Abstract:DESCRIPTION (Provided by the Applicant): The specific aims of the proposed
Phase II program are to design, fabricate, and test in the prostates of dogs an
improved instrument for hyperthermia treatments of localized prostate cancer.
The instrument will use two cooperating… more
Abstract:DESCRIPTION (Provided by the Applicant): The specific aims of the proposed
Phase II program are to design, fabricate, and test in the prostates of dogs an
improved instrument for hyperthermia treatments of localized prostate cancer.
The instrument will use two cooperating… more
Abstract:DESCRIPTION (Adapted from Applicant's Abstract): The long-term objective of
this program is to improve the efficacy of hyperthermia treatments for patients
with superficial skin diseases that cover large areas overlying contoured
anatomies, such as chestwall recurrence of… more
Abstract:The eventual goal of the current research is to develop probes for in vivo imaging of gene expression and for in vivo targeting of cells for killing or remediation. The current proposal describes a novel nucleic acid probe design that will provide the basis of the new technology required for these… more
Abstract:DESCRIPTION (Adapted from the application): Deep-seated mycoses are being
increasingly observed in immunocompromised patients and in patients receiving
aggressive cancer chemotherapy. The use of available drugs for the treatment of
these infections is limited by toxicity and… more
Abstract:Currently, dry-powder inhalers (DPI) are used to deliver various drugs to the lungs for localized or systemic delivery. Although current inhaled formulations are adequate for pulmonary drug therapy under normal gravity, inhalation therapies on earth and potentially in space are plagued by low… more
Abstract:Currently, dry-powder inhalers (DPI) are used to deliver various drugs to the lungs for localized or systemic delivery. Although current inhaled formulations are adequate for pulmonary drug therapy under normal gravity, inhalation therapies on earth and potentially in space are plagued by low… more
Abstract:Perfluorocarbons (PFCs), known greenhouse gases, are used widely in semiconductor manufacturing. Several options for reducing the emissions of PFCs are being considered, including: (1) optimizing the process; (2) reducing the nonproduction operation of the fabrication tool; (3) recovering and… more
Abstract:Disturbances in the earth's ionosphere can affect systems that rely on trans-ionospheric RF propagation. Validated DoD needs for real-time monitoring of ionospheric weather are not being met by current remote sensing techniques. Our proposal supportsdevelopment of an ionospheric imaging instrument… more
Abstract:Aircraft coatings are complex systems consisting of metal/conversioncoat-primer interface, primer coat, and topcoat. Degradation is caused by synergistic mechanical and chemical/environmental effects. This phase I proposal focuses on modeling the chemicaldegradation of the coating system due to UV… more
Abstract:. The proposed innovative research will provide an advanced stochastic framework for developing an integrated risk-based condition assessment and life prediction-analysis system for a cost effective maintenance system for aircraft components. Corrosionfatigue is a key damage mechanism. Based on the… more
Abstract:By exploiting the unique properties of single-crystal peizoceramic, STI will develop a new class of device for suppression of structural vibration. The proposed device, a frequency agile vibration absorber (FAVA), will be compact, robust, and demandminimal power for operation. Unlike today's… more
Abstract:OmniSite BioDiagnostics Inc. (OmniSite) proposes to aid in the field diagnosis of soft tissue injuries of DOD troops by development of DNA aptamer-based assays for protein markers and hydroxylated amino acids in diluted whole blood. DNA aptamers arenovel, inexpensive replacement reagents for… more
Abstract:OmniSite BioDiagnostics, Inc. (OmniSite), with Dr. Richard Lagow of the University of Texas at Austin, plan to develop a polymer electrolyte membrane (PEM) fuel cell based on microelectromechanical systems (MEMS) technology. Micromachining of silicon willbe used to prepare microelectrode array… more
Abstract:OmniSite BioDiagnostics (OmniSite) proposes to continue development of DNAaptamers to early ice crystal nuclei by Systematic Evolution of Ligands byEXponential enrichment (SELEX), which will be used to prevent damage tohuman red blood cells (RBCs) during lyophilization, thereby increasing the… more
Abstract:OmniSite BioDiagnostics (OmniSite) proposes to continue development of DNAaptamers to early ice crystal nuclei by Systematic Evolution of Ligands byEXponential enrichment (SELEX), which will be used to prevent damage tohuman red blood cells (RBCs) during lyophilization, thereby increasing the… more
Abstract:The objective of this Phase II research is to develop and test prototype mobile and portable Tagnite units to be used to selectively apply Tagnite anodized coatings to magnesium surfaces after final machining by the OEM and during the overhaul phase of thecomponent at the field and depot level.… more
Abstract:The high specific impulse and efficiency of ion propulsion thrusters has increased the popularity of these devices for a growing number of proposed missions, such as planetary and deep space, longer station keeping mission lifetimes, and tighter geosynchronous orbit tolerances. Grid erosion is one… more
Abstract:Substantial improvements in weight reduction, strength, modulus and wear resistance are essential in meeting the design criteria for the next generation of aircraft, spacecraft, and missiles. CCI proposes the development of a one step, low-costfabrication process for a novel AlB2 in-situ reinforced… more
Abstract:The next generation of rocket propulsion thrusters will be required to be lighter, and provide higher thrusts with no increase in the cost of manufacturing. The fabrication of a very light weight propulsion systems is proposed through the integration of alight weight ceramic injector with a ceramic… more
Abstract:The proposed research effort focuses on developing a method to synthesize and crystallize doped YAG to produce textured or single crystal fibers that exhibit little degredation in strength and excellent creep resistance at temperatures in excess of 1400C.YAG will be synthesized from polymerized sol… more
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