Abstract:THE REQUIREMENTS OF COMPLEX SAMPLE MONITORING PRESENT A GROWING NEED FOR A NEW GENERATION OF HIGHLY SPECIFIC ENZYME ELETRODES WITH MULTI-ANALYTE, MULTI-SIGNAL CAPABILITY. THIS PROJECT'S OBJECTIVE IS TO ESTABLISH THE FEASIBILITY OF NOVEL ELECTROCHEMICAL SENSORS BASED ON THE COMBINATION OF… more
Abstract:At this time it is very difficult to distinguish viral infections from bacterial infections. Published results suggest that some subtypes of interferon-alpha (INF-a) are present in viral infections and are not detected in bacterial infections but no clinically useful assay for this potential marker… more
Abstract:The requirements of complex sample monitoring present a growing need for a new generation of highlyenzyme electrodes that operate in non-processed or raw samples and have multi-analyte capability. This to establish the feasibility of novel colloidal gold/immobilized enzyme based raw… more
Abstract:Periodontal disease is a common problem affecting many Americans today. Earliest indicationof periodontal disease in change in bone and tissue mass. Both assessment of bone support and thedetection and measurement of small changes in bone and soft tissues are fundamental tot he intraoralexamination.… more
Abstract:Despite advances in other techniques, standard X-ray transmission film mammography is by farthe most common clinical diagnostic tool for detecting breast cancer. Unfortunately, the spatialresolution of mammograms taken with existing systems is still below that needed to allow visualizationof the… more
Abstract:Radioactive labeling of proteins using tritium is a very important technique used in neurological ridentify, isolate, and investigate the expression of proteins in biological systems. It is often necradiolabel for this work because 3H in vivo labeled proteins retain their conformal structure and… more
Abstract:Radioactive labeling of proteins using tritium is a very important technique used in neurological ridentify, isolate, and investigate the expression of proteins in biological systems. It is often necradiolabel for this work because tritium in vivo labeled proteins retain their conformal structure… more
Abstract:We will systematically examine whether complement activation plays a significant role in theplatelet storage lesion (PSL). The goals of the project are four-fold: (1) to assess the etiology of PSL bydepleting complement factor 8 from platelet storage plasma; (2) determine if monoclonal… more
Abstract:The inactivation of retroviral vectors derived from murine cells in human serum represents a formidmany potential applications of in vivo retroviral-mediated gene therapy. We have recently demonstratof amphotropic retroviral vector particles in human serum is primarily mediated by complement… more
Abstract:SIV infection of rhesus macaques serves as a valuable model for HIV infection in humans. Both virusthrough the CD4 T-lymphocyte receptor and are infectious and cytopathic for CD4+ T-lymphocytes and mviruses are genetically closely related: SIV shares approximately 50 percent homology with HIV-1… more
Abstract:A manufacturing process for the Vertical Cavity Surface Emitting Lasers (VCSELs) will be developed based on real time in situ monitoring and control. A fundamental challenge in spurring the wide acceptance of VCSELs lies in the development of a high yield crystal growth process. The study will focus… more
Abstract:Hypercholesterolemia constitutes a major risk factor for cardiovascular disease, the leading causeAmerica. Among the lipid-lowering therapeutics, non-systemics are frequently preferred over systemicassociated with fewer potential side effects. However, even the present non-systemics have… more
Abstract:The introduction of a whole new class of transform methods, notably the wavelet transforms, which permit decomposition of observed phenomena into different physical scales and the computational leverage provided by multiscale image processing tech- niques, when applied to multisensor Lmage data,… more
Abstract:THIS PROPOSAL WILL REFINE RECENT STABILITY-ROBUSTNESS AND PERFORMANCE-ROBUSTNESS METHODS FROM MULTIVARIABLE FEEDBACK CONTROL THEORY AND USE THESE CONCEPTS TO DEVELOP PRACTICAL TESTING TECHNIQUES, AND EVENTUALLY TESTING HARDWARE, FOR EVALUATING PERFORMANCE PROPERTIES OF ADAPTIVE OPTICS SYSTEMS. THE… more
Abstract:THE OBJECTIVE OF THIS RESEARCH IS TO DETERMINE THE FEASIBILITY OF USING ADVANCED PETRI NET TECHNOLOGY TO ANALYZE THE PERFORMANCE OF LARGE-SCALE C3 SYSTEMS. THE US AIR FORCE IS UNDERGOING A MAJOR RESTRUCTUTING OF ITS FORCES IN RESPONSE TO THE CHANGING GLOBAL SITUATION AND THE RESULTING SHIFT IN… more
Abstract:Under the performance levels currently achievable for automated target-recognition (ATR) systems, the human operator plays an essential role in screening ATR detections and rejecting false alarms. A critical advantage of human operators over ATR systems is their ability to make use of situation… more
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