Abstract:We will test a new approach to management of malignant pleural effusions (MPE) based on chemotherapintrapleural administration of AD 32 rather than pleurodesis. There are about 100,000 cases p.a. ofcauses significant morbidity in patients with advanced malignancies. MPE is currently treated… more
Abstract:In the fabrication of many electronic and opto-electronic products, such as multichip modules (MCMs), flat-panel displays (FPDs) and printed circuit boards (PCBs), it is necessary to fabricate millions of microscopic structures on a single large substrate. Large format manufacturing equiptment,… more
Abstract:APA Optics will develop a monolithic UV seeker for use in flame sensing and passive or tactical threat warning systems. The key to the technical approach is the deposition of high optical/electrical quality Al(x)Ga(1-x)N over GaAs substrates and using it to fabricate back to back Schottky barrier… more
Abstract:We propose a six month Phase I program to demonstrate the feasibility of growing A1N single crystals to serve as substrates for subsequent A1xGa1xN epitaxy. Our approach is to use a low pressure, high temperature (>>2000oC) furnace with a temperature gradient between the A1N charge and the… more
Abstract:High voltage semiconductor devices have found important applications in the areas of high power generation, power control, power conversion, surge protection, and industrial electronics. However, GaAs or Si based high voltage device are limited by a relatively low intrinsic breakdown voltage and… more
Abstract:We propose a six month Phase I research program aimed at developing compliant substrates for the epitaxy of GaN and AlGaN films. We present two alternate approaches one with silicon and the other with GaAs as the starting substrate material and a unique multilayer structure to be deposited using low… more
Abstract:THE END OF THE COLD WAR HAS SWITCHED THE FOCUS FROM BUILDING WEAPONS OF DETERRENCE TO MINIMIZING THE CHANCES FOR THE USE OR PROLIFERATION OF NUCLEAR WEAPONS. THUS, ARMS CONTROL VERIFICATION AND THE CAREFUL MONITORING OF THE NUCLEAR NON-PROLIFERATION TREATY ARE ESSENTIAL COMPONENTS OF ANY… more
Abstract:NUMEROUS COMPOUNDS SHOWING ANTINEOPLASTIC ACTIVITY HAVE BEEN IDENTIFIED IN THE ORGANIC SOLVENT EXTRACTS OF PLANT MATERIAL, MICROORGANISMS, AND MARINE ORGANISMS. FURTHER INVESTIGATION INTO THE UTILITY OF THESE COMPOUNDS AS CHEMOTHERAPEUTIC AND ANTI-HIV AGENTS HAS BEEN HAMPERED BY THEIR LOW NATURAL… more
Abstract:This Phase I effort will investigate the feasibility of basic concepts for a hillside straddle tractor. A true straddle tractor for tall crops on hillsides does not currently exist. This straddle tractor, the Smart Mountain Mule (SMM), will be designed as a tool for Christmas tree farms in hilly… more
Abstract:Crystallization of membrane-proteins has been a difficult problem because of their peculiar physiconature. We will develop detergents that closely mimic the biological milieu inhabited by membrane prdetergents are expected to form large micelles; thereby, allowing the formation of larger, and… more
Abstract:We have described a new technology called "preparative in situ hybridization (Prep-I.S.H.), which is capable of isolating a set of cDNA or genomic clones according to their chromosome location. The technology takes advantage of in situ hybridization of cloned DNAs to metaphase chromosome spreads,… more
Abstract:Our research decribes a strategy for producing a high density set of PCR-base microsatellite markerpolymorphic in L5178Y, the cell line used in the mouse lymphoma assay (MLA). These polymorphic marketwo detailed long range restriction maps in the vicinity of the thymidine kinase (tk-1) gene, with… more
Abstract:This proposal describes a set of reagents which will make gene mapping to chromosomes and chromosomas well as gene finding exercises, accessible to any molecular biologist or geneticist familiar withtechniques. These reagents, called the Gene. ID system, are a set of "dot-blots". The "Chromosome… more
Abstract:We propose using new molecular techniques to survey the spectrum of mutagenic events occurring at tL5178Y cells. We will compare this spectrum with the range of abnormalities occurring in human cancemouse lymphoma assy (MLA) as an accurate reflection of events of human significance. Specifically… more
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