJECT FOCUSES ON… more
Abstract:Our goal is to develop a new data collection technology for clinical trials that can reduce the effort needed to gather clinical research data and improve the timeliness and quality of the data. The technology is based on an integrated approach that uses the familiar case report form model to… more
Abstract:The goal of this research is to develop a new interactive software tool, called ClinTrans, to assist biostatisticians in transforming and combining clinical data in preparation for data analysis, data interchange, and cross-study pooling. Presently, the process of data preparation often requires… more
Abstract:A feasibility study of a new route to the formation of crystalline films of the ferroelectric LiNbO3 is proposed. Two aspects of the proposed route are unique in themselves and, combined, should permit the development of a low temperature, scalable production process, to make electronic grade LiNbO3… more
Abstract:Ice accretions on helicopter rotor blades occur as a result of the impact of supercooled water particles on the surface. Supercooled water particles are in an unstable state. Means are sought to "trip" these particles into ice crystals or amorphous snow so that the particles will not adhere to the… more
Abstract:THE PRINCIPAL OBJECTIVE OF THIS PROJECT IS TO DETERMINE THE TECHNICAL FEASIBILITY OF DEVELOPING A DRUG-RELEASING IMPLANTFOR TREATMENT OF ALCOHOLISM. SPECIFIC AIMS DURING PHASE I ARE TO DEVELOP PROTOTYPE IMPLANTS THAT RELEASE DISULFIRAM METABOLITES AND TO TEST THE EFFICACY OF THESE IMPLANTS IN RATS.… more
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